| Patton, Brooke |
Matthews, Sarah |
Global Relationships Through Service
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Abstract Text
I am studying International Business and Marketing and a minor in French with a European concentration. I am in the Responsible International Leadership cohort, a program that USC has with ESSEC Business School (Cergy, France). The RIL Cohort program focuses on leadership in a global context and emphasizes understanding societal and environmental impacts, sustainability, and ethical obligations in business analysis and decision-making, which are critical skills for business leaders in tomorrow’s global world. I was one of five students selected to be a part of the RIL 2 program, and we spent the year 2022 studying at ESSEC. I completed coursework in areas such as people and organizations, socially responsible marketing, globalization and business, business ethics, leading teams, and French. Between my studies and program requirements, I completed a field experience as a live-in volunteer at L’Arche, a community specializing in aiding handicapped adults. My time at L’Arche was profoundly rewarding as I built genuine, personal connections with its remarkable residents and staff. The connection between my volunteer experiences and my classes both at the University of South Carolina and ESSEC has provided me with the following key insights:
In today’s world, where quick judgments and labels are often passed without truly understanding the depths beneath the surface, embracing kindness has become my guiding principle. Kindness is not merely a virtue but a force that has the potential to bridge divides and foster a more compassionate and inclusive world.
The experience I had through global learning, was instrumental to my education and career, and ultimately in shaping me into a better global citizen.
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9:30-11:00 a.m.
Exhibit Hall (CMCC lower level) |
Poster: 242
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| Allen, Amelia |
Pate, Leigh
Dawson, Robin |
Skin Cancer Prevention Knowledge and Behaviors Among Health-Sciences Majors
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Abstract Text
Though skin cancer is the most common form of cancer in the United States, it is also considered one of the most preventable. By adopting habits to reduce ultraviolet (UV) ray exposure, an individual’s risk of developing skin cancer is greatly decreased, especially if these habits are initiated early and maintained throughout one’s life. For this reason, college students have a particular need to understand the importance of and correct implementation of these behaviors, especially those who are preparing for a career in health sciences. The purpose of this study was to explore health-sciences majors’ current knowledge and behaviors regarding skin cancer and prevention. This was a descriptive, concurrent mixed-methods study; data included quantitative survey responses and qualitative open-ended questions. Data integration involved mapping quantitative descriptive results to themes revealed by thematic analysis of qualitative data; comparative statistics examining differences between majors and year in school were also generated. Participants included 188 students representing 11 majors. There was no significant increase in student knowledge as year in school increased and minimal significant differences in knowledge among majors. Student behaviors were categorized into three themes: prioritization, knowledge, and conformity to societal expectations. 85% of responses noted prioritization as a key factor and others indicated that time, cost, discomfort, and heat prevented them from prioritizing skin cancer prevention. It is imperative that educators and healthcare providers address shortcomings in skin cancer education, along with community health initiatives to slow the rate of skin cancer. Attempts to educate young adults should focus on cessation or alteration of tanning behaviors along with prioritization. Further research and education should focus on student knowledge deficits to increase knowledge of the consequences of UV exposure and the importance of skin cancer prevention.
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1:00-2:30 p.m.
Exhibit Hall (CMCC lower level) |
Poster: 156
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| Wu, Xuanke |
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Electrifying Middle-Mile Truck Fleets with Minimal Infrastructure Requirements
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Abstract Text
Range anxiety has been a significant limitation in the electrification of ground freight fleets, particularly for middle-mile and long-haul electric trucks that heavily rely on highway-side charging facilities. In this paper, we propose a novel electric truck operations model that incorporates trailer battery exchange strategies to reduce the dependence on constructing charging infrastructure along highways. An operator manages two types of vehicle fleets with the objective of minimizing the total operational cost: (1) Trucks comprise an electric tractor and a trailer that may be equipped with backup batteries; (2) Feeder vehicles that distribute electric trailers at exchange locations. Trucks that drain out batteries can detour to these exchange locations and replace charged trailers to save charging times. The planning problem of this electric truck network is a location-and-routing problem that can be reformulated as a bi-level program, where the upper level seeks the optimal locations for exchanging trailer. and lower level is a Mixed Integer Program (MIP) for mixed fleet routing. We conduct computational experiments using the real-world Freight Analysis Framework (FAF) data in the Southeastern United States. Our results demonstrate that this novel network design can significantly enhance operational efficiency compared to traditional battery recharging methods, such as battery swapping stations, while reducing the demand for constructing new charging facilities. Moreover, our analysis provides detailed insights into how to choose between various electric truck operation strategies.
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1:00-2:30 p.m.
Columbia Ballroom (CMCC upper level) |
Poster: 227
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| Pace, Sarah |
Owens, Shaun |
AFRICAN AMERICAN OLDER ADULTS’ PERCEPTIONS OF THE ROLE OF TECHNOLOGY IN REDUCING LONELINESS
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Abstract Text
American older adults, a population where over a quarter experience loneliness, which is associated with a 26% increased risk of premature death rates (Holt-Lunstad, 2015). The study seeks to understand how this demographic perceives the role of technology in reducing feelings of loneliness and to identify the barriers and facilitators influencing their use of technology. With the U.S. Surgeon General, Vivek H. Murthy, M.D., calling for immediate attention to the "epidemic of loneliness and isolation," the research highlights the potential of technology, such as video calls, phone calls, messaging, and social media platforms, to reduce loneliness.
Despite the increasing use of technology across diverse populations, a digital divide persists due to social determinants like race, age, economic status, and infrastructure, leading to disparities in technology access and literacy. Prior research has largely focused on predominantly White participants, leaving a gap in understanding the experiences of African American older adults. This dissertation aims to fill that gap through semi-structured interviews with a convenience sample of 15 individuals, analyzed using thematic analysis.
The anticipated findings are expected to contribute to the development of targeted interventions that can leverage technology to enhance social connections and support for African American older adults, addressing a significant public health challenge.
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1:00-2:30 p.m.
Columbia Ballroom (CMCC upper level) |
Poster: 19
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| Strmel, Mallory |
Polley, Jeremy |
From Classroom to Boardroom: Cultivating Passion Through the Marketing Scholars Program
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Abstract Text
The thrill of uncovering new possibilities, solving challenges, and experiencing those "Aha!" moments has always existed within me; but it was the Marketing Scholars program that allowed me to go after that excitement and responsibility. The program only selects ten students per year to participate in a client-facing brand project, acting as a real agency to solve a client problem. When I was selected to be a member of the Fall 2023 cohort, I had done marketing internships and projects before, but not to this scale. Along with my team, we learned “through fire” how to create an integrated marketing plan, work efficiently with clients (even when their expectations are not what the consumer wants), set and achieve goals, run productive meetings, and effectively convey both the message and values of a brand. Through my Scholars experience, I learned what it means to “own a brand” and establish myself as a leader while working with an equally passionate team. With this knowledge, I am now confident in my ability to guide and motivate my peers toward achieving our common objectives. The project has allowed me to pursue personal passions as well, such as art direction via can design and web mockups as well as finding consumer insights through data. But the process of discovery and all the “Aha!” moments along the way showed me that I really did have a passion for finding the Why behind everything, and how to share that passion with a client. With my experience in Fall 2023, I was honored to come back to the program in Spring 2024 and complete a film marketing project with Lionsgate. Rather than shying away from the challenge of a Lionsgate project, I welcomed the adversity and risk with open arms. I am eager to channel this passion into tangible results, both for the program and as a foundation for my future endeavors in creative consulting. I have never been known to back away from a challenge, and the challenges encountered as a Marketing Scholar have been the most rewarding of my college experience.
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9:30-11:00 a.m.
Exhibit Hall (CMCC lower level) |
Poster: 275
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| Solorzano, Jazmine |
Matthews, Sarah |
Cultural Exchange and Community Empowerment: Insights from Les Mureaux, France
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Abstract Text
In May 2022, I was a volunteer at Les Rocher Oasis des Cités in Les Mureaux, France. Les Mureaux is a city heavily populated by immigrants. Les Rocher is an organization of community centers that focus on bridging the gap between the old lives of these immigrants and their new lives in France. I participated in this experience because the school where I studied abroad requires students to complete a month long field experience. The reasoning for this is so their students have the opportunity to make connections with people and see how different communities are affected by different factors, and not just how to send emails and answer phone calls at a job.
During this month-long experience I lived in Les Mureaux and participated in many different activities. I participated in homework help and games with younger kids, morning coffee with the ladies of the community, home visits to the elderly, and other community building activities.
During this time, I learned how a strong sense of community is important for somebody going through a transition as big as immigrating to a new country. In French 309: Reading French Texts, we learned about cultural adaptation, illustrated through the stories of immigrants. The people I interacted with during my experience shared the common story of having to start a new life in a new place. Though I learned stories like these in my class, I started to truly understand what it was like by seeing it first hand while volunteering at Les Rocher. The support that these community members had for each other, always willing to help or simply be a listening ear, made me want to be a supportive part of my community as well. It may not be something as big as immigrating to a new country, but there is always someone around you that might be going through the same things as you and being there for each other can be more powerful than one can imagine.
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9:30-11:00 a.m.
Exhibit Hall (CMCC lower level) |
Poster: 235
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Davis, Michael
Arora, Aastha |
Flach, Alicia |
Capturing Physical Activity, Symptom Presence, and Severity in People with Parkinson Disease in Real-Time: A Pilot Study
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Abstract Text
Physical activity (PA) has been shown to positively impact the frequency and severity of non-motor symptoms experienced by people with Parkinson’s Disease (pwPD). The purpose of this study was to determine the relationship between severity of non-motor symptoms (pain, fatigue, depression, and cognitive difficulty) and physical activity in pwPD. Fifteen pwPD completed seven days of remote PA monitoring (via accelerometer) while simultaneously rating presence and severity of non-motor symptoms five times per day. Spearman’s r was used for analysis. Significant correlations (p ≤ 0.05) were found between increased fatigue and increased age (rs=0.611), increased cognitive difficulty (rs=0.576) and increased pain (rs=0.604). Additionally, increased age was significantly correlated (p ≤ 0.05) with increased levels of pain (rs=0.537), between increased cognitive difficulty and increased levels of depression (rs=0.557), and with increased self-report PA with decreased severity of depression were found. No correlations were found between measured PA and pain (rs = -0.495), fatigue (rs=-0.416), depression (rs=-0.372) or cognitive difficulty (rs=-0.171). While the presence of non-motor symptoms was not found to be related to measured PA in pwPD, the presence of non-motor symptoms was found to be correlated with other non-motor symptoms. Further research is indicated for determining associations between non-motor symptoms and quality of life in pwPD.
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9:30-11:00 a.m.
Exhibit Hall (CMCC lower level) |
Poster: 145
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| Joseph, Mia |
Pena, Marj |
Effects of Pediatric Antibiotics on Incidence of Early Onset Colorectal Cancer
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Abstract Text
Early onset colorectal cancer (EOCRC) is the third leading cause of cancer deaths in patients under fifty years old in the USA. Several environmental factors may be correlated with the rise of EOCRC. Specifically, the increasing incidence of EOCRC over the past four decades parallels the increased use of antibiotics (Abx) globally. Abx revolutionize our ability to fight infections; however, its overuse has become a public health concern. Abx alters the gut microbiome (dysbiosis), leading to increased inflammation in the colon and increasing the risk of developing EOCRC. Previous studies in mice demonstrate that exposure to Abx at an early age (5-days old) to two commonly prescribed classes of Abx (beta-lactams and macrolides) altered the gut microbiota and predisposed mice to inflammation, immune disease, and obesity, which have been linked to colorectal cancer. The impact of Abx on the microbiota and the distal colon, where EOCRC occurs, and incidence of EOCRC have not been studied before. Thus, we proposed that early life exposure to Abx will cause dysbiosis that leads to faster, more frequent, and more aggressive tumors as compared to Abx exposure later in life. There are two separate studies that comprise this project. First, female A/J mouse models were exposed to multiple doses of Abx to observe the changes to the microenvironment of the colon. The results from this experiment prompted us to question if there is a developmental window of susceptibility to Abx which increases the risk of developing EOCRC. Next, exposure to Abx at the perinatal age (0-2 weeks of age) was examined using mouse models. Five-day old pups were exposed to Abx for seven days through their mother’s milk by administering Abx to nursing mothers. To induce tumor formation, the mice were injected with carcinogen after Abx exposure. We expect to see a developmental window of time where the colon is susceptible to dysbiosis, and changes in the microenvironment in response to Abx exposure will predispose mice to developing EOCRC. If proven, it will be important to implement probiotic supplementation after exposure to antibiotics in infancy and childhood to normalize the gut microbiome.
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9:30-11:00 a.m.
Exhibit Hall (CMCC lower level) |
Poster: 42
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| Tindall, Julisa |
Browne, Teri |
Judge Me Not: Exploring Black Mothers’ Perceptions of Maternal Health Services and Structural Racism in South Carolina
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Abstract Text
The United States has the highest maternal mortality rate among developed nations, with significant racial disparities. Black women suffer disproportionately, facing two to three times higher risks of pregnancy-related complications and severe disability than White women. In South Carolina, Black women and women of other races/ethnicities experienced 2.4 times higher mortality rates than White women. This research project aimed to address a crucial gap in understanding the lived experiences of Black mothers in the Southern United States, particularly in relation to the impact of structural racism on maternal health outcomes. Specifically, this qualitative study explored Black women’s perceptions of maternal health services and structural racism in South Carolina.
Data was gathered through semi-structured interviews with a purposive sample of 20 Black mothers in South Carolina, focusing on their experiences throughout the perinatal period. The study utilized Critical Race Theory and Black Feminist Thought to frame and analyze these experiences, with a focus on how structural racism shapes Black women’s interactions with healthcare systems. Using grounded theory analysis, preliminary results suggest that Black mothers’ perceptions of maternal health care in South Carolina are deeply influenced by their experiences of navigating structural inequities within the healthcare system. These experiences are shaped by a complex interplay of personal advocacy, regional disparities, provider biases, and systemic challenges, all of which are underpinned by underlying issues of structural racism. This understanding is further varied by individual differences in support systems and financial situations.
Overall, this project hopes to inform future research on this public health crisis in the Southern United States and nationally. Understanding the relationship between structural racism and maternal health outcomes is key to building collaborations between social work and other health-related disciplines working to reduce maternal morbidity and mortality. Furthermore, social workers can play a pivotal role in healthcare organizations to improve their typical practices to avoid the impacts of
structural racism.
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1:00-2:30 p.m.
Columbia Ballroom (CMCC upper level) |
Poster: 21
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| Bratnichenko, Vera |
McDonnell, Karen
Wirth, Michael |
Colorectal cancer: Adherence factors
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Abstract Text
Background/Significance
Colorectal cancer (CRC) is the second leading cause of cancer-related death in the U.S. In 2023, over 150,000 will be newly diagnosed with CRC and over 52,000 individuals will die. More than half of these cases will be attributed to causes that could have been detected with screening, like precancerous polyps. Adherence to CRC screening significantly decreases morbidity and mortality of the disease.
Purpose
The purpose of this study was to compare cancer screening adherence among individuals with and without health insurance, along with urban/rural status, using nationwide survey data.
Methods
A secondary analysis of the 2021 Behavioral Risk Factor Surveillance Survey was conducted. The sample included 7,472 total cases, male and female, over the age of 45. Logistic regression was used to estimate the odds of completing a CRC screening, using health insurance and urban/rural residence as the variables.
Evaluation
Gender and urban/rural residence were not significant when looking at CRC screening adherence. The odds of CRC screening adherence with an endoscopy was 20%, CI [.151, .265], higher with the presence of health insurance. The odds of CRC screening adherence with a stool test was 46.9%, CI [1.057,2.042], if living in an urban area. Insurance status and gender were not factors in stool testing adherence.
Discussion
Health insurance contributes to completing CRC screening with a sigmoidoscopy or colonoscopy. Urban residence accounted for higher adherence rates versus rural residence with stool tests. More research needs to be done to explore access to CRC screening for those who do not have health insurance and who live in rural areas.
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9:30-11:00 a.m.
Columbia Ballroom (CMCC upper level) |
Poster: 1
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| Harrison, Ashlyn |
Harrison, Theresa |
Working as a Professional While Playing Like a Kid
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Abstract Text
The summer after my freshman year of college, I had the opportunity to work as a senior cabin counselor at an overnight summer camp. I attended summer camp from a young age, and I had always dreamed of working as a camp counselor. When I was presented with the opportunity to work at Camp Highlander, I was excited to work somewhere that provided me with the opportunity to gain professional experience in a unique way. Working at Camp Highlander is not like working a typical job, you are responsible for leading your campers and constantly participating in different activities, leaving you feeling like a kid again. Camp Highlander is located outside of Asheville, North Carolina and their mission is focused on restoring and building confidence of school-aged boys and girls in a safe environment. Working as a counselor, I had the responsibility to apply basic youth development principles such as respecting diversity and building relationships when working with our campers. I was responsible for determining what was common and uncommon for campers of a certain age and understanding the importance of identifying campers’ socioemotional cues. Along the way, I learned counseling a younger camper was going to be very different from counseling an older camper as they are at different stages of life and need varying types of guidance and support. Using what I learned in my Developmental Psychology class, I was able to apply my knowledge of the different socioemotional cues associated with different stages of life to my counselor role. The experience I gained working with the different ages of campers provided an opportunity to see a vast difference in socio-emotional development. I was also successfully able to deal with situations between the different age groups, which gave me confidence in my ability to communicate with different aged individuals, which will help me in the future as I work towards my professional goals of becoming a nurse. Additionally, I was able to work in an environment that allowed me to gain different life-skills like patience, empathy, and decision-making, all while being able to act like a kid.
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1:00-2:30 p.m.
Exhibit Hall (CMCC lower level) |
Poster: 250
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| Platanis, Maria |
Wickersham, Karen |
Relationship of Diet and Nutrition with Self-Reported Heart Failure in Women
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Abstract Text
Relationship of Diet and Nutrition with Self-Reported Heart Failure in Women
Mari J. Platanis, RN, BSN, MA
Abstract
Background
Heart Failure (HF) affects nearly 6.5 million adults in the US with increasing prevalence¹ and malnutrition in HF is associated with increased mortality². Early detection of malnutrition and initiation of nutritional support for women experiencing HF may improve functional recovery.3, 4
Aim- The purpose of this study is to determine if women who self-report HF have poorer nutrition than those who do not. This study includes data on 20,458 women from the National Health and Nutrition Examination Survey5 (NHANES) dataset from 2005-2018.
Methods- Using SPSS®6 a binomial logistic regression was performed to ascertain the effect of BMI, carbohydrate, fat, and protein intake in grams, and race on the likelihood of women self-reporting HF. The independent variable was self-reported HF by women which was defined by yes/no. Data were analyzed using descriptive statistics and Chi-Squared tests of Independence was used to determine whether there is an association between marital status, and race.
Results- Of the five predictor models four were statistically significant: Race, BMI, fat intake, and protein intake. Overweight or obese women were 1.4 to 2.2 times as likely to report HF respectively. Women who consumed less fat (p<0.014)) and proteins (p<0.049) were at higher odds of reporting HF. Carbohydrate intake was not statistically significant but left in the model. Excessive protein and fat intake appeared to be protective of HF.
Conclusion- Women who reported HF were more likely to be overweight or obese yet appeared to consume less carbs and fats. While protein intake is borderline significant, eating an excessive amount of protein, may be protective of HF and warrants further study. It is unclear if inadequate nutritional intake is related to HF or provider recommendations. Future strategies will need to focus on the emerging issues of obesity as well as sarcopenia in the female HF population.
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1:00-2:30 p.m.
Columbia Ballroom (CMCC upper level) |
Poster: 28
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| Alluri, Sri Chaitanya Varma |
Cai, Chao |
Medication Adherence Impact on Cost and Outcomes of Schizophrenia Patients
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Abstract Text
This study investigates the multifaceted connection between medication adherence, healthcare utilization, and associated costs in schizophrenia patients based on their two routes of administration, oral and injectables, through a comprehensive third variable analysis framework.
-To analyze medication as interaction term in relation between treatment and healthcare utilization outcomes and economic outcomes.
-To analyze medication as mediator variable in relation between treatment and healthcare utilization outcomes and economic outcomes.
-To analyze medication as confounding variable in relation between treatment and healthcare utilization outcomes and economic outcomes.
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9:30-11:00 a.m.
Columbia Ballroom (CMCC upper level) |
Poster: 10
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| Zhang, Kangkang |
Huang, Kevin
Sun, Shichen |
Combined Carbon Capture and Catalytic Oxidative Dehydrogenation of Propane to Propylene Conversion Through a Plug-Flow Dual-Phase Membrane Reactor
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Abstract Text
Catalytic oxidative dehydrogenation of propane (CODHP) is a promising technology to produce propylene with high yield and stability. Currently, oxygen (O2) is commonly used as the oxidant in CODHP. However, O2 can lead to overoxidation of propylene, resulting in lower product selectivity. Replacing O2 with a soft oxidizer, such as CO2 (also a greenhouse gas) for CODHP could mitigate the overoxidation while delaying the release of CO2 into the atmosphere. However, the current CODHP-CO2 development is hindered by the severe catalyst fouling caused by coke formation. Here in this study, we show a tubular plug-flow reactor based on a mixed carbonate-ion and electron conducting membrane that is capable of capturing CO2/O2 from flue gas and instantly utilizing it for CODHP reaction with a CrOx/SiO2 catalyst. The tubular plug-flow design of the membrane reactor enables a gradual, continuous, and controlled addition of CO2/O2 (in 2:1 mole ratio) into C3H8 stream along the axial length of the membrane, thus striking an excellent balance between conversion and selectivity, while avoiding overoxidation and suppressing coking. The membrane reactor exhibits a C3H6 yield of ~30%, C3H8 conversion of ~35% and C3H6 selectivity of 85% at 600 oC for an impressive 173 hours of operation with minimal degradation.
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9:30-11:00 a.m.
Columbia Ballroom (CMCC upper level) |
Poster: 19
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| Ballou, Amy |
Wickersham, Karen |
Characteristics of Individuals with Early-Onset GI Cancer in South Carolina
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Abstract Text
Significance
There has been a significant increase in early-onset cancers, defined as cancer in adults under 50 years of age, especially gastrointestinal cancers. Furthermore, cancer diagnosis and treatment disparities continue to rise, especially in South Carolina (S.C.); however, risk factors contributing to early-onset cancer diagnoses are mainly unknown. To address this gap, we first examined the characteristics of patients with early-onset gastrointestinal cancers in S.C.
Purpose
To determine 1) prevalence of patients with early-onset gastrointestinal cancers in S.C. and 2) characteristics and social determinants of health of patients with early-onset gastrointestinal cancers in S.C.
Methods
We conducted a retrospective review of electronic medical records (EMR) (1/1/2020-8/30/2023) to identify patients with newly diagnosed early-onset colorectal or appendix cancer at a community oncology clinic in S.C. We determined potential cases using an electronic report (i.e., age, new patients, diagnosis). Eligibility criteria was confirmed by EMR review, and data was entered into REDCap database, including socio-demographics and cancer-related information. Using SAS (v.9.4), we computed descriptive statistics, including frequencies and percentages, to characterize the patient sample and chi-square of independence for potential associations among variables of interest.
Results
Total number of colorectal and appendix cancer cases (all ages) seen during the three years was N=562. Seventy-two cases met study entry criteria (N=63 colorectal; N=9 appendix). Early onset prevalence was 13%. Most patients had stage III (39%) or stage IV (35%) cancer. The average BMI was 30.21 (SD±6.85). Most were female (60%) and 40% were African American. Other sociodemographic characteristics included 50% married/partnered, 32% unemployed, and 53% lived in a rural area. About 48% had commercial insurance, 29% had Medicare/Medicaid, and 23% had no insurance, department of corrections, or veteran’s insurance. There was a statistically significant association between insurance and race (p=0.0010), employment (p=0.0002), and marital status (p=0.0067).
Discussion
Findings suggest disparities in healthcare access remain in S.C. and potentially for individuals with early-onset gastrointestinal cancers. Future research is needed to examine health disparities concerning race, geography, gender, and socioeconomic status to elucidate risk factors for early-onset cancer and provide a basis for creating multilevel screening and intervention strategies to improve patient mortality and survival.
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1:00-2:30 p.m.
Columbia Ballroom (CMCC upper level) |
Poster: 29
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| Huggins, Parker |
Downey, Austin |
Interpretable Machine Learning for Jet Fuel DCN Prediction Using a Compact TD-NMR System
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Abstract Text
The monitoring of jet fuel ignition characteristics is an integral part of ensuring the efficient and safe performance of an aircraft engine. The derived cetane number (DCN) is a commonly used metric that summarizes fuel ignition characteristics, including but not limited to ignition propensity and combustion quality. Traditional methods for determining the DCN of jet fuels are ASTM standards that involve large-scale, laboratory-based experiments. While recent advancements include the estimation of DCN via NMR and infrared spectroscopy, the search persists for a method capable of real-time and even in-situ estimations. This work proposes the use of a compact, time domain nuclear magnetic resonance (TD-NMR) system employing custom hardware and controls for the acquisition of jet fuel T2 relaxation curves. The system is validated using relaxometric experiments and demonstrates the ability to acquire consistent, structurally viable data on a time-scale of just minutes. Further, an interpretable approach for relaxometric data analysis is presented that allows for the estimation of a sample’s DCN with little computational complexity. The importance of extracted T2 relaxation curve features for DCN regression is considered, and a model trained on
less than 200 total observations is validated using four novel jet fuel samples. Finally, the performance and applicability of the proposed scheme are discussed.
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1:00-2:30 p.m.
Exhibit Hall (CMCC lower level) |
Poster: 108
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| Ghosh, Anusha |
Donaldson, Bobby |
A Historical Analysis of Health Institutions, Professionals, and Advocates in the Civil Rights Movement in Columbia, South Carolina
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Abstract Text
From 1900 to 1970, widespread racism, particularly in the form of Jim Crow Laws, severely restricted healthcare access for the African-American community in the South. African-Americans could not access the same healthcare resources as their white counterparts, leading them to establish and staff alternative healthcare institutions to support their community.
Such institutions faced debilitating issues such as chronic financial shortages and patient overflow. Despite these problems, oral histories, media, and primary written sources show that Black healthcare workers in alternative healthcare institutions demonstrated a greater ability to meet the health needs of Black patients due to specialized cultural understanding and external community involvement.
The Good Samaritan Waverly Hospital was an alternative healthcare institution created by the African-American community in Columbia, South Carolina. Though it struggled with an overflow of charity patients and with bankruptcy throughout its operation, the hospital staff demonstrated specialized cultural understanding with its patients through equitable hospital policy and compassionate patient interactions.
Dr. Matilda Evans was an African-American woman physician who became a leader in medicine, public health, and education. She founded the Taylor Lane Hospital and Training School for Nurses and subsequently, the Evans Clinic and the Zion Baptist Church Clinic. Outside of her medical practice, she constantly involved herself in uplifting the wellbeing of the Black community. Dr. Evans widely distributed public health education and operated a farm to provide jobs, food, and recreation to her community.
This presentation includes a cumulative biography of the Good Samaritan Waverly Hospital and Dr. Evans along with an extensive analysis of how each of them uniquely met the health needs of Black patients. The comparison of an institution versus an individual healthcare worker offers an additional perspective into how a group of healthcare workers worked together to improve public health versus an individual healthcare worker’s personal journey.
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9:30-11:00 a.m.
Exhibit Hall (CMCC lower level) |
Poster: 15
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| Walker, Evan |
Ismail, Briahnna |
The Agape Journey
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Abstract Text
Agape is a Greek concept for a universal love which stems from a dedication to creating a community of kindness with everyone you meet. An Agape community is one which is built on compassion, support, and forgiveness. Through this project, I will tell my own story of Agape, which started one cold November morning in the parking lot of a liquor store and has led me to a myriad of amazing experiences. This concept has motivated me to join amazing fundraising organizations such as Relay for Life and Dance Marathon, guided me throughout college and high school as I work to become a doctor, and helped me to find my own community of people with which I share this Agape love. In school, my love for biochemistry and the sciences has grown as I have found a passion for learning both in and out of the classroom. I have seen this agape spirit in my professors and peers as we navigate difficult courses and strive to succeed, creating a community of learning and discovery. As my communities have continued to grow and expand through every person I have met, my path for the future has been illuminated and made clearer, driving me to pursue a career in medicine so that I can make a difference in the lives of others. Along this journey, I have developed my character and grown as a person, learning countless lessons from the many people I have had the opportunity to meet. Everyone has a story to tell and a lesson to be learned. I have found that listening with compassion, empathy, and respect is the greatest way to bring others into your community and make people feel the Agape love. My mission in this world is to share the concept of Agape with everyone I meet, forming communities of love and respect that are dedicated to making the world a better place.
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9:30-11:00 a.m.
Exhibit Hall (CMCC lower level) |
Poster: 310
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| Bryant, Christopher |
Stephenson, Katheryn |
“A Breath of Fresh Air” Incorporating a Procedural Checklist to Improve the Care of Asthma Patients in the Children’s Hospital Outpatient Center
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Abstract Text
Introduction: Asthma is the most common chronic disease affecting children each year. Although there are specific qualifiers embedded in the EMR to help specify a diagnosis of asthma, there are still patients with an unspecified asthma diagnosis.
Project Aim: The goal of this quality improvement project aimed to have accurate asthma documentation, treatment and follow up appointments in 90% of patients over a 9-month period.
Methods: An “asthma checklist” was created to aid in correct documentation and to provide reminders to residents regarding a standard asthma visit. Charts were abstracted at random pre- and post-intervention. They were checked for diagnosis filed, medications prescribed, and if a follow up appointment was made. ***(PDSA 2?)
Results: Prior to the intervention, 64% of charts were found to have follow up appointments scheduled, 74% had a correct and specific diagnosis for their asthma based on history and 96% had the appropriate treatment for their asthma based on history. In the post-intervention group, 88% of charts had scheduled follow up, 92% had a correct and specific diagnosis for their asthma and 96% had the correct treatment prescribed.
Conclusions: We successfully increased the accuracy of asthma documentation and scheduled follow up appointments in the Children’s Hospital Outpatient Center while maintaining accuracy of treatment.
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9:30-11:00 a.m.
Columbia Ballroom (CMCC upper level) |
Poster: 183
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| King, Jaron |
Friedman, Daniela |
E-cigarette tobacco harm reduction perceptions among adult smokers and vapers in South Carolina
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Abstract Text
Background
Electronic cigarettes (e-cigarettes) are a controversial topic in tobacco control and public health more broadly. Recently the terminology around who uses cigarettes (smokes) and who uses e-cigarettes (vapes) has been debated with prominent journals and researchers calling for an end to the use of certain terms including “smoker”, “vaper”, and “dual user” among others. However, regardless of the terminology used by researchers, people who smoke and/or vape may still self-identifying as a smoker and/or vaper (those identifying as dual users being people who self-identify as a smoker and a vaper). The link between smoking and self-identity has been studied previously, indicating that identifying as a smoker can be barrier to successful and sustained smoking cessation (i.e., quitting).
Methods
This study is a secondary data analysis of the 2023 SC Adult Tobacco Survey (ATS). Respondents (n=1370) answered items relating to tobacco and nicotine use. Logistic regression was performed and compared responses from those who self-identified as smokers, vapers, dual users, and people who identified with neither label to responses from people with no history of tobacco use. This study focuses on differences in identity rather than differences in behavior.
Results
Among the analytic sample (n=596), people identifying as smokers were more likely to believe that breathing secondhand vape aerosol caused no harm than people with no history of tobacco use. About 10% of all current and former smokers and/or vapers in this study have a mismatch between their current behavior and their self-identity as a smoker and/or vaper respectively. Smokers who tried switching from cigarettes to e-cigarettes were no more likely to identify as a smoker or a vaper than those who did not report trying to switch products as a means of smoking cessation. Smokers were four times as likely to be susceptible to trying an e-cigarette in the next year than people who do not identify as a smoker.
Conclusion
Researchers should take care to use terms people identify with, such as smoker or vaper, while recognizing that not all people who smoke or vape identify with the respective behavior’s group identity or label.
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1:00-2:30 p.m.
Columbia Ballroom (CMCC upper level) |
Poster: 36
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| Datsko, Ashley |
Hiott, Ambra |
The Power of a Mentor: Aiding the Transition from Highschool to College
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Abstract Text
The power that mentorship holds is a major contributing factor to my personal and professional growth, development and success throughout my time at the University of South Carolina. One of my significant contributions to USC has taken place in my role as an Mentor for the Pillars for Carolina Program. The program allows incoming students an opportunity to feel encouraged, welcomed, and excited over an extended orientation program the summer leading into their first semester on campus. In this position I was able to develop relationships between incoming students, create a supportive community, and provide support as they enter a new environment for the first time. Through facilitating group activities and being intentional in all conversations and interactions, I was able to foster an inclusive space where all members of my family group felt valued. Following this experience, my passion led me to support the transition not only from high school to college, but from their first semester and beyond in the classroom as a University 101 Peer Leader. Through my time in these roles, I learned how impactful it is to be part of and contribute to a student's journey to success, and how every small action is a pivotal part of the larger picture. My presentation underscores the positive impacts and teachings these experiences have shaped a value I never knew would become so integral to my life today.
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1:00-2:30 p.m.
Exhibit Hall (CMCC lower level) |
Poster: 310
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| Leone, Giovanna |
Ertel, Michael
Brian, Ali
Porter, Jason
Hikmet, Neset
Sacko, Ryan
Stodden, David |
Predicting Future Physical Military Readiness Using Youth Motor Competence and Fitness Growth Curve Trajectories
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Abstract Text
A secular decline in motor competence (MC) and physical fitness among U.S. youth has contributed to a national security crisis due to the alarming number of young adults unable to demonstrate adequate physical fitness levels to qualify for Army service. Previous research reveals strong associations among MC levels, physical fitness, and Army fitness test performance/failure rates in adults. As MC levels track across youth, a continued decline in youth MC levels may further exacerbate recruitment issues and physical military readiness. The purpose of this study was to apply growth curve modeling coefficients from longitudinal MC data to predict future recruitment age physical fitness and potential Army fitness test performance. An initial sample of children (N = 262, female = 135, Mage = 8.8 years) completed MC (standing long jump distance, throw speed, & kick speed) and physical fitness (grip strength & push-ups) assessments across three years. Using linear regression, tracking coefficients were calculated for MC and physical fitness measures to predict MC and physical fitness levels at age 14 (β =.44 to 1.01). Using growth curve modeling, we further extrapolated MC and physical fitness levels to military recruitment age (17 years) by applying longitudinal tracking coefficients for the same MC and physical fitness variables from a different longitudinal data set (ages 15 to 18 years - β = 0.34 to 0.68). Predicted MC and physical fitness levels at age 17 years were compared to MC and physical fitness levels from a current sample of young adults in a pre-military setting (N = 306, Mage = 19.55) to calculate the initial sample’s predicted MC and physical fitness percentiles. The extrapolated growth curves revealed that 80% of females and 63% of males are predicted to be in the lowest 25%tile of MC and physical fitness at age 17. Approximately 75% of individuals at or below the 25%tile of MC are predicted to fail the current Army fitness test at age 17 (Terlizzi et al., 2022). This innovative predictive growth curve modeling application highlights the potential significance of developing MC as a critical antecedent for future physical military readiness.
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1:00-2:30 p.m.
Columbia Ballroom (CMCC upper level) |
Poster: 46
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| Jannusch, Taylor |
Singh, Narendra |
Differential Effects of Aryl Hydrocarbon Receptor (AhR) Ligands on Gut Microbiota
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Abstract Text
Aryl hydrocarbon receptor (AhR) is a ligand-activated transcription factor that plays an important role in sensing environmental signals such as changes in the circadian rhythm, oxygen tension, or redox potential. Along with regulating many genes, AhR also mediates the toxicity of environmental pollutants such as TCDD (Dioxin). In this study, we investigated the effect of four AhR ligands: TCDD, Resveratrol (RES), Indole-3-Carbinol (I3C), and 6-Formylindolo [3,2-bicarbazole (FICZ) on the gut microbiota in mice. To this end, C57BL/6 mice were treated with either vehicle (VEH), TCDD (10 µg/kg), RES (100 mg/kg), I3C (50 mg/kg), or FICZ (50 µg/kg). On day 3, the mice were euthanized, and fecal contents were collected. Using gut microbiome DNA, 16S sequencing was performed on Illumina MySeq platform. Data generated from MySeq were analyzed using Nephele and Partek software. There was significant dysbiosis in the gut microbiota population in mice treated with TCDD, RES, I3C or FICZ when compared to gut microbiota populations of mice treated with Vehicle (VEH). There were also significant changes in the gut microbiota of mice at family, genera, and species levels treated with TCDD, RES, I3C, or FICZ, when compared to VEH-treated mice. Moreover, a significant increase in the population of Clostridium leptum was observed in FICZ-treated mice, and a significant increase in Muribaculum intestinale, was observed in RES- and I3C-treated mice, when compared to VEH-treated mice. These bacteria are associated with regulating intestinal immune system homeostasis and colitis. In summary, the current study demonstrated that various AhR ligands have differential effects on the regulation of the gut microbiota populations in mice. Differential effects of AhR ligands on dysbiosis of gut microbiota may play a crucial role in the health of the gut as well as in the regulation of the mucosal immune system (This work was supported in part by NIH grants R01ES030144, P20GM103641, R01AI123947, and R01AI160896).
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1:00-2:30 p.m.
Exhibit Hall (CMCC lower level) |
Poster: 48
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| Turnage, Elizabeth |
Reed, Rico |
Leadership Provides Opportunity For Change
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Abstract Text
In 2023, I joined Carolina Productions, a branch of Gamecock Entertainment on the University of South Carolina campus. I was assigned to be the event coordinator for Cockstock. Cockstock is the University of South Carolina’s annual homecoming concert. On October 6, 2023, COIN took the stage and performed on Greene Street. We welcomed 1,558 students. I joined this organization and worked for Cockstock in order to gain unique music industry experience. I was able to learn to negotiate contracts, budget, coordinate production, and work directly with a band and their team. I am blessed to have had the opportunity to be a part of an organization that impacts all students at the university. In order to make this event a success, I had to collaborate with other students across campus and work directly with the booking agent in order to secure a band. Through this opportunity I found that people are placed in leadership positions to improve the lives of the people they are leading. Being in a leadership role and remaining stagnant is nearly pointless. Therefore, it is essential that leadership provides an opportunity for change. Working as an event coordinator for Carolina Productions taught me a lot about the music industry and the importance of change. Moving forward, I will take these lessons with me as I enter the workforce and begin my professional career. In this presentation I will cover my journey as the event coordinator for Cockstock, and how that experience led me to where I am today in terms of making changes. I will reflect on how I can use what I learned in this experience to be successful in my professional career.
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9:30-11:00 a.m.
Exhibit Hall (CMCC lower level) |
Poster: 344
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| O'Keefe, Hally |
Spence, Gina |
An Understanding of Cultural Values is Crucial to a Modern Global Work Environment
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Abstract Text
In my second semester of junior year, I studied abroad for the second time as a member of the International Business Education Alliance cohort studying IB/Managment/German in Singapore at ESSEC Asia Pacific. There, I traveled and encountered many new cultures with different traditions and behaviors to my own. I had to adapt to these to be successful in my friendships and schoolwork. Singapore is a diverse mix of people, predominantly of Malay, Chinese, and Indian backgrounds. However, ESSEC was a French international school with students from every continent. Living in Singapore and studying at ESSEC meant interacting and adapting my behavior to the expected cultural norms, from eating at restaurants to completing group projects. I had to use various models for cultural values that I learned in Management classes, most notably Hofstede’s 6 values. Everyone comes from a unique background and upbringing that shapes who they are. Understanding whether someone is risk-avoidant or comes from a collective society is beneficial to connect with them on a deeper level. As someone who wants to continue to work and live abroad, these principles will guide my actions and behavior to successfully adapt to any environment.
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1:00-2:30 p.m.
Exhibit Hall (CMCC lower level) |
Poster: 243
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| Cocenza, Nathalia |
CHILDS, MATT |
Soybeans and Sorriso: Charting the Growth of Brazil's Agricultural Titan
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Abstract Text
This article explores the complex history and extensive effects of soybean cultivation in Sorriso, Mato Grosso, Brazil, highlighting its critical influence on shaping the economic landscapes at local, national, and international levels. Over the last forty years, a significant metamorphosis has occurred within Brazil's agricultural sector, with the development of agriculture in Sorriso playing a vital role in this change. The amalgamation of rich natural resources, technological advances, and a forward-thinking community has propelled Sorriso to the forefront of soybean production worldwide. This study argues that examining soybean cultivation's historical and ongoing impacts on Sorriso fills essential gaps in historical, geographical, economic, and agricultural studies. It scrutinizes Sorriso's evolution from a small farming community to a formidable agribusiness titan. The area's advantageous position, ideal climate, and fertile lands were pivotal for its swift agricultural expansion. This document underscores the socioeconomic benefits of such growth, including attracting investments, enriching the local economy, and creating job opportunities. Furthermore, the surge of people moving to the area for better living conditions has led to rapid population increase and urbanization, turning Sorriso into a thriving and economically varied hub.
Key words: agribusiness; mato grosso; soybean; crop production; sorriso
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1:00-2:30 p.m.
Columbia Ballroom (CMCC upper level) |
Poster: 23
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| Maloney, Sam |
Ozturk, Orgul
Babaei-Balderlou, Saharnaz |
Performance Bonus or Whimper? Individual Teacher Incentive Bonuses in North Carolina Public Schools
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Abstract Text
Due to the continuing lag in achievement in the US, and the difficulty retaining qualified teachers in public schools, many localities use performance bonuses to retain the “best” teachers and improve student outcomes. North Carolina introduced an annual performance bonus of $1500-$2500 for top teachers within their local school or the state, notably with no concurrent (teacher) cohort incentives or professional development. This allows us to exclusively examine the individual incentives’ effects on both teacher turnover and student proficiency. Using administrative data provided by the North Carolina Education Research Data Center, we estimate an “intent to treat” effect of being within a bonus-eligible cohort. We used Synthetic Difference-in-Differences and Callaway Sant’anna (2021) staggered TWFE and models, leveraging grade/subject boundaries for identification. We observe statistically significant results for student outcomes; however, both models report economically negligible effect sizes for teacher retention and student outcomes. We believe negligible results are driven by the small amount of the bonus relative to the effort required, although lack of information may play a part.
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1:00-2:30 p.m.
Exhibit Hall (CMCC lower level) |
Poster: 8
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| Fernandez, Ademar |
Frost, Dan |
Crustal Structure Underneath South Carolina Determined by Teleseismic Receiver Function Analysis; an Approach to Resolve the Crustal Configuration Under the Elgin–Lugoff Seismic Swarm
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Abstract Text
Following the 27 December 2021 Mw=3.3 Elgin–Lugoff earthquake in South Carolina (SC), a swarm of small-magnitude earthquakes has been consistently occurring in the area. The origin of the Elgin–Lugoff swarm is subject of current research to improve the understanding of the causes behind the swarm. This research aims at analyzing the crustal structure in South Carolina from the coast to the Appalachians. We will map two perpendicular 2D profiles; first from Charleston to Lake Jocassee (~365 km), and later from Hawthorne to Birdtown (~190 km). The second cross-section will allow us to map across the Eastern Piedmont Fault System (EPFS), which serves as a tectonic boundary between the predominantly sedimentary southeast and the cratonic northwest of SC. By using the time domain deconvolution method, we will calculate teleseismic receiver functions (RFs) for a set of 1567 Mw≥5.5 earthquakes from 2010–2023. For converting the RFs to depth, we will use a recently developed local velocity model determined by using the seismic data recorded by our SmartSolo 5Hz three-component nodes deployed between Elgin and Lugoff from October 2022 until February 2023. Our results will improve the accuracy of the velocity model and test the effectiveness of the SmartSolo 5Hz three-component nodes in RF determinations, by examining the RFs from a co-located node and broadband station in the place of the swarm. We test the hypothesis of an east-west dipping Moho, with the most pronounced Moho discontinuity located beneath the EPFS. We suggest the oceanic crust to be ~25 km thick, increasing rapidly to the northwest and reaching about ~45 km thick under Lake Jocassee. A thinning of the crust underneath the Elgin–Lugoff swarm is suggested (probably by delamination) allowing fluid migration from the upper mantle to the shallow crust, which could explain the continuous seismic activity in the zone. Our findings would corroborate the existence of a dipping Moho along the east coast of the United States and also a thinning of the crust under the Elgin swarm. This research will contribute valuable insights for a better understanding of the Elgin–Lugoff swarm and also the tectonics of the east coast.
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9:30-11:00 a.m.
Columbia Ballroom (CMCC upper level) |
Poster: 28
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| Quickel, Laney |
Matthews, Sarah |
From Passion to Profession
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Abstract Text
During my Spring 2023 semester, I studied abroad on exchange at the ESSEC Business School in Cergy, France. I had been studying French from the beginning of middle school onward, and I had hopes to study in France in order to achieve linguistic and professional goals that I had set for myself. In college, I majored in International Business and Accounting with a minor in French because I have hopes of practicing international corporate law – potentially tax. I also simply have a passion for cultural experience and wanted to develop firsthand experiences to contribute to my Honors Thesis on the topic of ethnocentrism. The ESSEC Business School offered a wide variety of business classes on topics beyond what is offered in the United States, and these classes counted toward my USC coursework. As an aspiring International Tax Lawyer, I wanted to understand French (and general European) culture through the lens of business, and I did this by traveling to over 20 locations in Europe during my semester abroad. This was a significant experience in my life, as I was raised in a multicultural family, yet I had never traveled outside of the United States. I have always been told that the best place to grow in your cultural understanding and awareness as well as your language skills is through firsthand immersion, and that is what I did. I threw myself into the unknown – I grew, I learned, and I became more culturally aware and more open to new ideas and perspectives. I learned to communicate better with French individuals not only through language development but also through understanding French behavior and etiquette. I met individuals in my exchange program from almost every country in Europe and Asia, creating a HUGE network of individuals that I can learn and grow from. I began to understand myself and my behaviors more, beginning to understand that I am a product of my own culture. It was a life-changing experience that has only fueled my passion for culture, for learning, and for traveling even more.
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9:30-11:00 a.m.
Exhibit Hall (CMCC lower level) |
Poster: 236
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Lyons, Teresa
Wilson, Marcus |
LeBlanc, Kevin |
Erector Spinae Block Education Implementation
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Abstract Text
The national opioid crisis has raised awareness of alternative modalities to reduce opioid usage in surgical patients. There is a large body of evidence showing that poor postoperative pain control is associated with increased opioid use and abuse postoperatively. Peripheral nerve blocks using local anesthetics have been suggested as an effective alternative to opioid analgesics for intraoperative and postoperative pain management. Cardiac surgery anesthesia traditionally relies heavily on opioid analgesics, and as such is an area of interest for potential alternative analgesia modalities. This paper details a systematic literature review which highlights the effectiveness of erector spinae plane block (ESPB) as an analgesic for cardiac surgery and reducing postoperative opioid use. The pre- and post-test survey results of the study represent the impact of the educational presentation on the knowledge of the cardiac anesthesia team and their perceptions of the ESPB.
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9:30-11:00 a.m.
Columbia Ballroom (CMCC upper level) |
Poster: 61
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| Ripp, Stephanie |
Spence, Gina |
The Dangers of a Single Story
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Abstract Text
My name is Stephanie Ripp and indulging myself in different cultures and experiences makes me who I am. While I could go on and on about these topics, I have chosen the most memorable moments to give you some insight into what exactly I want to say about the tourism industry. I clearly remember walking onto the Semester at Sea boat filled with just about every emotion possible. Oblivious to the profound wisdom I was about to hear, I sat down in the massive auditorium to hear the Dean of student affairs introduce himself. Dean Dan, who would soon become one of my favorite professors, told the entire ship the danger of a single story. For word count purposes I will just sum it up by saying it is a warning about going into a new situation with a predetermined image of someone or something. I didn’t realize it then, but that story directly correlates with each of my key points. My first key insight is discussing the differences between a tourist and a traveler. Before going to Semester at Sea, I completed my education abroad pre-departure class in Fall 22’ and it taught me so much about how to be an aware traveler, not an obnoxious tourist. No one is perfect, and it’s hard to fit in when you're a foreigner, but there are ways to show respect and be considerate of others which is something I experienced firsthand during my time in India. The next topic I want to discuss is the importance of having access to information. During my time in Jordan, I realized how much power the freedom of speech can have. Sustainable tourism, which I took in the fall of 2023, reassured my conclusions about the significance of information. Finally, I would like to talk about the power of finding your niche and using your voice for good. Taking public communications in the fall of 2021 taught me that you need to speak about things that you are passionate and knowledgeable about or else you won’t make any difference.
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1:00-2:30 p.m.
Exhibit Hall (CMCC lower level) |
Poster: 324
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Greene, Cassie
Hanson, Monyetta |
Rhodes, Morgan
Bean, LJ |
Lifestyle Management
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Abstract Text
Purpose: Defined as having a body mass index (BMI) greater than 30, obesity has been linked to numerous medical conditions and significant healthcare costs. The Prisma Health/USC Family Medicine Center cares for an underserved patient population in an under resourced area in Columbia, SC. Our patients often have difficult access to obesity medications and other evidence-based weight management tools. This study aims to address the growing obesity rate through a quality improvement program by decreasing total body weight and increasing perceived quality of life for participants. This project is a resident-driven implementation of group visits for weight management.
Methods: Approximately 50 obese participants will be recruited and meet for 1-hour sessions, 6 times over 3 months. Each meeting will include a physical activity component and educational information on lifestyle modification variables such as nutrition and goal setting.
Results: Weight trends before and after group visits will be analyzed, as well as patient quality of life. The study anticipates a 5 percent reduction in total body weight for all participants who complete the intervention. Additionally, the study anticipates a significant increase in perceived quality of life from pre- to post-intervention. We also hope to demonstrate the feasibility of this type of intervention in a residency clinic.
Conclusion: This study will provide preliminary data on the effectiveness of a quality improvement intervention on total body weight and perceived quality of life in individuals living with obesity. It will also provide information on the applicability of such a service in residency clinic setting. A successful outcome could have large-scale implications on how medical clinics approach the growing obesity epidemic facing as many as 41 percent of Americans.
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1:00-2:30 p.m.
Columbia Ballroom (CMCC upper level) |
Poster: 201
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| Bean, Lindsay |
Reed, Rico |
Preparing for the Job Market in an Increasingly Competitive World
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Abstract Text
For my Beyond the Classroom experience, I interned as a Workplace Health and Safety Specialist at an Amazon Sort Center in Fife, Washington. In the Spring 2023 semester, I took ENHS 321, Environmental Health and Pollutants, where I learned about different pollutants in our environment, and I found that the section on workplace pollutants really interested me, and I wanted to explore it as a career. During the internship, I learned about common workplace hazards, and I got to work on a project to address a common source of injuries at the job site I was at. I found that many of these injuries were caused by a lack of education, another of my public health interests. I was able to leave a guide for an implementation of what the site could do to educate new employees and re-educate current employees to reduce injuries. This experience was very meaningful to me, as it solidified my choice in my career, and I plan to work in this field and improve workplace safety for all.
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1:00-2:30 p.m.
Exhibit Hall (CMCC lower level) |
Poster: 345
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| Wright, Ymani |
Armstrong, Alissa |
Amino Acid Transporter Expression Screen Across Distinct Tissues in Drosophila melanogaster Adults
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Abstract Text
Dietary amino acids play important roles in metabolic processes that support normal tissue growth, repair, and development. Amino acid transporters facilitate migration of amino acids into the cell. In Drosophila, we have previously shown that amino acid transporter knockdown in adult adipocytes mediates ovarian responses to dietary protein input. The Drosophila genome encodes 51 genes thought to be amino acid transporters and high-throughput studies suggest differential tissue expression. We hypothesize that distinct tissues including the fat body, ovary, brain, muscle, and gut require distinct dietary protein inputs to mediate their normal physiological functions. Thus, we first set out to determine the complement of amino acid transporters expressed by several tissues using an RT-PCR screen of 26 solute carrier amino acid transporters. We find that expression of the 26 amino acid transporters tested varies between these distinct tissues. For example, the ovary expresses low levels while the brain expressed high levels of Aralar1. Currently, we are determining if an organism’s physiological state influences amino acid transporter expression by measuring amino acid transporter transcript and protein levels in tissues across different ages, diets, and sexes. In future studies, we will focus on determining amino acid transporter expression under obesogenic conditions. The genetic screen of amino acid transporter expression will help elucidate specific amino acid requirements for distinct tissues under D. melanogaster homeostatic and non-homeostatic conditions.
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9:30-11:00 a.m.
Columbia Ballroom (CMCC upper level) |
Poster: 37
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| Truong, Kylie |
Yturralde, Kylee
Kelly, Katherine |
Early Screening for Gestational Diabetes Mellitus: A Quality Improvement Project
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Abstract Text
The American College of Obstetricians and Gynecologists (ACOG) recommends early GDM screenings for patients with a combination of BMI > 25 and one other risk factor due to the increased risk of type 2 diabetes mellitus (T2DM) and gestational diabetes mellitus (GDM) in patients with higher BMI. Our previous study with the MOMs Clinic, a program that specializes in pregnancy diabetes care for rural South Carolina, showed that 100% of patients who had diabetes mellitus and were diagnosed with an IUFD had a BMI > 25.0. Based on these findings, we suggested that pregnant patients with BMI > 25 should undergo glucose challenges before 24-28 weeks, which are the current guidelines. We decided to implement a quality improvement project for glucose tolerance testing in high-risk patients at their initial prenatal visit. We implemented interventions such as provider education and technology improvements with the ultimate goal of increasing prenatal A1c collections for high-risk women by 25% in 6 weeks.
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9:30-11:00 a.m.
Columbia Ballroom (CMCC upper level) |
Poster: 192
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| Yin, Yunhang |
Shi, Dexin |
The Effect of Model Size on Fit Indices in Ordinal Factor Analysis Models
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Abstract Text
This study investigated the effect of the number of observed variables (p) on SEM fit indices in the context of ordinal data. The behaviors of three fit indices including the comparative fit index (CFI), the Tucker–Lewis index (TLI), and the root mean square error of approximation (RMSEA) were examined under ordinal factor analysis models with the unweighted least squares (ULS) estimation method. We manipulated various simulation conditions by varying the number of observed variables, levels of model misspecification, sample size, number of response categories, and magnitude of factor loadings. The results showed that given the same level of model misspecification, the population values of CFI, TLI, and RMSEA were generally stable as the model size (p) increased. At the sample level, as p increased, the sample CFI estimates became closer to their corresponding population values, especially when the sample size was small, and the magnitude of factor loadings was low. No clear pattern was observed regarding the effect of p on the sample TLI and RMSEA. Drawing on our findings, we discussed the practical implications of our study and suggested directions for future research.
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9:30-11:00 a.m.
Columbia Ballroom (CMCC upper level) |
Poster: 46
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| Mulligan, Alayna |
Harrison, Theresa |
Leadership in Public Education - Graduation with Leadership Distinction
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Abstract Text
During my time at the University of South Carolina, I served as president of the University of South Carolina’s Teaching Fellows organization, which is the state’s collegiate teacher recruitment program. This program recruits high school seniors into the teaching profession and helps them develop leadership qualities through providing professional development opportunities. As president, my role included assisting in refining our program manual, convening and chairing meetings of the Teaching Fellows’ organization, as well as continuously monitoring and addressing areas of improvement for the program. A defining moment for me while serving as president was addressing a need I observed within the field of education by highlighting relevant legislation and the importance of advocacy at one of our meetings. More specifically, I spoke in January 2023 about legislative updates including the Governor's Inaugural Address, in which Henry McMaster stated his plan to raise teacher pay to $50,000 over the next four years. Additionally, I spoke about the importance of our members joining teacher advocacy organizations such as The Palmetto State Teachers Association (PSTA). As a future educator, I did this because I developed a personal passion for political advocacy after taking EDLP 517: Law and Policy Studies in Education. In this course, I was required to learn about a plethora of legislation that pertains to education in the United States. In this course, we also heard from guest speakers including legislators and educator advocates who often advocated for increased teacher engagement in politics in our state. These in-class experiences compelled me to share this newfound understanding of the importance of engaging in political advocacy with all Teaching Fellows. I learned to use my role as president to educate and inform future teachers so that they are aware of what political advocacy is and its importance in the field of education, so that we can collectively address pressing policy issues in South Carolina. I plan to continue my political advocacy into my future role as an educator and I hope to inspire other teachers to do the same.
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1:00-2:30 p.m.
Exhibit Hall (CMCC lower level) |
Poster: 263
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| Bogdon, Raymond |
Busbee, Philip |
Aryl hydrocarbon receptor ligand supplementation impacts colitis-associated depressive-like behavior
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Abstract Text
Colitis is an inflammatory bowel disease (IBD) with increased incidences of depression in patients. The mechanisms that define this comorbidity remain poorly understood. Our lab previously showed supplementation with indole-3-carbinol (I3C), an aryl hydrocarbon receptor (AhR) ligand, can reduce disease severity in models of colitis. We aimed to determine the behavioral impact I3C supplementation has on colitis-induced depression via alterations in the gut metabolome. Colitis was induced in using the dextran sodium sulfate (DSS) method and treatment groups were given a regimen of 40 mg/kg I3C as previously reported. Untargeted metabolomic studies revealed quinolinic acid (QA), a metabolite produced by the kynurenine (KYN) pathway and linked to depression, was found to be significantly reduced in I3C-treated mice when compared to colitis controls. To determine the effects of I3C and QA modulation on depressive-like behavior, colitis mice were treated with either I3C or an inhibitor of a major enzyme involved in QA production. Depressive-like behavior was measured using the Tail Suspension Test (TST) method, along with evaluation of neural biomarkers of depression (dopamine, BDNF, GFAP) and stabilization of the blood brain barrier (BBB). Results showed I3C reduced depressive-like behavior and altered select biomarkers associated with depression. These studies provide evidence that AhR can be a potential therapeutic target for both colitis and colitis-associated depression.
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1:00-2:30 p.m.
Columbia Ballroom (CMCC upper level) |
Poster: 37
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Dennison, Elizabeth
Marshall, Mallory |
Brook, Sylvia |
Foster & Kinship Care: Improving Resident Competence, Confidence, and Practice
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Abstract Text
Background and Objectives. Pediatricians have the unique responsibility of caring for children in foster and kinship care. It is of the utmost importance for pediatric residents, and clinicians in general, to provide care that is specific, informed, and thorough because this population is subject to pervasive health outcomes. This quality improvement project aims to improve resident confidence, competence, and practice in caring for children in foster and kinship care using an educational method that is effective and non-burdensome.
Methods. This project was conducted within a pediatric residency program and included residents from all three post-graduate years; 38 total. A reference sheet addressing confidence, competence, and practice pertaining to children in foster and kinship care was created and displayed in resident work areas. A pre and post survey with statements relevant to the three areas was sent via Google Forms, and residents rated them using a Likert scale. Resident perception of the burden of medical education was queried with questions on how residents best learn/retain information.
Results. The study demonstrated improvement in all three categories- confidence, competence, and practice. However, there was a marked decrease in response rate between the two surveys. Experiential learning was voted the best format for retaining knowledge, although educational handouts were also effective.
Conclusion. There is an ongoing need for pediatric graduate medical education to prepare trainees for quality care of children in foster and kinship care. Methods for incorporating this topic can be as simple as an identifiable and accessible reference guide.
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9:30-11:00 a.m.
Columbia Ballroom (CMCC upper level) |
Poster: 175
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Collins, Grayson
Fuller, Catherine |
Morris, Sheena |
Substance Missuse Among SRNAs: A Wellness Assessment
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Abstract Text
Substance misuse is an occupational hazard for anesthesia providers, with stress identified as the most prevalent risk factor within the literature review conducted in this study. Student Registered Nurse Anesthesiologists (SRNAs) are at similarly high risk for substance misuse due to the addition of rigorous clinical training and educational demands. Substance misuse by SRNAs has devastating and far-reaching consequences, warranting efforts to identify and address the risk factors specific to this population. A wellness assessment survey was created and administered to voluntary SRNA participants attending 32 graduate nurse anesthesia programs across the Southeastern United States (U.S.), which successfully identified the most deficient areas of wellness among SRNAs. The findings in this study indicate that wellness is impaired among SRNAs, and specific areas, including physical, emotional, and occupational wellness, are the most insufficient. These findings could aid future research efforts to create targeted wellness-improvement programs for SRNAs, ultimately reducing the risk of substance misuse.
Keywords: student registered nurse anesthetists, SRNA, certified nurse anesthetist, CRNA, controlled substance misuse, substance abuse, substance use disorder, substance-related disorders, stress, wellness, coping
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9:30-11:00 a.m.
Columbia Ballroom (CMCC upper level) |
Poster: 62
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| Tu, Amber |
Hiott, Ambra |
GLD In Global Learning: Finding My Voice
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Abstract Text
In pursuit of graduating with Leadership Distinction in Global Learning, I studied abroad at the Chinese University of Hong Kong my sophomore year as a member of the IBCE cohort. Spending at least a semester abroad is a requirement for International Business majors, and I have always been interested in becoming more culturally awareness and working abroad after graduation. During my time there, I was able to take courses with regional focus, become more independent and flexible, better understand myself and the Hong Kong culture, and build an international network. I lived on-campus with both local and exchange students and was able to explore the hidden gems of Hong Kong during my time there. Thanks to GLD, I have been able to connect within-the-classroom experiences with beyond-the-classroom ones. Specifically, the focus on being an effective and convincing debater in my IBUS 310 class, combined with my previous experiences of camera fright with SGTV and not being able to speak the main dialect in Hong Kong, allowed me to rediscover my voice in an academic setting and build confidence as I did so. The GLD process has showed me not only the benefits of diversity and multiculturalism but also how to use what I learn in class and apply it to my own development on personal, educational, and professional levels. Having participated in several enhancement experiences and completed additional coursework, I understand that there is power in feeling like you belong; I aim to foster this sense of belonging in the clubs I lead and plan to continue encouraging acceptance wherever life takes me in the future. I hope others will also see the advantages of study abroad and approach everything with an open mind and heart.
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9:30-11:00 a.m.
Exhibit Hall (CMCC lower level) |
Poster: 237
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Pulliam, Conor
Campbell, Andrew |
Li, Jie |
A Novel Lasso Peptide from Paenibacillus Exhibits Potent Antimicrobial Activity Against ESKAPE Pathogens
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Abstract Text
A novel lasso peptide, taiwanodin, from Paenibacillus taiwanensis DSM18679 was bioinformatically identified and subsequently purified and studied. Taiwanodin contains unique structural elements including a highly hydrophobic tail region. The biosynthetic gene cluster (BGC) encoding the biosynthetic machinery required to synthesize taiwanodin additionally contains three putative transport proteins with homology to the nisin transport system. Nisin is an extremely potent antimicrobial lanthipeptide discovered found in the related genus Bacillus. Due to the similarity of the taiwanodin BGC transporters and the nisin BGC transporters, we reasoned that taiwanodin may also exhibit potent antimicrobial activity. We also observed cell death in an attempted heterologous expression host, further suggesting that taiwanodin may have antimicrobial activity. We performed an agar disk diffusion assay and a 96-well plate minimum inhibitory concentration (MIC) assay using se veral ES KAPE pathogens. We demonstrated that taiwanodin has activity against several of these pathogens and found that taiwanodin exhibits potent activity against Klebsiella pneumoniae and Bacillus subtilis at 6.3 micromolar.
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9:30-11:00 a.m.
Exhibit Hall (CMCC lower level) |
Poster: 98
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Kirkley, Kaitlin
Chamberlain, Jillian |
Andersen, Tia |
Empowering Resilience and Growth: Positive Youth Development Strategies in an Alternative School-Based Mentoring Program for High School Students
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Abstract Text
The school-to-prison pipeline is a metaphor used to describe the ways in which educational policies and practices funnel youth out of public schools and into the justice system. Exclusionary school discipline, such as school expulsion, is an important component of the school-to-prison pipeline and associated with youth drop out, delinquency, and justice system contact. Mentoring interventions for students who have been expelled from school may represent a key, untapped potential lever of change for promoting positive youth development and resilience, thereby disrupting the school-to-prison pipeline from a midstream vantage.
This poster presents data from a university-school partnership program that matches trained university student mentors with youth who have been expelled from their traditional high school and attend a disciplinary alternative school. We explore the strategies employed by mentors to foster the 5Cs of Positive Youth Development (PYD) – competence, confidence, connection, character, and caring. Through a mixed methods analysis of mentor-mentee interactions as described in weekly mentoring journals, the research unveils how mentors effectively adapt PYD principles to meet the unique needs and circumstances of their mentees.
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9:30-11:00 a.m.
Columbia Ballroom (CMCC upper level) |
Poster: 100
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| McDermott, Allie |
Reed, Rico |
How Volunteering in Barcelona Deepened My Connection to the Local Community and Strengthened My Understanding of Culture as Related to Society and Healthcare
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Abstract Text
While in Barcelona during Spring 2023, through the help of my study abroad program, SAI, I deepened my connection with the local community by volunteering weekly as a teaching assistant in an English class at a local elementary school. I am passionate about engaging in experiences that support youth and was encouraged to volunteer at Escola Pia Sant Antoni as a requirement for SAI’s Global Leadership Certificate and International Service Certificate. Over the course of the semester, I dedicated over 15 hours to this role, helping young students in this classroom from all over the world feel more confident in their abilities to speak English. The most significant aspect of this volunteer experience was the day in which I was responsible for planning and leading the entire class period. I met with the teacher outside of class time in order to effectively prepare for this endeavor. One aspect of my lesson plan was to teach the young kids about English body parts through the “Head, Shoulders, Knees, and Toes” song and dance. Following, I observed a heightened excitement for learning among the children during my leadership. Through this volunteer experience, I was reminded of the importance of compassion and open-mindedness, especially when working with diverse populations. Cultural competency is a crucial aspect of the Arnold School of Public Health curriculum, and the positive environment of Escola Pia Sant Antoni represented broader themes related to Barcelona’s cultural norms. Furthermore, looking at the bigger picture of my experience studying abroad, I realize that volunteering, coupled with other requirements of the Global Leadership and International Service Certificates, allowed me to compare and contrast Spanish and American sociocultural norms. This ultimately led to a better understanding of the differences of the healthcare systems of these countries. In summary, as I prepare for a career in medicine with a foundation in public health, I am equipped with a newfound understanding of connecting with diverse populations, of community building, and of the importance of considering sociocultural norms in assessing populations’ opinions of their healthcare system thanks to my semester-long emergence in the culture of Barcelona.
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1:00-2:30 p.m.
Exhibit Hall (CMCC lower level) |
Poster: 244
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| Cruz, Itzeli |
Kettler, Andrew |
Dental Improvements: Technological Advancements and the History of Oral Health in the South
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Abstract Text
Technology advancements have greatly improved oral health in the south trough providing more efficient and effective methods of diagnosis, treatment, and prevention of oral diseases. The history of dentistry offers a pathway to better understand how these improvements have helped rural and impoverished populations in the region. In the twentieth century, traditional X-rays were commonly used for dental imaging, but included limitations regarding image quality and radiation exposure. Digital imaging technologies such as digital X-rays, intraoral cameras, and 3D imaging have revolutionized the way dentists diagnose and treat oral health issues, which has also allowed dentists to provide greater access of care to broader populations. These tools provide more detailed and accurate images, allowing for better diagnosis and planning of treatment. Tele-dentistry, or virtual dental consultations, have become more common in recent years, especially in rural areas where access to dental care is more limited. This technology specifically allows patients to connect with a dentist remotely for consultations, follow-ups, and treatment recommendations. Implant technology has also advanced significantly, leading to more durable and natural-looking results. Despite these advancements, there are still some challenges and problems that have created the need for these tools in the first place, such as limited access to dental care in impoverished rural communities. Many areas in the south, particularly in rural and underserved communities, face a shortage of dental providers. This lack of access to care, often cause by historical health disparities, can result in delayed diagnosis and treatment of oral health issues. Certain populations in the south, including low-income individuals, minorities, and rural residents, are more likely to experience disparities in oral health outcomes due to these structural remnants from historical oppressions. These current disparities can be attributed to factors such as socioeconomic status, education level, and access to preventive services. Also, some individuals may not prioritize their oral health or may not be aware of the importance of regular dental care. This lack of awareness can lead to the development of preventable oral health issues.
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9:30-11:00 a.m.
Exhibit Hall (CMCC lower level) |
Poster: 8
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| Patel, Milap |
Stephenson, Kathryn |
Consistency is key: Improving clinical documentation for developmental delay during the 6-months-old to 36-months-old well-child check visits
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Abstract Text
Background: Lack of precise clinical documentation of developmental delay can make it difficult to find the supporting evidence CHAMPS needs for SSI disability cases. Current templates for well-child check notes do not include any specific descriptors for the severity of developmental delay when present.
Project Aim: Improve clinical documentation of developmental delay in patients ages 6-months to 36-months at the Children’s Hospital Outpatient Clinic at Prisma Health by embedding a developmental delay assessment tool within the age-specific well-child check note templates with the goal of achieving 70% consistent documentation of this tool by May 24, 2023.
Methods: Created a series of interlinked SmartPhrases and SmartLists that utilizes Ages and Stages Questionairre-3 to assess severity of developmental delay using specific descriptors. The tool also gives general recommendations based on findings.
Results: There were 279 well-child check visits for 6-months to 36-months-old patients between 3/22/23 and 5/24/23, and the developmental delay assessment tool was included in 246 notes from these visits.
Conclusion: There was 88% compliance with using this tool for routine well-child check visits between 6- to 36-month-olds. Based on resident feedback, this tool is a useful reminder for using ASQ3 and what interventions are recommended based on the severity of delay. The effectiveness of this tool on improving chart review and increasing efficiency for successful case closures will need to be investigated in the future.
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9:30-11:00 a.m.
Columbia Ballroom (CMCC upper level) |
Poster: 193
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| Klein, Katie |
Freeburg, Darin |
Using Audio Diaries to Uncover Identity-Based Routines in Public Libraries
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Abstract Text
Library careers are rewarding, but any workplace can be a “nexus point for social oppression” (Blustein, 2008). Work routines constructed in public libraries whose professional workforce is largely white females can pose barriers to workers with marginalized identities. To understand routines and the affordances, disaffordances, and workarounds encountered and used by library workers, we used a combination of audio diaries and interviews. Diary methods allow research participants to record their experiences and thoughts close to the event, allowing a “life as it is lived” perspective (Bolger, Davis, & Rafaeli, 2003). In addition to flexibility and ease of use, the audio diaries allowed participants to speak candidly about their experiences without a researcher present. Since the PI and RA are white, straight, and cisgender, our absence during audio diary recording provided a layer of safety for participants. During subsequent interviews we unpacked the intersection of identity and work routines with participants.
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9:30-11:00 a.m.
Columbia Ballroom (CMCC upper level) |
Poster: 101
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Wolfer, David
Brady, Megan |
Morris, Sheena |
CERTIFIED REGISTERED NURSE ANESTHESIOLOGIST BURNOUT
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Abstract Text
Certified Registered Nurse Anesthesiologists (CRNAs) present an increased risk for burnout given the demanding nature of the education, coupled with the responsibilities associated with the role. Burnout is defined as “a state of physical, emotional, and mental exhaustion caused by long-term exposure to demanding work situations, or the cumulative result of stress” (Chipas & McKenna, 2011). Elevated levels of burnout in this population leading to CRNAs leaving the profession will impact the entire healthcare landscape, including patient care and safety. This project aimed to assess the severity of burnout amongst CRNAs at a large Level 1 Trauma Center. The Burnout Assessment Tool-12 (BAT-12), a twelve-question survey utilizing the Likert scale to measure the severity of burnout, was sent securely via email to sixty-five CRNAs employed by the Level 1 Trauma Center. The survey results were stored securely and anonymously in REDCaps, from which they were exported and analyzed in Excel. Out of sixty-five individual CRNAs, thirty-one complete and one incomplete response were obtained and analyzed, rendering a response rate of 49.23%. The average scores were divided into four categories: Low, Medium, High, and Very High individual average burnout scores. The Low, Medium, High, and Very High classifications included two (6.25%), fifteen (46.875%), fourteen (43.75%), and one (3.125%) participants, respectively. Based on a Two-sample Z-test between this study and results found in Hadžibajramović et al. (2022), the P-value of 0.0138 of the -2.77 Z-score was found to be statistically significant. This can lead us to derive that there is a more significant proportion of individuals experiencing higher burnout rates as qualified by the BAT-12 scoring system in this study population. With this information, looking at contributing factors and investigating different interventions could potentially ameliorate the severity of burnout amongst CRNAs.
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9:30-11:00 a.m.
Columbia Ballroom (CMCC upper level) |
Poster: 55
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| Dailey, Kelsey |
Ismail, Briahnna
Miles, Heather |
Preventative Health: A Concentration in Women’s Health Prophylaxis
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Abstract Text
During the summer of 2023, I shadowed at Eau Claire Cooperative Women’s Health Hopkins (WHH). The outpatient practice works to facilitate medical OB/GYN care of underinsured and uninsured women and families. My time at WHH encompassed a variety of prophylactic treatments, assessments, and patient education. Prophylaxis can be defined as taking preventive action to decrease the risk of a certain disease or complication among a population. Patient prophylaxis encompasses this while also incorporating patient health promotion and education, which is known as preventive health. Preventative women’s health is my focus and the clinical insight I gained at WHH. We facilitated birth control placement and removal, offered vaccinations, provided pre-pregnancy counseling and prenatal care up to the 36th week of gestation, conducted sexual health counseling, and comprehensive well-women examinations.
I became increasingly passionate about women’s health during my time here at Carolina as a nursing major. Holistic and affordable women’s health is a big part of my life and is an underrepresented sector of the medical field where many women who experience health disparities do to have access to preventive women’s health facilities. It is my aspiration in the future to promote more efficient quality access to prophylactic women’s health treatment plans. In addition, during my Maternal and Newborn course, along with my time at WHH, I learned the importance of preventative health through civic engagement. Understanding how to provide patient prophylaxis impacted the kind of nurse I want to be post-grad. The clinical significance of women’s health prophylaxis highlights preventing infection and providing longevity and safety to our patients from all backgrounds. I want to educate women to ask for preventive health interventions going forward in their continuation and continuity of care. My plans include applying to be a Labor and Delivery nurse and eventually working to be a women’s health nurse practitioner (WHNP) after earning an advanced practice registered nursing degree.
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1:00-2:30 p.m.
Exhibit Hall (CMCC lower level) |
Poster: 270
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| Burden, Julia |
Ismail, Briahnna |
Leading by Example
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Abstract Text
Over the summer, I had the opportunity to work as a youth chaperone leader in Memphis, Tennessee for Eastminster Presbyterian Church. I found that the work was hard and tiring- but totally worth it! There are always people and places that need help, the work will never run out.
To get to Memphis, youth and chaperones took a 12-hour bus ride to Memphis. While there, we assisted 3 main organizations: Mid-South Food Bank, Project Transformation Summer Day Camp, and First Congressional Church. My motivation for volunteering was because I have had first-hand experience of the positive impact of communities coming together. In 2015 my family’s house flooded killing some of our pets and destroying most of our house. Although the experience resulted in loss, it was eye opening to see so many people that I knew and even strangers pulling together in support of my family. I have now completed over 300 hours of community service to pay forward what others did for me and my family during a time of hardship.
While working with different organizations, we completed tasks such as clearing and sanitizing children’s day schools, picking up trash on the street/roads, helping children practice reading, and delivering meals. The most memorable part of the mission trip was making connections with people. Some were volunteers from other organizations, and some were clients. Being able to talk and work with others from various situations helps me to gain perspective and continue to learn how I can be of service and help others.
When reflecting on my experience I want to let others know that there will always be communities and people who need help. You never know what someone is going through. Even one small gesture or conversation will change someone, especially yourself.
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9:30-11:00 a.m.
Exhibit Hall (CMCC lower level) |
Poster: 317
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Pelletier, Bridgette
Sabin, Diana |
Gutshall, Catherine |
Stress and the SRNA- Can Peer Mentorship Improve Self-Efficacy?
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Abstract Text
To evaluate the impact of mentorship on self-efficacy, convenience sampling was utilized
at the University of South Carolina’s Nurse Anesthesia program to construct a new peer
mentorship program. Implementation of this program included: participation survey, pairing
survey, mentorship education, as well as guidelines to ensure outreach during the mentorship
phase. Tools used to evaluate the effectiveness of the program included: baseline, mid-point, and
post General Self Efficacy (GSE) surveys taken by the underclassmen being mentored in this
program. Overall results of this study were positive, with a 2.14 point average improvement in
GSE score from baseline to post-test results.
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9:30-11:00 a.m.
Columbia Ballroom (CMCC upper level) |
Poster: 56
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Hendrix, Andrew
Eckert, Thomas |
Carlyle, Logan |
SVT and CVA. Should You Get the Echo?
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Abstract Text
Introduction
Ischemic stroke significantly contributes to morbidity and mortality, impacting quality of life and work capacity, especially among younger individuals. It is widely recognized that the risk factors and etiology of stroke in young adults vary considerably from those observed in older patients. Supraventricular tachycardia (SVT) is a common cardiac arrhythmia characterized by recurrent episodes of narrow QRS complex tachycardia initiated by the atria and/or atrioventricular node. Traditionally considered as a benign rhythm disorder, recent studies have suggested that patients with SVT may have a higher risk of ischemic stroke. However, there is limited literature on the subject of cardioversion in the setting of SVT and the associated risk of CVA. In this case we present a 25 year old female who underwent cardioversion for SVT and subsequently developed a right ICA stroke.
Case Presentation:
A 25 year old female presented to the ED with a heart rate in the 250s bpm. Cardiology was consulted and the patient was chemically cardioverted with adenosine 6 mg. No echocardiography was performed at the time of cardioversion. Hours after cardioversion, the patient developed acute onset of left lower facial paralysis, dense left hemiplegia, and sensory loss resulting in a NIHSS of 14. Noncontrast CT head showed no acute hemorrhage and the patient received Tenecteplase. CTA head/neck demonstrated a right ICA occlusion. Mechanical thrombectomy was performed with TICI 3 flow achieved post-intervention. The patient had significant recovery, with full strength and sensation on post-stroke day 1. Post-op MRI brain showed areas of acute ischemic infarction predominantly in the right frontal lobe as well as basal ganglia. Patient progressed well and was transferred out of the ICU on post-stroke day 4.
Discussion:
The risk of CVA following cardioversion of atrial fibrillation is well established and thus guidelines dictate when to get a transesophageal echocardiogram (TEE) prior to cardioversion. However, TEE is not found in the cardioversion protocol for SVT. This unique case presents an interesting discussion on the etiology of the patient’s stroke as well as the futility or efficacy of TEE prior to SVT cardioversion.
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1:00-2:30 p.m.
Columbia Ballroom (CMCC upper level) |
Poster: 149
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Hendrix, Andrew
Kerrison, Caroline |
Sanders, Thomas
Hall, SaraRose
Becker, Elise |
Serendipity in Scalpels: A Historical Analysis of Accidental Surgical Innovation
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Abstract Text
The history of accidental surgical inventions serves as a rich tapestry that encapsulates the unpredictable nature of scientific exploration and innovation. These stories illuminate the fact that some of the most transformative breakthroughs have emerged not from meticulously planned endeavors but from chance encounters, accidental observations, and unintended consequences. As we reflect on the past, the lessons gleaned from serendipity guide us toward future surgical frontiers. Embracing the spirit of exploration and remaining open to unexpected discoveries may well be the catalysts for the next wave of surgical innovations. This historical analysis weaves together stories of chance and brilliance, beckoning the audience to appreciate the interconnectedness of serendipity and surgical progress; we invite contemplation on the untrodden paths that may lead to groundbreaking revelations in the future. In this historical analysis, we will delve deeper into specific instances of accidental surgical inventions, including laparoscopy, laser eye surgery, Surgicel™, and pacemakers. Through this journey, we aim to inspire a new generation of surgeons, researchers, and innovators to embrace the unpredictability of scientific exploration and harness the power of serendipity in shaping the future of surgical practice.
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1:00-2:30 p.m.
Columbia Ballroom (CMCC upper level) |
Poster: 150
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| Kanich, Maya |
Matthews, Sarah |
Opportunity Presents Growth
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Abstract Text
I am currently a Sports and Entertainment Management student with minors in events management as well as Advertising and Public Relations. As a student in the sports and entertainment program, I am required to complete 2 internship opportunities during my time here at the University of South Carolina. While my out-of-classroom work experiences did not stop at just those two, they had the biggest impact on my career choices and my outlook on the industry. I was able to complete not only one but two internships my summer going into my junior year of college to complete SPTE 295, my first practicum. was able to work with Key Signature Entertainment as a Sales and Marketing intern and Live Nation as an Operations and Production intern. Throughout this process, I learned how important it is not only to learn what you do like, but what you do not as well. Expanding your horizons and trying new things is important and allows you to flourish in the path you are truly passionate about. It was also important to me to see how many departments in the entertainment world correlated with one
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1:00-2:30 p.m.
Exhibit Hall (CMCC lower level) |
Poster: 303
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| Dennis, Colby |
Wellman, Denise |
Global Learning: The Influence of the Nordic Lifestyle on My Life
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Abstract Text
In the spring of 2023, I spent four months living in Helsinki, Finland as part of an exchange program between the University of South Carolina and Aalto University. Since I am studying international business I was able to participate in this exchange program. I had previously travelled to Norway for an international business maymester and wanted to have another Nordic experience in a different country and for an extended period of time.
I had the opportunity to be completely immersed in the Nordic way of living and have a firsthand look into their culture. I took masters and undergraduate level courses at Aalto University as well as travelled around Finland to different cities where I explored the different ways of living. I used my spare time when I wasn’t taking classes to travel to Northern Finland and other neighboring countries in order to get an additional perspective on different cultures around Europe. Something especially meaningful to me that I was able to experience was spending two weeks in Lapland, which is located in Northern Finland. Here I was able to see the Northern Lights, sleep in an igloo for a night in order to see what a night is like there, as well as go snowshoeing and snowmobiling.
This experience has had a lasting impact on me and has given me experiences I will carry with me as a future international business professional. This year is the 40th year of a partnership between Aalto University and the University of South Carolina. To celebrate this, the Dean of Aalto University Business School visited Darla Moore School of Business. We were able to have lunch together at the McCutchen House on the USC campus. I was so grateful to be able to celebrate such an influential period of my life with the people who made the experience possible. I am hopeful to return to Finland in the future and plan to use sustainability tactics, management and communication skills, and overall experiences I learned and apply them to my personal and professional life.
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9:30-11:00 a.m.
Exhibit Hall (CMCC lower level) |
Poster: 276
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Lyons, Sawyer
Benevento, Antonio |
Stallworth, James |
Presentation of Moyamoya disease in an 8-year-old Caucasian Female
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Abstract Text
We report the case of a female Caucasian child who presented initially with seizure-like activity. Further seizure-like episodes occurred with symptoms including headache, bladder incontinence, loss of speech, single-sided weakness, and more. Following the discovery of a possible infarct, the patient was transferred to a regional children’s hospital, where she was later diagnosed with Moyamoya when a CT scan confirmed vascular hyperdensity. The patient was placed on a regimen for symptom management and referred for neuropsychiatric evaluation. This case study demonstrates that, although Moyamoya is most commonly diagnosed in people of East Asian descent, it is an important diagnostic consideration for patients of other ethnicities when symptoms such as ischemic seizure present.
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1:00-2:30 p.m.
Columbia Ballroom (CMCC upper level) |
Poster: 166
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| Coe, Macie |
Zarrett, Nicole |
Positive Physical Activity in After-School Programs: The Impact it Has on Adolescent’s Overall Wellbeing
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Abstract Text
The CONNECT Lab (Zarrett, PI) is a research lab focused on examining how the implementation of a social-motivational climate physical activity (PA) program can improve adolescent’s motivation and daily activity levels. The lab hopes to make a connection between increasing PA in student’s lives and preventing negative health outcomes. I began with the lab as a Research Assistant in 2021 and I am now the Intervention Specialist, and oversee the implementation of our Intervention programs. I originally began working with the project to share my passion for exercise with others. Since beginning, my goal has grown, I hope to analyze the relationship between having a positive outlook on PA and the implications it has on overall wellbeing.
The CONNECT intervention implements one of two programs (CONNECT Wellness and CONNECT Move) at six schools each year. CONNECT Wellness schools receive a one-day a week classroom-based initiative that educates students on the importance of healthy habits. CONNECT Move schools receive a PA curriculum in which PA games are introduced three times a week for 16 weeks. During the study, we provide students with accelerometers that are worn at baseline, midpoint, and endpoint for five days to measure their levels of activity. Concurrently, the measurement team conducts systematic observations of the social-motivational climate, measures anthropometrics, and collects self-report surveys of the students and staff.
To date, the data has shown that between baseline and endpoint there is an increase in student physical activity levels within the afterschool program (ASP) and across outside student settings. Therefore, it seems there is a correlation between improving the social-motivational climate in ASP for both increasing PA and motivating students to engage in PA outside the program. Through personal observation, I watched student’s attitudes and demeanors change tremendously from baseline to endpoint.
Observing the positive changes in mental, physical, and emotional health; in these students gives me hope that what we are teaching will remain with the students as they mature. It also gives me hope for the future success in using physical activity to prevent negative outcomes.
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9:30-11:00 a.m.
Exhibit Hall (CMCC lower level) |
Poster: 194
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| Burts, Charlotte |
Wright, Pamela
Dawson, Robin |
Analyzing Perceptions of Mental Health Among Individuals with Polycystic Ovary Syndrome
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Abstract Text
Individuals of reproductive years with polycystic ovary syndrome (PCOS) are up to three times more likely to have mental health issues such as depression, and seven times more likely to attempt suicide. However, mental health issues associated with PCOS often go unrecognized. Without proper treatment, mental health conditions can worsen over time. Purpose: The purpose of this study was to explore how physical, mental, and social experiences and perspectives impact the mental health of individuals with PCOS aged 18-26 years. Methods: Participants were recruited using flyers, social media, the snowball method, and ResearchMatch (NIH digital recruiting technology). Using a semi-structured interview guide created through the lens of the biopsychosocial theory, interviews were conducted and audio recorded using Zoom and surveys were sent to be returned after the interview. All data were de-identified. Interview data were transcribed and analyzed using thematic analysis. Survey data were entered in SPSS and analyzed. Results: Participants (n=24) were aged 22.2 (+/- 2.3) years, single (75%), and resided in different regions of the United States. Mean depressive symptom scores (PHQ-8) were 10.9 (+/- 7.3), indicating moderate depression. Preliminary interview themes were: 1) feeling initially dismissed by healthcare providers when discussing PCOS and pharmacological interventions; but validated after receiving a PCOS diagnosis; 2) perceiving that mental health was affected by physical symptoms, such as weight gain, hirsutism, and fatigue; and 3) expressing concerns about the future given recent changes concerning reproductive rights. Conclusion: HCPs should consider biopsychosocial aspects of PCOS to better provide patient-centered care and earlier recognize signs of mental health distress. A holistic medical assessment could improve patient-provider communication, inform individualized treatment plans, and ultimately lead to better mental health outcomes for individuals with PCOS. Further research could help develop PCOS-specific evidence-based biopsychosocial screenings, consider their point of integration, and create decision-trees based on results.
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1:00-2:30 p.m.
Exhibit Hall (CMCC lower level) |
Poster: 143
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| Le, Kimanh |
Monroe, Courtney |
The TikTok experience and content moderation of nonsuicidal self-injury: A qualitative and content analysis
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Abstract Text
Background: Individuals who engage in nonsuicidal self-injury are stigmatized in offline spaces and will find platforms such as TikTok appealing. Users can share mental health topics, yet the Community Guidelines ban content that shows evidence of self-harm. The nonsuicidal self-injury community faces biased surveillance surrounding this form of mental health, leading to marginalization in this digital space.
Objective: To understand how users who have previously engaged or are engaging in nonsuicidal self-injury avoid algorithmic detection while staying within the bounds of the Community Guidelines in the seeking, using, sharing, and creating of nonsuicidal self-injury content.
Methods: Adults aged 18 and older who resided in the United States, spent at least 2 hours a week using TikTok, and have a history of nonsuicidal self-injury were eligible to participate in the 1-hour semi-structured interviews on Zoom. Demographics were collected during the pre-screening questionnaire. NVivo 12 was used to code interview transcripts, and themes were identified via formal thematic analysis using emic and etic perspectives. Content analysis of 150 TikTok videos labeled with #scars, #sh, and #shawareness were also collected and analyzed independently by two researchers (κ=0.74) to triangulate findings from the interviews.
Results: Eight participants (M age=24.50±2.07 years; 75% female) completed the interviews. Qualitative findings illuminated four emergent themes: sense of community, coping strategies, normalizing self-harm discussions, and awareness of audience. Themes from the content analysis (81% female; 92% White) included using nonsuicidal self-injury related hashtags, signaling, and algospeak to avoid algorithmic detection and violating the Community Guidelines to remain transparent on TikTok. Avoiding detection has allowed users to participate in discussions of nonsuicidal self-injury, increase social support, reduce stigma, and promote a safe, online space.
Conclusion: Users who engage or have previously engaged in nonsuicidal self-injury have an understanding of how to get around the TikTok guidelines as it relates to seeking, using, sharing, and creating of nonsuicidal self-injury content via self-surveillance and self-censorship. Content moderation, however, will continue to obstruct progress towards reducing stigmatization of nonsuicidal self-injury. Future research should identify other ways users circumvent the algorithm and Community Guidelines to amend current policies regarding nonsuicidal self-injury content on TikTok.
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9:30-11:00 a.m.
Columbia Ballroom (CMCC upper level) |
Poster: 64
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| Hollis, Payton |
Hiott, Ambra |
Embodying Social Work Values: A Journey of Service and Recognition as a Resident Mentor
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Abstract Text
In my journey through Social Work 201, I delved deeply into the core values and principles of social work, including service, social justice, individual dignity, human relationships, integrity, and competence. Concurrently, during my sophomore year at USC, I served as a resident mentor, where I integrated these principles into my daily interactions. The element of service, fundamental to social work, guided my efforts in providing support and prioritizing the needs of my fellow students over my own. Building trusting relationships with my residents was paramount, and I actively engaged in one-on-one interactions to foster rapport. Organizing events aligned with their interests, such as crafting Valentine's cards for senior citizens, exemplified the application of these values in action. The impact of the Valentine's Day event resonated deeply, culminating in my recognition with the "Rookie of the Year" award at the Residence Life Banquet at the end of the year. This acknowledgment underscores the importance of embodying social work values in practical roles and serving as a role model for peers.
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1:00-2:30 p.m.
Exhibit Hall (CMCC lower level) |
Poster: 311
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Frattaroli, Nina
Frattaroli, Nicole |
Fernando, Tharangi |
Peer Leader at the Student Success Center
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Abstract Text
Being a peer leader, specifically a peer consultant, at the Student Success Center here at the University of South Carolina has been such a pivotal experience and one that we are both very grateful for. In this role, we have been able to develop numerous skills including communication, time management, and leadership and ultimately, this opportunity has positively shaped our university experience. When first starting this role our fall semester of our sophomore year, we did not know the impact that it would cause in our college journey. As a peer consultant, you are responsible for a considerable amount of the operations of the student success center, including working the front desk to check in students to their appointments, as well as making and taking calls from students who are interested in the resources offered at the Student Success Center, but you are also responsible for working with students to guide them down their journey of academic success through one hour consultations called success consultations. In these success consultations topics such as academic success and study skills, prioritization and procrastination, motivation and discipline, and prepping for exams can be discussed and are all geared to lead the student to success. Overall, in this role, we have been able to develop numerous skills, but most importantly we have also been able to fulfill a calling of helping others proceed in their college academic journey to the best of their abilities, which is something that we both would not trade for the world.
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1:00-2:30 p.m.
Exhibit Hall (CMCC lower level) |
Poster: 312
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| Hood, Taylor |
Taylor, Jay |
Twiddler’s Syndrome – a rare case of pacemaker malfunction
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Abstract Text
Introduction
Pacemakers are often implanted in patients to solve cardiac dysrhythmic problems. As with any implanted medical device sometimes malfunctions occur. This case illustrates a rare cause of pacemaker malfunction in a newly implanted device.
Case Presentation
JM is a 61-year-old female who presented to the ED for evaluation of “palpations”. Her first episode occurred 3 days prior and felt like “tight intense contractions” that began in her lower right ribs and migrated to the center of her chest. The “palpitations” began again in the center of her chest about 1-2 hours before her presentation to the emergency department and have consistently been present since then. She described the “palpitations” as a contraction type feeling that you could see involving the muscles of her chest. She stated that her pacemaker that had been placed 17 weeks prior to evaluation had been irritating her and she had been rubbing it.
On evaluation in the ED, she was in no acute distress, had clear bilateral breath sounds, and regular heart rate and rhythm. She had a healed surgical incision over her left pectoralis muscle and the pacemaker could be felt low in her Left chest. Her chest wall pectoralis muscles were contracting at the same rate as her heart on auscultation. Chest x-ray in the ED showed “interval retraction of a left sided cardiac pacer leads” with complete dislocation of the pacer leads from the heart. The leads were coiled around the pacemaker generator.
Outcome
Cardiology was consulted for pacemaker dislodgement and replacement. Her left sided pacemaker was removed the next day and a new right sided pacemaker was placed without difficulty.
Discussion
This case represents an extremely rare case of Twiddler’s Syndrome in which the patient admitted to unintentionally manipulating the pacemaker generator. The manipulation caused the leads to be removed from her heart, coil around the pacemaker, and reimplant into her chest wall causing cell wall stimulation and contraction. Fortunately, she suffered no other ill effects and underwent replacement without difficulty.
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1:00-2:30 p.m.
Columbia Ballroom (CMCC upper level) |
Poster: 142
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Townsley, Athena
Decker, Kristen |
Gutshall, Catherine |
Virtual Reality Induction Simulation
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Abstract Text
Despite classroom instruction and high-fidelity simulation exercises, anesthesia induction sequencing remains a critical and stressful aspect of clinical training for first-year student registered nurse anesthetists (SRNAs). Based on the literature review conducted as a part of this project, virtual reality (VR) simulation is a beneficial tool in anesthesia education. This project examined what effect the addition of computerized VR simulation to induction training had on reducing stress levels in first year SRNAs prior to starting clinical training. This project was produced at the University of South Carolina School of Medicine Graduate Program in Nurse Anesthesia (USC GPNA). Participants included students in the 2025 graduating class, split randomly into intervention and control groups. Both groups received classroom instruction followed by high-fidelity simulation experiences. In addition, the intervention group participants received a didactic presentation of computerized VR anesthesia induction sequencing and home access to the computerized VR program, with the requirement to complete a minimum of five inductions. Pre-survey results showed similar induction stress baseline characteristics between the two groups. The intervention group showed improvement between pre- and post-training stress levels related to induction sequencing with 100% agreement on understanding anesthesia induction. The control group did not show a difference between pre- and post-training stress. Therefore, computerized VR training was found to be a useful adjunctive learning tool to help reduce stress related to the induction process for first-year USC GPNA SRNAs.
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9:30-11:00 a.m.
Columbia Ballroom (CMCC upper level) |
Poster: 58
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| Miller, Keaton |
Matthews, Sarah |
The Art (Gallery) of Brainstorm: How Study Abroad Taught Me About Perspectives
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Abstract Text
As an international business major with aspirations of working for multinational corporations, it is essential for me to learn how to work with people from diverse backgrounds with differing perspectives. As a part of the International Business Education Alliance (IBEA) Cohort Program, I studied abroad in Germany for months during the spring of 2022, and I had experience working with 41 different students from countries all around the world. During the spring of 2023, I studied abroad at ESSEC University in Singapore, Singapore. Through a partnership with a local art gallery in Singapore, I was able to work with students from Brazil, China, Germany, and the US to help bring our expertise to our Singaporean client to work on profitability measures and potential ways to expand using different internal measures. While I had worked on previous projects with other students on previous consulting projects in both Germany and the United States, this experience was especially significant for me because I felt like I had finally gained enough in class knowledge and project experience to finally understand the importance of maintaining and encouraging diverse perspectives. The three months that I spent on this project was full of collaborating on our individual ideas to contribute unique knowledge, challenging each other to think beyond the traditional metrics, and using innovative brainstorming activities that helped to exponentially increase our idea fecundity. We used this brainstorming activity to suggest ideas out of range, ideas free of charge, and actual viable solutions to our problems. Through this, we were able to develop more than 90 unique ideas, and while we weren’t able to implement them all, several of them turned into profitable measures for expansion and addressed the primary concerns of our client, which is an invaluable skill I know I will utilize in every aspect of consulting in the future. Understanding the inherent value of utilizing unique perspectives to their full capacity is essential for any aspiring international business professional, and this experience taught me about the many unique ways to maximize this value in the future.
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9:30-11:00 a.m.
Exhibit Hall (CMCC lower level) |
Poster: 277
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| Bailey, Rianna |
Hiott, Ambra |
Effecting Education Everywhere Through Service
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Abstract Text
Through dedicated community service I have gained plentiful knowledge relating to the field of community service and its impact within the field of education. Differentiation, specified instruction, and comprehensive research allows for a positive impact within the field of education and beyond. Through these, we can give students the best possible education that is available, specifically giving them the time and attention they so desperately deserve. Despite prevalent research regarding different aspects towards literature and education, the learners are key aspects towards the successfulness of the learning. Individuals doing the best for other individuals allows for the betterment of all learning, no matter the environment or capabilities denounced by other individuals. Through the active engagement of individuals connected through community service, education, and outcome awareness can make a significant impact towards the betterment of those as well, not defined by any other attributes such as location and ability. In a way to continue to better the world of education and growth, recognition of the effects of the future and outcome are detrimental to the overall success.
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9:30-11:00 a.m.
Exhibit Hall (CMCC lower level) |
Poster: 255
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DeVivo, Katherine
Ansani, Tyson |
Pellegrini, Christine
Burkhart, Sarah |
Dog Walking Is PAWSitively Related With Sleep Quality Among Dog Owners
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Abstract Text
Background: Nearly 1 in 2 US households own a dog, and dog walking may be a common form of activity among dog owners. Participation in physical activity has many health benefits, including improved sleep quality. Therefore, this study aimed to explore differences in sleep quality among dog walkers and non-dog walkers.
Methods: Dog owners (primary caregiver of their dog(s) and at last 18 years old) completed an online survey (between August-September 2023) that assessed human demographics, sleep quality via the Pittsburgh Sleep Quality Index (PSQI), and dog walking behaviors. A PSQI global score was computed (sum of the 7 component scores: subjective sleep quality, sleep latency, sleep duration, sleep efficiency, sleep disturbance, use of sleep medication, and daytime dysfunction) on a scale of 0-21, with a higher score indicating worse sleep quality. Participants were split into two groups; 1) “dog walker” if they reported walking their dog at least once per week when asked how many d/wk they walked their dog(s) (0-7 days), and 2) “non-dog walker” if they reported 0 days. Independent t-tests compared sleep quality between dog walkers vs. non-dog walkers.
Results: Dog owners (n=301) from 38 US states completed the survey. Participants were primarily white (92%) and female (86%) with an average age of 35.212.9 years and BMI of 26.96.1 kg/m2. Eighty-eight percent of the dog owners were considered dog walkers and the participants walked their dog(s) an average of 5.52.6 d/wk. Additionally, participants PSQI global score was 6.33.2. Dog walkers (6.13.1 PSQI global score) had a significantly lower/better PSQI global score than non-dog walkers (7.53.8 PSQI global score, p= 0.041).
Conclusion: The current study found dog walkers reported a better sleep quality score than non-dog walkers. Dog walking may influence one or multiple determinates of sleep quality including lifestyle, mental health, social, and/or physical factors. In addition to the benefits from the physical activity, dog walking, or being active with a furry companion, may serve as social support, aid in stress reduction, or positively influence mental health. Promoting dog walking among dog owners, ~50% of US households, may improve sleep quality in these individuals.
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9:30-11:00 a.m.
Columbia Ballroom (CMCC upper level) |
Poster: 73
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| Shaik, Maherah |
Ely, Bert |
A Career in Biochemistry
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Abstract Text
My name is Maherah Shaik, and I selected Research as my pathway of distinction. I am currently majoring in Biochemistry and Molecular Biology. My goals post-graduation involve pursuing admission into graduate school related to biochemistry, specifically drug discovery. My long-term goal is to work as a researcher and contribute to healthcare development in underprivileged countries.
While I was always aware of my passion for chemistry, I initially thought I wanted to pursue medical school and choose biochemistry as my major with that goal in mind. However, very soon, classes like Biochemistry and Genetics changed my mind and diverted my goal to pursue a career as a researcher instead. I took BIOL303 Honors with Dr. Ely, which allowed me to express my interests to him and join his lab, which led to a 2-year long research internship and Dr. Ely becoming my primary research mentor. This experience combined with my previous microbiology internship with Dr. Selvan reinforced my commitment to medical research and a career as a scientist. Volunteering as an educator with organizations like Parikrma and Carolina Survivors Clinic which initially began as a way to contribute back to my community soon allowed me to gain confidence and apply and pursue teaching assistantships within the Department of Biochemistry. Being a TA for Organic Chemistry has been my most full-filling experience thus far and further reinforces my commitment to academia.
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9:30-11:00 a.m.
Exhibit Hall (CMCC lower level) |
Poster: 49
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| Ford, Jason |
Strohmier Berry, Hala |
Feasibility of Machine Learning-Enhanced Detection for QR Code Images in Email-Based Threats
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With the ubiquity of QR codes in contemporary digital communication, cybercriminals have rapidly adopted this technology as a convincing lure for URL-based email phishing attacks. These malicious QR codes often serve as vectors for crimeware, exploiting the quick response mechanism to mislead victims into disclosing sensitive information. The challenge confronting cybersecurity vendors is the daunting task of scrutinizing each email for embedded QR codes, a process which is both computationally intensive and impractical at large scale. This research addresses this challenge by exploring the application of convolutional neural networks (CNNs) to automate the detection of QR code images embedded in email messages. It details the iterative development and refinement of a CNN model aimed at distinguishing between benign and malicious QR codes and assesses its integration potential within email scanning workflows. Extensive experimentation reveals a machine learning approach that achieves high accuracy in initial generations but faces the common pitfall of overfitting, highlighting the delicate balance required in model training. The research culminates in a proof of concept that demonstrates the viability of CNNs for scalable threat detection solutions and underscores the importance of model adaptability in the ever-evolving cybersecurity landscape. This advancement suggests a new frontier in email security, offering a sophisticated tool to counteract the surge of QR code-based phishing threats.
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1:00-2:30 p.m.
Exhibit Hall (CMCC lower level) |
Poster: 122
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| Fuentes, America |
Meyer-Gutbrod, Joshua
Spence, Gina |
From Prosecution to Defense: A Double Perspective of Criminal Law in South Carolina
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During my time as an undergraduate student, I had the opportunity to intern for both a private law firm, Evan Guthrie Law Firm, and a state agency, the South Carolina Department of Public Safety. My role at Evan Guthrie Law Firm was to conduct research for the defense of the attorney’s clients, whereas my role at SCDPS General Counsel was to shadow and aid in the prosecution side. With these two roles, I had the unique perspective of seeing and working for both sides of the criminal justice system. All together, I have 240 hours of experience total—120 hours each—of both prosecution and defense experience. This presentation will introduce and inform the audience of the two sides of criminal law, how they work together, and give a first hand account of an experience working in criminal justicre, as well as how this ties into classroom experience at UofSC.
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1:00-2:30 p.m.
Exhibit Hall (CMCC lower level) |
Poster: 264
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| Abdulrahman, Zach |
Sun, Yi |
Advancing Computational Neuroscience: Modeling Neuronal Dynamics Through Programming and Mathematics
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Abstract Text
This project aims to advance computational neuroscience by utilizing programming and mathematical expertise to simulate dynamic systems and construct neuronal network models using imperative languages such as C, Python, and MATLAB. The main objective is to develop multi-neuron models that can simulate and generalize neuronal network dynamics. Starting with fundamental mathematical principles, the study introduces various neuron models, including the Hodgkin-Huxley and integrate-and-fire models, and explains their programming implementations. Using these mathematical frameworks, numerical simulations of neuronal dynamics are performed, resulting in the creation of neuronal network models that incorporate stimulus inputs and electrical outputs. The project seeks to extract generalized principles from these simulations that can be applied to broader contexts within neuronal dynamics. The anticipated outcomes include the use of generated data for event tree analysis, which will provide insights into the complex interplay of neuronal activities. Upon completion, this interdisciplinary endeavor promises to contribute to a comprehensive understanding of computational neuroscience, fostering proficiency in developing sophisticated multi-neuron models that emulate intricate neuronal network dynamics. This research not only advances theoretical understanding but also cultivates practical skills in programming, mathematical modeling, and data analysis, providing a strong foundation for further exploration and innovation in the field of computational neuroscience.
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9:30-11:00 a.m.
Exhibit Hall (CMCC lower level) |
Poster: 104
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| Ansani, Tyson |
Pellegrini, Christine
Devivo, Katherine
Burkart, Sarah |
Does Co-Sleeping With A Dog Influence Dog Owners' Sleep Quality Or PA Levels?
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Abstract Text
In the U.S., 45% of households own dogs, with many allowing them to share beds. This study aims to explore how co-sleeping with dogs affects sleep quality and physical activity (PA) among dog owners. Adults who are a primary caregiver of a dog (at least 6-months old) were recruited for an online survey which asked about human demographics, sleep quality using the Pittsburgh Sleep Quality Index (PSQI; higher scores indicate worse sleep quality), and PA. Demographics included race, sex, age, and number of dogs in the household. Participants reported their weekly PA frequency (days with at least 30 minutes of PA sufficient to raise their breathing rate). Participants were categorized as "co-sleepers" if they shared their bed with their dog or if their dog slept in the bedroom and as "non-co-sleepers" if their dogs slept in a different room. Independent t-tests compared sleep quality and PA across the two groups. Participants (n=301, age = 35±13 years) were primarily white (92%) and female (86%). Most participants (60%) owned only one dog and 46% of participants reported co-sleeping with a dog. There was no significant difference in the numbers of active days reported by co-sleepers (3.9±2.0 d/wk) and non-co-sleepers (4.0±2.2 d/wk, p=.655). Global PSQI scores did not significantly differ between the groups (6.6±3.3 vs. 6.0±3.2, p=.102). Sleep efficiency scores were significantly higher for those who co-slept than those who did not (.76±.96 vs. .48±.79, p=.006). Sleep duration scores trended higher for those who co-sleep than those who did not (1.0±0.8 vs. 8.4±0.8 p=0.098).The lack of significant distinction in PA levels may suggest that disturbances caused by co-sleeping with dogs do not notably affect daytime PA. Co-sleepers had lower sleep efficiency, possibly due to interactions with their dogs at night. Monitoring both human and dog behavior in future studies could clarify how co-sleeping affects physical activity and sleep patterns.
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1:00-2:30 p.m.
Exhibit Hall (CMCC lower level) |
Poster: 144
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| DiCintio, Alannah |
Waldman, Alan |
The Effect of ZMPSTE24 Deficiency on Chromosomal Break Accumulation and Repair
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Abstract Text
Restrictive Dermopathy (RD), is an autosomal recessive rare genetic disorder that is neonatal lethal. If children are liveborn, they usually do not make it through the first week of life due to pulmonary insufficiency. RD is commonly caused by insertion mutations that produce premature termination codons in both copies of the ZMPSTE24 gene. ZMPSTE24 is a protease that plays a key role in the post-translational processing of lamin A, an essential protein in a structure called the nuclear lamina that plays a critical role in a variety of nuclear functions. The form of lamin A produced in the absence of ZMPSTE24 is permanently farnesylated and methylated. Previous studies from our lab and other groups have shown that other mutant forms of lamin A that are incompletely processed disrupt the repair of DNA double-strand breaks (DSBs) and cause a decreased ability to maintain genomic integrity. To enhance our understanding of the biology of RD, we are investigating the effects of ZMPSTE24 deficiency on DNA repair and damage accumulation. To do so we have stably transfected a DSB repair reporter substrate into the genome of a HeLa cell line that expresses ZMPSTE24 and into a second HeLa cell line in which ZMPSTE24 expression had been knocked out by CRISPR/Cas9. A DSB can be induced within the substrate through exogenous expression of endonuclease I-SceI, and DSB repair events occurring via either homologous recombination (HR) or non-homologous end-joining (NHEJ) are recoverable by genetic selection. Repair by HR is an accurate and templated form of repair, while NHEJ is an error-prone non-templated rejoining of DNA ends that may lead to deletion or insertion mutations. Our work aims to reveal the impact of ZMPSTE24 deficiency on repair pathway choice. We are also investigating DNA damage accumulation in cells that express ZMPSTE24 and ones that do not by directly visualizing γH2AX foci using immunofluorescence approaches. Results to date indicate increased damage in the absence of ZMPSTE24. We present our ongoing studies using our model system to investigate the effects of ZMPSTE24 deficiency on genome integrity.
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9:30-11:00 a.m.
Columbia Ballroom (CMCC upper level) |
Poster: 38
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Puckett, Hannah
Shaffer, Meredyth |
Tomlin, Kristl
Smith, Shelby |
ED to OR Door-to-Door Time After Implementation of the Composite Adnexal Torsion Prediction Score in Adolescent Patients at Prisma Health Midlands
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Abstract Text
Background: Adnexal torsion is a surgical emergency and is a diagnosis that continues to stump healthcare providers. Independent predictors of torsion have been identified and incorporated into a composite scoring system. Research studies are underway to determine the generalizability of these scores in hopes that they aid in improving efficiency in diagnosis and treatment of adnexal torsion. Previously, a retrospective chart review using this composite score on the Prisma Health pediatric population found an average door-to-door time from ED to OR of 47.1 hours for adnexal torsion cases between 2010 and 2019.
Purpose: The purpose of this study is to use the original Schwartz et al. composite score and apply it to our patient population at Prisma Health Midlands in a prospective manner in order to further validate its generalizability. We aim to investigate the average time to OR for suspected cases of torsion between 2021 to 2023 after implementing the CAT score and compare this time to that of previous retrospective studies to assess improvement in time to intervention.
Methods: We created an Epic smartphrase for the torsion predictor scoring system and encouraged providers at Prisma Health Midlands to utilize this diagnostic tool. Statistical analysis will then be performed to determine the reliability of the CAT score in identifying adnexal torsion in pediatric and adolescent patients as well as identifying any improvement in ER to OR door-to-door time.
Results: Our early prospective data appears to be corroborating the utility of this composite score in predicting adnexal torsion. Composite score had 100% sensitivity and 96% specificity in our patient population. Average time to OR for confirmed torsion cases, thus far, after presentation to the ED decreased from 47.1 hours to 8.14 hours.
Conclusions and Implications: The torsion predictor score appears to be generalizable to our diverse patient population and will likely serve as a valuable diagnostic tool in providing prompt surgical management for adnexal torsion in the future. From the data gathered thus far, ER to OR door-to-door time has significantly decreased. However, our sample size of surgically proven torsion cases remains low and data is still being collected.
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9:30-11:00 a.m.
Columbia Ballroom (CMCC upper level) |
Poster: 200
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| Otterson, Jack |
Smith, Deanna
Matoo, Samaneh |
Depletion of LIS1 Within Adult Mouse Projection Neurons Causes Severe Neurological Deficits
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Abstract Text
The LIS1 gene, present in nearly all animal cells, is vital for diverse cellular functions. The primary function of the LIS1 protein is to regulate dynein, a microtubule motor protein. Dynein transports cargo along microtubules and is critical for the appropriate localization of cellular components to subdomains within the cell. In humans, mutations in the LIS1 gene cause lissencephaly, a severe developmental brain malformation accompanied by seizures, learning disabilities, and a severely shortened life expectancy. LIS1 is critical for both the developing and developed nervous system when depleted from all tissues in adult mice. However, the underlying cellular defects causing these severe phenotypes remain unknown. Given the important role of LIS1 in regulating dynein-dependent axonal transport, we hypothesized that LIS1 depletion in axons contributed to the phenotypes observed in the global knockout of LIS1 in adult mice. Projection neurons are cells of the nervous system with long axons, this places significant demands on microtubule-based intracellular transport. We therefore tested the role of the LIS1 protein specifically within projection neurons in adult mice. We selectively knocked out LIS1 in adult mouse projection neurons using a Cre/LoxP system in which the Cre recombinase expression was driven by the Thy1 promoter in mice that also carried “depletable” LIS1 genes(Thy1-LIS1iKO). The Thy1 promoter also drives YFP expression in these mice, enabling visualization of the specific neurons expressing the Cre recombinase. Tamoxifen was administered to activate Cre, at a dosage of 0.05 mg/g body weight per day for 5 days. The experimental mice, but none of the controls, exhibited neurological phenotypes, including severe shivering and leg clasping behaviors, followed by seizures that ultimately resulted in their death within 10 days after the initial injection. We confirmed knockdown of the LIS1 protein in tissues and cultured neurons by performing immunostaining on brain sections and dorsal root ganglion neurons of Thy1-LIS1iKO mice. We have also seen structural changes to axons via confocal microscopy in Thy1-LIS1iKO mice compared to control mice. Our results indicate that Lis1 has a critical role in the post-developmental mammalian nervous system, specifically within projection neurons.
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9:30-11:00 a.m.
Exhibit Hall (CMCC lower level) |
Poster: 173
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| Duncan, David |
Armstrong, Alissa |
Characterizing the effects of obesogenic diets on Drosophila melanogaster immune responses across control lines
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Abstract Text
Diet impacts organismal health by providing macromolecules to support cellular survival and function. Obesogenic, or high-fat and high-sugar, diets can lead to long-term detrimental health effects including multiple cancer types, type 2 diabetes, insulin resistance and excess body fat. Over 60% of adults in the United States are overweight or obese and 42% of obese individuals also present with chronic inflammation. Despite this association, the cellular and molecular mechanisms that link obesity and associated diseases remain unclear. We use Drosophila melanogaster as an in vivo model to better understand the effects of obesogenic diets on the immune response and begin examining the potential therapeutic effects of dietary plant compounds on obesity-associated chronic inflammation. Given the broad range of “standard” diets and “control” fly lines used in the field, we are first characterizing lifespan and reproduction of several control lines across commercially and non-commercially available foods to identify an optimal base diet. Thus far, we find there is a difference in lifespan and reproduction patterns across the different control lines fed different standard diets. Oregon-R and yw control lines have a longer lifespan on a diet in which the sugar source is molasses, while w1118 control line has the shortest lifespan. A high fecundity rate was observed in yw control line fed a corn syrup-based diet and molasses diet. While molasses diet supports higher egg production for all control lines. We will also identify an obesogenic dietary condition that induces immune responses in adult flies by measuring immune response pathway activity and antimicrobial peptide production in flies fed high-sugar or high-fat diets. In future studies, we will use this approach to screen botanical supplements for their ability to suppress the diet-activated immune response. We hope that this work will inform the development of treatments for diet-induced obesity-associated diseases in humans.
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9:30-11:00 a.m.
Columbia Ballroom (CMCC upper level) |
Poster: 39
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Mason, Ashton
Kernodle, Elizabeth |
Iliff, Gabrielle
Reddig, Courtney
Patel, Kavita |
Utilization of Diuretic Bolus Prior to Initiating a Continuous Infusion in Acute Decompensated Heart Failure
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Abstract Text
Background/Purpose: The DOSE trial compared bolus vs. continuous infusion loop diuretic therapy and found no significant difference in patient symptoms or renal function. Due to no bolus given prior to continuous infusion in this trial, there is further need for investigation into optimal diuresis strategies. The purpose of this study is to determine the effect of bolus dosing prior to continuous infusion compared to continuous infusion alone on urine output.
Methodology: This was a retrospective, cohort study of adult patients hospitalized in the heart failure unit or CPICU at Prisma Health Richland from June 2022 through June 2023. Patients diagnosed with acute decompensated heart failure who received a continuous infusion of furosemide or bumetanide for at least 24 hours were included in the study. The primary outcome was cumulative urine output at 72 hours. The secondary outcomes were changes in serum creatinine, days to euvolemia, and changes in weight.
Results: In Progress
Conclusions: In Progress
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1:00-2:30 p.m.
Columbia Ballroom (CMCC upper level) |
Poster: 219
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| Mahmood, Kendall |
Neils-Strunjas, Jean
Nguyen, Katlyn |
A Follow-Up to a Mindful Walking Program for Older Adults
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Abstract Text
This follow-up project provides data on the longer-term effects of a mindful walking program on previous participants’ mood, cognition, physical fitness, and quality of life through the execution of various surveys and assessments. 20 past participants were contacted and asked a series of questions, including if mindful walking was sustained after program completion and whether they are experiencing one or more modifiable risk factors (activity level <150 mins, BMI > 25, subjective memory complaint, and high blood pressure). The outcome will help determine if mindful walking has a positive effect by administration of surveys and tests that are comparable as to what was done in the baseline visit. Data collection is ongoing. As of February 15, 14 out of 20 participants agreed to come in for a follow-up and we anticipate completion of data collection by the end of February. Change in variables collected during the mindful walking study will be determined by comparing baseline measures to follow up measures. Additionally, we will report the frequency of the use of mindful walking and its critical components at follow-up. These components include staying off your phone, recognizing but dismissing distracting thoughts, attention to breath or steps, completing a body scan, and walking alone or in silence.
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9:30-11:00 a.m.
Exhibit Hall (CMCC lower level) |
Poster: 146
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| Capps, Anna |
DeWeil, David |
Carolina Judicial Council: More than Just Sanctions
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Abstract Text
Carolina Judicial Council (CJC) is a student-run organization through the Office of Student Conduct and Academic Integrity. The main role that CJC members play on campus is participating in hearings concerning alleged violations of the USC Student Code of Conduct and Honor Code. Hearings are a way for students to be heard by a panel of their peers, presenting their case and allowing the council to come to a finding of responsible or not responsible. Members also serve as ambassadors of the Carolinian Creed, promoting USC’s values and striving to instill them in others. We also participate in regular trainings and professional development, as well as one-on-ones with advisors and weekly discussion boards. I was able to serve as the Vice President of Creed Programming, planning and executing tabling events, promoting service activities, and highlighting academic achievements. I joined CJC as a way to get more involved, specifically within my future career interests. CJC allowed me to practice legal ideas and see policies enacted, with a strong impact on students. As a member of the executive board, as well as a hearing panelist, I learned how to communicate more effectively and practice empathy when having difficult conversations. I became a better writer, communicator, and listener through writing and delivering rationales. I’ve been able to see ideas that I learned within the classroom come to life as a member of CJC. CJC has shown me ideas such as policy implementation when dealing with institutional constraints, standards of proof, and the need for cooperative existence. I have also been able to improve my speaking skills and build upon ideas that I was taught in my speech classes. Through educational sanctions, I have been able to have an impact on students and help them learn through their mistakes, rather than experience punitive sanctions, while at the same time bettering myself. Being able to see these ideals take place within USC has reaffirmed my decision to attend law school. Based upon everything I’ve learned and my experience as a member of CJC, I know this is the right career path
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1:00-2:30 p.m.
Exhibit Hall (CMCC lower level) |
Poster: 358
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| Wong, Leeanna |
DeWeil, David |
The Impact of Student Leadership
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Abstract Text
Student leaders come in various forms and I believe that having an involvement on campus can make a student’s experience more exciting and fulfilling. My biggest contribution to the University of South Carolina has been my involvement with the Conference Center. Within this organization I have had the privilege of starting off as a conference assistant, then moving up to an event manager, office staff, and lastly, a summer building manager this past summer. I had little to no hospitality experience prior to this so I was hesitant to apply, but I decided to step outside of my comfort zone and give myself the room to grow. Not only did this experience give me a great introduction to the world of hospitality, but it also allowed me to enhance my critical thinking and leadership skills. Each of my roles within the office have given me the opportunity to work with hundreds of clients from various backgrounds and cultures. This was a benefit that I did not expect to gain when I initially applied, but I am very glad that I did. To add a bit more to the list of benefits, I have also been able to develop my professional skills, discover my leadership/work styles, and implement team building practices. The main reason I am so passionate about this is because of how transferable the skills are. My post-graduation goal is to take what I have learned from this experience and apply it to my future roles, regardless of its relevance to hospitality or not. This presentation will allow me to share my insights and hopefully inspire future student leaders to do the same.
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9:30-11:00 a.m.
Exhibit Hall (CMCC lower level) |
Poster: 318
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| Socia, Cassidy |
Enos, Reilly
Hope, Trey |
A Novel Tissue-Specific Insight into Sex Steroid Fluctuations Throughout the Murine Estrous Cycle
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Abstract Text
Serum sex steroid levels fluctuate throughout the reproductive cycle. However, the degree to which sex steroid tissue content mimics circulating content is unknown. Understanding the flux and physiological quantity of tissue steroid content is imperative for targeted hormonal therapy development. Utilizing a gold-standard ultrasensitive liquid chromatography–mass spectrometry (LC/MS) method we determined sex steroid (17β-estradiol [E2], testosterone, androstenedione, and progesterone) fluctuations in serum and in 15 tissues throughout the murine estrous cycle (proestrus, estrus, and diestrus I) and in ovariectomized (OVX) mice. We observed dynamic fluctuations in serum and tissue steroid content throughout the estrous cycle with proestrus generally presenting the highest content of E2, testosterone, and androstenedione, and lowest content of progesterone. In general, the trend in circulating steroid content between the stages of the estrous cycle was mimicked in tissue. However, the absolute amounts of steroid levels when normalized to tissue weight were found to be significantly different between the tissues with the serum steroid quantity often being significantly lower than the tissue quantity. Additionally, we found that OVX mice generally displayed a depletion of all steroids in the various tissues assessed, except in the adrenal glands which were determined to be the main site of peripheral E2 production after ovary removal. This investigation provides a comprehensive analysis of steroid content throughout the estrous cycle in a multitude of tissues and serum. We believe this information will help serve as the basis for the development of physiologically relevant, tissue-specific hormonal therapies.
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9:30-11:00 a.m.
Exhibit Hall (CMCC lower level) |
Poster: 43
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| Sakarcan, Eren |
Dash, Chiranjeev
Loffredo, Christopher |
The Effect of Race and Ethnicity on the Association Between Metabolic Syndrome, Nativity, and Diet Quality: A Cross-Sectional Analysis of the National Health and Nutrition Examination Survey (NHANES) 2013-2018
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Abstract Text
BACKGROUND/OBJECTIVE: This analysis investigates the potential
effects of race/ethnicity on the associations between metabolic syndrome
(MetS), Nativity, and Diet Quality (DQ). A clear inverse relationship
between DQ and MetS exists[26]. Associations between MetS and other
exposures are reported, as are those between nativity and various
cardiometabolic factors within a single race/ethnicity. Current literature
does not thoroughly explore race-based differences in the association
between MetS, Nativity, and DQ [2-3, 9, 20, 28-32, 37-38]. This analysis fills gaps
in current literature by accounting for multiple races/ethnicities and DQ in
its analysis of the known association between MetS and Nativity.
METHODS: All analyses were performed through SAS Studio 3.8 Survey
Procedures. DQ was measured using the Healthy Eating Index-2015
(HEI-2015)[5, 22-25, 34]. Differences in proportions and means were
analyzed using chi-square and 1-way ANOVA tests. RESULTS:
Race/ethnicity had significant interaction with nativity (P = 0.0124).
Stratifying logistic models by race/ethnicity showed that U.S.-native non-
Hispanic Blacks (NHBs) have significantly higher odds of developing
MetS than their non-U.S.-native counterparts (OR: 0.430, 95%CI: 0.196 -
0.944), even after controlling for diet quality (OR: 0.391, 95%CI: 0.174 -
0.881). CONCLUSION: The U.S. has more immigrants than any other
country, who bring diverse values, beliefs, lifestyles, attitudes, and food
consumption patterns. Exploring race and nativity-based differences in
cardiometabolic and nutrition-related health outcomes, alongside
surveillance of the changes in food demand trends in the U.S. can be
valuable predictors of health outcomes and advance the development of
culturally-relevant preventative and treatment approaches.
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1:00-2:30 p.m.
Columbia Ballroom (CMCC upper level) |
Poster: 202
|
| Powers, Claire |
Sayers, Christina |
Promoting Health Equity: In and Out of Healthcare
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Abstract Text
Over the past few summer and winter breaks, I have had the opportunity to work as a Patient Care Technician in a Women’s Care Unit. I worked at Rochester General Hospital, where we had twenty rooms to care for forty patients (mom and baby couplets). Growing up, my best friend’s mom was a Neonatal Nurse Practitioner, and I was always so interested to hear what she did at work. This was one of the first reasons I decided to pursue nursing. I had always been interested in women's health and thought this would be a great way to gain healthcare experience. I participated in the hands-on care of both the moms and babies during their stay. I worked with patients to show them how to bathe, swaddle, and feed their newborns. Before patients could go home, they had to learn how to properly take care of themselves and their new baby. Many patients were non-native English speakers, had learning disabilities, or had low health literacy. I saw this firsthand as many patients were readmitted due to improper care of themselves or their infants. As a student in the College of Nursing, many of my classes have focused on social determinants of health and how these can affect our patients. Classes have also discussed the importance of patient education and individualizing patient resources. I hope to use my knowledge of social determinants of health when educating and providing resources to my patients. I also hope to use this knowledge outside of my practice as a nurse. Learning about health equity benefits everyone. Healthcare workers can use this knowledge in practice, and patients can use this knowledge to advocate for themselves. My presentation will discuss in further detail the importance of promoting health equity for patients and peers.
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9:30-11:00 a.m.
Exhibit Hall (CMCC lower level) |
Poster: 303
|
| Al Mansi, Sarah |
Al-Hasan, MBBS, Majdi
Winders, Hana |
Utilization of Echocardiograms in Streptococcus Species Bloodstream Infection: A Diagnostic Stewardship Opportunity
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Abstract Text
Background: The risk of infective endocarditis (IE) in streptococcal bloodstream infection (BSI) is species-specific. The updated Duke-International Society for Cardiovascular Infectious Diseases criteria consider Streptococcus species as typical for IE, except for group A Streptococcus and Streptococcus pneumoniae. This retrospective cohort analyzed echocardiogram utilization in BSI patients with low-risk vs. other Streptococcus species.
Method: The study included patients with Streptococcus species BSI admitted to Prisma Health hospitals in South Carolina from February 1, 2016, to June 30, 2020. Excluded were patients with polymicrobial BSI, missing data, and clinically insignificant positive blood cultures as determined by the treating provider. Chi-square analyzed echocardiogram use between low-risk and other Streptococcus species. Kaplan-Meier assessed 90-day mortality with and without echocardiograms.
Results: Among 166 patients with streptococcal BSI, the median age was 62 years (interquartile range 53-71) and 88 (53%) were women. Most patients had BSI due to low-risk Streptococcus species (56 [34%] S. pneumoniae and 30 [18%] group A Streptococcus). Group B and viridans group streptococci accounted for 42 (25%) and 38 (23%) of BSI, respectively. The most common source of BSI was skin and soft tissue (58; 35%) followed by respiratory tract infection (60; 36%). Overall, 94 (57%) patients with Streptococcus species BSI had echocardiograms performed. Patients with low-risk Streptococcus species BSI were less likely to have echocardiograms than those with other species (41/86 [48%] vs. 53/80 [66%], P=0.02). None of the 41 echocardiograms obtained in patients with BSI due to low-risk Streptococcus species demonstrated evidence of valvular vegetation. Acute severity of illness measured by Pitt bacteremia score and delayed response to antimicrobial therapy within the first 3-4 days of BSI determined by early clinical failure criteria were not associated with the probability of obtaining echocardiograms (P=0.95 and P=0.76, respectively). Obtaining an echocardiogram was not associated with improved survival (log-rank P=0.50).
Conclusion: Although echocardiograms were performed less often in BSI due to low-risk Streptococcus species, there was still overutilization despite low diagnostic yield and lack of significant impact on overall prognosis. Educational and other diagnostic stewardship efforts may reduce the cost of unnecessary echocardiograms in this population in the future.
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9:30-11:00 a.m.
Columbia Ballroom (CMCC upper level) |
Poster: 201
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| Dewitt, Beata |
Kilpatrick, Daniel
Long, Keisha |
Testing the Waters: Collaborating with Environmental Justice Communities and Partners in Citizen Science to Monitor Creeks of Congaree National Park in Hopkins, South Carolina.
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Abstract Text
In collaboration with the University of South Carolina's SCAWWA/WEASC Carolina Water Club Student Chapter, EJ Strong has initiated a significant water monitoring endeavor in partnership with Lower Richland High School students as part of the Lower Richland's CEAL Initiative. Beginning in November 2022, collaboration efforts identified flooding and water quality concerns in the area, leading to the establishment of a Community Water Monitoring Group spearheaded by Beata Dewitt, La'Nya Green, and Robert Reese of EJ Strong. On February 10th, 2024, students conducted water sampling along Cedar Creek of Congaree National Park using DHEC's Adopt-a-Stream Freshwater Monitoring Kits, facilitated by the Carolina Water Club. This event marks the start of several planned student-led sampling sessions aiming to enhance understanding of water quality's impact on Lower Richland, analyze and communicate collected data to the public, and foster student and community engagement in water monitoring and sampling activities throughout the spring semester.
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9:30-11:00 a.m.
Columbia Ballroom (CMCC upper level) |
Poster: 115
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| Shablenko, Volodymyr |
Bazaliy, Yaroslaw |
Spin transfer torque in F/F devices with non-identical half-metallic layers
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Abstract Text
Using half-metals (e.g., Heusler alloys) as ferromagnetic elements in spintronic devices sometimes leads to unexpected results. While using identical magnetic materials for both fixed and free layers already generate some interesting properties [1], it may be challenging to implement magnetization switching in such system experimentally because the boundary between materials is not well defined in their parallel state. Moreover, materials’ symmetry cancels the linear term in voltage dependence of the out-of-plane torque. In this study, we calculate electric and spin currents using a Stoner model description of half metals and find the out-of-plane torque and exchange energy of an F/F device. Voltage dependence of the out-of-plane torque is calculated as well. The lack of material’s symmetry generates additional anisotropy in this torque’s angular dependence.
[1] V. Shablenko, Ya. B. Bazaliy, APS March Meeting 2023, S56.00012: Spin-transfer torque for two half metals in direct contact
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1:00-2:30 p.m.
Columbia Ballroom (CMCC upper level) |
Poster: 99
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| Keen, Deborah |
Fulton, Jeanette |
Investigating the usefulness of supplemental radiology resources in anatomy teaching for first year medical students
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Abstract Text
Radiology is a specialty that is used in virtually all specialties of medicine (1). Medical students also believe that more radiology should be incorporated into their medical education, and they believe they need it to become a competent physician (2). The purpose of this study was to evaluate the usefulness of a supplemental radiology teaching resource for assisting with learning anatomy for first year medical students and to investigate the difference in knowledge between students who did and did not use this resource. A supplemental radiology database was developed using the Anki flashcard software commonly used by medical students (3). The database had 965 cards that covered high-yield anatomy and radiology concepts for each of the four blocks of anatomy (back and thorax, abdomen and pelvis, upper extremity and lower extremity, and head and neck). This database was made available to all first-year medical students during their fall semester anatomy course after they consented. A survey was obtained at the end of the semester which evaluated the utilization and effectiveness of the supplemental resource. The student’s name and database utilization were merged with the student’s examination scores by block and then de-identified. Of the 96 students that consented, 81 responded to the survey, which was an 84% response rate. Of the students who indicated that they utilized the database frequently, 75% of them thought it was very useful. Of the students who used the database occasionally or less frequently, 83% indicated that the database was useful. Therefore, the database was found to be useful for those students that used it, and further research should be done to see if this model could be used at other medical schools.
References:
1. Straus CM, Webb EM, Kondo KL, et al. Medical student radiology education: summary and recommendations from a national survey of medical school and radiology department leadership. J Am Coll Radiol JACR. 2014;11(6):606-610. doi:10.1016/j.jacr.2014.01.012
2. Poot JD, Hartman MS, Daffner RH. Understanding the US medical school requirements and medical students’ attitudes about radiology rotations. Acad Radiol. 2012;19(3):369-373. doi:10.1016/j.acra.2011.11.005
3. Anki - powerful, intelligent flashcards. Accessed January 23, 2024. https://apps.ankiweb.net/
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9:30-11:00 a.m.
Columbia Ballroom (CMCC upper level) |
Poster: 158
|
| Sheveland, Colter |
Creech, Erin
Caulder, Celeste
Teng, Chengwen |
Evaluation of periprocedural antibiotics for EVD placement in the NSICU at an academic medical center
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Abstract Text
Background: External ventricular drains (EVD) allow for monitoring of intracranial pressure (ICP) and for cerebrospinal fluid diversion in the setting of acute hydrocephalus. Infectious complications have been reported in up to nearly one-third of patients following EVD placement. The purpose of this study is to compare the utilization of periprocedural antibiotics for infection prophylaxis for Neuroscience Intensive Care Unit (NSICU) patients undergoing EVD placement before and after the implementation of an EVD bundle.
Methods: An IRB-approved, retrospective, pre-/post-study was conducted on adult patients who underwent EVD placement and were admitted to the NSICU during the same admission. Notable exclusions were those patients with a documented ventriculitis and/or meningitis prior to EVD placement or a ventricular drain present upon admission. Baseline characteristics and endpoints were manually collected using a pre-specified REDCap form. The primary endpoint of the proportion of patients who meet the criteria of receiving perioperative antibiotics was evaluated in the pre-EVD group from August 1, 2021 to July 31 2022 and in the post-EVD group from September 1, 2022 to August 31, 2023. Key secondary endpoints included the rate of documented or suspected CNS infections per 1000-EVD days, length of hospital and ICU stay, and 30-day inpatient mortality.
Results: In Progress
Conclusions: In Progress
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1:00-2:30 p.m.
Columbia Ballroom (CMCC upper level) |
Poster: 220
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| Lanpher, Megan |
Bradshaw, Kathleen
Patterson, Brooke |
Use of an Audit and Feedback Tool and SGLT2 Inhibitors to Delay Progression of Chronic Kidney Disease
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Abstract Text
Problem Statement: Adults with both Type 2 diabetes mellitus and chronic kidney disease experience higher risk for progression to end stage kidney disease, which negatively impacts health, increases medical costs, and decreases quality of life. Purpose: Determine if an audit and feedback intervention in a local nephrology clinic can increase provider adherence to a clinical practice guideline that supports prescription of sodium glucose cotransporter-2 (SGLT2) inhibitors to decrease progression of renal disease in adults with Type 2 diabetes mellitus and chronic kidney disease. Methods: A pretest-posttest design will be used to determine if an audit and feedback tool delivered to providers at three-week intervals for a duration of three months increases provider adherence to a clinical practice guideline that supports prescription of SGLT2 inhibitors in adults with Type 2 diabetes and chronic kidney disease. A clinical decision guide and personalized one-on-one education will be provided to participants at the onset of the intervention with follow-up face-to-face discussion accompanying the audit and feedback data distribution. Inclusion Criteria: English speaking physicians and mid-level providers will be recruited from a local nephrology outpatient clinic in the southeastern United States. Analysis: Paired t-tests will be used to evaluate whether providers increased prescription of SGLT2 inhibitors to patients with Type 2 diabetes mellitus and chronic kidney disease three months after the intervention compared to the three months prior to the intervention. Multivariate logistic regression will further examine the relationship between the intervention and proportion of new SGLT2 inhibitor prescriptions generated during the project. Implications for Practice: Increasing prescription of SGLT2 inhibitors in adults with Type 2 diabetes and chronic kidney disease may lead to a decrease in progression of chronic kidney disease, lower healthcare costs, and better quality of life for adults with Type 2 diabetes mellitus and chronic kidney disease.
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1:00-2:30 p.m.
Columbia Ballroom (CMCC upper level) |
Poster: 32
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| Singh, Aman |
Owens, Otis |
Evaluation of Alexa, Google Assistant, and Siri for Supporting Informed Prostate Cancer Screening Decisions for African-American Men?
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Abstract Text
Prostate cancer is the most prevalent non-skin cancer among all men, but African-Americans have morbidity and mortality at significantly higher rates than White men. To reduce this burden, authorities such as the American Cancer Society recommend that men make informed/shared screening decisions with a healthcare provider. Informed/shared screening decisions require that men have adequate prostate cancer knowledge. Virtual assistants are interactive communication technologies that have become popular for seeking health information, though information quality has been mixed. No prior research has investigated the quality of prostate cancer information disseminated by virtual assistants. The purpose of this study was to determine the response rates, accuracy, breadth, and credibility of three popular virtual assistants (Alexa, Google Assistant, and Siri) for supporting informed/shared prostate cancer screening decisions for African-American men. Each virtual assistant was evaluated on a tablet, cell phone, and smart speaker using 12 frequently asked screening questions. Responses were rated dichotomously (i.e., yes/no), and analyses were conducted using SPSS. Alexa on a phone or tablet and Google Assistant on a smart speaker had the best overall performance based on a combination of response, accuracy, and credibility scores. All other assistants scored below 75% in one or more areas. Additionally, all virtual assistants lacked the breadth to support an informed/shared prostate cancer screening decision. African-American men may be especially disadvantaged by using virtual assistants for prostate cancer information because of the lack of emphasis on their greater disease risk, higher mortality rates, and appropriate ages at which they should begin screening conversations.
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9:30-11:00 a.m.
Columbia Ballroom (CMCC upper level) |
Poster: 176
|
Hamilton, Selena
Hemphill, Chandler |
Leblanc, Kevin |
Mindful Meditation to Decrease Burnout Amongst Nurse Anesthesia Interns
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Abstract Text
Burnout is a common issue affecting many individuals. However, healthcare workers are at enhanced risk due to fast-paced and stressful work environments. Burnout has been shown to have negative consequences on academic performance, decreased quality of care for patients, and significant mental and physical impacts (Chipas & McKenna, 2011). Student Registered Nurse Anesthetist (SRNAs) are at increased risk for burnout when compared to Certified Registered Nurse Anesthetists (CRNAs) and reported more depressive symptoms and even suicidal ideations during their schooling program (Horvath & Grass, 2021). For these reasons, an evidence-based practice project was developed and implemented to determine if mindful meditation via Headspace application would reduce burnout amongst SRNAs in the University of South Carolina (USC) Doctor of Nurse Anesthesia Practice (DNAP) class of 2024 cohort. This project implementation took place when SRNAs attended a lecture where burnout was discussed as well as the project implementation plan. After the lecture, a pretest survey was then sent to students to determine their baseline burnout score prior to mindful meditation interventions. The students then participated in guided meditation of at least 10 minutes per day using the Headspace application for 14 days. A posttest survey was sent to compare pre and post test results. Results showed statistically significant reductions in burnout when Headspace was used for the recommended 10–14-day period. Our findings indicated that mindful meditation could decrease burnout amongst SRNAs and should be implemented as a prevention strategy during anesthesia training programs.
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9:30-11:00 a.m.
Columbia Ballroom (CMCC upper level) |
Poster: 57
|
Hensing, Caroline
Litzenberger, Stephanie |
Reagan, Lawrence |
Improving Diabetic Patient Enrollment & A1C Screening Capabilities at South Carolina Free Clinics
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Abstract Text
Background/Aim
Med Students Making Change (MSMC), led by USC SOM medical students in collaboration with The Free Medical Clinic, aims to improve diabetic control in South Carolina. Approximately 13.2% of South Carolina’s adult population has diabetes, with an additional estimated 123,000 individuals having undiagnosed diabetes. With serious complications such as heart disease, stroke, and amputation, diabetes costs South Carolina an estimated $5.9 billion each year (Dall et al., 2019). By pairing medical student volunteers with diabetic patients for routine check-ins, MSMC seeks to strengthen patient understanding of their health and lifestyle trends with the goal of improving patient glycemic control as measured by A1C levels. Previously relying on clinic personnel for patient recruitment, six patients were enrolled in the fall of 2023. By implementing a new recruitment method of sending medical student volunteers to the clinic weekly to participate in A1C screening and patient recruitment, MSMC patient enrollment and A1C screening capabilities at the clinic will increase.
Methods
Recognizing resource shortages at The Free Medical Clinic, MSMC implemented a weekly A1C screening and enrollment clinic in 2024. During this session, medical student volunteers review A1Cs from the previous week, contact eligible patients, and attempt to enroll those meeting criteria: age >18 years old, diagnosed type 2 diabetes, and an A1C >6.5%.
Results
133 patients have been screened at the Columbia, SC location between January 10, 2024 and February 7, 2024. Twentynine patients met inclusion criteria and were contacted. Of those, five patients enrolled in the program. Ineligible patients either had an A1C <6.5% or language barriers.
Discussion
The average A1C for the enrolled patients is 8.85. Nationally, 11.5% of patients have an A1C of 8.0% - 9.0% (CDC, 2023). The clinic’s high A1C average highlights a need for lifestyle and therapeutic interventions within this demographic. This preliminary data further emphasizes the need for patient education and intervention to improve glycemic control and thereby attenuate the complications associated with insulin resistance/type 2 diabetes. Our goal is to increase patient recruitment and further enhance preventative healthcare endeavors (e.g., including pre-diabetics in the screening process) to assess the effectiveness of our current methods.
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9:30-11:00 a.m.
Columbia Ballroom (CMCC upper level) |
Poster: 184
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| Hinds, Olivia |
Andrews, Christina |
Screening, Treatment, and Referral for Substance Use Disorder in Medicaid Health Homes: Results of a National Pilot Study
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Abstract Text
Introduction. Established under the Affordable Care Act, Medicaid health homes are designed to provide comprehensive health care for enrollees with chronic health conditions. Given high rates of substance use disorder (SUD) in Medicaid, health homes have the potential to enhance SUD identification and treatment. In this study, we assessed the proportion that health homes screen, treat, and refer for SUD, the extent to which health homes are compliant with state regulations, and how these trends may differ among health homes that focus on physical versus behavioral health conditions.
Methods. We administered a pilot survey in 2022 to all health care providers in active Medicaid health home plans. Health home models were categorized as physical- or behavioral health-focused. We estimated the percentage of health homes engaged in SUD screening, treatment, and referral practices, and the percentage of health homes that complied with state requirements in these domains.
Results. Our sample included responses from 113 health homes in 15 states and the District of Columbia. Findings indicate that Medicaid physical health-focused health homes were more likely to conduct at least some screening for SUD than behavioral health-focused health homes (81.0% and 61.5% respectively). The majority of physical health-(81.8%) and behavioral health homes (84.6%) referred out at least some SUD treatment, and among those health homes that did refer out, fewer than 20% had a formal contractual agreement with an SUD treatment program. The vast majority of health homes complied with state requirements for referral. However, among health homes required by their state to offer SUD screening, 38.5% of physical health-focused health homes and 16.0% of behavioral health homes failed to do so. Similarly, 5.9% of physical health-focused health homes and 67.8% of behavioral health homes did not offer onsite treatment for SUD, even when required to do so by the state.
Conclusions. While Medicaid health home plans were established to promote care coordination and integration, relatively few health homes in this study reported doing so. Moreover, a concerning number of health homes also fail to comply with state plan requirements regarding screening and treatment.
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1:00-2:30 p.m.
Columbia Ballroom (CMCC upper level) |
Poster: 71
|
Soto, Joshua
Sensenbach, Sylvie |
Richardson, Susan
Justen, Patrick |
Transfer of Synthetic Fragrance Chemicals into Bottled Drinking Water
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Abstract Text
Synthetic musk fragrances are used in almost all scented consumer products, such as perfumes, cosmetics, dryer sheets, and laundry detergent. While some musk human exposure routes are clear, it is suspected that bottled drinking water stored in close contact with products containing musk fragrances may be a route of exposure. In our research, different cleaning products were exposed to different bottled water brands and the water was analyzed using a liquid-liquid extraction followed by gas chromatography-mass spectrometry to determine if any musks transferred into the water.
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9:30-11:00 a.m.
Exhibit Hall (CMCC lower level) |
Poster: 91
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| Buniak, Daniela |
Matthews, Sarah |
Nurturing My Passion: A Summer Internship Journey in Healthcare Marketing and Bioscience
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Abstract Text
During the summer of 2023, I had the opportunity to be the Bioscience Marketing Intern at Lonza, a multinational company specializing in pharmaceuticals, biotechnology, and nutrition. Part of my responsibilities within my role was to lead major projects. The first project was the Web Redesign project, for which I was responsible for conducting a comprehensive website audit to assess strengths and identify areas for improvement. This included evaluating content, product photos, documentation, data, and FAQs. Additionally, I was responsible for harmonizing and updating FFM product website pages.
My second project was Portfolio Rationalization, in which I reviewed the company's product offerings and provided recommendations for discontinuations or deactivations of SKUs. I collaborated closely with the product managers and demonstrated a strong understanding of product lifecycle development.
As a Biochemistry and Molecular Biology Major with a major interest in healthcare marketing, pharmaceuticals, biotechnology, and life sciences research, my future goal is to make a positive impact on human health and well-being by combining my love for both science and marketing. My summer internship with Lonza provided valuable exposure to the business and marketing aspects of the pharmaceutical and biotech industry. I also improved my leadership skills and gained professional experience. From my SPCH 140 class, I was able to use my public communication and persuasive skills to deliver great presentations to my team and provide better communication with the product managers.
Being the Bioscience and Marketing Intern confirmed my passion for making a difference in the science and healthcare industry by delivering healthcare products and new technologies to the market. Through this experience, I hope to continue my career path in healthcare marketing and the bioscience industry, pursuing my passion for making a difference.
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9:30-11:00 a.m.
Exhibit Hall (CMCC lower level) |
Poster: 331
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| Allen, Rachel |
Winkelmann, Zachary |
Vasovagal response to a concussion in a high school Wrestling athlete: a case study
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Abstract Text
A 17-year-old African American male wrestler suffered a head injury during a match. He was pushed headfirst down onto the gym floor off the mat. The AT approached him after he stood and looked dizzy and felt his neck for any deformities before walking him to the bench to sit down and continue the evaluation. He was immediately sensitive to light, had a headache, pain in his head, dizziness, blurry vision and ringing in his ears. Within 5-10 minutes he was unable to focus his eyes and his grip strength was weak bilaterally. His dermatomes were WNL, but he reported tingling in his right hand. The AT advised his parents to go to the ER for further evaluation. He was diagnosed with a concussion, vasovagal syncope/response to pain. 5 days of rest at home, then return to learn and play progressions were started. He was offered adjustments to school assignments and class work and schedules due to his concussion. He chose to take some assessments because he didn’t want to get behind in school. He had 4 days of no activity once he returned to school because he was symptomatic. Once he did present asymptomatically, he began riding the bike for 20 minutes and then he was reevaluated to check for any symptoms. Next was running and jogging with his body weight exercises. Next, he did a 20-minute run with a 5-minute cool down, and he had 30 minutes of non-contact drills with his coach. After this he had a spike in symptoms, so his RTP was paused until he was asymptomatic again. Once he reported asymptomatic, he biked for 20 minutes to see if symptoms increased. When it didn’t, he went to the doctor to be cleared and he participated in a full non-contact practice without symptoms. This case shows how important it is to know your athletes and how they react to pain because his vasovagal response pointed to something more going on that we couldn’t see when it is his body’s response to pain. It also highlights the importance of patient, coach, and parent education on concussions.
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1:00-2:30 p.m.
Columbia Ballroom (CMCC upper level) |
Poster: 70
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| Burns, Samantha |
Hancock, Nathan |
Identifying the causative mutations underlying a dwarf soybean phenotype
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Abstract Text
Glycine max, commonly known as soybean, is an important crop that make up 90% of all United States oilseed production. The U. S. is currently #1 in the world for soybean production and #2 in the world for soybean export. Identifying the genes that control soybean growth is critical to the genetic improvement of this crop. The Hancock laboratory identified a G. max plant line with decreased height, smaller leaves, and significantly lower yields in a mutant population. To identify the mutations present in the dwarf mutant, we Illumina sequenced the entire genome and assembled it to the Williams 82 reference soybean genome using Burrows-Wheeler Aligner. Picard was used to mark duplicates and convert it to a BAM file. Genome Analysis Toolkit (GATK) was then used to identify the variants present in the genome. Candidate mutations that disrupt genes will be identified using SNPEff. Once candidate genes are identified, the team will use PCR analysis of an F2 segregating population to determine which mutation is linked to the phenotype. Once the Hancock laboratory team can identify what gene is causing the mutation, further research into the function of the gene can be conducted.
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1:00-2:30 p.m.
Exhibit Hall (CMCC lower level) |
Poster: 81
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| Hu, Ziyi |
Reed, Rico |
Mentorship, Networking, and Advocacy
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Abstract Text
My name is Jenny Hu, and I'm a senior at the University of South Carolina, majoring in International Business and Operations and Supply Chain with a minor in Chinese. This presentation will show my journey and transformative experiences throughout my time at the university, focusing on my first key insight and leadership experience, how my experiences as a student and a peer leader help me make a positive impact on the student body. I've honed my leadership skills through roles like being a Supplemental Instructor and Program Assistant Mentor at the Student Success Center. These positions allowed me to interact with diverse students, shaping my understanding of the impact I can have as a peer leader and mentor.
One of the most significant lessons from my undergraduate is the impact of connection. Studies highlight its importance in guiding students through post-graduation uncertainties. As a SI, I engage with students, offering guidance on academic and career paths. As I continue my involvement with the SSC, I'm proud to be a resource for my peers, both academically and personally. I use my voice to advocate for students whose academic needs are not being met. I help them navigate higher education as mostly Freshmen and Sophomores by accommodating their needs during SI sessions with a variety of session plans that they respond the best to. I also help connect them with further campus resources so further needs can be met. I help my mentor group each year as a PAM by helping lead bi-weekly staff meetings for continuous improvement on the quality of education the University can provide. As I approach graduation, I reflect on my journey at the University of South Carolina, recognizing the growth and lessons learned along the way. I've come to understand the importance of humility and openness to new perspectives, realizing that there's always something to learn from everyone, even the most unexpected sources.
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9:30-11:00 a.m.
Exhibit Hall (CMCC lower level) |
Poster: 268
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| Norment, Taylor |
Reed, Rico |
Six Months At Advanced Prosthetics: The Value Of Self-Image
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From May through November of 2024, excluding August, I worked at Advanced Prosthetics, a prosthetics and orthotics clinic in Columbia, South Carolina. Initially, I worked as a shadow. I followed the practitioners and technicians as they went about their days interacting with patients and fabricating devices. My mentors in this role believed that hands-on learning is the best way to grow, so I was allowed to get involved very quickly. I spent May through July working full time laminating prosthetic sockets, pulling materials for orthotics, and interacting with patients under supervision, as well as going on house calls and hospital trips with the prosthetist-orthotists. Over the course of the summer, my skills grew significantly, and I was hired as a technician, a role I worked in part time from September through November. This role kept me in the lab at the clinic, where I contributed to the fabrication of prosthetics and orthotics more independently. I took on this role because I am going into prosthetics and orthotics. Not only was I eager to learn more about the field, but I also wanted to build a strong application for graduate school. One of the most significant things I took from this experience was the importance of mental health to a recovering amputee. Losing a limb can be an incredibly traumatic experience, so a recovering amputee must also recover mentally, and struggling with one can make the other harder. This is reflected in what I learned in Dr. Yang’s class, Psychology of Physical Activity (EXSC 410), in which we were taught how mental health can impact one’s achievement of a physical goal. I also learned that having control over what a prosthesis looks like can contribute greatly to a patient’s confidence in wearing, and therefore using, a prosthesis. This impacted me by firmly establishing to me the value of self-image and autonomy to those using prosthetics and orthotics. Based on this, I will demonstrate a variety of ways in which self-image and autonomy can be supported in amputees.
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9:30-11:00 a.m.
Exhibit Hall (CMCC lower level) |
Poster: 304
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| Hill, Kari |
Elyaderani, Hadis |
Assessing Dollar Store Food Environments in Alignment to Nutrition Support Programs in the Lowcountry
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Abstract Text
The proliferation of dollar stores across the United States, particularly in impoverished communities and communities of color, has ignited concerns regarding their impact on community health, economic development, and food security. This study aims to investigate the food environment within dollar stores, focusing on their potential to offer healthier food options and participate in federal nutrition assistance programs such as the Special Supplemental Nutrition Program for Women, Infants, and Children (WIC). Recent assessments have highlighted a prevalence of highly processed and limited food selections in dollar stores, though initiatives like “DG Fresh” suggest a potential shift towards offering fresher food options. With nearly 30 municipalities having already implemented policies to regulate the presence and offerings of dollar stores, there is a pressing need for a standardized assessment tool to systematically evaluate and compare the food environment across different dollar stores. This study proposes the development and piloting of a new tool, the NEMS-DS, across 300-dollar stores in 11 states, to assess their readiness for WIC participation and other healthy retail metrics. The tool will measure the availability, affordability, and quality of key food items, alongside the presence of ultra-processed foods and food marketing strategies. This comprehensive approach aims to enhance our understanding of the dollar store food environment, inform policy and program development, and ultimately, improve food access and nutrition security in underserved communities.
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1:00-2:30 p.m.
Exhibit Hall (CMCC lower level) |
Poster: 157
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| Stryker, Zachary |
Leon, Juan |
Design and Synthesis of Novel Amino-Phytocannabinoids as Neurological Therapeutics
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Abstract Text
Depressive disorders, including Major Depressive Disorder (MDD) and Bipolar Depression, form the class of neurological conditions with the most significant contribution to the global burden of disease. This global burden is driven by an estimated 280 million people in the world living with a depressive disorder, affecting roughly 5% of adults globally. Modern therapeutics like Selective Serotonin Reuptake Inhibitors (SSRIs) represent an improvement to traditional tricyclic antidepressants, but may elicit considerable side effects including serotonin syndrome. Thus, there is an urgent need to design efficacious anti-depressants based on novel mechanisms.
Recent literature suggests that the most successful antipsychotic medications of the current generation interact with multiple targets in the brain to attenuate different circuits in the central nervous system simultaneously. This theory directly contradicts the traditional drug design paradigm based on the “magic bullet” concept – where one drug is intended to interact with a unique target to treat a singular condition. The new theory, first postulated by Dr. Bryan Roth to explain the relative success of atypical antipsychotic drugs, has been called the “magic shotgun” concept. As evidence of this theory, many of the most effective neurological drugs of the modern age are often “dirty” drugs; drugs that act promiscuously at various targets in the brain. For example, clozapine, the former gold standard of antipsychotic medications, exhibits a highly complex pharmacological profile acting on dopamine, serotonin, muscarinic, and adrenergic receptors at the same time. However, this conceptual approach remains largely unexplored in the context of other neurological conditions, including depression.
This project describes the design and synthesis of novel monoaminergic phytocannabinoids intended for multimodal activity at neurological receptors implicated in depression. To this end, compounds were conceived based on the monoamine hypothesis of endogenous neurotransmitters norepinephrine and serotonin in depressive disorders. Cannabidiol was chosen as a starting point due to its modest affinity towards several monoamine receptors, with the goal of enhancing affinity and potency towards a subset of these targets, starting with the serotonin 2C (5-HT2C) receptor.
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9:30-11:00 a.m.
Columbia Ballroom (CMCC upper level) |
Poster: 110
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Summerell, Lauren
Cunningham, Jessica |
Balica, Adrian |
Asymptomatic Uterine Rupture
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Abstract Text
A 34-year-old G5P1121 with history of multiple uterine dilation and curettages presented for a growth ultrasound at 34 weeks secondary to Gestational diabetes. Sonographically a uterine wall defect and 8cm sacculation was noted with fetal parts present outside the uterus. Obstetrical ultrasound 5 weeks prior was reported within normal limits. She was delivered urgently via low transverse cesarean section and Intraoperatively, a uterine defect with scarred, hemostatic margins was noted along the posterior right uterine wall with protruding placenta. The defect was closed in layers of 0-Vicryl.
Fourteen months prior to delivery, the patient underwent laparoscopic myomectomy of a 5cm transmural fibroid located in the posterior wall of the right cornua. The endometrial cavity was entered creating a 1cm defect. The uterine surgical bed was closed in multiple layers using 2.0-V-loc for endometrium and 0-V-loc for myometrium and serosa. A foley ballon was placed into the endometrial cavity. Following normal sonohysterogram, initial embryo transfer was performed three months post-myomectomy resulting in failed pregnancy. Second transfer was performed at 7 months post-myomectomy resulting in gestation of interest.
In cases of fibroids as the suspected cause of infertility, myomectomies are indicated to restore normal anatomy and allow for successful pregnancy. MIS laparoscopic or robotic are the commonly used methods. Both uterine rupture (.5%) and uterine sacculation (1/3000) are rare, but potential complications in pregnancy following myomectomy. Currently, data suggests similar outcomes for different approaches for non-hysteroscopic myomectomies (2). In this case, what was initially sonographically diagnosed as uterine sacculation, was found intra-operatively to be a asymptomatic myometrial rupture with intact serosa. Early identification and delivery likely prevented a catastrophic outcome. There is no clear approach on how to methodically identify these events, though surveillance with MRI imaging could be considered.
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9:30-11:00 a.m.
Columbia Ballroom (CMCC upper level) |
Poster: 168
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| Mace, Olivia |
Kitchen, Michelle |
First Generation Student Success at USC Columbia
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Prior research has shown that both academic and financial support is crucial to the success of first-generation students, however, it is also crucial to understand the guilt felt by undergraduate students. This is so faculty and staff know how to support them in their endeavors better after they arrive at USC. This study aims to find the academic support and familial support of first-generation students at the University of South Carolina, with the following research question in mind: Do undergraduate first-generation students have the overall support they need at the University of South Carolina to succeed academically compared to that of continuing generation students? Three hypotheses will be evaluated to answer the research question: (1) First-generation students will score differently than continuing-generation students on the Student Support Needs Scale, (2) First-generation students will score differently on the Family Achievement Guilt Scale-Revised, and (3) First-generation students will have different academic performance than continuing-generation students, relative to their academic and familial support impact. Online methods were used, with participant recruitment via email and word of mouth, data collection via a Google form questionnaire, and data analysis on SPSS. This seminal study has received IRB exemption and is currently ongoing; however, it is predicted that through this research project, first-generation student understanding will be heightened at USC, possibly opening an opportunity to add a new non-financial resource specifically for first-generation students. With the poster presentation of this research project at DiscoverUSC, audience members will learn of the implications of first-generation student support at USC. Undergraduate student success is important, especially in populations with less fortunate circumstances.
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1:00-2:30 p.m.
Exhibit Hall (CMCC lower level) |
Poster: 168
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| Hill, Ellie |
Spence, Gina |
Dell Match Play
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Abstract Text
As a senior Sport and Entertainment Management major at the University of South Carolina, I have many opportunities to work at different sporting events across the country. In March of 2023, I was able to travel with eight other Hospitality, Retail, and Sport Management (HRSM) students to work at the WGC Dell Match Play, a golf tournament within the PGA, in Austin, Texas. I went with hopes of learning how events work outside of my classroom knowledge from SPTE 444: Event Management in SPTE, and gained so much more than that. I was chosen to stand in as a supervisor of event staff for the player-only accessible areas, and was able to gain experience in managing part-time employees and volunteers, as well as collaborating with other staff members in each area. Working together with the other supervisor, we learned the roles for each location and rotated out our staff for breaks throughout the day. We were successful in our position as no players were made to feel uncomfortable by fans while in our private area. This work experience is what led me to take SPTE 545: Managing Part-Time Employees and Volunteers at UofSC. I led various part-time employees throughout the event, but I know there were some things that I could do better as a manager, so SPTE 545 aided those shortcomings. By taking part in this event, I gained insight into different departments that I was working side by side with, like Media and Marketing. I ended the experience with so much more knowledge than I started with, and found new areas towards a career path that I had never considered. My world after graduation will now look different as I look for more managerial-inspired roles and positions that allow me to put my newfound knowledge to use.
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1:00-2:30 p.m.
Exhibit Hall (CMCC lower level) |
Poster: 296
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| Davis, Amanda |
McQuillin, Samuel |
Developing a Behavior-Based Measure of Teacher-Student Relationship Quality
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Students benefit from close, supportive relationships with their teachers. When students feel supported by their teachers, they tend to perform more strongly on social, emotional, behavioral, and academic outcomes compared to peers whose relationships with their teachers are conflictual or strained. Emerging evidence suggests that the quality of these relationships may be improved through interventions that increase teachers’ relationship-building behaviors. Yet, the field lacks a measure that explores teacher-student relationship quality by examining the frequency of the specific relationship-building behaviors that may be subject to intervention. The current study aims to address this problem by developing and pilot testing a behavior-based measure of teacher-student relationship quality. Findings from the large-scale field test suggest that the scale demonstrates adequate preliminary evidence of reliability and construct validity. Implications for future research and practice are discussed.
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9:30-11:00 a.m.
Columbia Ballroom (CMCC upper level) |
Poster: 49
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| Lanning, Rachael |
Goldberg, Kelly
King, Adam |
Thinking Outside the Vessel: A New Approach to Analyzing Alkaline-Glazed Stoneware Distribution Patterns in South Carolina
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The American South, and specifically South Carolina, is home to the innovation of alkaline-glazed ceramics, which replaced lead and salt-glazed stoneware for many storage and heavy duty vessels and aided in the reduction of imported vessels. Edgefield, South Carolina is often studied by archaeologists and historians for its relevance in South Carolina folklife, especially since it was home to the famous African American potter, Dave. There is extensive research from Edgefield, where alkaline-glazed stoneware was produced, but was found in other areas of South Carolina as well. In assisting Dr. Kelly Goldberg in her analysis of artifacts excavated in 2022 and 2023 from Sesquicentennial State Park, we seek to investigate the origins of the alkaline-glazed stoneware found there. Once home to enslaved individuals, and then tenant farmers and turned into a State Park by the CCC, important information has been lost about the history of the individuals who lived there. Locating the production sites of the stoneware that belonged to the African American individuals living there can reveal details about pre and post Reconstruction ceramics economies. By the 1840s, potteries were in operation in Columbia, South Carolina, further complicating stoneware exchange patterns between Columbia, Edgefield, and local residents. My research compares ceramics produced at Edgefield with locations throughout the state in order to better understand alkaline-glazed stoneware distribution patterns. Learning more about local history can help to show Columbia locals more context about the interactions of those that lived here before them.
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1:00-2:30 p.m.
Exhibit Hall (CMCC lower level) |
Poster: 22
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| McLaughlin, Ainsley |
DeWeil, David |
Success in Math: Supporting Students as a Supplemental Instructor
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Impacting the University of South Carolina community through the Student Success Center as a supplemental instructor defined my college experience. As a supplemental instructor, I attended the class periods of the course I supported, held three, fifty minute sessions weekly for over two hundred students to enhance their understanding of the material, attended cohort training and biweekly staff development training, and collaborated with the professor of my course to best support the students. As someone who is passionate about math, I wanted others to know this subject was something they could master and even enjoy. I was surprised to find that not only did my students glean much from the sessions, but I did also. I honed my public speaking abilities, time management skills, professionalism, confidence, perseverance, adaptability, creativity, critical reflection skills, collaboration, and feedback delivery. Besides this, I learned that the best way to enhance someone’s success is to build their self efficacy so that they can build anything. As I look forward to a career in data science and analytics, I know that these skills will allow me to achieve excellence as I work with teams and present my work.
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1:00-2:30 p.m.
Exhibit Hall (CMCC lower level) |
Poster: 251
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Douglass, Megan
Campbell, Cayla |
Hoffman, Chase
Carpenter, Sheldon |
Don't Sweat the Small Stuff: Incidental Appendectomy in Traumatic Exploratory Laparotomy Reveals Neuroendocrine Tumor
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Incidental appendectomies (IAs) are often performed in laparotomies to prevent future complications caused by the buildup of scar tissue. Although neoplastic findings are rare, all appendectomy specimens should be sent for histopathological analysis. We present the case of a 38-year-old man found to have an appendiceal neuroendocrine tumor (NET) after receiving an IA secondary to a traumatic rectal perforation requiring exploratory laparotomy. Well-differentiated NETs isolated to the appendix have an excellent prognosis. Appendectomies are considered curative for NETs smaller than 2 cm that have not metastasized beyond the appendix. Appendiceal NETs are capable of secreting vasoactive substances and, therefore, causing carcinoid syndrome. However, the progression to carcinoid syndrome generally coincides with metastasis to the liver, indicating a poor prognosis. While histopathological analysis of appendectomy specimens rarely yields atypical findings, this analysis is crucial to ensure that the proper treatment is selected based on tumor progression in an appendectomy specimen staining positive for somatotropin and chromogranin.
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9:30-11:00 a.m.
Columbia Ballroom (CMCC upper level) |
Poster: 159
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| Petersen, Kennedy |
Derrick, Maureen |
Carolina Judicial Council: A Lesson in Empathetic Communication
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My time at the University of South Carolina was marked by my engagement in the Carolina Judicial Council. As defined by the University: “The Carolina Judicial Council (CJC) is a recognized Experiential Learning Opportunity in which students uphold and promote the standards of the Carolina community. Members of CJC serve on panels in judicial council hearings while upholding the strictest confidentiality, in addition to promoting the vision set forth by the Carolinian Creed”. As a part of this engagement, I was placed in unique situations in the form of student hearings where I served as a panel member to determine the responsibility findings for students in a situation where they were alleged to have violated the Carolinian Honor Code or Code of Conduct. These situations allowed me to grow as an empathic professional with the ability to navigate tense situations. Additionally, I gained impactful leadership skills after serving as President of the CJC that will continue to positively impact me as a future professional. The main lesson I learnt was of the importance of professional, empathetic communication to be an effective leader and professional. My presentation will aim to share this learning and how it impacted my involvement in the CJC as I communicated with my peers and how it will continue to impact my professional life.
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9:30-11:00 a.m.
Exhibit Hall (CMCC lower level) |
Poster: 282
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| Kampmann Marodin, Helen |
Childs, Matt |
Distant Cooking: Analyzing Brazilian Identity through Digital Text Analysis of Cookbooks (1840-1945)
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This poster showcases my current research on food history in Brazil and the development of a curated online collection of Brazilian cookbooks from the pivotal period of 1840 to 1945. Employing digital humanities methodologies, or "distant reading," examine the construction of taste in Brazil, delving into the connections between foodways, national inclusion, and identity. By scrutinizing cookbooks, I am able to identify patterns and evolutionary shifts in culinary practices, shedding light on the underlying social, racial, and gender dynamics that shaped Brazilian history. Combining Natural Language Processing (NPL) techniques with close textual analysis, the project dissects the multiple layers of these culinary texts, revealing a wealth of cultural influences from European traditions rooted in the colonial era to indigenous and African legacies. My study illuminates how diverse racial backgrounds contributed to the culinary landscape, particularly through the lens of the intellectual elite who authored these cookbooks. Gender dynamics figure prominently in culinary literature through aspects such as authorship, target audiences, and visual representations that aid in deciphering evolving patriarchal hierarchies in Brazilian society. By contextualizing culinary evolution within broader historical narratives, my research offers unique insights into nation-building processes and the incorporation of diverse cultural legacies under the umbrella of national identity. The significance of this research lies in its pivotal contribution to expanding our understanding of Brazilian history through the lens of culinary literature, unlocking the wealth of knowledge contained within previously overlooked sources. Moreover, by rescuing and preserving these neglected titles through digitization, the project champions the preservation of invaluable cultural heritage.
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1:00-2:30 p.m.
Columbia Ballroom (CMCC upper level) |
Poster: 22
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| Hiepler, Amelia |
Deweil, David |
Joie de Vivre: A Semester in Paris
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Since I started learning French when I was 12, I knew I wanted to study abroad in France. I had big dreams to visit the place where Ballet gained popularity and to finally eat an authentic croissant. In the spring semester of my junior year of college, I finally embarked on my journey to Paris, France. Even though I am not a French major or minor, throughout my time at USC I yearned to travel as much as possible and see as much of the world as I could. I wanted to go to France to learn the language, but more importantly, I wanted to immerse myself in a brand new culture and learn a new way of life. During my four months abroad I traveled to seven countries. I was able to see the Chateaus of France, experience SpringFest in Germany, have afternoon tea in England, explore the beaches of Spain, marvel at art in Italy, eat chocolate in Belgium, and witness King’s Day in the Netherlands. Throughout my time abroad, I learned the importance of respecting and appreciating cultures that I am not familiar with, how to best learn and teach a new language, and that how people live can greatly impact their health and quality of life. Studying in France will forever be one of my favorite times in my life. I gained independence, confidence in my abilities to communicate with others (regardless of language barriers), and as the French say, “joie de vivre.” In my future career as a Public Health professional, it is necessary for me to be able to interact with people from different backgrounds, cultures, and values. It is vital that I am able to look at the culture of whatever community I am serving through their own eyes to understand how to provide the best aid. My time abroad taught me that culture is not a one size fits all model, and that every culture has its own unique beauty and story to tell.
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1:00-2:30 p.m.
Exhibit Hall (CMCC lower level) |
Poster: 359
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| Kirkise, Nikita |
Welshhans, Kristy |
Laminin and BDNF Synergistically Increase Local Translation and Point Contact Density in Axonal Growth Cones
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Abstract Text
Accurate neural wiring in the developing brain is mediated by growth cones, which are the pathfinding tips of growing axons that respond to environmental cues to find their synaptic partners. Environmental cues stimulate the local translation of mRNAs, such as beta-actin, within growth cones to regulate this process of axon guidance. Although it is well-established that neurotrophic factors, such as brain-derived neurotrophic factor (BDNF), stimulate local translation, the contribution of extracellular matrix (ECM) proteins, such as laminins, to this process is poorly understood. Our lab has previously shown that point contacts, which are growth cone adhesions that link the ECM to the intracellular cytoskeleton, are a preferred site for local translation of beta-actin mRNA. Thus, we hypothesized that laminin may stimulate local translation in axonal growth cones. Embryonic day 17 mouse cortical neurons were acutely stimulated with laminin 111 +/- BDNF by bath application and used in (1) an O-propargyl puromycin (OPP) assay to label nascent protein synthesis and (2) a puromycin-proximity ligation assay (Puro-PLA) to label only newly translated beta-actin. Stimulation with laminin 111 and BDNF together significantly increases local protein synthesis, as compared to either laminin 111 or BDNF alone. Stimulation with laminin 111 and BDNF together also increases axon length and point contact density. Interestingly, stimulation with BDNF alone significantly increases beta-actin local translation, suggesting that laminin 111 signaling may not be needed for beta-actin local translation. However, there are multiple isoforms of laminin, each with unique temporal and spatial distributions. Thus, we repeated the puromycin assay using BDNF and either Laminin 111, 511, 211, or 221. Neurons cultured on laminins 211 and 221 in the presence of BDNF show a remarkable decrease in local protein synthesis and axon length compared to the other isoforms, suggesting that laminin isoforms have differential functions during development. Thus, these results indicate that laminin and BDNF synergistically affect local translation, thereby impacting neuronal growth during axon guidance.
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9:30-11:00 a.m.
Columbia Ballroom (CMCC upper level) |
Poster: 40
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| Goodman, Macie |
Hastings, Tessa |
Student perceptions of ability to address vaccine hesitancy using health behavior models and motivational interviewing
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Abstract Text
Objectives
Pharmacists play an important role in addressing vaccine hesitancy and training student pharmacists to do so is critical. Therefore, the objective was to assess students’ perceptions of their ability to address vaccine hesitancy using health behavior models and motivational interviewing after completion of a vaccine hesitancy assignment.
Methods
Student pharmacists received instructions on vaccine hesitancy, motivational interviewing, and health behavior models within a first-year Introduction to Pharmacy Practice course. Students were presented with a vaccine hesitancy scenario and asked to respond to a series of questions. These included identification of the patient’s stage of change, management strategy, health belief model construct to be emphasized, motivational interviewing technique, and communication plan. Student perceptions were solicited via a brief and anonymous Qualtrics survey in 2022 and 2023. Students were provided the survey link via Blackboard and announcements in class. The anonymous survey included six items in a Likert-type format as well as student demographics.
Results
68 students (2022) and 29 students (2023) completed the survey for a 72% and 32% response rate in 2022 and 2023, respectively. Over the two years, the majority of students strongly agreed that the vaccine hesitancy assignment improved their understanding of the pharmacists’ role in addressing vaccine concerns (70%), improved their understanding of the Health Belief Model (63%), improved their application of motivational interviewing (73%), improved their understanding of transtheoretical model (62%), overall was valuable to their learning experience (72%), and should be continued in the future of the course (73%).
Conclusion
After completion of this assignment, students had positive perceptions of their ability to address vaccine concerns. Future iterations may incorporate more active role play to test the effectiveness of these interactions.
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9:30-11:00 a.m.
Columbia Ballroom (CMCC upper level) |
Poster: 111
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| Earle, Charlita |
Childs, Matthew |
The Lasting Effects of the Racial Hierarchy on the Afro-Caribbean Social Structure
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Abstract Text
Abstract: Beginning in the early 16th century, Europeans began to import 1000s of enslaved Africans into the Caribbean to transform their islands into profitable colonies based upon plantation agriculture. The social structure of plantation slavery created a hierarchy that would place those of European ancestry classified as White at the top. In contrast, those of African ancestry are classified as Black at the bottom. In between the top and the bottom of this social hierarchy based on race and legal status, there was a range of other classifications reflective of job tasks, wealth, being mixed race, and gender. For example, Europeans created social divisions among the slaves to keep them divided, which also included skin color, slaves with certain job skills such as artisans, and field hands. My research poster will explain how these social divisions served to maintain a white minority on top of the Caribbean social structure and served to maintain colonial rule. In explaining this Afro-Caribbean Social Structure my research poster relies on research using published articles such as “The Afro Caribbean Community, a story”, “Colorism in the Caribbean, and The Casta System”. These articles explain the history of and the legacy of the plantation hierarchy system. These social structures set up throughout the Caribbean to serve colonialism and slavery have had a long-lasting effect on present-day Afro-Caribbean people. Over a century after the abolition of slavery in the Caribbean in the 19th century, the lasting effect of this racial hierarchy based upon skin color from light-skinned to dark-skinned, and white to black still influences such factors as employment, education, and class relations in the Caribbean today.
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9:30-11:00 a.m.
Columbia Ballroom (CMCC upper level) |
Poster: 102
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| O'Neal, Riley |
Kim, Minji |
The Associations Between Ad Exposure and Appeal with E-Cigarette Use Susceptibility Among Youth in the US
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Abstract Text
E-cigarettes are the most commonly used tobacco product among US youth. Previous studies identified positive associations between youth exposure to e-cigarette ads and susceptibility to e-cigarette use; however, many were conducted prior to recent market changes, such as the rise of disposables. This study used recent data to investigate associations between e-cigarette ad exposure, ad appeal, and susceptibility to e-cigarette use among youth. Methods: We analyzed US data from the 2022 International Tobacco Control Policy Evaluation Project (ITC) Youth Tobacco and Vaping Survey, an online survey of youth (ages 16-19). US youth with no prior e-cigarette use (n=2367) were included in analyses. We measured ad exposure as self-reported frequency [1=Never, 5=Very often] and total channels of exposure [e.g. websites/social media, range=0-17]. Participants with any exposure also reported perceived ad appeal [1=Very unappealing, 5=Very appealing]. Susceptibility was measured using 4 items: 1) curiosity about using e-cigarettes, 2) potential to use e-cigarettes in 1 year, 3) potential to use e-cigarettes if a friend offers, and 4) potential to use e-cigarettes in 5 years [1=Definitely not, 4=Definitely yes]. Participants with responses other than “Definitely not” on one or more items were defined as susceptible. Regression models investigated ad exposure and perceived ad appeal as predictors of susceptibility to e-cigarette use. Results: The sample was mostly female (65.5%), White (50.1%), and students (86.5%), with a mean age of 17.6 years (SD=1.0). Ad exposure frequency was not a significant predictor of youth susceptibility to e-cigarettes (OR=1.08, 95% CI=1.00-1.16), whereas total number of channels (OR=1.04, 95% CI=1.01-1.06) was significant. Higher ad appeal ratings were associated with susceptibility among youth (OR=1.20, 95% CI=1.11-1.30). Conclusion: Number of ad exposure channels and ad appeal were associated with e-cigarette susceptibility among US youth, whereas ad exposure frequency was not. Perhaps the number of channels of ad exposure, in addition to the content of ads and its perceived appeal, are important in explaining youth susceptibility to e-cigarettes. This analysis used cross-sectional data and thus cannot ascertain the causal direction between ad exposure/appeal and susceptibility. Future analyses will investigate predictors of ad exposure and potential mediating effects in adjusted models.
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9:30-11:00 a.m.
Exhibit Hall (CMCC lower level) |
Poster: 166
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| Keiper, Grace |
Derrick, Maureen |
In Tune with South Carolina Educational TV & Public Radio
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Abstract Text
Since August 2023, I have been the sole production and content intern at South Carolina Educational Television and Public Radio (SCETV). SCETV is South Carolina’s public educational broadcasting network, providing news to educate and strengthen the public while creating a more connected and informed state. As PBS and NPR affiliates, SCETV provides national and local news content to viewers, reporting on anything impacting the Palmetto state. This role has introduced me to political journalism in reporting on the 2024 presidential election, tasking me with creating concise and unbiased political pieces that shape public opinion. At SCETV, I research presidential candidates, attend rallies, interview voters, and contribute as a guest speaker on the political podcast, SC Lede. These responsibilities have enhanced my ability to educate others on politics while following the principles of ethical journalism: accuracy, clarity, and fairness. This internship has deepened my understanding of how the First Amendment and media law influence broadcasting, inspiring me to pursue a specialization in media law in law school. SCETV has provided me with a platform to apply the knowledge gained at USC in real-world scenarios. Moving forward, I aim to utilize the skills cultivated at SCETV to lead efforts in creating a more politically informed and engaged society.
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9:30-11:00 a.m.
Exhibit Hall (CMCC lower level) |
Poster: 262
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| McCormick, Gabrielle |
Spence, Gina |
Cultivating Culinary Communities
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For over one year, I have served as Editorial Director for the USC Student Organization, Spoon University. Spoon University is a national online publication of food-related content created by college students, with chapters at over 80 colleges in the United States. I began as a writer with the club in September 2022, producing articles that explored the many facets of the Columbia, South Carolina culinary scene. As an English major and avid foodie, I was quick to apply for membership when I discovered it on Garnet Gate, USC’s student organization website. When I came into my role as Editorial Director in January of 2023, I found that my responsibilities extended far beyond just editing, fact-checking, and publishing articles for the chapter. My role is more like an acting president, requiring me to schedule and conduct chapter meetings, oversee the chapter’s social media channels, and initiate food-related gatherings outside of the regular school week. I struggled learning to be real leader for the club, but it was my enrollment in the Capstone Scholars Leadership Program that helped me to refine my leadership skills and come into my own in my position. The main idea of CSLP (as us Capstone Scholars call it) is that leadership is learned, not innate. Over the course of eight weeks, I acquired ways to be a strong leader and created a Campus Impact Plan to apply them to my role with Spoon University. By implementing this plan over the past year, I discovered that the meaning of the club is about so much more than writing. Spoon University is a publication, but it is first and foremost a culinary community. I have learned the importance of balancing chapter productivity with fostering a positive environment that shares a love for all things food. I want to continue this leadership style in the future, valuing the importance of team accomplishment and shared passion.
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9:30-11:00 a.m.
Exhibit Hall (CMCC lower level) |
Poster: 351
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Paytes, Emma
Montgomery, Arran |
Mefford, Breanne
Cox, Jenna
Love, Bryan |
Impact of Intravenous Hydrocortisone in Patients Receiving Vasopressor Support Following On-Pump Coronary Artery Bypass Grafting
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Background: Although 2019 EACTS Guidelines on Cardiopulmonary Bypass in Adult Cardiac Surgery recommend against routine use of prophylactic corticosteroids, perioperative glucocorticoids are still often used to mitigate hypotension, cardiac arrhythmias and respiratory failure following cardiopulmonary bypass surgery. This study evaluated the effect of postoperative intravenous (IV) hydrocortisone use after on-pump coronary artery bypass grafting surgery, which has not been described in current literature.
Methods: The Society of Thoracic Surgeons database was used to identify patients at a single academic medical center from 2021 to 2023. Adult patients who underwent on-pump coronary artery bypass surgery and required vasopressor support postoperatively were included. Patients who were in atrial fibrillation at the start of surgery were excluded. The primary outcome will evaluate incidence of postoperative atrial fibrillation in patients who received or did not receive IV hydrocortisone postoperatively. Secondary outcomes will evaluate the impact of IV hydrocortisone on pulmonary complications, insulin requirements, hospital length of stay, surgical site infections, and vasopressor requirements. A logistical regression analysis will be performed to further elucidate the relationship between hydrocortisone and atrial fibrillation and identify variables that influence the incidence of postoperative atrial fibrillation.
Results: In progress with anticipated date of completion March 1, 2024. Of the 643 patients identified, 452 patients did not meet vasopressor requirements, 38 patients had documented atrial fibrillation at the time of surgery. Ultimately, 153 patients will be analyzed.
Conclusion: The results will be discussed.
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9:30-11:00 a.m.
Columbia Ballroom (CMCC upper level) |
Poster: 217
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| Miller, Madeline |
Blake, Christine
Boncyk, Morgan |
Age of Introduction to Animal Source Foods Influence on Child Nutritional Status in Low-income Informal Settlements of Nairobi, Kenya
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Animal-sourced foods (ASF) contain essential nutrients for human growth, maintenance, and repair. This study quantifies the relationship between the age of ASF introduction and later child nutritional outcomes in low-income Kenya informal settlements.
A two-stage sampling method selected seven wards with high ASF value chain activity in Nairobi, Kenya, and randomly sampled 304 mother and child (6-59 months) dyads from low-income households in September to October 2019. Mothers completed a cross-sectional survey that assessed breastfeeding duration, exclusive breastfeeding for six months, and age of introduction of animal milk, poultry, red meat, and eggs. Child anthropometrics were collected. Linear regressions examined associations between breastfeeding and complementary feeding practices with child anthropometrics, adjusted for maternal age, education, household size, and income, stratified by child age in years.
Over 99% of children were breastfed, averaging 19 ± SD=6 months, and 35% were still breastfeeding during assessment. Exclusive breastfeeding lasted 4±3 months, with 58% exclusively breastfed for six months. Breastfeeding was not associated with child anthropometrics. Mothers introduced animal milk earliest (6±3 months), followed by poultry and red meat (8±5 months), and eggs (9±5 months). Later introduction to ASFs associated with higher weight-for-age z-scores at 24-36 months: animal milk β=0.07 [95% CI=0.01,0.12]; poultry 0.04 ± 0.02 [0.003,00.08]; red meat 0.04 ± 0.02 [0.002,0.08]; eggs 0.05 ± 0.02 [0.001,0.09]). Age of introduction to ASFs were not associated with length-for-age, weight-for-length, or BMI z-scores.
In Nairobi’s informal settlements, we found that most children were breastfed, with over half exclusively breastfed for the first six months. Mothers typically introduced animal milk first, followed by meat and eggs. Later introduction to ASFs is associated with improved nutritional.
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1:00-2:30 p.m.
Exhibit Hall (CMCC lower level) |
Poster: 136
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| Jajee, Sankalp |
Zand, Ramtin |
Smart Glasses Enhancements with Deep Learning: Image Captioning, Facial Recognition, and Sentiment Analysis.
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Our project aims to transform the already cutting edge smart glasses by employing advanced deep learning techniques for an enriched user-environment interaction. our innovation is a sophisticated image captioning system, utilizing state-of-the-art computer vision and natural language processing (NLP) to instantaneously generate descriptive textual captions for visuals. This system is intricately designed to interpret a diverse range of images in a human-like manner, thus rendering digital interactions more natural and enlightening.
Furthermore, we integrate facial recognition technology to identify individuals within the user's immediate view, enhancing both social interactions and personal security. Complementing this, sentiment analysis is utilized to gauge emotional cues from conversations, offering users a deeper understanding of social dynamics. This project, by melding these innovative technologies, seeks to develop smart glasses that not only augment visual perception but significantly improve social connectivity, personal navigation, and overall quality of life.
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9:30-11:00 a.m.
Columbia Ballroom (CMCC upper level) |
Poster: 11
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| Carpenter, Sheldon |
Carpenter, Sheldon |
Trisomy 13 in the Teenage Years: A Case Report on the Complex Management of a 15 Year Old Patient with Trisomy 13 and a Congenital Double Outlet Right Ventricle Anomaly
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Trisomy 13 is one of the more common and more lethal trisomy disorders with patients rarely surviving the gestational period, and even fewer surviving the neonatal period. Within the constellation of potential symptoms patients with heart defect abnormalities have been correlated with more severe outcomes and decreased survivability. Despite the association some patients with heart related sequelae do survive the neonatal window and potentially live well into their teenage years. Providers should be aware of the clinical presentation and treatment approach for an adolescent patient with Trisomy 13 related heart abnormalities. We present a case report on a 15 year old with Trisomy 13 and complex comorbidities including congenital heart defects presented to the children’s hospital in multi-organ failure induced septic shock. Despite the heart related sequelae of trisomy 13 being a leading of cause of intra-uterine demise and neonatal death of affected patients, a Trisomy 13 adolescent with heart sequelae faces greater risks from comorbid and iatrogenic conditions than from heart functionality. Throughout our provided treatment timeline the patient’s chronic lung disease resulted in most focused care directed toward proper oxygenation while imaging studies were obstructed by scoliosis of the thoracic spine. Her time to discharge was impacted by hospital acquired bacteremia but recovered with treatment further showcasing the relative strength of her heart. While heart sequelae are a known comorbidity for trisomy 13 patients, this case report highlights the priority of care for treating physicians should always focus on the immediate issues at hand rather than a syndrome’s expected complications.
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9:30-11:00 a.m.
Columbia Ballroom (CMCC upper level) |
Poster: 166
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| Carpenter, Sheldon |
Carpenter, Sheldon |
Incident Predictors of Thyroid Cancer Subtypes: An analysis of the NCCR Database
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This project’s goal was to analyze and compare population data for papillary and follicular thyroid cancer to determine at risk populations for further investigation of novel exposures and potential causes associated with the disparity between incident rates of thyroid cancers. The NCCR SEER database identified patients diagnosed with thyroid cancer from 1975-2020. Demographic, pathologic subtype, and survival trends were analyzed by year over year trendline progression followed with a thorough literature review of known and theorized risk factors for thyroid cancer development in discussion. Calculated Annual percent change for Follicular Thyroid Cancer found a noticeable difference in incidence rate between 1997-2009 amongst male and female patients with net 7.5% difference in reported rate per 100,000 with men (12.1%) more than doubling the reported percent change rate for women (4.6%). Analysis for papillary thyroid cancer however found no significant difference between male and female rates with a slight, statistically insignificant difference of 0.3% favoring men (10.9%) over women (10.6%). When analyzed along racial or age demographic lines no variations between historic annual percent changes to analyzed data sets were observed. Comparing the incidence rates between both papillary and follicular subtypes of thyroid cancer revealed an asymmetric distribution between gender for reported cases of Follicular thyroid cancer between the years of 2000-2010. Both subtypes share the same risk factors of family history, genetic family syndromes and radiation exposure, with radiation therapy at a young age being the leading risk factor for both cancer subtypes. Despite the shared risk factors between subtypes only the Follicular subtype favored an increased incidence amongst men suggesting additional factors at play. The likelihood of social exposure trends being the cause for the gender discrepancy remains in question and would benefit from additional epidemiologic studies. A final takeaway from these finding is that there is a statistically significant discrepancy in the incidence rate of follicular thyroid cancer diagnoses amongst men when compared to women and more epidemiologic studies are warranted to determine the root cause of these worrying trends.
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1:00-2:30 p.m.
Columbia Ballroom (CMCC upper level) |
Poster: 183
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| Sisto, Ian |
Ely, Bert |
Examining the efficiency of restriction modification systems of the Caulobacter strains CB2 and CB13
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Bacteria have evolved restriction modification systems to counteract bacteriophages, viruses that infect bacteria. Phages often have a limited range of hosts that they can infect, and their infection efficiency varies with each host. Two Caulobacter strains, CB2 and CB13, are believed to have an efficient restriction and modification system. They restrict (cut) incoming foreign DNA but methylate (modify) their own DNA to protect it from the restriction enzyme. Previous studies with CB2 have shown that phage infection efficiency is reduced when CB2 is the host strain. In contrast, the strain SC1004 is highly vulnerable to phage infections and plating efficiency is high on this strain. To better characterize these differences in plating efficiency, we exposed CB2, CB13, and SC1004 to five different Caulobacter phages, ERS, KSC, Lullwater, RBC9, and RBC21. Plating efficiencies were consistently lower with CB2 and CB13 hosts when compared to the SC1004 host. However, plating efficiencies were high on the CB2 and CB13 hosts if the phage lysate had been grown on these hosts. Since prior growth on a CB2 or CB13 host would modify the phage DNA, subsequent infection of the same host strain would not result in restriction since the incoming phage DNA would have the protecting modification. Therefore, these results reinforce the idea that CB2 and CB13 have strong restriction modification systems.
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1:00-2:30 p.m.
Columbia Ballroom (CMCC upper level) |
Poster: 38
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| Vikas, Athul |
Hofseth, Lorne |
Artificially Red, Naturally Risky: Exposing the Health Hazards of Common Food Dyes
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"Artificially Red, Naturally Risky: Exposing the Health Hazards of Common Food Dyes," authored by Athul Vikas, investigates the adverse health effects of Allura Red AC (Red 40), a prevalent synthetic food dye, on colonic health. This paper employs a rigorous literature review to examine the multifaceted impacts of Red 40, including its potential to trigger inflammation, cause DNA damage, and alter the gut microbiome. These alterations are critically evaluated for their role in the pathogenesis of colorectal cancer (CRC), a significant public health concern. The research highlights the extensive use of Allura Red AC in ultra-processed foods and uncovers the profound disconnect between the existing scientific evidence of its hazards and the general public's awareness. Utilizing a unique and innovative approach, this paper provides clear, specific actionable steps along with the integration of scientific analysis with public engagement through art. The study presents a unique interdisciplinary approach to heightening awareness and fostering a deeper understanding of the implications of synthetic dye consumption; the findings advocate for an immediate reevaluation of dietary choices, stricter regulatory standards, and proactive public health policies to mitigate the identified risks. Additionally, it outlines a direction for future research, emphasizing the need for comprehensive studies to further explore the mechanisms by which processed foods impact colonic health and contribute to CRC risk.
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9:30-11:00 a.m.
Exhibit Hall (CMCC lower level) |
Poster: 50
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| Hamlin, Kelsey |
Cooper, Lindsey |
Effect of oral adjuncts on norepinephrine duration in patients with elevated MAP goals after spinal cord injury
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Background: Spinal cord injuries (SCI) are devastating neurological insults that can lead to significant hemodynamic disturbances. Secondary injury can occur due to impairment of blood flow that can lead to ischemia of the spinal cord therefore, maintaining spinal cord perfusion is recommended to improve neurological outcomes. The majority of data supporting the use of vasoactive agents in SCI pertains to intravenous (IV) agents with alpha and beta effects. The use of IV vasopressors can lead to complications as well as prolonged stays in the ICU. Enteral agents, such as midodrine and pseudoephedrine have been studied to decrease patients’ needs for norepinephrine to maintain elevated MAP goals. The purpose of this study is to evaluate all patients requiring norepinephrine to maintain elevated MAP goals following spine surgery or spinal cord injury and if the addition of oral adjuncts, midodrine or pseudoephedrine, reduces the duration of norepinephrine.
Methods: A retrospective cohort study of persons 15 years or older who are admitted to the trauma service for spinal cord injury or post spinal surgery between March 1st, 2021 and December 31st, 2023 at Prisma Health Richland, will be conducted. The primary outcome is the duration of IV norepinephrine in patients with and without oral adjuncts. Secondary outcomes include ICU length of stay, incidence of bradycardia (heart rate < 50 beats/minute), incidence of tachycardia (heart rate > 110 beats/minute) and proportion of patients that were continued on an oral agent after MAP goals were discontinued.
Results: In progress
Conclusion: In progress
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9:30-11:00 a.m.
Columbia Ballroom (CMCC upper level) |
Poster: 218
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Hankey, Danielle
Oen, Kathryn |
Waldman, Alan |
The Effect of ZMPSTE24 Protease Inhibition on DNA Repair
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Restrictive Dermopathy (RD) is an autosomal recessive rare genetic disorder that is neonatal lethal. If children are liveborn, they usually do not make it through the first week of life due to pulmonary insufficiency. RD is commonly caused by mutations in both copies of the ZMPSTE24 gene. Expression of ZMPSTE24 also decreases with age in healthy people. ZMPSTE24 is a protease that plays a key role in the post-translational processing of lamin A, an essential protein in a structure called the nuclear lamina that plays a critical role in a variety of nuclear functions. The form of lamin A produced in the absence of ZMPSTE24 is permanently farnesylated and methylated. Previous studies from our lab and other groups have shown that other mutant forms of lamin A that are incompletely processed disrupt the repair of DNA double-strand breaks (DSBs) and cause a decreased ability to maintain genomic integrity. To enhance our understanding of the biology of RD and of possible changes in genome stability with age, we are investigating the effects of ZMPSTE24 deficiency on DNA repair. To do so we have stably transfected a DSB repair reporter substrate into the genome of normal human fibroblasts. A DSB can be induced within the substrate contained in these cells through exogenous expression of endonuclease I-SceI, and DSB repair events occurring via either homologous recombination (HR) or non-homologous end-joining (NHEJ) are recoverable by genetic selection. Repair by HR is an accurate and templated form of repair, while NHEJ is an error-prone non-templated rejoining of DNA ends that may lead to a variety of mutations. We have induced DSBs in cells that had been treated with HIV protease inhibitors (HIV-PIs) and in cells that remained untreated. HIV-PIs, such as Lopinavir and Ritonavir, have been shown to inhibit the activity of ZMPSTE24, causing prelamin A accumulation like that seen in RD patients. Our work aims to reveal the impact of biochemical inhibition of ZMPSTE24 activity on DSB repair pathway choice. We present our findings to date on the role played by ZMPSTE24 in maintaining genome integrity.
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1:00-2:30 p.m.
Exhibit Hall (CMCC lower level) |
Poster: 36
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O'Leary, Shannon
Schlekat, Katrina |
Qiao, Shan
Aggarwal, Abhishek |
Measurement Instruments Assessing Multi-Faceted Stigma Regarding Sexual and Gender Minorities: A Systematic Review of Psychometric Properties
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Stigma against sexual and gender minorities (SGM) populations has negative health effects for SGM populations. Despite the growing need for accurate stigma measurement in SGM, there are insufficient valid measurement instruments. Moreover, the lack of consistency in construct usage makes comparisons across studies particularly challenging. A critical review and comparative evaluation of the psychometric properties of the stigma measures for SGM is necessary to advance our understanding regarding stigma measurement. Based on the PRISMA (Preferred Reporting Items for Systematic Reviews & Meta-Analyses) guidelines, a search was conducted in 4 databases (MEDLINE, PsycINFO, CINAHL, & Web of Science) for empirical articles published from 2010 to 2022 that evaluated the psychometrics properties of measurement instruments assessing stigma against SGMs. The extraction and scoring of the psychometric properties and methodological quality of instruments were performed by following the established standards and COSMIN (Consensus-based Standards for the selection of health Measurement Instruments) checklist. Of the 2031 studies identified, 19 studies were included that reported psychometric properties of 17 measurement instruments. All instruments, except two, were developed for SGMs (n=15/17). Most instruments included men who have sex with men (MSM) (n=11/15), whereas less than half of the instruments assessed stigma among SGM women (n=6/15). Internal consistency and content validity was reported for all instruments (n=17); construct and structural validity was also reported for majority of the instruments (n=15 and 10, respectively). However, test-retest reliability and criterion validity was reported for very few instruments (n=5 each). Based on the COSMIN checklist, we identified the most psychometrically and methodologically robust instruments for each of the five stigma types: combined stigma, enacted stigma, internalized stigma, intersectional stigma, and perceived stigma.
For each stigma type, except anticipated stigma, at least one instrument demonstrated strong promise for use in empirical research; however, the selection of instruments depends on the population and context of the study. Findings indicated a growing use of instruments assessing stigma types. Future studies must develop intersectional stigma instruments that account for the intersecting social identities of SGMs. Existing instruments would benefit from further psychometric testing to different LGBTQ+ populations.
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9:30-11:00 a.m.
Exhibit Hall (CMCC lower level) |
Poster: 147
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| Cobb, Ashley |
Valerio, Wendy |
Fourth-Grade Music Students' Perceptions of Music Improvisation: An Ethnographic Case Study
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I facilitated this ethnographic case study to better understand potential successes and difficulties music improvisation presents in music facilitating and learning from the student perspective. The purpose of this research was to examine my fourth-grade music students’ perceptions of music improvisation via improvisatory music circles using the following guiding research questions. Regarding 30-minute improvisatory music circles: 1) How do fourth-grade students (a) define music improvisation, (b) respond to facilitator-selected improvisatory music activities during improvisatory music circles, and (c) make decisions while participating in improvisatory music circles? 2) How did those students’ perceptions change throughout data collection?
During this study, I collected data from five, 45-minute fourth-grade music classes over the course of three weeks. To achieve triangulation, I employed a variety of data collection sources: my learning plans, voice-recorded small-group opening discussions, video recordings of improvisatory music circles, student projection sheets, voice-recorded small-group closing discussions, passive participant-observer fieldnotes, moderate participant-observer memos, a focus-group discussion with member-checking, students’ personal transcriptions, and voice-recorded, member-checking interviews. Through my data analysis process, I identified six emergent themes: students defined music improvisation in a variety of ways, determined our classroom music community elicited feelings of trust and prompted students to help each other and respond with empathy, utilized music improvisation as a tool to express their emotions and focus their energy, used a variety of thinking strategies to inform their decision-making during improvisatory music circles, reported a balance between novelty and familiarity in facilitator-selected activities for improvisatory music circles improved their situational interests and engagement, and realized that improvisation, as an extramusical skill, may be used outside of music classes.
Through those findings, I gleaned insight from students’ perceptions of music improvisation to determine that a co-constructed classroom music community is essential to developing an effective music learning environment. Exploring improvisatory music circles within that effective learning environment yields benefits for both music education and Social-Emotional Learning (SEL).
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1:00-2:30 p.m.
Columbia Ballroom (CMCC upper level) |
Poster: 47
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| Truesdale-Caskey, Sherry |
Aghasafari, Sahar
Malloy, Mark |
Blending Media Arts with STEAM: A Journey Towards Creative and Interactive Learning
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In today's world, blending Media Arts with STEAM (Science, Technology, Engineering, Arts, and Mathematics) is changing traditional teaching methods. It creates a space where creativity and logic merge to spark endless innovation. Our poster presentation discusses our journey in integrating media arts with STEAM, with a particular focus on chemistry, to make learning more engaging and profound. Driven by our eagerness to discover new things and innovate, this research demonstrates how media arts and sciences can work together. We show that media arts can simplify scientific concepts and transform learning into an enjoyable journey of discovery. We share examples of how media arts can transform complex scientific concepts into tangible, imaginative experiences. These stories highlight successes and how STEAM education can evolve to meet future demands. Indeed, we faced challenges such as integrating different subjects, adapting our use of technology, and securing resources. However, the significant benefits—such as igniting new ideas, fostering creativity, and enhancing understanding of complex topics—far outweigh these difficulties. We invite faculty and students to explore this innovative approach to learning with us. By incorporating media arts into STEM, especially chemistry, we can demystify academic subjects and ignite creativity. This effort prepares a new generation of thinkers, creators, and innovators ready to navigate and shape the future.
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1:00-2:30 p.m.
Exhibit Hall (CMCC lower level) |
Poster: 23
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| Gardiner, Josephine |
Welshhans, Kristy |
Dysregulation of Local Translation and Ribosomes May Contribute to Altered Motility of Down Syndrome Fibroblasts
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Down syndrome (DS) results from the trisomy of human chromosome 21. Phenotypes of DS include intellectual disability and impaired wound healing. This study uses fibroblasts, cells that contribute to the wound healing response, to provide insight into both of these phenotypes; this is because fibroblasts utilize similar migration mechanisms to neuronal growth cones, which are found at the tips of developing neurons and help regulate the formation of neural wiring during neurodevelopment. Two mechanisms that regulate motility are adhesion and local translation. Focal adhesions are cellular structures that link the extracellular matrix to the intracellular actin cytoskeleton and are important for both fibroblast motility and axon guidance. Local translation is the process by which mRNAs are transported to specific cellular regions and translated in response to molecular cues. Previous studies have shown that fibroblast and growth cone motility are dependent on the local translation of b-actin mRNA at focal adhesions. Taken together, these studies call for further investigation into fibroblast motility and local b-actin translation in DS, to better understand the molecular basis for the intellectual disability and wound healing phenotypes of DS. Using a transwell membrane assay, we found decreased migration of DS fibroblasts. We then used a puromycin assay and found decreased local translation in the leading edge of DS fibroblasts. We are currently using immunocytochemistry to quantify ribosomal subunits in fibroblasts, as well as colocalization analysis of the adhesion protein vinculin with ribosomal subunits, to determine if ribosomes are localized to adhesion sites, and if this is altered in DS. Taken together, our results suggest that decreased local translation may contribute to migration deficits in DS fibroblasts. Future research will determine if the local translation of target mRNAs, such as b-actin, at adhesions is decreased in DS to better understand the migration and translational deficits in DS fibroblasts. This will provide a foundation for future research on the molecular basis of neurodevelopmental and wound healing changes that occur in Down syndrome.
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1:00-2:30 p.m.
Exhibit Hall (CMCC lower level) |
Poster: 37
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| Rocha, Megan |
Wellman, Denise |
Dimensions of Health: Analyzing the Impact of Occupational Therapy Treatments on Different Aspects of Patient Life
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Abstract Text
Since my junior year of high school, I have known I wanted to be an occupational therapist. My undergraduate education has been filled with lessons on what the field means to me and how I can make the largest impact on our communities. In 2022, I was involved in an Early Learner’s Summer Camp through Skills on the Hill in Arlington, Virginia. Skills on the Hill, a private practice pediatric therapy group, focuses on empowering children through learning and addressing a variety of disabilities through speech, physical, and occupational therapy. I was immersed in the therapy process and learned the importance of creating a supportive environment to elicit positive treatment outcomes for patients. The following year I interned at Prisma Health’s Rehabilitation Clinic in Lexington, South Carolina. In addition to strengthening my knowledge in pediatric therapy, I observed and assisted with hand and spine treatments with occupational therapists. My time at Prisma allowed me to become more involved with patient experience beyond our thirty minutes of treatment. I began to evaluate the meaning of holistic approaches to rehabilitation, as occupational therapy is often categorized as using comprehensive methods for healing. Reflecting on my observation opportunities, I identified challenge areas for patients and how they were addressed within my organization. While occupational therapy treatments can address cognitive, physical, and mental deficits I plan to place special importance on advocacy as well. My presentation will include different dimensions of health that occupational therapy can treat and discuss the increasingly pertinent foundation advocacy creates for occupational therapists and their patients.
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1:00-2:30 p.m.
Exhibit Hall (CMCC lower level) |
Poster: 360
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| Hammond, Neal |
McQuail, Joseph |
The Role of the Locus Coeruleus in Working Memory During Stress and Aging
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Abstract Text
The locus coeruleus (LC) is the main source of norepinephrine (NE) to the cerebral cortex, where this modulatory neurotransmitter calibrates neural activity in response to arousing or stressful stimuli. The effects of normal aging on LC cellular integrity and activity are sparse and conflicting. Due to these contradictions and the fact that the LC mediates arousal and coordinates responses to perceived stressors, influences of the LC-NE system on cognition during normal aging may vary in response to stress. To address these questions, we examined the effects of chronic variable stress (CVS) on working memory and the LC in aging (4-6 or 22-24 months) male and female F344 rats. Working memory was assessed using a delayed match-to-sample operant task. In unstressed (UNS) rats, working memory accuracy of female rats was superior to males, who exhibited marked, age-dependent working memory deficits. Exposure to CVS, entailing twice-daily exposure to stressors (forced swims, physical restraint, predator urine exposure, and cage floods) for 21 days after working memory testing, led to significant improvement of working memory in aged males relative to age-matched UNS controls, returning working memory to a level of accuracy indistinguishable from young rats. To determine whether the LC is involved in this sex- and age-specific behavioral effect of stress, we harvested brains from all rats immediately following the final working memory testing session, approximately 18 hours after the final stress exposure. The hindbrain, containing the LC, was dissected, fixed, and prepared for immunohistochemical staining. Ongoing studies will quantify the number of tyrosine hydroxylase (TH+) neurons in the LC. We predict that chronic stress may reverse age-related changes in TH expression in the LC or increase the fraction of active LC neurons in males, and these increases will associate with working memory rescue. Once complete, our results will establish interactions among biological sex, aging, and LC-NE cellular responses to stress and how these changes may influence working memory. These data will improve our understanding of the role this brain nucleus plays in mental health and cognitive well-being over the lifespan and may direct the development of future therapeutics.
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9:30-11:00 a.m.
Exhibit Hall (CMCC lower level) |
Poster: 174
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| Weyer, Chloe |
Nagarkatti, Mitzi
Nagarkatti, Prakash
Carter, Taylor
Aladhami, Ahmed |
Single-cell RNA Sequencing Reveals Mechanisms of TCDD-mediated Attenuation of Acute Respiratory Distress Syndrome Through Down-regulating Chemokines and Their Receptors on Myeloid Cells in the Lungs
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Abstract Text
Acute Respiratory Distress Syndrome (ARDS) is a severe clinical disorder characterized by increased vascular permeability, pulmonary edema, and inflammation. Therapeutic options are sparse and often ineffective, leading to over 40% mortality. There are limited studies addressing the role of the Aryl Hydrocarbon Receptor (AHR) in the regulation of ARDS. To that end, we used 2,3,7,8-tetrachlorodibenzodioxin (TCDD), a potent AHR ligand, to study the effect on lipopolysaccharide (LPS)-mediated ARDS.
C57Bl/6 mice were treated with 30 ug/kg TCDD via intraperitoneal injection. ARDS was induced via intratracheal injection of 10 mg/kg LPS 24 hours post-TCDD treatment. Lungs were collected 48 hours after ARDS induction and whole-body plethysmography, flow cytometric analysis, and single-cell RNA sequencing (scRNA-seq) were carried out.
Plethysmography data demonstrated that LPS at 24 hrs increased enhanced pause, an indicator bronchoconstriction, and reduced breathing rate, effects which were reversed by TCDD. LPS exposure led to a significant increase of neutrophils and monocytes in the lungs while the LPS+TCDD group showed a significant decrease. Single-cell RNA sequencing revealed that several chemokines and their receptors expressed on neutrophils and monocytes such as CXCL3, CXCL1, CCL2, CCL7, and CCL9 were significantly decreased after TCDD exposure. Also, endothelial cells from the LPS+TCDD group showed significantly downregulated levels of pro-inflammatory molecules S100a8/S100a9, which act through TLR-4 pathway.
Taken together, these data suggest that AHR activation ameliorates the ARDS phenotype. Also, scRNA-seq data demonstrated that part of this mechanism involves the prevention of leukocyte chemotaxis to the alveolar space by downregulation of chemokines and their receptors (This work was supported in part by NIH grants R01ES030144, P20GM103641, R01AI123947, and R01AI160896).
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9:30-11:00 a.m.
Columbia Ballroom (CMCC upper level) |
Poster: 82
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| Cardinale, Amelia |
Outten, Wayne
Miller, Kennedy |
Spectroscopically Monitored Fe-S Cluster Transfer Between GrxD-BolA and A-Type Carriers in E. Coli
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Abstract Text
Iron-sulfur (Fe-S) clusters are essential iron cofactors used for various metabolic and redox functions in most organisms. Fe-S cluster formation in E. coli occurs in two primary biogenesis pathways, Isc and Suf. Each pathway contains trafficking A-type carrier type II (ATC-II) proteins, IscA or SufA, that have previously been shown to traffic [2Fe-2S] to downstream targets such as ATC-I protein ErpA. In addition to ATCs, in vivo evidence has suggested a role in Fe-S trafficking for the sole monothiol glutaredoxin found in E. coli, GrxD. GrxD Fe-S cluster coordination involves an active site cysteine residue and glutathione thiol from each monomer to form a GrxD homodimer. Additionally, E. coli houses two BolA-like proteins, BolA and IbaG, that can form heterodimers with GrxD. The heterodimers can also coordinate [2Fe-2S] clusters due to the contribution of new coordination ligands by BolA or IbaG. This prompted investigation of the BolA/IbaG interactions with GrxD that may occur during iron-sulfur cluster biogenesis. Specifically, this project probes the extent to which the GrxD heterodimers can traffic [2Fe-2S] to the ATCs during Fe-S biogenesis. Cluster transfer experiments are performed anaerobically due to the oxygen sensitivity of the clusters. Transfer is monitored via UV-visible absorption and circular dichroism spectroscopies in the visible region of the spectrum that can differentiate between different cluster-bound proteins.
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1:00-2:30 p.m.
Exhibit Hall (CMCC lower level) |
Poster: 87
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| Garcia-Sanchez, Jeffrey |
Nagarkatti, Mitzi
Nagarkatti, Prakash |
Delta-8-Tetrahydrocannabinol ameliorates colitis through suppression of inflammatory myeloid cells in the colon
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Abstract Text
Colitis is an inflammatory bowel disease that affects 1.5 million people in the United States. Past studies from our laboratory have shown that Delta-9-Tetrahydrocannabinol (Δ9 THC), a cannabinoid, can attenuate colitis through its anti-inflammatory properties. However, one of the drawbacks of using Δ9 THC is that it is highly psychoactive. In the current study, we tested the efficacy of Δ8 THC to determine its efficacy to attenuate the pathogenesis of colitis. Colitis was induced in C57BL/6 mice using dextran sodium sulfate (DSS) and these mice were treated with vehicle or 30 mg/kg of Δ8 THC i.p. every other day for 8 days and mice were euthanized on day 9. Δ8 THC reversed the loss of body weight and decreased colon lengths in mice with DSS-colitis. Colonoscopies, and histopathological studies showed that the overall structure of the colonic tissue was disrupted by colitis accompanied by inflammatory cells, while Δ8 THC treatment mitigated these pathological changes seen during colitis. Δ8 THC treatment caused a significant decrease in the number of CD45+ CD11b+ CCR2+ macrophages, granulocytes (CD45+ CD11b+ Ly6G+) and neutrophils. Δ8 THC decreased TNF-α secretion by the bone marrow derived macrophages. In summary, Δ8 THC treatment effectively attenuated colitis through suppression of inflammatory myeloid populations, especially macrophages. Together these studies demonstrate that Δ8 THC, which is less psychoactive, may constitute an effective treatment agent against colitis (This work was supported in part by NIH grants R01AI160896, R01ES030144, P20GM103641, R01AI123947, R01AI160896 to MN and PN as well as by R0160986 Supplement to JG-S).
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1:00-2:30 p.m.
Columbia Ballroom (CMCC upper level) |
Poster: 39
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| Hunter, Emily |
Blake, Christine
Bonyck, Morgan |
Animal Source Food Beliefs, Perceptions, and Dietary Intake Among Mothers and Children in Kenya Informal Settlements
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Abstract Text
To explore how beliefs and perceptions about animal-source foods (ASFs) influence mother and child dietary intake in Nairobi, Kenya.
Cross-sectional surveys assessed ASF beliefs and perceptions in informal settlements from 7 wards with high ASF activity in Nairobi, Kenya in Sept-Oct 2019. A random sample of 304 low-income mothers with children 6-59 months reported how much ASFs they and their child should consume per week and likelihood of getting sick or fat from ASFs. ASF intakes were collected with 24-hour recalls. Open-ended responses on sickness causes and mitigation were thematically analyzed. Logistic regressions assessed associations between ASF beliefs and perceptions with intake, stratified by 6-23 24-59 child mo of age, gender, and maternal primary education.
Most mothers (88%) and children (91%) consumed ASF, mainly milk (81%, 88%). Mothers believed they should consume one more egg than children, but similar amounts of meat, fish, and milk. Belief in higher milk and meat intake increased odds of intake in girls (OR: 1.51 [95% CI: 1.21,1.88]; 1.32 [1.003,1.74]) and older children (1.28 [1.05,1.58]; 1.30 [1.01,1.66]). Mothers perceived eggs, meat, and poultry led to weight gain (69%, 58%, 58%) and sickness (39%, 49%, 32%). Perceived weight gain from eggs reduced odds of intake in mothers older (0.97 [0.95,0.99]) and less educated (0.96 [0.94,0.99]). Sickness concerns from lack of processing raw milk (65%), overprocessing packaged milk (24%), animal health in poultry, organs, and red meat production (25%, 14%, 14%), and overconsuming eggs (45%). Mothers (77-97%) mitigated concerns by boiling milk, properly cooking poultry and organs, and reducing red meat and egg intake. General mitigation included trusted sources; proper hygiene, handling, preparation; and fresh consumption. Perceived sickness from eggs increased odds of any ASF intake in girls (1.02 [1.001,1.05]), while sickness from raw milk reduced odds of any ASF intake in younger children (0.96 [0.93,0.99]). All other associations were insignificant.
ASF beliefs and perceptions influence diets, particularly for older girls and older, less educated mothers. Individual-level mitigation addressed food safety concerns along the supply chain.
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1:00-2:30 p.m.
Exhibit Hall (CMCC lower level) |
Poster: 145
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| Phillips, Laura |
West, Delia
Yang, Chih-Hsiang |
Sweat It off With Taylor Swift: Designing a Physical Activity Promotion Platform for Young Adult Women to Maintain Physical Activity Levels
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Abstract Text
The majority of young adult women do not do daily physical activity, putting them at a greater risk for negative health effects. Through the use of technology, specifically a smartphone fitness app, young women can gain the tools and motivation necessary to achieve higher levels of physical activity. A review of the epidemiology of physical activity trajectories among young adult women points to the need to harness the relationships between social components of apps and psychological constructs associated with physical activity (motivation, self-efficacy, social support) to promote physical activity in this target population. Additionally, the mHealth behavior change literature points to four key evidence-behavioral strategies that a solid fitness app should have. These four strategies are self-monitoring, goal setting, gamification, and social support. I use existing research and theories to outline (and illustrate with mocked-up screenshots) the elements of a fitness app tailored for this at-risk population. The app incorporates physical activity promotion principles with Taylor Swift to appeal to young adult women. This combines their interest in the music and life of Taylor Swift plus encourages ongoing physical activity engagement, which will enhance the uptake and success of physical activity apps in this target population. There will be workouts synched to Taylor Swift’s discography, daily challenges, goals, and badges. Overall, my fitness app targets young adult women, combining their interest of Taylor Swift with exercise to promote greater physical activity.
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1:00-2:30 p.m.
Columbia Ballroom (CMCC upper level) |
Poster: 64
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| Vess, Gracie |
Maskiell, Nicole |
A Nation of God: A History of Providential Rhetoric in England from 1625-1660
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Abstract Text
This article explores the rhetoric of providentialism in England from 1625, when Charles I became King of England, to 1660, when Charles II was restored to the throne. During this period, England welcomed a new King to the throne, broke into Civil War, executed its sovereign, established a commonwealth with Oliver Cromwell as its Lord Protector, watched the commonwealth fail, and reinstated its monarchy. Before this period, English ministers and leaders used providential rhetoric to show God as the writer of English history, supporting England for its continued faithfulness to his true religion of Protestantism. This article seeks to understand how the rhetoric of providentialism changed, why it changed, and the effects of this change from 1625 to 1660. Providential rhetoric remained largely the same throughout the period, but a diverse range of employers used it. Sometimes political and religious groups used the same rhetoric against one another as changing events favored different groups at different times. The rhetoric that built up a kingdom could be used to tear it down years later. Furthermore, the merging of religious and national identity that began previously during the reign of Elizabeth I led to the development of such nationalistic providential rhetoric that strengthened during the heightened tensions of the Civil War and the interregnum period. This rhetoric encouraged a bold reformation against the reign of King Charles I, and after this reformation failed, it encouraged a return to monarchy. The rhetoric of providentialism has long been used to encourage bold actions and is employed in modern times. Much courage comes from being told that failure is impossible because God supernaturally guides his faithful nation. Looking back on past uses for this rhetoric and its implications heightens the senses to its fickle nature and purposes in modern use.
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1:00-2:30 p.m.
Exhibit Hall (CMCC lower level) |
Poster: 9
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| Jindal, Dakshu |
Chen, Brian
Brooks, John |
Do state laws permitting more direct access to physical therapy decrease opioid use? An instrumental variable analysis of Medicare patients with atraumatic rotator cuff tears
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Abstract Text
Objective
Seeking physical therapy for pain management before seeing a physician for treatment has the potential to reduce opioid use among patients with musculoskeletal conditions. In this study, we assessed whether greater initial or early use of physical therapy in states permitting more direct access was associated with reductions in subsequent opioid use.
Methods
We used instrumental variable methods to assess opioid use among patients whose physical therapy use was influenced by state direct access laws. Using Medicare claims data from 2016 to 2018, we selected opioid-naïve beneficiaries with a new onset of shoulder pain (index date) in 2017 with a subsequent diagnosis of atraumatic rotator cuff tear (N = 75,859). Outcome measures included any opioid use, total morphine milligram equivalent (MME), days of opioid use, and long-term opioid during the first year after diagnosis. We used an instrumental variable estimator with state direct access laws as an instrument that promotes initial physical therapy use.
Results
Among the subset of patients whose initial provider choice was influenced by state direct access laws, our instrumental variable results show that patients who visited a physical therapist first had lower MME (by 3843 mg), reduced total number of days of opioid supply (by 70.74 days) and a 20% lower rate of long-term opioid use. Those who saw a physical therapist within the first 30 days of the index date (early physical therapy) also had lower MME (by 958 mg), reduced total number of days of opioid supply (by 19.2 days), and a 10% lower rate of long-term opioid use. All p-value < .05
Conclusion
Among Medicare patients with atraumatic rotator cuff tear, greater initial or early use of physical therapy in states permitting more direct access is associated with lower opioid use. Our results suggest that opioid use could be reduced by liberalizing state direct access laws to physical therapy, with further implications for health insurance policies that require physician referral for physical therapy. Future studies should examine the impact of these laws on other orthopedic conditions and include the impact of such laws on health expenditures.
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1:00-2:30 p.m.
Columbia Ballroom (CMCC upper level) |
Poster: 72
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| Vandermast, Larsyn |
Kubickova, Marketa |
Creative Thinking for Residents: Identifying a Problem and Creating a Solution
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Abstract Text
The Resident Assistant job is a full-time student selected position to advise, refer resources, and be a positive role model to residents through their Carolina experience. With a focus on fostering a safe and supportive community, Resident Assistant provides and ensures the safety of residents through protocols, administrative support, and larger departmental initiatives.
As a Resident Assistant I oversaw 27 out of 54 residents in my building, playing a crucial role in their transition to independent living on campus. I built strong relationships through positive communication, planning events, weekly staff meetings, desk shifts, and participating in duty shifts at night and on weekends.
My motivation for pursuing this position stems from my desire to be the mentor I wish I had starting my college journey. Recognizing the value of guidance and support in college, I wanted to pay it forward by empowering others to make the most of their college experience.
This experience has completely changed the way I look at conflict and my career. Through navigating conflicts, collaborating with my team, orchestrating events, and handling administrative tasks, I’ve learned valuable skills in leadership, interpersonal dynamics, problem-solving, conflict resolution, time management, and community building. These skills have taught me how to learn new skills and apply them quickly to my current and future career.
Within your college journey, it’s crucial to recognize that you’re never alone. Here at USC, a vibrant community is dedicated to supporting your social and academic growth. There are so many people who want you to succeed and will offer assistance and guidance socially and academically.
In May 2024, I will be proudly graduating with a major in Visual Communications complemented by a minor in Studio Arts, with a Double Concentration in Graphic Design and Photography. Currently, I’m applying for jobs as a Graphic Designer, Product Designer, and Account Manager as a steppingstone to becoming a Creative Director in the future. I plan to take all these new skills I have learned and apply them to my future career.
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1:00-2:30 p.m.
Exhibit Hall (CMCC lower level) |
Poster: 304
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| Carboni, Andrew |
DeWeil, David |
Leadership Through Service: Building Better Communities
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Abstract Text
When I chose to attend the University of South Carolina, I was nervous leaving my comfort zone back home in Raleigh, North Carolina. I was a scared freshman during the COVID-19 pandemic, so I signed up for a program called Pillars for Carolina, hoping to ease the college transition. Pillars is a program designed for incoming students to meet other Carolina students, learn more about campus life, and gain the confidence that they can succeed here at USC. I met some of my best friends and mentors that I’ve carried with me over my past three years here at Carolina. Once I had gotten settled, I chose to serve as an Extended Mentor, wanting to give back the love and support that Pillars had offered me as a freshman to other incoming students. I spent as much time as I could in the Leadership and Service Center, gaining valuable connections and learning more about my leadership abilities within the Pillars program.. Most Extended Mentors only serve one summer, but I wanted to give more. I became the Director of Staff Development on the Leadership Team, where I spent hundreds of hours planning the summer program. As Staff Dev, my responsibility was training the largest staff in program history and building a family built upon love, mutual trust, and confidence in one another. Each member of that 71 person staff has a piece of my heart forever, and they taught me how to be a better leader, a better Gamecock, and a better human. I learned how to cater my mission to those I serve and to create change with my community in mind. Finally, I realized the power of grassroots efforts to improve our community, as Pillars is entirely student-run and reliant upon the passion of students giving back to the next generation of gamecocks. Pillars had an immeasurable impact on myself and countless other students, rooting us to Carolina as a place to call home. I hope to continue serving my community through work in the public history field, educating others on their passions and interests.
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9:30-11:00 a.m.
Exhibit Hall (CMCC lower level) |
Poster: 319
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| Korunova, Elizaveta |
Shtutman, Michael |
The influence of stress granules on viscoelastic properties of cytoplasm during senescence
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Abstract Text
The rheological properties of cytoplasm, such as elasticity, diffusion, and viscosity, play a crucial role in regulating cellular processes. However, our understanding of how cells regulate and utilize these properties remains limited. This study presents a model that elucidates the regulation of rheological properties via the formation of stress granules, a type of liquid-liquid phase separation. Stress granules assemble from RNA and proteins in response to various types of stress, including osmotic stress, temperature shock, oxidative stress, and ER stress. While stress granules are typically described in the context of translation arrest, evidence of their involvement in other processes, such as transport and metabolism, has started to emerge. However, there is surprisingly still very limited data regarding the connection between stress granules and the viscoelastic properties of the cytoplasm. The importance of understanding this link is heightened in the context of senescence. Cell senescence leads to a drastic enlargement of cell volume, resulting in an abnormal decrease in cytoplasm density and an increase in diffusion of macromolecules. However, under stress conditions, senescent cells exhibit increased formation of stress granules, which disassemble at a slower rate and tend to form persistent stress granules. This contradicts the research that showed the positive correlation between the decrease in cytoplasm density and stress granule disassembly under hypoosmotic conditions. We hypothesize that the formation of stress granules in senescent cells compensates for changes in viscoelastic properties during senescence, potentially supporting the functioning of senescence-associated secretory cell phenotypes that contribute to neurodegenerative and age-associated disorders. To test the hypothesis, we measured the viscoelastic properties through particle tracking of 40 nm genetically encoded nanoparticles (GEM) and Fluorescence Recovery After Photobleaching (FRAP) of tdTomato in U2OS cells before and after the induction of oxidative stress-associated stress granules during induced senescence. FRAP of tdTomato shows the behavior of cytoplasmic proteins. Tracking of 40 nm nanoparticles shows changes in the level of ribosomes. As a result, we show an increase in diffusion at the level of ribosomes after the formation of stress granules. The changes in viscoelastic properties in normal and senescent conditions will be compared.
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1:00-2:30 p.m.
Columbia Ballroom (CMCC upper level) |
Poster: 45
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| Johnson, Andrea |
Hill Chapman, Crystal |
Perspectives on Transition to Adult Healthcare for Adults with Williams Syndrome and their Caregivers
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Abstract Text
Transitioning to adult care services is a crucial time for young adults with a genetic disorder. Many of these conditions are diagnosed early in childhood, with follow-up care fragmented and dependent on the specific needs of the individual. Williams Syndrome (WS) is a complex genetic disorder characterized by multisystemic features. The variation in clinical presentation of adults with WS can influence the individual’s ability to transition from pediatric care because of its medical complications, variable and poorly characterized psychiatric needs, and intellectual disability that cause difficulty communicating health-related needs to providers. This study focused on understanding the needs of adults with WS and their caregivers during adulthood and the current landscape of transitional healthcare for these families. An electronic survey was distributed to caregivers of adults with WS over the age of 18 to provide insights into the care accessed and resources desired. Following the survey, virtual paired interviews were completed with an adult with WS and their caregiver. 177 survey responses from caregivers were recorded with 97 completed and 8 virtual paired interviews were performed. Descriptive and comparative statistical analyses were performed. Free response questions and interviews were transcribed, and a ground theory approach was performed for thematic analysis. Over 45% of caregivers reported being dissatisfied with the adult with WS's care, with the most dissatisfaction present in relation to mental health care (63.9%). Both caregivers and adults with WS note improvements to satisfaction of care and
perceived provider knowledge about WS when they were involved with a WS clinic, were provided resources on the transitional process, and received information on adult health issues. These findings highlight the importance of continued support and education to adults with WS and their caregivers. Several recommendations for adult care have been made including increased access to WS clinics, providing open communication with adults with WS, and expanding practice guidelines to address adult health needs. Future research should continue to explore the needs of the WS community during the transition to adult health care.
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1:00-2:30 p.m.
Columbia Ballroom (CMCC upper level) |
Poster: 73
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| Giridhar, Tanvi |
Hogan, Abigail
Sarmukadam, Kim |
Changes in Social Anxiety from Early to Middle Childhood in Neurodevelopmental Disorders
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Abstract Text
Social anxiety disorder is characterized by consistent fear or anxiety in social or performance situations and can be developed at an early age (APA, 2013). It has the potential to severely interfere with a child’s daily routine and quality of life, resulting in significant distress and avoidance of social situations (Hitchcock et al., 2009). While social anxiety is prevalent in children with neurodevelopmental disorders (NDDs), such as autism spectrum disorder (ASD) and fragile X Syndrome (FXS), little is known about how social anxiety symptoms change across childhood in these neurodevelopmental disorders. This knowledge is critical to informing early identification and treatment of social anxiety in high-risk populations (e.g., NDDs). The present study analyzed symptoms of anxiety in early and middle childhood across ASD, FXS, and TD groups, using the Modified Anxiety Dimensional Observational Scale (M-Anx-Dos) and the Social Anxiety and Motivation Scale (SAMS). The M-Anx-Dos is an observational measure that includes “presses” designed to elicit different dimensions of anxious responses (e.g., affective and behavioral displays of fear and separation distress) in young children with NDDs. The SAMS, a behavioral observational measure designed to elicit behaviors related to social anxiety and social motivation, was used to assess anxiety symptoms in middle-aged children with NDDs. Specifically, the SAMS contains four distinct conditions with varying levels of social demand and is coded from video for behaviors associated with social anxiety (e.g., gaze, vocal length, time to first utterance) and social motivation (e.g., social responsiveness, positive emotional affect, social initiation). This study includes 8 children with ASD or FXS, and 4 typically developing children ranging from in age from 3-7 years and 6-11 years. The M-Anx-Dos and SAMS scores will be compared between the early childhood and middle childhood ages. I hypothesize that the M-Anx-Dos scores from early childhood will be a predictor for the SAMS scores from middle childhood.
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1:00-2:30 p.m.
Exhibit Hall (CMCC lower level) |
Poster: 146
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| Trinh, Tanya |
Reinhardt, Sara |
Beyond Stereotypes: Exploring Asian Heritage and Community Through Sorority Life
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Abstract Text
In the spring of my freshman year, I decided to rush Alpha Sigma Rho Sorority Inc. (ASR), an Asian-interest organization that strives to promote sisterhood and Asian awareness within the university campus and the community. Initially, I joined this organization because I felt a bit isolated from the community during my first semester here and knew that I needed to get out there. Through this wonderful organization however, I have been able to further engage with my community, demonstrate my leadership capabilities, and formulate connections that I would not have made otherwise! In ASR, we participate in a variety of activities for our local philanthropy, Sistercare, and national philanthropy, Ovarian Cancer Awareness. We also participate in sisterhoods, fundraising, and recruitment efforts. Taking part in these activities with fellow sisters who have had similar backgrounds and experiences as me has allowed me to further connect with my Asian culture and learn more about a variety of other Asian ethnicities. Throughout the years, I have even taken the Sisterhood and Fundraising chair positions, as well as the executive-board Secretary position. With both the sisterhood and fundraising positions, I learned how to organize events that meet necessary goals for sorority connection and financial security. With the secretary position, I learned how to navigate and resolve internal conflicts and participate in decision-making that benefits the entire organization as a whole. In these roles, I gained valuable professional skills that are universal to any workplace. Ultimately, I am proud to say that I am a part of an organization that prioritizes sisterhood bonding, academic excellence, philanthropy, and service. ASR has given me a multitude of opportunities for growth and connection that I will forever be grateful for.
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1:00-2:30 p.m.
Exhibit Hall (CMCC lower level) |
Poster: 305
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| Pilewicz, Julia |
Klusek, Jessica
Friedman, Laura |
Behaviors of Individuals with FXS are Associated with their Mothers’ Mental Health
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Abstract Text
Fragile X syndrome (FXS) is a genetic disorder and the leading inherited cause of intellectual disability, resulting from a mutation on the FMR1 gene. Common behaviors of children with FXS include ADHD, anxiety, sensitivity to touch and sounds, and temper tantrums. Typically, mothers of children with FXS have the fragile X premutation (FXpm), which results from a partial mutation of the FMR1 gene. Women with the FXpm often have neuropsychiatric disorders, such as anxiety and depression. Some studies have linked maternal well-being and child behaviors, but these were all in samples of young children (Fielding-Gebhardt et al., 2020; Potter et al., 2022). This study examined relationships between child behaviors and maternal well-being (e.g., anxiety and depression symptoms) in an older sample of children, as well as whether these relationships changed with age.
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1:00-2:30 p.m.
Exhibit Hall (CMCC lower level) |
Poster: 147
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| Noonan, Sean |
Smith, Deanna
Matoo, Samaneh |
LIS1 Function in Adult Neurons Using an Inducible Knock-Out Mouse
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Abstract Text
LIS1 (PAFAH1B) is a dynein regulatory protein that stimulates dynein motor activity by binding to dynein heavy chains (DYNC1H1) and promoting the formation of active motor complexes. Dynein is a motor protein responsible for various cellular processes including transporting cellular cargo. Mutations in LIS1 have been known to cause lissencephaly, a rare disorder characterized by severe cognitive and motor impairment. Our previous research showed globally induced LIS1 knockout (iKO) causes severe neurological defects and rapid lethality in adult mice, showing a vital post-developmental role for LIS1. Recombination occurred in a mosaic fashion in both neurons and glia. However, the specific cell type responsible for the observed neurological phenotypes remains unclear.
We used two tamoxifen-inducible CreERT2 driver strains, Thy1 promoter and Aldh1/1 promoter, to selectively remove LIS1 from projection neurons (Thy1LIS1iKO) and astrocytes (Aldh1/1LIS1iKO), respectively. This approach will help us determine whether either of these cell types contributes to the severe phenotypes observed in global LIS1KO mice. To determine the cellular source of the severe phenotype, we administered a tamoxifen dosage of 0.05 mg/body weight for five consecutive days to both Thy1LIS1iKO and Aldh1/1LIS1iKO mice. Our results show that selectively depleting LIS1 from adult mouse projection neurons promptly induces severe neurological phenotypes, including shivering, leg clasping, gait abnormalities, and seizures, ultimately leading to death within 10 days. Contrarily, the targeted depletion of LIS1 specifically from astrocytes did not cause any noticeable neurological symptoms over the same timeframe, highlighting the observed phenotypes were due to LIS1 depletion specifically in neurons. No observable phenotypes were seen in control groups treated only with vehicle. The dosage of tamoxifen correlated with the phenotype in Thy1LIS1iKO mice, as a lower dosage resulted in a milder phenotype, implying the involvement of fewer projection neurons. In future studies, we will assess long-term behavioral changes in Aldh1/1LIS1iKO strains compared to Thy1LIS1iKO strains. The rapid onset of phenotypes observed in Thy1LIS1iKO mice indicates possible synaptic-level alterations. Additionally, the synaptic structure will be examined using advanced imaging techniques.
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9:30-11:00 a.m.
Exhibit Hall (CMCC lower level) |
Poster: 187
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| Carter, Taylor |
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Delta-9-Tetrahydrocannabinol attenuates macrophage differentiation through downregulation of intra-cellular Reactive Oxygen Species
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Abstract Text
Reactive Oxygen Species (ROS) play a vital role in macrophage differentiation. The production of ROS has previously been shown to be required for macrophage-colony stimulating factor (M-CSF)-induced differentiation of macrophages from bone marrow cells. M-CSF is a secreted cytokine that results in the differentiation of hematopoietic stem cells (HSCs) into macrophages, as well as the proliferation of myeloid cells. Delta-9-Tetrahydrocannabinol (THC), a well- studied cannabinoid, has previously been shown to exhibit anti-oxidant properties and thus, in the current study, we examined the role of THC in blocking ROS production and its impact on macrophage differentiation. The addition of THC to the M-CSF cultured bone marrow cells from C57BL/6 mice resulted in marked blocking of macrophage differentiation. Additionally, in the same cultures, THC decreased ROS levels as measured by CellROX Deep Red assay at 3hrs, 24hrs, and 48hrs following culture. RNAseq analysis of cultured cells at 48hrs showed that the addition of THC resulted in the increased expression of Antioxidant Response Element (ARE) genes such as Hmox1, Sqstm1, Nqo1, and Gclm. The majority of the differentially expressed genes were shown to be induced by NRF2 in both KEGG and IPA pathway analysis. Western Blot analysis showed an increase in Nrf2 protein levels in the THC group at 48hrs. Interestingly, some of the antioxidant genes induced were shown to be Nrf2-independent, showing that THC can induce multiple antioxidant pathways. Together, the current study demonstrates that THC can effectively block macrophage differentiation from the bone marrow stem cells in vitro through downregulation of ROS (This work was supported in part by NIH grants R01ES030144, P20GM103641, R01AI123947, and R01AI160896).
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1:00-2:30 p.m.
Columbia Ballroom (CMCC upper level) |
Poster: 228
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| Al-Fahdi, Mohammed |
Hu, Ming |
High-Throughput Thermoelectric Materials Screening by Deep Convolutional Neural Network with Fused Orbital Field Matrix and Composition Descriptors
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Abstract Text
Thermoelectric materials harvest waste heat and convert it into reusable electricity. Thermoelectrics are also widely used in inverse ways such as refrigerators and cooling electronics. However, most popular and known thermoelectric materials to date were proposed and found by intuition, mostly through experiments. Unfortunately, it is extremely time and resource consuming to synthesize and measure the thermoelectric properties through trial-and-error experiments. Here, we develop a convolutional neural network (CNN) classification model that utilizes the fused orbital field matrix (OFM) and composition descriptors to screen a large pool of materials to discover new thermoelectric candidates with power factor higher than 10 μW/cmK2. The model used our own data generated by high-throughput density functional theory (DFT) calculations coupled with ab initio scattering and transport (AMSET) package to obtain electronic transport properties without assuming constant relaxation time of electrons, which ensures more reliable electronic transport properties calculations than previous studies. The classification model was also compared to some traditional machine learning algorithms such as gradient boosting and random forest. We deployed the classification model on 3,465 cubic dynamically stable structures with non-zero band gap screened from Open Quantum Materials Database. We identified many high performance thermoelectric materials with ZT > 1 or close to 1 across a wide temperature range from 300 K to 700 K and for both n- and p-type doping with different doping concentrations. Moreover, our feature importance and maximal information coefficient analysis demonstrates two previously unreported material descriptors, namely mean melting temperature and low average deviation of electronegativity, that are strongly correlated with power factor and thus provide a new route for quickly screening potential thermoelectrics with high success rate. Our deep CNN model with fused orbital field matrix and composition descriptors is very promising for screening high power factor thermoelectrics from large-scale hypothetical structures.
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9:30-11:00 a.m.
Columbia Ballroom (CMCC upper level) |
Poster: 20
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| Knight, Sabrina |
Tang, Hengtao |
Navigating the Heart of Healthcare: My Experiences as a Patient Care Technician
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Abstract Text
Experiential learning experiences that expand in-class learning to the real world is impactful, but none so much as working as a Patient Care Technician (PCT) at Ascension St. Thomas West Hospital in Nashville, Tennessee. Aligning with Ascension's core values and their emphasis on inclusivity, I assisted in providing care to the greater Nashville community. This position not only exposed me to a variety of medical specialties and specific needs of each patient, but also deepened my understanding of holistic patient care.
Each day began with comprehensive reports from the departing techs, moved quickly into rounds of vital assessments, making sure to note any deviations in temperature, blood pressure, or respiration. Outside of these clinical tasks, I took the time to introduce myself to each patient, establishing a personal connection as well as learning about any mental or physical restrictions. The bulk of my responsibilities involved assisting six to twelve patients with various activities of daily living. These ranged from traversing the hall to aiding in basic personal hygiene tasks. Additional tasks required of me included drawing labs, assisting other healthcare professionals in procedure and exercises, and liaising with patient families.
Initially, this position was a stepping stone on my path to medical school but quickly became a pivotal juncture in my educational journey the summer after my junior year. This role confirmed my inclination towards a career in healthcare, underscored the significance of a person-oriented approach to care, and emphasized the collaborative efforts of a multidisciplinary team. In an effort to become part of this team, I utilized skills I learned in EDLP 520 in order to apply leadership to even the smallest role. In advocating for my patients and setting a good example, I practice leadership in my everyday life.
I realized that spending time with patients on an individual level encouraged healing in a way that traditional medicine cannot and that genuine patient care extends beyond procedures and consultations. This experience has not only encouraged my passions as a healthcare professional but also enhanced my understanding of the collaborative and person-centric essence of the field.
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1:00-2:30 p.m.
Exhibit Hall (CMCC lower level) |
Poster: 271
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| Collins, Megan |
Hancock, Nathan
Liu, Peng
Slokin, Keith |
Analysis of Cas9 Targeted mPing Insertion in Yeast
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Abstract Text
Transposable elements (TEs) are segments of DNA that naturally alter plant genomes by excising and reinserting when mobilized by specific transposase proteins. Our research focuses on the highly active mPing miniature TE from rice which relies on ORF1 and TPase protein provided by the Ping or Pong element for mobilization. Insertion of mPing-based activation tags was previously shown to upregulate nearby genes and recent studies have shown that fusing Pong TPase to Cas9 allows for targeted mPing insertion in plants. To improve the efficiency of this system, we are developing a yeast assay for Cas9-mediated targeted mPing insertion. We previously showed that the TPase:Cas9 fusion proteins can induce mPing transposition in yeast, while maintaining Cas9 function. We are developing a mPing-based activation tag and yeast reporter strain that will indicate when targeted insertion occurs. The hyperactive mPing carrying the GPD promoter was inserted into MET15 gene to allow for selection of excision events. The target sequence we are using is an ADE2 gene controlled by the GAL2 promoter, paired with a gRNA specific to the GAL2 promoter. We will measure the targeted insertion rate by screening for ADE2 expression in the Met15 revertant colonies in the absence of galactose. We anticipate that TPase:Cas9 fusion constructs will allow for targeted insertion of mPing:GDP into the GAL2 promoter, thus producing adenine on plates lacking galactose, resulting in white colonies. The development of this assay will provide an efficient method for studying the mechanism of targeted insertion so that we may further develop this system for plant genome engineering.
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1:00-2:30 p.m.
Exhibit Hall (CMCC lower level) |
Poster: 60
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| Brown, Katherine |
Nolan, Melissa
Owens Pickle, Emily |
Eco-epidemiology study of ectoparasites, vector-borne pathogens, enzootic, and zoonotic disease at a South Carolina zoo
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Abstract Text
Katherine Brown, Emily Owens Pickle, Sean Sweeney, Kyndall Braumuller, Wayne Knee, Michael Skvarla, Kayla Bramlett, Martha Weber, Melissa Nolan
Zoos are vital societal resources that provide conservation education, cultural value, and economic revenue to their local community. Further, they provide a unique opportunity to study the impact of native vector-borne diseases in exotic zoologic species. This pilot study brought together medical entomologists, vector-borne disease epidemiologists, and exotic animal veterinarians to examine vector-borne disease risk in Columbia, South Carolina. From August to December 2023, researchers executed a prospective surveillance initiative of host-seeking and host-attached ectoparasites. Tick trapping included CO2-baited traps and density-dragging methodologies. Mosquito trapping included CDC light traps baited with CO2. Avian ked collections, performed by zoo staff, involved attached ectoparasites extraction from wild raptors originating from surrounding counties that were undergoing medical care at the zoo—IACUC approval was provided by the zoo’s Animal Welfare Committee. Tick and mosquito collections were conducted along the property perimeter adjacent to animal habitats and a wooded area abutting the Saluda River embankment. Over a four-month period, 600 mosquitoes representing 17 distinct species, one nymphal Ixodes scapularis tick, and 29 Icosta americana avian keds were collected. The avian ked identification was a significant and novel discovery, as Icosta americana species can vector West Nile virus and are understudied vectors in the USA. These study results fostered a new international collaboration and have prompted an exciting second phase of research. An unexpected finding was the low number of Ixodes scapularis ticks collected in an area known to be rich with native deer populations. Vector pathogen testing is underway. In closing, this collaborative pilot surveillance identified several vectors of public health importance at a popular tourist destination, that warrants further study of prospective human and zoonotic health implications.
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1:00-2:30 p.m.
Columbia Ballroom (CMCC upper level) |
Poster: 102
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| Abiodun, Titilayomi |
Nolan, Melissa
Gual-Gonzalez, Lidia |
Defining the Tick-borne Disease Occupational Risk Among Three High-Risk Groups from South Carolina
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Abstract Text
Tick-borne diseases (TBD) are the primary cause of vector-borne disease in the United States (USA) accounting for 75% of the total annual burden. TBD incidence has tripled since 2016 with seven novel pathogens being detected in the same time frame. In South Carolina (SC) tick and TBD public health surveillance are deficient and evidence suggests TBD could be emerging. A grass-roots effort tick surveillance program implemented in 2019, revealed that 83% of host-attached collected ticks from humane societies, and 79% of host-seeking ticks collected from state parks have evidence of at least one pathogen including Rickettsia, Anaplasma, Ehrlichia, or Borrelia. Despite the high pathogen prevalence among ticks, TBD cases reach roughly 100 reported human cases annually, which are likely underrepresented by physician unawareness. Among exposed groups, outdoor workers and animal handlers are at risk of tick bites and thus, are susceptible to TBD. Three occupational groups were identified in SC as high-risk: veterinarians, state park employees, and SC Department of Natural Resources (SCDNR) employees. Our aim is to identify differences among these high-risk groups, to better understand occupational exposure, and determine potential interventions. For this reason, a Knowledge Attitudes and Practices survey was developed to unearth the estimated occupational exposure rate among SC state employees and characterize the common practices and concerns that would require intervention. A survey with 38 questions on tick-bite exposure, illness development, prevention and management, and level of concern was emailed to 240 employees across 29 state parks, 21 animal shelters, and 12 SCDNR programs. Associations between knowledge and exposure risk were assessed using Spearman’s correlation and univariable regression analyses. The results of this study provided preliminary tick-exposure assessment results among occupational risk groups. Targeted education programs and interventions are warranted to adapt TBD risk prevention across the different disciplines, and should aim to create occupational risk assessments and management in the future.
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9:30-11:00 a.m.
Exhibit Hall (CMCC lower level) |
Poster: 138
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| Deese, Sarai |
Edmunds, Sarah |
COLABorate: Enabling Inclusive Dialogue for Accessible Emotional Regulation Resources Aligned with the Social Model of Autism
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Abstract Text
Caregivers of young autistic children frequently turn to the internet for emotional regulation (ER) resources, while autistic adults are actively producing psychoeducational materials related to emotion regulation. However, these two communities often operate in separate spheres, leading to a lack of communication. Moreover, the perspectives of the most marginalized autistic adults are often excluded. By incorporating a photo elicitation component, the researchers aim to amplify the voices of all stakeholders involved. The aims of this study were 1) to identify perceived gaps as identified by parents of birth to 5-year-olds with Autism in accessible & printable ER resources (main idea: what parents need now) and 2) among autistic adults, investigate the perceived effectiveness of current printable ER resources to enhance coping strategies for autistic birth to 5-year-olds (main idea: what autistic adults wish they had then). COLABorate will utilize a two-population focus group to engage in a community partnered exploration approach to access the acceptability, accessibility, and feasibility of emotional regulation psychoeducation. The researchers will explore stakeholder perspectives on Autism psychoeducation to bridge accessibility gaps among caregivers of Autistic young children access to ER resources. I hypothesize that qualitative content analysis results will reveal gaps in functional health literacy, awareness of available resources, and content differences between what parents of autistic parents need and what autistic adults will recommend. Future directions include analyzing the photo elicitation elements for both focus groups as well as the emotion regulation measures (EDI, EDI-YC, and DERS) in conjunction to the themes of the focus groups through a mixed-methods approach. These results will be considered to design and distribute autistic-designed ER resources to caregivers.
Key Words: Autism, caregivers, health literacy, emotion regulation, photo elicitation, implementation science, qualitative analysis, intellectual disability, plain language, community partnered exploration, social model of disability
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9:30-11:00 a.m.
Exhibit Hall (CMCC lower level) |
Poster: 201
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| Collins, Abby |
Schryer, Ashley |
We Are Here to Help Not to Judge
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Abstract Text
National Alliance on Mental Illness (NAMI) Tri-County is a non-profit organization that strives to enhance the quality of life for individuals with mental health issues through education, support, and advocacy. We are in Lancaster, Rock Hill, and Chester. One of the many things that we do is go to different community events and let people know that we are here to help and support them in any way that deals with mental health. We talk about the services that we provide and what we do. In my role as an Intern, we pass out packets with information about suicide and the warning signs of it, along with a bracelet that has the suicide hotline number on it too. We pass these packets out to the schools, local businesses, and anyone who wants one. We attend events that other non-profits organizations have, along with attending community festivals.
We are here to help those who need it and want it, to give people support to those who are struggling. During my Internship, I have helped with a couple of different events that NAMI does, like the NAMI Walk and the golf tournament. I also run errands for my boss and attend events that she can’t make it to, along with helping create posters for the different events that they do. It is important to let people know we are here to help, so then we can prevent them from doing something drastic like committing suicide. During my time interning at NAMI, it has allowed me to see the positive impact that they have on the people in my community. Seeing the positive impact of the NAMI has motivated me even more to go into counseling and help people with mental health issues. I am planning on getting my master’s in psychology and then getting license as a therapist or counselor.
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9:30-11:00 a.m.
Exhibit Hall (CMCC lower level) |
Poster: 296
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| Filaseta, Margaret |
Dawson, Robin
Walsh, Michael |
Transition From Pediatric to Adult Care: People with Physical Disabilities' Experiences
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Abstract Text
Background/significance: The healthcare transition (HCT) from pediatric to adult care is a complex, multifaceted process. This HCT involves healthcare interventions, learning long-term management of one’s health, developmental changes, and negotiating new systems and procedures.1 For people with physical disabilities (PWPDs), successful HCT requires even more collaboration among the patient, their caretaker(s), and their current and future providers. However, little research has explored pediatric to adult HCT in the context of physical disabilities.
Purpose: To explore experiences of PWPDs who are currently going through or have recently undergone HCT, with a goal of better understanding HCT challenges, successes, facilitators, and outcomes.
Methods: This qualitative, descriptive study was guided by Meleis’ Transitions Theory (TT)2. PWPDs aged 15-35 years old were recruited from social media sites and snowball technique. An interview guide was developed with questions addressing TT constructs. Interviews were digitally recorded, transcribed, and de-identified to protect privacy. Data were analyzed using thematic analysis;3 resultant themes were theoretically organized. Results: Sixteen individuals participated. Three themes with 11 subthemes emerged from the data analysis: nature of transitions (two subthemes), facilitators and inhibitors (three subthemes), and patterns of response (six subthemes). Participants reported several hardships within the HCT, creating excess stress and frustration. One female participant with a spinal cord injury recounted barriers to accessing care: It is easier to go get a gun than it is for me to get a wheelchair.
Discussion: PWPDs experience unique challenges when undergoing HCT. There is a need for better communication, interprofessional collaboration, and compassion to facilitate an efficient and successful HCT.
Implications: Health sciences programs should integrate information about HCTs in general and the specific challenges PWPDs face. Pediatric healthcare providers that care for PWPDs should initiate early conversations about processes and challenges associated with HCT and offer specific resources, guidance, support, and education.
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1:00-2:30 p.m.
Exhibit Hall (CMCC lower level) |
Poster: 129
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Thomas, Mattie
Arnel, Madison |
Sims, Kerry |
Postpartum Contraception Rates in a Multidisciplinary Model of Diabetes Care in Pregnancy
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Abstract Text
Short interval pregnancies are strongly associated with poor maternal, child and social health outcomes. The American Congress of Obstetricians and Gynecologists reports that in the first year postpartum, at least 70% of pregnancies are unintended. Initiation of postpartum contraception plays a significant role in lowering the rate of unintended and short interval pregnancies and reduces adverse maternal and fetal health outcomes. This is especially true when considering high-risk pregnancies, such as those pregnancies complicated by gestational diabetes mellitus (GDM). GDM carries a category 1 rating in the US Medical Eligibility Criteria for all contraceptive methods. To determine the association between multidisciplinary care and postpartum contraceptive outcomes to reduce short interval pregnancy, we conducted a retrospective cohort study to examine postpartum contraception methods and rates in women 18-55 with prediabetes, diabetes, or a history of gestational diabetes receiving care in a multispecialty pregnancy diabetes clinic in Sumter, South Carolina. Out of a total of 177 women, 87% attended a 6 week postpartum visit and 47.8% were documented to be on a method of contraception at the time of follow up. Only 13 women had a repeat positive pregnancy test within one year of delivery. Our findings underscore the positive impact of a multidisciplinary approach on comprehensive postpartum follow up and highlight the importance of postpartum counseling to include contraceptive health.
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9:30-11:00 a.m.
Columbia Ballroom (CMCC upper level) |
Poster: 194
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| Roznowski, Stephanie |
Britton, Jeanne
Swartwood House, Anna |
Historical Artworks and Modern Media: The Digital Piranesi
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Abstract Text
How can rare artworks be made more accessible through digital technology for students, scholars, and interested users? For this project, I work alongside Dr. Jeanne Britton once again to better her project, The Digital Piranesi, by using my art history interest and knowledge to properly categorize images according to metadata standards, which is done through my recognition of elements in each piece that I then catalog individually. In the generation of metadata, blocks of information are put into a spreadsheet that can be utilized to make a website and its contents easier to navigate, such as recognizing keywords per image; through this work, I pursue my interests in architectural history by choosing keywords from a controlled vocabulary that will help users locate images with specific subjects.
Jeanne Britton has been working on her project, The Digital Piranesi, for many years. I began working with her last year when she hired me with a grant she had received to fund student research and aid within her work. This website, Digitalpiranesi.org, is a digital record of the copies of Piranesi’s art books, of which the Irvin Dept of Rare Books and Special Collections has 29 volumes (1835-39), and these copies date into the 1800s. Since older books must be handled with care and not all persons have access to such content, the website’s goal is to share the work in an easily accessible way without risking the books’ care and preservation. These etchings of Giovanni Battista Piranesi are beautifully done and well-known, depicting classical Italian life in an almost fictitious manner; he illustrates the daily life of people and animals, as well as ruins and studies of architecture. Additionally, the project makes his works searchable in ways that his images and books are not. While Dr. Britton has hired me to write metadata for her, she herself has written full metadata for two volumes but needed additional aid to finish all books.
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1:00-2:30 p.m.
Exhibit Hall (CMCC lower level) |
Poster: 29
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| Loewke, Brianna |
Palomares, Melanie
Tang, Hengtao |
Brianna Loewke Professional and Civic Engagement
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Abstract Text
During my time at the University of South Carolina, I have had the opportunity to work multiple internships to learn more about the professional world and my career journey after I graduate. I have had the great fortune to start my experience journey as the Vice President of Community Relations (VPCR) for my sorority, Pi Beta Phi Fraternity for Women, then became a sports event operations intern for the Amateur Athletic Union (AAU), and most recently been able to intern at Poston Communications as a public relations intern. As a mass communications major and business administration minor, these opportunities and internships have helped me gain first-hand experience in the fields that interest me, event management and communication. As the VPCR I was able to help build my sorority’s brand through social media and philanthropic efforts to all stakeholders and constituents. Then, moving to Florida for my internship with AAU, I was able to see what it is like moving to a new place for work and understanding what goes into events and supporting those efforts. Finally, at Poston, I have been able to work directly with my clients in creating a brand for them and pushing them in their desired markets to grow their businesses. Participating in these opportunities has helped develop me into a professional who can thrive in my dream career as a public relations professional and expanded my skills in so many fields and industries, diversifying my knowledge. Through these experiences, I hope to pursue a career at my current internship at Poston Communications post-graduation.
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9:30-11:00 a.m.
Exhibit Hall (CMCC lower level) |
Poster: 337
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Price, Caroline
Dunn, Rebecca |
LeBlanc, Kevin |
TAP BLOCKS AS AN EFFECTIVE ANALGESIC ALTERNATIVE TO INTRATHECAL MORPHINE FOR PATIENTS UNDERGOING CESAREAN SECTION
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Abstract Text
Cesarean section is associated with moderate to severe postoperative pain that is typically managed with intrathecal morphine (ITM) due to its proven efficacy. However, opioid related adverse effects associated with this method remain problematic, highlighting the need to explore alternative techniques with a more favorable adverse effect and safety profile. The purpose of the project was to determine through an extensive literature review whether or not Transversus Abdominis Plane Blocks (TAPBs) could serve as this alternative solution, and to provide education regarding this potential solution to anesthesia providers. The results of the literature review suggested that TAPBs performed under ultrasound guidance were not associated with any procedural related complications of toxicities (Ma et al., 2017). Conversely, ITM was associated with nausea and vomiting, pruritus, delayed respiratory
depression, and urinary retention (Ryu et al., 2022). Additional findings included the ability of TAPBs to contribute to expedited recovery and improved patient satisfaction related to decreased opiate related adverse effects (Jarraya et al., 2016). Findings were disseminated to the anesthesia department of a level one trauma center in South Carolina in the form of a PowerPoint presentation. Data was collected using a quasi-experimental pretest-posttest design with comparison to norms through the platform survey monkey. Survey results demonstrated that the intervention was successful in educating the providers of the benefits of using TAPB and given the opportunity, would advocate for its use over ITM.
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9:30-11:00 a.m.
Columbia Ballroom (CMCC upper level) |
Poster: 59
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| Hirschegger, Noah |
DeWeil, David |
Finding My Path in Mechanical Engineering at Bosch
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I worked at Bosch as a co-op manufacturing engineer from Jan 2023 to Jan 2024. I was assigned to EV14 - a team focused on manufacturing automotive fuel injectors. Our job was to manage and improve the manufacturing process. I specifically worked on designing, developing, and monitoring small sub-processes. It was ordinary for me to manage more than five projects at a time, bringing them from A to Z. This was a new endeavor for me, and this fast-paced industry challenged me to develop technically and professionally. I was surrounded by brilliant engineers, and exposed to new techniques such as lean manufacturing, measurement system analysis, injection molding, and laser welding. All this contributed to a deeper understanding of what it means to be an engineer.
Mechanical engineers can be employed in a variety of fields, so this co-op was critical in guiding me to which fields of engineering I want to take my career. I learned mostly about two fields that I am excited about - automotive and manufacturing. I gained experience in employing classroom knowledge in the industry and developed new skills in communication and leadership that can only be described as monumental to my professional development.
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1:00-2:30 p.m.
Exhibit Hall (CMCC lower level) |
Poster: 317
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| Southworth, Riwin |
Schryer, Asheley |
Substitute Teaching: The Inside Scoop
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Substitute teaching is a career path that focuses on fulfilling the responsibilities of teachers during their leave of absence, ranging from half-days to perhaps months. Every county and school district has their own requirements for substitutes, my experience being in the Chester County School District. During my involvement, I worked at middle and elementary school levels. It was my job to sign in, prepare the classroom, welcome the students, guide them through different learning activities, take them to lunch, walk them to electives, make sure they are properly dismissed from the school, clean the classroom, and sign out. It was my duty to act as a leader to the students and be responsible for their learning accomplishments of the day. Such a role is extremely important to the function and continued growth of society. As we all know, knowledge is power. Without substitute teaching, students can face a gap within the curriculum, causing their learning to idle. For me, my purpose is to not only booster their educational goals, but to allow students to feel capable. I enjoyed leading them to their self-confidence, whether it be academic or personal. I let them know that someone was there to help them along the way, someone to support and root for them. In turn, the knowledge that I gained from substitute teaching has permanently changed my career pathway. Realizing the impact I can have on future generations has propelled me to earn a degree with which I can teach.
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9:30-11:00 a.m.
Exhibit Hall (CMCC lower level) |
Poster: 269
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| Pettit, Marissa |
Barfield, Reagan K.
Bookstaver, P. Brandon
McGee, Miranda
Royals, Carrington |
Impact of a pharmacist-led chronic care management program in patients with type two diabetes mellitus at a federally qualified health center within a medically underserved area
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Abstract Text
Background: In 2015, Centers for Medicare and Medicaid Services allowed for chronic care management (CCM) to be billed under the Physician Fee Schedule. Patients are eligible for CCM if they are enrolled in Medicare and have two or more chronic disease states, including, but not limited to, diabetes, hypertension, cardiovascular disease, and depression. For patients enrolled in CCM at Tandem Health, a federally qualified health center (FQHC) in rural South Carolina, the average A1c is uncontrolled at 8.5%. Of these patients, 20% have an A1c ≥ 10%. CCM offers pharmacists as part of the interdisciplinary team, the opportunity to optimize patients on guideline directed medical therapy (GDMT) as indicated by the 2024 American Diabetes Association guidelines. There are few data available about the impact of CCM services on chronic disease metrics within a FQHC.
Methods: This retrospective, multi-center, observational cohort analysis evaluated the impact of the newly implemented pharmacist-led CCM program in patients with type 2 diabetes mellitus. This study analyzed mean change in hemoglobin A1c in the pharmacist-led CCM group compared to patients not routinely followed by a pharmacist. The proportion of patients who achieved a hemoglobin A1c less than 7% was also assessed. Secondary objectives included to determine the proportion of patients placed on GDMT, proportion of patients who achieved blood pressure < 130/80 mmHg, and proportion of patients who achieved individualized LDL goals. Descriptive statistics were used to summarize the data.
Results: In progress
Conclusion: In progress
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9:30-11:00 a.m.
Columbia Ballroom (CMCC upper level) |
Poster: 208
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| McManus, Jennifer |
Morris, Caleb |
Bridging Healthcare Gaps in Guatemala Through Community, Care, and Compassion
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Abstract Text
During my sophomore year, I was given the opportunity to go on a spring break study abroad trip to Guatemala. With a cohort of 11 other members of the Association of Pre-Physician Assistant Students (APPAS), we traveled to Panajachel, Guatemala to run a free medical clinic in a remote village nearby. I had the opportunity to practice basic medical Spanish, learn how to perform basic diagnostic tests such as blood glucose and urinalysis exams, practice taking vitals, and learn how to write prescriptions all while collaborating with doctors to provide care to an underserved population. We also made home visits to see the living conditions of villagers where we were able to have meaningful conversations with them about their experiences and learn about their culture. I chose to take this opportunity in order to learn about healthcare systems in other countries and have a unique chance to develop critical skills necessary for my future as a PA. I was able to make connections with patients who had backgrounds that differed greatly from my own, challenging my prior idealistic view of healthcare, and raising my cultural competency. It was through this experience that I learned how important it is for providers to listen to patients, to hear their whole story, to be able to provide the best quality of care. I believe this experience has motivated and equipped me to be a better future provider for my future patients.
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9:30-11:00 a.m.
Exhibit Hall (CMCC lower level) |
Poster: 297
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| Kern, Kaitlyn |
Morris, Caleb |
Cultivating Patient-Centered Care Through Education, Advocacy, and Primary Prevention
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Abstract Text
Much of my time outside of the classroom at USC has been devoted to preparing myself for physician assistant school by gaining hands-on clinical experience, specifically working as a medical assistant (MA) in pain management. As an MA, I had the opportunity to play a key role on the clinical care team for each patient and worked with other nurses, doctors, and physician assistants to provide quality, patient-centered care. In my role, I held several responsibilities including obtaining detailed past medical histories, identifying chief complaints, monitoring vital signs, and maintaining medical records and referrals. Additionally, I also assisted PAs and physicians in preparing patients for epidurals, rhizotomies, botox injections, and trigger point injections by performing intravenous cannulation, as well as constituting various medications. After being exposed to patients representing many different populations during my time in pain management, I’ve had the opportunity to observe and learn about a vast array of clinical presentations and their corresponding diagnoses, allowing me to gain further knowledge about common diseases and conditions in the field of pain. During my position as an MA, one of my key takeaways has been learning the importance of patient education, patient advocacy, and preventative care. For many patients, being referred to pain management comes towards the end of their clinical journey, oftentimes being the result of a lack of preventative care leading to the development of chronic diseases. Gathering clinical experience as a medical assistant and supporting member of the clinical care team has enabled me to encourage, empathize with, and educate patients on a smaller scale, which I hope to one day continue practicing and pursuing as a physician assistant.
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9:30-11:00 a.m.
Exhibit Hall (CMCC lower level) |
Poster: 305
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| Huff, Madison |
Morris, Caleb |
Global Healthcare Barriers: The Social Determinants Explored
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Abstract Text
Every aspect of our daily lives, from the time spent outdoors to the contents of our dinner plate, plays a pivotal role in shaping our health outcomes. These seemingly mundane details are linked to the broader framework of social determinants of health, which encompass the circumstances in which individuals are born, grow, live, work, and age. The profound impact of social determinants is especially apparent in underserved communities' health outcomes. Through partnering with Global Community Health Volunteers, I was able to see the disparities faced by individuals in rural, mountainous regions of Guatemala, where factors such as inadequate housing, limited education, and geographical barriers to healthcare access exacerbate health inequalities. I witnessed firsthand the detrimental effects this had on children and families in impoverished communities. As a future healthcare provider, I know there is a crucial role of understanding and addressing the social determinants of health for patients. It emphasizes the importance of fostering health literacy, creating safe environments for patients, and taking a preventive approach to medicine. As I embark on a long journey to becoming a physician, I will continue to be mindful of the social determinants of health and their intricate linkage to every aspect of our wellbeing.
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9:30-11:00 a.m.
Exhibit Hall (CMCC lower level) |
Poster: 306
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| Awhinawhi, Anthonia |
Spence, Lucy |
Exploring the Impact of Genre on Undergraduate Students' Reader Response
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Literature is a medium that transcends time and space, and one of its most fascinating aspects is the way readers react to it. According to Rosenblatt's Reader Response Theory (1938;1978), the meaning of a text can be constructed through the interaction between its author and the reader. Readers can have varying emotional responses to the text depending on their backgrounds, knowledge, and personal experiences. This study explored five undergraduate students' responses to various literary genres and the factors shaping these responses. Guided by three research questions, this study explored individual and textual influences on readers' responses and examined the role of prior genre experience. Understanding reader response is essential for educators, scholars, and writers seeking to comprehend literature's impact on individuals and society. Specifically, this study holds significance in three domains: facilitating educators' selection of engaging texts, informing scholars studying the psychology of reading, and aiding writers in crafting resonant literature. Drawing from genre theory, which posits that each genre carries distinct styles and conventions shaping reader expectations, this study engages a qualitative design to explore subjective experiences. The study comprises five undergraduate students from diverse academic backgrounds, ensuring a varied perspective on the texts examined. Data collection involves a pre-survey capturing participants' demographics, reading habits, and motivations. Subsequently, participants engage with three texts—non-fiction, fiction, and poetry—chosen for their exploration of social themes across different genres. The findings of this study contributes to literary education, advocating for inclusive learning environments that honor students' cultural backgrounds, and enriches our understanding of how literature intersects with readers' lives, offering insights into the intricate dynamics shaping literary engagement and interpretation.
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9:30-11:00 a.m.
Columbia Ballroom (CMCC upper level) |
Poster: 103
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| Lara Guerrero, Jazmine |
Shaw, Todd |
Descriptive Representation in Politics and its Impact on Voting Turnout and Behavior on College-Aged Women of Color
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Voting is an integral part of a democracy. Scholars have looked at the multiple factors that impact voter turnout and behavior, among them political affiliation, education level, and the perceived identity of the candidate. Studies have shown that women of color tend to vote for more women of color than white women. This paper explores the role of descriptive representation in voter turnout and behavior. Description representation is the characteristics of representatives that match their citizens. Drawing on a review of the literature and a small sample of interviews with college-aged women of color, I examine whether descriptive representation affects people’s decision to vote and their choice of candidate. With an increasingly diverse government, this research will provide insight into the future of women of color in elective offices.
Keywords: descriptive representation, women of color, voter turnout, voter behavior
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9:30-11:00 a.m.
Exhibit Hall (CMCC lower level) |
Poster: 1
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| Beetle, Tyler |
Davis, Benjamin
Franco, Jean Michel |
Human Fall Detection From Structural Vibrations
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Abstract Text
Only 5% of seniors live in nursing homes, yet they account for a shocking 20% of fall-related deaths in their age group. The purpose of this study is the development of intelligent infrastructure solutions for nursing homes. Through the utilization of vibration technology to detect and predict falls, the researchers primarily aim to reduce fall related deaths in nursing homes. The start of the study dates to 2009 and is a collaborative effort between the University of South Carolina, the National Institute of Health, and Advanced Smart Systems and Evaluation Technologies. The primary focus of the research is the development of a non-intrusive vibration-based product through supervised machine learning and object localization. The usage of supervised learning in combination with a fall detection product will enable the researchers to classify and detect various event types such as a fall versus someone’s footsteps. The continued development of intelligent infrastructure solutions will enable the researchers a new way to locate activity anywhere in or on any structure.
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9:30-11:00 a.m.
Exhibit Hall (CMCC lower level) |
Poster: 124
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| Fridriksson, Elba |
Nolan, Melissa |
The Effect of Seasonal Temperature Change and Geospatial Factors on Mosquito West Nile Virus Vectors and Baseline WNV Seroprevalence in Columbia, South Carolina, USA
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Abstract Text
Mosquito-borne diseases continue to be a leading cause of morbidity and mortality globally. The transmission process of infectious pathogens from mosquitoes to humans occurs through the bite of a disease-carrying mosquito. A pathogen-carrying mosquito can transmit life-threatening diseases such as dengue, yellow fever, malaria, West Nile virus (WNV), Zika virus, Chikungunya virus, etc. WNV is a mosquito-borne virus that leaves 80% of those infected asymptomatic, <20% infected with mild flu-like symptoms such as fever, fatigue as well as neck and joint pain, and <1% will have West Nile Neuroinvasive Disease (WNND). WNND can cause encephalitis, meningitis, and flaccid paralysis and may end in death. Approximately 1 in 150 cases of WNV will acquire WNND. In the state of South Carolina in 2022, there were at least 11 confirmed West Nile Virus (WNV) cases in the Midlands region, with more than half coming from Richland County. Unfortunately, one death was also reported. In poor mosquito surveillance communities, pathogen-carrying mosquitoes remain a public health threat. The primary vector of WNV is the culex quinquefasciatus mosquito. We focused on two seasonal temperature changes that may affect the incidence of this vector: increased temperature and increased precipitation. Culex quinquefasciatus mosquitoes rely on a hot and humid environment for optimal breeding habitats. Water pools may be built in birdbaths, abandoned fountains, and puddles throughout communities as climate change worsens. Female mosquitoes only require a small pool of water and will lay up to 100 eggs at a time. Once these mosquitoes lay eggs, an accumulation of vectors are born that can acquire WNV and spread it to humans. In Richland County, six endemic neighborhoods were surveyed for geospatial factors as well as the prevalence of vectors. 200-meter buffers were used to analyze five homes in each endemic neighborhood and survey the surrounding environment. We tested people who lived in the surveyed homes and those who lived in these endemic neighborhoods. Utilizing immunoassays for WNV-specific IgM, we discovered the seroprevalence rate of WNV to be ≈22%. Further outbreaks can be prevented by examining the spatiotemporal relationship between mosquito WNV vector incidence and climatic changes.
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9:30-11:00 a.m.
Exhibit Hall (CMCC lower level) |
Poster: 167
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| Barlow, Rachel |
Battle, Sarah |
Left sided weakness leading to new diagnosis HIV with CD4 <35
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Abstract Text
Clinical case: A 30-year-old male with past medical history IV drug use presented to an outside hospital with several months of progressive left sided weakness leading to difficulty with ambulation. CT head showed patchy areas of decreased density in white matter of right frontoparietal region. He was found to have HIV with CD4 count of 19/37% and viral load of approximately 2 million. MRI Brain w/ and w/o contrast revealed hyperintensity involving right cerebral hemisphere and right pons with mild involvement of left hemisphere. Lumbar puncture showed normal opening pressure, protein 54, glucose 50, and 3 white cells. Other CSF studies included: meningitis/encephalitis PCR panel negative, CSF cryptococcal antigen negative, CSF VDRL negative, negative CSF bacterial and AFB cultures, and JC virus PCR inconclusive. Serum toxoplasma IgG negative. Repeat lumbar puncture verified JC virus PCR negative. He was discharged on Biktarvy for HIV and bactrim for pneumocystisjiroveci pneumonia (PJP) prophylaxis. He was seen in clinic one month later and had mild worsening of his motor symptoms. HIV viral load had fortunately improved to 1720. Repeat MRI brain showed markedly abnormal appearance of the white matter in the right cerebral hemisphere; however, this had improved as compared to imaging one month prior. This repeat MRI showed no enhancement or other features characteristic of progressive multifocal leukoencephalopathy (PML), nor was there a mass or other findings concerning for CNS lymphoma. Given improvement on imaging after initiation of antiretroviral therapy, his overall clinical picture was determined likely to be HIV-associated neurocognitive disorder. The current plan is to continue Biktarvy and bactrim with repeat MRI brain in 4-6 weeks.
Discussion: Important diagnoses to consider in this immunocompromised patient with new neurological deficits include cryptococcus meningitis, CNS tuberculosis, cerebral toxoplasmosis, primary CNS lymphoma, and PML/JC virus. All of these were evaluated and ruled-out, leaving HIV encephalitis/HIV-associated neurocognitive disorder as this patient’s diagnosis. In addition, his mild worsening of neurologic symptoms approximately 4 weeks into Biktarvy raised concern for Immune reconstitution inflammatory syndrome (IRIS), however thankfully no other labs or imaging suggested this complication.
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1:00-2:30 p.m.
Columbia Ballroom (CMCC upper level) |
Poster: 168
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| Schacht, Lance |
Bailey, Pamela
Seal, Patricia |
Cefoxitin for Intra-amniotic Infections and Endometritis: A Retrospective Comparison to Traditional Antimicrobial Therapy Regimens Within a Healthcare System
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Abstract Text
Background:, We developed institutional guidelines to prioritize cefoxitin monotherapy for intra amniotic infections and endometritis over prior ampicillin and gentamicin plus potentially clindamycin based recommendations and order sets. This change was motivated by the recent intravenous clindamycin shortage, toxicity concerns about aminoglycosides and the availability of modern cephalosporin antibiotics with improved antimicrobial coverage profiles.
Methods: We performed retrospective review comparing treatment outcomes of patients who had an ICD diagnosis of chorioamnionitis, endometritis, or septic abortion receiving intravenous antimicrobial therapy before and after initiation of our new protocol. Primary outcome was a composite of serious clinical events post-delivery, including readmission, ICU admission, death, need for surgical debridement and deep surgical site infections. Differences between groups were compared with t-testing for continuous variables and chi square testing for categorical variables. Outcomes were controlled with logistic regression analysis.
Results: 472 patients were identified, 350 (74%) prior to the treatment change and 122 (26%) after. Groups were different by race, Medicaid eligibility, and delivery site. Prior to the guidelines, cefoxitin was rarely used (n=1, 0.3%) compared to after implementation (n=86, 71.1%). After controlling for group differences, patients receiving cefoxitin had decreased odds of a serious event post-delivery (0.372 [95% CI: 0.166 - 0.760], p=0.010), with significant decrease in the readmission (OR 0.306 [95% CI: 0.085 - 0.840], p=0.037).
Conclusion: Cefoxitin provides an acceptable alternative to traditional antimicrobial regimens for IAI, with a favorable toxicity and administration profile.
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1:00-2:30 p.m.
Columbia Ballroom (CMCC upper level) |
Poster: 221
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| Russell, Lea |
Kelly, Katherine
Yturralde, Kylee |
C-section scar endometriosis transformation into clear cell carcinoma: a case report and review of the literature
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Abstract Text
Clear cell carcinoma of the anterior abdominal wall is extremely rare and is thought to arise from ectopic implantation of endometrial tissue on a previous uterine surgical scar. In this case, we present a patient with rapidly growing metastatic clear cell carcinoma of the abdominal wall requiring extensive surgical interventions. Due to its rarity, there is no established treatment protocol, and after a comprehensive review of existing literature, we created a stepwise diagnostic workup and treatment plan to guide future clinicians with suspected cases.
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1:00-2:30 p.m.
Columbia Ballroom (CMCC upper level) |
Poster: 169
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| Loomis, Ashley |
Twiss, Jeffery
Morris, Caleb
Vaughn, Lauren
Zdradzinski, Matthew |
Characterization of the RNA Binding Proteins Regulating Axonal Localization of Prenyl-Cdc42 mRNA
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Abstract Text
Following traumatic injury, axons in the peripheral nervous system (PNS) can spontaneously regenerate, albeit rather slowly. This regeneration requires messenger RNA (mRNA)-localization into and translation within the axons. One such mRNA originates from the CDC42 gene, which produces two mRNA splice variants: prenyl-Cdc42 and palm-Cdc42 mRNAs. Prenyl-Cdc42 mRNA, is particularly significant for promoting axon growth and regeneration. The prenyl-Cdc42 mRNA is found in both central nervous system (CNS) and PNS axons, where it can be translated into the Prenyl-CDC42 protein. Prenyl-Cdc42 mRNA’s axonal localization is dependent on a short motif within the 3’ untranslated region (UTR), within nucleotides (nt) 764-800. RNA affinity mass spectrometry (RAMS) using biotinylated synthetic oligonucleotides [764-838 nt (localization motif), 801-875 nt (AU rich region), scramble] as bait were used to identify RNA binding proteins that recognize these regions. To validate candidates identified from the RAMS experiment, RNA affinity western blot was performed using the 764-800 nt sequence as bait and probing for specific RNA binding protein targets CCAR1, PTBP3, and MBNL1, from PC12 cell lysates. This showed CCAR1 and PTBP3 bind to the oligo containing the axon localization sequence, but MBNL1 interaction was not validated. To further test possible interaction between the localization motif on prenyl-Cdc42's mRNA, CCAR1 and PTBP3, fluorescence in situ hybridization and immunofluorescence (FISH/IF) was performed using mouse primary dorsal root ganglion (DRG) cells. CCAR1 showed colocalization with axonal prenyl-Cdc42 mRNA. siRNA knockdowns for CCAR1, but not PTBP3, in DRG cultures showed significantly decreased axonal signal for prenyl-Cdc42 mRNA in DRG axons compared to the non-targeting condition. These findings suggest that CCAR1 is necessary in axonal localization of the mRNA of Cdc42.
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9:30-11:00 a.m.
Exhibit Hall (CMCC lower level) |
Poster: 51
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| Yoon, Brian |
Welshhans, Kristy
Rygel, Katelyn |
Cellular Morphology is Altered in Down Syndrome Fibroblasts
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Abstract Text
Down Syndrome (DS) is a neurodevelopmental disorder resulting from the triplication of human chromosome 21 and can lead to multiple phenotypes such as congenital heart disease, intellectual disability, and slow wound healing. Down syndrome is a complex disorder with numerous downstream effects on the genome that are not well understood. To examine the mechanisms underlying these phenotypes, we utilized fibroblasts from individuals with DS and age, race, and sex-matched apparently healthy control individuals to determine changes in cellular morphology. We find that DS fibroblasts have a greater area, perimeter, and smaller aspect ratio (length/width) than control fibroblasts. One primary mechanism that regulates cellular morphology and motility is adhesion. Focal adhesions link the intracellular actin cytoskeleton to the extracellular matrix and are made up of a multi-protein complex, including vinculin, paxillin, talin, and focal adhesion kinase (FAK). Using immunocytochemistry, we examined the adhesion protein, vinculin, and found no significant changes in the fluorescence intensity of vinculin between DS and control fibroblasts. This suggests that vinculin is not a major contributor to the cellular morphology changes in DS. We are currently investigating FAK because it regulates focal adhesion dynamics. FAK is recruited to focal adhesions in response to integrin activation, and together with Src, it catalyzes phosphorylation events, which affect important cellular processes such as morphology and motility. Overall, investigating the proteins responsible for altered morphology and motility will give us greater insight into the slow wound healing and intellectual disability phenotypes of DS because fibroblasts share many similar cellular and molecular mechanisms with developing neurons.
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1:00-2:30 p.m.
Exhibit Hall (CMCC lower level) |
Poster: 54
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| Manchio, Carly |
Derrick, Maureen |
My University 101 Peer Leader Experience
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Abstract Text
The University of South Carolina ranks #1 among public universities for its first-year student experience and the University 101 course that is designed to transition students into life at the university. In the fall of my senior year, I had the opportunity to hold the role of a peer leader, a student teacher who co-teaches the course with a faculty member of the university. The faculty member I taught with is a career coach for the College of Engineering and we expressed our professional interests and goals to our students early on to create a safe, fun, and inclusive environment. The course teaches first-year students a variety of important topics in order to be successful as a student at USC. Some of these topics include alcohol education, university resources, registration information, housing options, etc. The class is very interactive and encourages participation and collaboration from our students. We also incorporated teamwork into fun activities such as Jeopardy and a trivia game show against another section. Throughout the semester, it was rewarding to watch these first-year students grow from naive high schoolers to college students experiencing independence for the first time. My instructor and I met weekly and kept open lines of communication with each other to ensure we were prepared with each class's lesson plan. I also facilitated lessons and activities to give my students the perspective of someone who was in their shoes three years prior. U101 is an excellent way for new students to become comfortable at the university and learn tips to increase their chances of success. As a peer leader, it was rewarding and beneficial for me to learn mentoring and leadership skills through assisting my students and sharing my personal experiences to better connect with them. I am appreciative of my co-instructor and how our relationship demonstrates the importance of teamwork.
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9:30-11:00 a.m.
Exhibit Hall (CMCC lower level) |
Poster: 338
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| Sokolis, Paige |
Platt, Emma
Bradshaw, Jessica |
Early Sex Differences in Infants at an Elevated Likelihood for ASD
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Abstract Text
Background: Girls are four times less likely to be diagnosed with autism spectrum disorder (ASD) compared to boys, yet parents express concerns at similar ages regardless of sex (Hiller et al., 2015). To better understand how ASD manifests differently in males and females, sex-related differences should be examined in infants who have an older sibling with ASD (ASibs). ASibs are 15-20% more likely to develop ASD, which allows early sex differences to be studied prospectively during infancy. Using an eye-tracking paradigm, Chawarska et al. (2016) found that ASib females demonstrated greater attention to social targets than ASib males from 6 to 12 months of age, and this heightened social attention was associated with less severe social impairment at 2 years old. Their results suggest that enhanced social orienting in the first year of life may have long-term implications for social communication. In our study, we will be looking at infants at ages 9, 12, 18, and 24 months to see how social attention differs among genders during these critical periods.
Objectives: This project aims to examine sex-related differences in ASib infants, specifically their social communication skills. Social communication is the use of verbal and nonverbal skills, social interaction and understanding. These actions make look like: gestures, object use, emotion, sounds, etc. Based on previous research, we expect that female ASibs will display greater social engagement than male ASibs. Our findings will focus on critical time points in which differences may be more or less apparent, signaling a critical period for identification.
Methods: Participants (n=38) were enrolled in a longitudinal of infant development and assessed at 9, 12, 18, and 24 months of age. Parents completed the Communication and Symbolic Behavior (CSBS) questionnaire to report their child’s social communication skills across three distinct domains: Social (Emotion and Eye Gaze, Communication and Gestures), Speech (Sounds and Words), Symbolic (Understanding and Object Use). This questionnaire provides raw and standardized scores that will be used to compare groups. We plan to use Excel and RStudio for data analysis.
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9:30-11:00 a.m.
Exhibit Hall (CMCC lower level) |
Poster: 175
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| Lodge, Juliette |
Keane-Dawes, Anthony |
Leading with Purpose
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Abstract Text
The Student Success Center at UofSC offers students an opportunity to receive academic support in an easily accessible manner; roles include peer tutors, specializing in writing and financials, and the supplemental instruction program. My most significant contribution during my time here has been accepting and pursuing a role as a Supplemental Instruction Leader for Introduction to Finance. When I first became an SI Leader, I was unaware of how impactful this experience would be. The role taught me leadership skills, patience, and an immense amount of time management. SI leaders provide a supportive atmosphere where students can come on their own time and build confidence in their understanding of course material. During each session, there was one student who consistently attended, contributing to a strong sense of connection and engagement. Building on that connection, we stayed in touch afterward which has further enriched my experience as an SI leader. The small-group setting allowed me to have a more personalized approach, addressing individual concerns and fostering a sense of academic self-efficacy. While my chapter as an SI Leader has been closed, the impact it had on me is enduring. I am grateful for the unique insights, personal growth, and sense of fulfillment that came with helping my peers succeed academically. This role not only enhanced my understanding of the subject matter but also instilled in me a passion for facilitating learning experiences. In retrospect, being a Supplemental Instruction Leader for Introduction to Finance was a transformative journey that shaped me into a more capable and empathetic individual. I carry forward the valuable lessons and skills acquired during this experience, knowing that my contributions have played a part in the success stories of my fellow students.
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1:00-2:30 p.m.
Exhibit Hall (CMCC lower level) |
Poster: 252
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| Taylor, Emilie |
Lavigne, John
Boyt, James |
Utilization of Boronic Acid Functionalized Synthetic Lectins for Identification of Triple-Negative Breast Cancer Biomarkers
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Abstract Text
Triple-negative breast cancer (TNBC) is the most difficult form of breast cancer to treat due to a lack of diagnostic and drug targets. TNBC is also more aggressive and harder to detect than other forms of breast cancer, making it the deadliest subtype of this disease. The discovery of novel biomarkers is necessary for the development of targeted drug therapies and improved detection methods. Our lab developed synthetic lectins (SLs), which are short amino acid sequences immobilized on a bead with the capability to bind selectively to glycoproteins. Glycoproteins are convenient biomarkers in the detection and treatment of cancer due to aberrant glycosylation, a common occurrence in cancer. A library of SLs was configured, which consists of over 160,000 SLs, each with a unique binding potential to glycoproteins using a “lock and key” mechanism. We developed a dual-dye competitive screen to isolate SLs that act as preferential binders to glycoproteins from cancerous samples in vitro. These preferential SLs were sequenced and resynthesized to act as a solid phase for isolating these unique biomarkers. Once isolated, the biomarkers were removed from the SL and analyzed via liquid chromatography electrospray ionization orbitrap mass spectrometry, which utilizes protein fragmentation for structural analysis and library comparison of these fragments for accurate identification. Identification and analysis of these glycoproteins will lead to further studies involving the development of drugs and diagnostic screenings which utilize these biomarkers.
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9:30-11:00 a.m.
Exhibit Hall (CMCC lower level) |
Poster: 105
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| McCarty, Jenna |
Borgianini, Steve |
The death of Opuntia spp. in the dunes, a multifaceted front from habitat degradation and erosion to the invasive moth Cactoblastis cactorum
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Abstract Text
Prickly pears, belonging to the Cactaceae family, a group of around 1,800 species predominantly found in the New World, are a fascinating subject of study. Among them, the Opuntia genus, comprising approximately 150 species, stands out as an ancient and noteworthy cohort. The Eastern Prickly Pear, with its distribution spanning east of the Rockies, holds prominence in the United States.
This resilient species exhibits distinctive characteristics, such as photosynthetic stems serving as leaves, efficient water storage mechanisms, and an ability to withstand freezing temperatures in the northern and central states. Flourishing in open, arid environments on calcareous rock or thin soils, it populates diverse locations, including fencerows, roadsides, rocky glades, cliffs, old quarries, dunes, and prairies. Interestingly, despite recent challenges in water availability, the Eastern Prickly Pear has expanded its territorial range.
The Opuntia genus demonstrates a preference for high temperatures, elevated CO2 levels, and low rainfall. Simultaneously, it showcases remarkable biomass productivity and extensive root system growth. However, the concerning issue arises when observing declining numbers in Coastal South Carolina.
Several factors contribute to this decline, including the intricate interplay of climate change, erosion as a response to long-term sea level changes, habitat loss due to development pressures, and the introduction of an invasive species identified as Cactoblastis cactorum.
Understanding the dynamics influencing the population trends of the Eastern Prickly Pear in Coastal South Carolina requires a comprehensive investigation into these multifaceted environmental factors. This research not only contributes to our understanding of plant ecology but also sheds light on the intricate balance between native species and environmental stressors, serving as a crucial aspect in biodiversity conservation efforts.
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9:30-11:00 a.m.
Exhibit Hall (CMCC lower level) |
Poster: 77
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West, Abbie
Alex, Ashley |
Poston, Mary Beth |
Acute Pancreatitis: Rheumatologic Related?
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Abstract Text
62 y/o female with history of Sjogren’s, diffuse large B-cell lymphoma (s/p chemotherapy), and hypogammaglobulinemia presented with a two-day history of 8/10 epigastric abdominal pain. She reported nausea and vomiting but denied fever, hematemesis, melena, hematochezia, dysuria, or hematuria. She also presented with a diffuse erythematous maculopapular rash affecting her face, chest, and upper extremities that began two weeks prior; she had similar rashes in the past.
Significant workup included a lipase of 1950; CT abdomen/pelvis showed acute pancreatitis with small volume ascites. Incidental CT findings showed avascular necrosis of both hips secondary to prior steroid use due to Sjogren’s. Additional labs included normal liver function enzymes, alkaline phosphatase, bilirubin, lipids, and serum calcium. Past surgical history included cholecystectomy 20 years prior. She denied alcohol use. A right upper quadrant ultrasound was negative for any acute pathology. Given her rheumatologic history, there was a question if her pancreatitis could be related to Sjogren’s versus possible autoimmune pancreatitis.
Further evaluation included a magnetic resonance cholangiopancreatography (MRCP) and endoscopic ultrasound (EUS). Both studies were consistent with interstitial acute pancreatitis. Given concern of possible autoimmune pancreatitis, a rheumatologic panel was obtained. Results showed positive ANA at 1:160 homogenous pattern, ESR 34, CRP 155.4, anti-SSA 5.7, anti-SSB >8.0, normal C3 and C4, IgG 575 (low), and normal IgG4 subclass at 11. CBC showed pancytopenia. Normal IgG4 made the diagnosis of autoimmune pancreatitis less likely. So, the primary cause of her pancreatitis was thought to be secondary to Sjogren’s disease. Additionally, given her pancytopenia, erythematous rash, positive ANA, and high anti-SSA and SSB titers, she met criteria for systemic lupus erythematous (SLE). Biopsy of her rash showed interface dermatitis, a nonspecific finding seen in SLE. She was diagnosed with overlap syndrome between SLE and Sjogren’s. She was started on hydroxychloroquine and prednisone, with improvement. However, given avascular necrosis noted on CT, steroid use was judicious. Additionally, due to history of lymphoma and hypogammaglobulinemia, further immunosuppressive therapy was to be reassessed outpatient. She was later discharged with close rheumatology and oncology follow-up.
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1:00-2:30 p.m.
Columbia Ballroom (CMCC upper level) |
Poster: 143
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| Wellons, Eden |
Roberts, Jane
Arnold, Holley |
Cardiac Autonomic Measures of Frustration in Children with Autism Spectrum Disorder
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Abstract Text
The autonomic nervous system (ANS) is responsible for involuntary functions such as breathing and heart rate. ANS dysfunction is correlated with difficulty regulating emotional responses, which is often observed in neurodevelopmental disorders like autism spectrum disorder (ASD). ANS dysfunction can be indexed by respiratory sinus arrhythmia (RSA), a measure of heart rate variability coordinated with breathing (Porges et al., 1996). Higher RSA indicates greater variability determined by the vagus nerve; the higher one's vagal tone, the more efficiently one can respond to stressful stimuli and return to a restful state.
In this study, I will investigate the physiological response of 36 ASD children and 41 neurotypical (NT) children ranging from 36-72 months during a previously recorded frustration task (“End of the Line”). This is part of the Laboratory Temperament Assessment Battery, a standardized test designed to evaluate temperament. Physiological data was collected using heart rate monitors and analyzed using QRSTool, CardioEdit, and CardioBatch software programs. During this task, researchers give the child a toy to play with (Toy Play); after 30 seconds, the parent takes the toy away (Challenge). They then return the toy after 30 more seconds (Toy Return).
Based on prior findings with children with fragile X syndrome, I expect to find a significant difference in RSA between ASD and NT groups (Roberts et al., 2012). During the Challenge phase, the ASD group will display more blunted suppression (i.e., less of a decrease in RSA) than the NT group. During Toy Return, the ASD group will remain in a state of suppression (i.e., RSA will have dropped during Challenge and will remain low during Toy Return; Hogan et al., 2021). The NT group, however, will return to a state similar to the Toy Play phase. Overall, the ASD group will exhibit a less intense physiological response to frustration as well as a slower recovery. Emotion dysregulation is a key characteristic observed in neurodevelopmental disorders, and understanding underlying biological mechanisms in ASD will help build compassionate therapies and promote widespread awareness of reasons for the emotional and physiological characteristics observed in neurodevelopmental disorders.
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1:00-2:30 p.m.
Exhibit Hall (CMCC lower level) |
Poster: 183
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| Machimada, Riya |
Vaughn, Lauren
Twiss, Jeff |
Effect of Non-Muscle Myosin II Inhibition on Axon Growth through Disassembly of Stress Granules
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Abstract Text
Neurons are the largest cells in the human body as their axons can extend for more than a meter. These axons serve as the basis of long-range communication in both the central (CNS) and peripheral nervous systems (PNS) which are the basis of all movement and sensation. After an injury, CNS neurons are unable to spontaneously regenerate their axons, which is from failure to activate growth-promoting gene expression and an inhibitory microenvironment in the injured brain and spinal cord. Conversely, PNS axons spontaneously regenerate, but at a limited speed such that function is typically only regained when short distances are needed to reach their targets of innervation. A recent study identified blebbistatin, a non-muscle myosin II (NMII) inhibitor, as an axon growth-accelerating agent in human iPSC-derived motor neurons. NMIIs contribute to cell migration and growth via interactions with the actin cytoskeleton. Similarly, we found that disruption of stress granules (SG) using a short peptide derived from G3BP1 protein also accelerates axon regeneration. A mass spectrometry screen for proteins binding to the G3BP1 peptide identified NMII proteins as the top hits. This raises the possibility that blebbistatin promotes axon growth by disrupting SGs and releasing mRNAs for translation. Initial testing shows that cultured primary mouse dorsal root ganglion (DRG) have altered SG numbers and sizes upon exposure to blebbistatin. Additional testing will identify functional outcomes of this SG disruption, including changes in global translation or SG protein-RNA composition. The overall goal of the project is to identify how inhibition of NMII modulates axonal growth and growth-promoting pathways in primary neuronal cultures, specifically how alterations of the actin cytoskeleton activity can impact protein synthesis in the axon.
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1:00-2:30 p.m.
Exhibit Hall (CMCC lower level) |
Poster: 38
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| Lamm, Jacqueline |
Norton, Duncan |
Atypical Kawasaki Disease in 5-Month-Old
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Abstract Text
Kawasaki disease (KD) is an acute disease of unknown etiology that primarily affects children under the age of 5. It is the most common cause of acquired heart disease in children in developed countries, involving inflammation of medium-sized arteries, with the coronary arteries being of main concern. The diagnosis is one of exclusion and revolves around a set of clinical criteria, though it can become much more difficult to diagnose when presented as atypical or incomplete KD. Presented here, a child with high fever was reported and subsequently misdiagnosed with an upper respiratory infection and sent home with children’s Tylenol. The child presented the following day fever, elevated CRP, and erythematous tympanic membrane, for which he was misdiagnosed with acute otitis media. The child developed a characteristic maculopapular rash, periorbital swelling, and persistent fever, for which an atypical KD diagnosis was made and an echocardiogram was ordered. Treatment with IVIG, aspirin, and steroid revealed diminished symptoms at 10-day follow-up. This case highlights the diverse possible presentations of atypical KD and the importance of continuing to look for classic symptoms, even late in the disease presentation.
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9:30-11:00 a.m.
Columbia Ballroom (CMCC upper level) |
Poster: 167
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| Sims, Shyterria |
Morris, Caleb |
Social Work and Buddhism
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Abstract Text
In May 2023, I attended a Maymester trip with the College of Social Work to Japan. While here, we explored, integrated, and immersed ourselves through Tokyo, Kyoto, Hiroshima, and overall Japanese culture. I decided to participate in this program to get the study abroad experience from a social work lens. With this major, not many opportunities are available to apply classroom knowledge abroad. With this understanding, I took it upon myself to join this program. To prepare for this trip, I attended a series of meetings to get familiar with the itinerary, group members, and the country. Prior to departing from the country, I recorded a brief video of my expectations, what I hope to learn, and any challenges I thought I would face. While on this trip, I got to experience traditional Japanese cuisine, sleeping experiences, travel, and culture. I also participated in local tours of historic Japan from farming techniques to the bombing and aftermath of Hiroshima. Through these experiences, I was able to identify and apply several Council on Social Work Education competencies to each and engage in critical self-reflection which would be useful at then future practicum placement working with international students. To me, this program was impactful to me because not only did I fulfil a desire of my college experience, but I was also able to learn about the applications of the social work profession in multiple forms and be a part of the representation of being Black and Abroad.
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9:30-11:00 a.m.
Exhibit Hall (CMCC lower level) |
Poster: 243
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| Mills, Grace |
Reinhardt, Sara |
Navigating Cultural Crossroads: A Journey of Marketing, PR, and Global Insight through Eight Countries and 16 Cities
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Abstract Text
During my junior spring semester, I studied abroad in Florence, Italy, and visited eight different countries along with 16 different cities. This experience allowed me to integrate my academic studies at USC with real-world experiences seamlessly. My primary focus was on immersing myself in various cultures and approaching them through the lens of a PR/marketing student. My goal was to gain insights from each city visited and fully engage with Florence to experience life as a local. Throughout my time abroad, I attended a French Food Fair in Paris, adopted a Florentine lifestyle, explored Munich and Germany, and immersed myself in many different cultures. These diverse experiences and academic insights enabled me to explore the intersection of different cultures, living in a foreign country, and historical reconciliation. Motivated to bridge my marketing and public relations background with global learning experiences, I aimed to draw connections between these elements. Integrating these experiences, I applied frameworks from marketing and public relations classes to analyze the delicate balance between cultural immersion, marketing strategies, and historical comprehension. While at USC, I took Principles of Marketing, where I learned how important marketing is for consumers and organizations in any economy. I took how crucial global marketing is to attract tourists and tied it to my experiences abroad. Taking what I have learned for my future career in marketing, I see the potential to implement similar strategies in various industries. The French Food Fair highlighted how marketing strategies could transform cultural experiences, emphasizing the importance of unconventional approaches. My Italian marketing class enabled me to compare global marketing approaches, shedding light on how countries present themselves globally. The visit to Dachau underscored Germany's commitment to remembrance and rebuilding, showcasing the role of public relations in managing crises, fostering intercultural understanding, and reshaping national narratives. My time abroad exemplifies the profound impact of immersive experiences on shaping perspectives. I am well-prepared to contribute meaningfully to the multifaceted marketing and public relations landscapes within and beyond the classroom.
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9:30-11:00 a.m.
Exhibit Hall (CMCC lower level) |
Poster: 249
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| Belt, Savanah |
Simoska, Olja
Whisonant, Megan |
Electrochemical Study of Extracellular Electron Transfer Mechanisms of Gut Bacteria
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Abstract Text
Recent research studies have revealed intricate connections between the human gut microbiome and prevalent health conditions (e.g., Alzheimer’s disease) with it exhibiting considerable variations in biogenic signaling molecules and external factors. However, there are significant gaps in the understanding of the interplay between these factors, cellular signaling molecules, and human health conditions. Within this context, one avenue that requires exploration and understanding is electron transfer mechanisms in the gut. Several bacteria, including Escherichia coli, present in the human gut can transfer electrons to and from external electron acceptors in a process called extracellular electron transfer (EET). This process can be mediated by soluble electron shuttles (also known as mediators), such as quinones. Although proposals have been made for where EET occurs along the cellular membrane, this question remains unanswered. This project investigates quinone-based EET mechanisms in the glucose oxidation metabolism of E. coli using quantitative electrochemical techniques. Cyclic voltammetry was first used to determine the reversibility of quinone-based electron transfer. The results indicate that quinones demonstrate quasi-reversible electron transfer mechanisms. The impact of different quinone structures and concentrations during glucose oxidation in E. coli was then evaluated using chronoamperometric methods, where the resulting current from oxidation metabolism was monitored over time. Additionally, the impact of quinone mediators was examined with regard to E. coli growth rates to provide qualitative data supporting the quantitative electrochemical measurements. Our results demonstrate that the structure and concentration of quinones has an impact on the magnitudes of oxidative currents measured as well as the growth rate of E. coli. In general, increasing concentrations of quinone lead to increasing oxidative currents, suggesting the ability of quinone mediators to shuttle electrons to and from the conductive electrode surface during glucose oxidation metabolism in E. coli. Based on the data, it is hypothesized that quinone-based EET in gut E. coli occurs within the cellular membrane. In future studies, the experimental electrochemical results will be integrated with a computational model based on density functional theory and multivariate linear regression modeling to confirm that the limiting electron transfer step occurs in the lipophilic membrane of bacterial cells.
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9:30-11:00 a.m.
Exhibit Hall (CMCC lower level) |
Poster: 92
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| Pompi, Alexandra |
Matthews, Sarah |
Emergency Medicine In Crisis: Navigating The Broken System
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Since the summer of 2022, I have worked at Atrium Health Carolinas Medical Center in the Emergency Department (ED) as a patient care technician (PCT). The ED is a level 1 trauma center used to provide emergency medical care and provide life saving measures to patients. I work alongside doctors, PA’s, and nurses to provide care to these patients. I was primarily responsible for obtaining EKGs for patients experiencing chest pain to rule out a STEMI (heart attack), taking manual blood pressure on our trauma patients, obtaining vitals upon patients checking in, and providing compressions to patients who are coding. I learned about what needs to be done in emergency situations and how to assess what situations were more serious. I also learned what it looked like for patients to present symptoms of stroke, allowing me to take them back immediately for evaluation. I decided to be a PCT in the ED because it is a good way to obtain patient care for Physician Assistant school and also because I desired to work in a fast-paced and demanding environment. Also, every day is different and you never know what can come through the doors. I also got involved because it is my passion to help people from all different backgrounds and be there for patients on some of the worst days of their life. Through working in the ED and my PUBH 302 class, I have learned about the health disparities in our society between different races, ethnicities, and socioeconomic statuses. I also learned how the ED system is not being used for what it was originally intended to do because there are patients coming in with non-life threatening issues that make the ED demand increase significantly. Working in the ED has impacted me by making me think quickly on my feet and be able to remain calm in emergency situations. It has furthered my desire to become a PA and provide care to patients in all populations. I learned that the healthcare field is not all sunshine and rainbows, but instead there are many flaws that need solutions.
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9:30-11:00 a.m.
Exhibit Hall (CMCC lower level) |
Poster: 298
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| Thomas, Madeline |
Stubblefield, Brittany |
Leadership in Greek Life
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A sorority put simply is an organization of women on a college campus formed around common goals and aspirations. My sorority, Gamma Phi Beta, is an organization that builds confident women of character who celebrate sisterhood and make a difference in the world. The chapter of Gamma Phi Beta at the University of South Carolina has given me the opportunity to better myself and the world around me as a member and a sister to almost 300 other girls. This year I am the president of Gamma Phi Beta at USC, and I am able to create the environment the organization strives for, by promoting academic excellence, fostering sisterhood, and encouraging philanthropy. As president, I am the principal executive officer for all members, and devote time to chapter operations, crisis management, strategic planning, exit interviews, and various meetings with other officers. This experience in leadership has introduced me to my passion, which is to lead others toward excellence, especially in large organizations. I joined the sorority in 2021 because of my father, and his experience as a fraternity man in college. He is the reason I have so much love for the Greek community, and I would not have had all of these incredible opportunities without him helping me to make this decision. I chose this path of leadership because of the women involved in the chapter. The people I have met in this organization are the reason I am confident enough to lead and have helped me learn my path. In my leadership, I have been able to inspire this confidence in other women and show them how they can do more than they ever thought possible. I am able to inspire kindness and understanding in others, and have made lifelong connections with women who have the same motivation I have found through sorority life. I want to use my experience to show others how life-changing it can be to join Greek life, and show how the sorority experience can be the most positive and impactful choice a woman can make.
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9:30-11:00 a.m.
Exhibit Hall (CMCC lower level) |
Poster: 352
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| Simmons, Chad |
Armstrong, Alissa
Bradshaw, Tancia |
Growth-critical Adipokines and their Role in Adipocyte to Ovary Signaling in Drosophila melanogaster
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Obesity, a longstanding health concern, contributes to the risk for several pathophysiologies including type two diabetes, cancer, and reproductive issues. In addition to adipose tissue accumulation, obesity disrupts the endocrine function of adipocytes, leading to altered inter-organ communication. Using Drosophila melanogaster as a model organism, our goal is to identify the fat-derived molecules that relay nutritional information to other organs. Recently, several adipokines have been shown to be critical for tissue growth during larval development. We set out to determine if these larval adipokines are also utilized for inter-organ signaling in adults. Since we know that nutrient sensing by the Drosophila fat body influences oogenesis, we focus on how larval adipokines may mediate fat-to-ovary communication in adults.
Our study focuses on upd2, egr, ccha1, ccha2, gbp3 and sun, a group of adipokines that are critical to larval development, homeostasis, and growth. Utilizing the UAS/Gal4 system along with fat-body specific drivers, we generated progeny that had temperature sensitive knockdown of our target adipokines. After at least 10 days of transgene expression, ovaries were dissected to examine blocked ovulation patterns, changes to the germline stem cell number, and presence of cell death during vitellogenesis through confocal microscopy. Triglyceride content and adipocyte size were also examined to determine phenotypical changes to the fat body. Knockdown of upd2 and egr in adult adipocytes have no effect on the number of GSC or cap cells in the germaria, but may disrupt vitellogenesis, as higher levels of cell death was present in egg chambers that were post-vitellogenic. Gbp3 knockdown in the fat had no immediate effects on GSC or CC counts, but did alter the morphology of the adipocytes, with fat bodies that had less triglycerides and lower sizes. In future experiments, we want to use the Crispr/Cas9 system as an alternative method to determine if ovary function is disturbed after adipokine knockdown in the fat. We also want to look at how fecundity is affected by adipokine knockdown. In future projects, we would like to examine how dietary changes influence adipokine production and if they are relevant for maintaining adipokine to ovary signaling.
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1:00-2:30 p.m.
Columbia Ballroom (CMCC upper level) |
Poster: 87
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| Janakis, Madison |
Speiser, Daniel |
Light in tidal creeks: How mud crabs may enhance visual contrast using color and polarization cues
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Different light environments pose distinct challenges to animal visual systems. For example, tidal creeks are challenging for vision because contrast is often low. These environments can be spectrally narrow, which decreases contrast between colors; in addition, suspended particles in the water scatter light, which reduces the sighting distances of objects. As a further challenge, the light environment in tidal creeks is constantly shifting due to local conditions like weather and tides. To learn how visual systems enhance contrast within tidal creeks, we investigated the vision of the Atlantic mud crab, Panopeus herbstii. We used behavioral optomotor assays to estimate visual acuity and test polarization sensitivity in P. herbstii, and electroretinography (ERG) to measure spectral responses from its eyes. Using achromatic optomotor stimuli, we found mud crabs have a visual spatial acuity between 4 and 10°. We then tested how crabs responded to polarized optomotor cues created by arranging strips of linear polarized filter 10° wide. For experimental trials we arranged the strips so their angles of polarization were perpendicular, and for control trials we arranged them in parallel. Mud crabs followed perpendicularly arranged strips but not parallel ones, suggesting they are sensitive to the angle of linearly polarized light (AOLP). By fitting known visual pigment templates to spectral response curves from ERG, we found P. herbstii have two classes of photoreceptors with peak spectral sensitivities at about 470 nm and 540 nm. To investigate whether polarization sensitivity is wavelength-dependent, we tested whether crabs still followed polarized stimuli under spectrally narrow conditions. We re-ran polarized optomotor trials under four different colors of narrow-spectrum light, UV (410 nm), blue (450 nm), green (515 nm) and red (660 nm), and tested each color at two different light intensities. We found that mud crabs are still sensitive to AOLP under UV, blue and green light but only when the light is bright enough. Mud crab vision appears to be sensitive to AOLP and dichromatic. We hypothesize P. herbstii uses color and AOLP to increase contrast within the visually challenging tidal creeks in which they live, but only when there is sufficient light available.
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1:00-2:30 p.m.
Columbia Ballroom (CMCC upper level) |
Poster: 88
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| Foster, T'Aja |
Reed, Rico |
The Impact of Presence
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I discovered that making my presence know on campus at a Predominately White Institution as an African American student has helped encouraged my peer to go after what they want no matter the circumstances. I did this my getting involved in many clubs and organizations that has opened door for me to do what I love which is helping other succeed. These organizations mainly focus on the importance of mentoring/mentorship. My main purpose is to help others to make their transition into college smooth and prevent them from making the same mistakes I made coming into college and as a college student.
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9:30-11:00 a.m.
Exhibit Hall (CMCC lower level) |
Poster: 250
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| Weston, Madelyn |
Boyken, Julie |
Encouraging CrossTalk: Sharing Knowledge and Leading Effectively
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My passion for writing, learning about the world and meeting new people converged when I joined Carolina CrossTalk my sophomore year. Carolina CrossTalk is the student-led undergraduate research magazine at USC. We feature researchers from any discipline, conveying their studies in a way that a reader from any academic background can understand. Carolina CrossTalk provided me a supportive setting to develop crucial interviewing skills and hone my writing abilities. Each semester as an associate writer I interviewed researchers, then wrote personalized and informative stories about how their experience influenced them. I also collaborated with CIEL to facilitate the certification of Carolina CrossTalk as an academic publication towards the Graduation with Leadership Distinction program. It attracted more researchers, leading some to pursue GLD. Also, I created a new spotlight series focused on alumni who graduated with GLD in research. It demonstrated how GLD can enhance your college experience while supporting professional and post-undergraduate academic goals.
In Spring 2023, I was promoted to editor-in-chief. While I still write articles, I am also responsible for guiding researchers through the writing process, copyediting all articles, and approving the magazine for publication. Additionally, I recruit researchers and new members, write email marketing campaigns, and lead staff trainings. I learned how to build promotional material and create website content. As editor-in-chief, I understand the magazine publishing process from beginning to end. Our team’s open communication and willingness to share knowledge with others helps us run efficiently. My experience with Carolina CrossTalk has taught me how to manage my time, write clearly, and effectively lead a team. It confirmed my love for publishing, which I will pursue as a career after graduation.
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1:00-2:30 p.m.
Exhibit Hall (CMCC lower level) |
Poster: 325
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| Sabel, Carly |
Epps, Lauren |
How a Dictatorship Impacts Culture - my time abroad in Santiago, Chile
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In 2023, I studied abroad for two semesters at the Facultad de Economía y Negocios (FEN)– Universidad de Chile in Santiago, Chile. I am an International Business major with a Spanish minor, which partnered together, allowed me to learn about different cultures inside and outside of the business world, and how they impacted business on a global scale. In Chile, I was able to use my knowledge from classes at USC to create international relationships, use cultural frameworks to adapt and understand a new culture, and open my mind to a transnational mindset. During my time, I learned a lot in university about the Pinochet dictatorship and how it affected the economic status of the country, but while living with my host family, I was able to use the Hofstede Framework to explain the Chilean culture today and the aspects of their culture that is influenced by the Pinochet dictatorship. This experience was significant to my future as I wish to pursue a position in a Latin American focused division of a company. I feel confident that I can use my experiences in Chilean to adjust and overcome the challenges of living in a different country or assimilate to different work cultures in the future.
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1:00-2:30 p.m.
Exhibit Hall (CMCC lower level) |
Poster: 236
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| Miller, Olivia |
Crammer, Robyn |
Details Matter: My Growth through Contract Review and Communication at the University of South Carolina Office of Board of Trustees
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Throughout the past three years, I have been the sole intern at the Office of the Board of Trustees here at the University of South Carolina. I navigated a steep learning curve, primarily focusing on contract review and approval. My role requires meticulous attention to detail, especially in coordinating communication between the Trustees and the University and working with the General Counsel's Legal office. Initially struggling with a lack of confidence and misplaced priorities, I grew my skills through practical experiences and mentorship from Cameron Howell, the Secretary of the University. Using information taught in my Constitutional Law course, I learned the ability of effective communication by identifying key details and delivering information concisely. This newfound precision not only improved my function in contract approval but also enhanced my role as a liaison, ensuring swift and accurate responses to Trustees’ questions. Recognizing the significance of attention to detail and effective communication, I prepare to enter law school following my graduation in May, equipped with the vital skills of attention to detail and effective communication, learned through my internship experience with the Board of Trustees Office.
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1:00-2:30 p.m.
Exhibit Hall (CMCC lower level) |
Poster: 338
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| Goss, Shannon |
Morris, Caleb |
Discovering Transformational Leadership in Air Force ROTC
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Four years ago, I chose to transform myself by enrolling as a cadet in the Air Force ROTC program. This opportunity has allowed me to discover crucial leadership skills to prepare myself for a career as a United States Air Force officer. I had the remarkable experience of attending Air Force ROTC Field Training, a rigorous two weeklong evaluation of weapons and survival instruction, deployment skills, aircraft indoctrination, and physical conditioning. Above that, it’s an essential test for cadets to exhibit followership, teamwork, and leadership skills. This training is designed to be a high stress environment, to best evaluate military discipline and organization that will be crucial when serving as an officer. Within the first day, I quickly discovered the goal of the program was not to simply be the best, it was to see how effectively you can work with others, lead peers, and adapt to challenging scenarios. My experiences made me recognize the strong values behind adopting transformational leadership. I learned that transformational leadership involves creating personal relationships with followers, by building positivity and striving to help them reach their fullest potential. I wanted to be a leader that would inspire my followers with challenging goals, provide vision and meaning, all while stimulating the expansion of their own skills and abilities. I have been able to use transformational leadership in my professional and personal endeavors, so that I am best able to succeed in my career as a Second Lieutenant in the U.S. Air Force.
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1:00-2:30 p.m.
Exhibit Hall (CMCC lower level) |
Poster: 306
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| Unger, Gabriella |
Cranmer, Robyn |
Developing the Proper Skills to Prevent Harm and Substance Abuse in Greek Life
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Although at 17 years old I did not know much, I am very thankful I knew that I belonged in Chi Omega here at the University of South Carolina. I will always be proud of that shy and nervous girl, knowing that she set me up for the single handedly best experience of my life by joining an organization with so many overachieving, supportive, and intelligent women. Suddenly, three years later, and still trying to figure out who I was during the most formative years of my life, I was unexpectedly chosen to be on the Executive Board as the Social and Risk Management Chair. Through this position I learned skills such as self-assurance, how to accept liability and responsibility, navigate uncomfortable conversations, budget and event plan, contract negotiation, and most importantly prevent Risk in an environment where unsafe drinking practices are so normalized. This experience not only taught me valuable leadership and interpersonal skills that I will carry for years to come, but made me realize how lucky I am to be a member in such an amazing Chapter who saw these skills in me and knew I would rise to the occasion gracefully. The education and risk protocols I implemented have not only changed the way I view alcohol misuse but have promoted alcohol safety and education in our Chapter members for years to come, which will follow me into adulthood, as well as my peers. I hope this gives you a glimpse into the leadership skills I gained and the knowledge I learned from being in such a safety and prevention-based position in Chi Omega.
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9:30-11:00 a.m.
Exhibit Hall (CMCC lower level) |
Poster: 270
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| Cassels, Louise |
Crammer, Robyn |
Harmonizing Learning and Professionalism: Bridging Success from Student Life to Post-Graduation
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My days at the University of South Carolina haven't followed the conventional path of a typical student. Instead, they've been a blend of academic and hands-on professional growth, better explained as class in business casual every day. Serving as a page for Senator Ross Turner, I confronted real-world challenges, refining the professionalism and effective communication skills instilled through my Professional Communication, MGMT 250 class. Discovering opportunities through Handshake, I joined the Alumni Engagement team at the Moore School. This experience became a melting pot of refined marketing skills and insights from marketing courses. Beyond the practical, it ignited a passion for alumni engagement, potentially steering my future career in this impactful field. Reflecting on this journey, I've learned the art of intentional time management and prioritization. Juggling academics, work, and extracurriculars has been more than a challenge; it's been a masterclass in structured multitasking. This structured approach not only streamlined my tasks but also laid the foundation for a seamless transition post-graduation. Essentially, my USC journey showcases the integration of classroom-acquired knowledge with hands-on experience in various professional settings. Each position, be it at the State House or within the Alumni Engagement team, has contributed to my multifaceted skill that I know will prove to be valuable well beyond graduation.
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9:30-11:00 a.m.
Exhibit Hall (CMCC lower level) |
Poster: 339
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| Walliser, Emily |
LaVoie, Holly |
Effects of MMP14 overexpression on cardiac and ovarian connective tissue and myocyte size in pregnant and postpartum mice
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Background: The main protein component of extracellular matrix is collagen, which fills spaces and supports cells. In the heart, collagen provides the scaffolding for cardiomyocytes and aids in contractile forces. In the ovary, collagen gives follicles their structural support. MMP14 or membrane type 1 matrix metalloproteinase is a membrane bound proteinase that cleaves extracellular matrix proteins, including type I and III collagens. MMP-14 is important for remodeling of cardiac and ovarian tissue.
Goal of Study: Our goal was to evaluate the effects of overexpression of a human MMP14 (hMMP14) transgene in fibroblasts on the levels of collagen in heart and ovarian tissue and cardiomyocyte size.
Methods and Results: hMMP14 transgenic and FVB/NJ wildtype mice were sacrificed at pregnancy day 17 (ed17) or postpartum day 49 (ppd49) or as age-matched virgins. Heart and ovarian tissues were histologically prepared and stained with picrosirius red (PSR) and Masson’s trichrome stain. Cardiomyocyte cross-sectional area and PSR content were measured using Image J. Data was analyzed by Two-way ANOVA and by Sidak’s (for genotype) or Tukey’s (for reproductive status within genotype) post-hoc test. Two-way ANOVA revealed a significant interaction of reproductive status and genotype for percent PSR content in ovarian tissue, P=0.04. Sidak’s post-hoc test showed that ppd49 ovaries had significantly higher PSR content in hMMP14 mice than wildtypes, P=0.04. Comparison of PSR content in left ventricles between wildtype and hMMP14 mice revealed no differences with reproductive status or genotype. There was no significant effects of reproductive status or genotype on cardiomyocyte area in left ventricle tissue.
Conclusions: hMMP14 expression did not have an effect on type I and type III collagen abundance in the left ventricles and did not affect cardiomyocyte cross-sectional area. In addition, there was no effect of reproductive status on these cardiac endpoints. hMMP14 exhibited altered collagen content in ovaries compared to wildtypes, but collagen content was not affected by reproductive status.
Funded by SC INBRE P20GM103499 & USC ASPIRE I award.
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9:30-11:00 a.m.
Columbia Ballroom (CMCC upper level) |
Poster: 83
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| Jani, Niti |
Pena, Marj |
Multiple exposures to antibiotics and increased risk of colorectal cancer
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Colorectal cancer (CRC) is the second leading cause of cancer related deaths in the United States and worldwide. CRC in younger patients (less than 55 years) is known as early onset colorectal cancer (EOCRC). It is a growing global phenomenon whose incidence and mortality has incidence from 11% to 20% between 1995 to 2019 and is expected to increase by 140% by 2030. The cause and mechanism of EOCRC are unknown. Based on our current knowledge of the disease we believe that exposure to certain exposomes during childhood and young adult years can increase the risk of EOCRC development. In our study, we hypothesized that early life exposure to antibiotic causes dysbiosis and inflammation in the colon which leads to mutation and epigenetic alterations that promotes EOCRC. We treated A/J mice multiple times with commonly prescribed antibiotics and then exposed them to azoxymethane carcinogen to develop tumors. Our results showed higher tumor burden, systemic inflammation and increased immune cell infiltration in the colon of antibiotic treated mice compared to control mice. Moreover, antibiotic treatment was able to cause dysbiosis in the gut. Results of this experiment suggests possible involvement of antibiotics on increased risk of EOCRC.
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1:00-2:30 p.m.
Columbia Ballroom (CMCC upper level) |
Poster: 82
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| Seabolt, Madelyn |
Tandon, Keah |
Diving Into The Galapagos 2022 Maymester Experience
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I studied abroad in the Galapagos Islands during the 2022 Maymester. I took a class called SPTE 490 that focused on sustainability in the scuba diving industry, lived with a host family, and was immersed in Ecuadorian culture. My classmates and I were responsible for designing our own liveaboard experience based on what we learned from Blue Evolution (the dive shop we partnered with) and from our personal experiences on the island.
I am very passionate about the ocean and grew up watching David Attenborough talk about the wonders of the Galapagos. I was taking MSCI 210 with Dr. Zolkowski and she announced the trip to our class and went into further detail about what kinds of experiences would be offered there. The motivation behind designing the liveaboard experience was to blend the lucrative world of tourism with the vital world of sustainability. We learned how to be responsible when profiting off of precious land.
I learned about the importance of sustainability in tourism, got first-hand experience with Ecuadorian life and culture, and learned about the work that goes into defending the precious wildlife found on the islands. This experience opened my eyes to how we can appreciate the beauty of the world and profit off of it without destroying it.
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1:00-2:30 p.m.
Exhibit Hall (CMCC lower level) |
Poster: 245
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| Lee, Madison |
Keane-Dawes, Antony |
Seeing the Bigger Picture: Where Strategy Meets Student Media
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The university experience is defined not only by academics but also by the organizations you choose to devote your time to. In my three years at the University of South Carolina, I found myself a home in Garnet Media Group’s marketing team within the Department of Student Media. Within my time serving as an Event Coordinator for two years and now serving as the Assistant Director of Promotions, I have been able to learn valuable skills in multiple areas that I hope to take into my future career. Garnet Media Group strives on communication, creativity, and freedom of student speech. I have been able to grow these skills by publishing articles in our biannual publications, Carolina Insider and Best of Carolina, as well as drafting and editing social post copy for the entire team. Digital media has become a large part of marketing in such a short period of time, and as time passes, we as a society are relying more and more on this outlet. As I learn about this in my classes, it’s been beneficial to put that knowledge into application with running the Garnet Media Group social media pages. I also got to see how events can fit strategically into plans while working as an Event Coordinator. Planning events for the mass student body was definitely a lot of fun and hard work but also rewarding when our team won a national student media award. When I started college, I had no idea what would be in store for me. I didn’t know that I would have published pieces of writing, plan events for the USC student body, or even travel halfway across the country to better my career development. Participating in Garnet Media Group has shown me and let me explore the multiple avenues of the future careers I could have with my marketing degree but has also developed my leadership and team building skills that I will carry with me long after graduation.
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1:00-2:30 p.m.
Exhibit Hall (CMCC lower level) |
Poster: 313
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| Salguedo, Kayla |
Derrick, Maureen |
Multiple Perspectives and Multiple Experiences: A Journey to Learn More
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As a student at the University of South Carolina, I was given the opportunity to expand my beliefs academically and individually by studying beyond the classroom in a study abroad experience. During the Spring 2023 semester, I studied in Paris, France as a part of a French language immersion semester program. I was highly driven to participate in a semester abroad as I aimed to be able use my education from USC and build on it while abroad. During this experience away from the University of South Carolina, I was challenged in unexpected ways. I was able to emphasize with multiple different groups of people while traveling and in the classroom. For example, I learned about multiple different religions and visited holy sites to grasp the true meaning of the religion. I also visited museums and saw artifacts of time periods I have spent a great deal learning about. Finally, I talked to real people from the countries I visited. I learned about what was important to them and how they viewed their surroundings. Since having my experience abroad, I have taken what I gained there and implemented it into my life in Columbia. I continue to search for multiple perspectives and hope to achieve the same in my future professional career.
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1:00-2:30 p.m.
Exhibit Hall (CMCC lower level) |
Poster: 331
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| Ryan, Jennifer |
Wardyn, Amy
Kaminksi, Ashley
Elrefai, Sara |
Cancer Screening for Patients With Intellectual Disability: Exploring Parent and Caregiver Perspectives
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Intellectual disability (ID) is defined as a combination of deficits in cognitive and adaptive function, both of which must be present early in life. Adults with ID frequently have unique healthcare needs; however, they also require care that is routine for all adults. This includes cancer screening. The goal of this study was to evaluate whether or not adults with ID are undergoing cancer screening, understand the barriers they have faced in obtaining screening, and collect recommendations from parents and caregivers on ways to improve access to and facilitate screening for this population. We surveyed parents and caregivers of adults with ID via an original electronic questionnaire on REDCap. Data from 20 respondents was analyzed using frequencies, percentages, and quotes from open-ended responses. Twelve patients were noted to have a family history of cancer, and nine had undergone one type of cancer screen at least once. The majority of parents or caregivers had thought about cancer screening for the patient with ID and had mentioned this topic to healthcare providers in the past. Respondents cited a variety of barriers to obtaining cancer screening for the patient with ID, including lack of healthcare provider knowledge in how to care for adults with ID and the inaccessibility of routine cancer screening options. Some suggestions to improve accessibility of cancer screening included better communication between caregivers and medical professionals, alternative, less invasive screening options, and the ability to bring a support person or item to appointments and procedures.
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1:00-2:30 p.m.
Columbia Ballroom (CMCC upper level) |
Poster: 74
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| Edson, Isabelle |
Cranmer, Robyn |
Social Media Manager Internship
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During the fall semester of my senior year, I worked as the social media manager for a small business, Seed to Spoons. The owner of the business had no spare time to devote to marketing, so developed a social media marketing strategy after extensive market research. Each week after using my strategy, I would track the Meta Business Suite insights to see my progress. My strategy was a success and I ended up doubling the number of Facebook followers after only 3 months of managing and gaining some new customers. During this internship, I learned how to apply what I have learned in the retail major to help a small business grow. It made me feel confident in my studies to see the effects of my hard work adding value to a company. I have spent a lot of time and money in the pursuit of my diploma, so it can feel scary not knowing if it will pay off for the rest of my life. I believe that by applying what we have learned to work experience while still in school, we can gain even more knowledge about the field and gain confidence in ourselves. After my internship was over, the owner Seed to Spoons asked me to continue working as the social media manager.
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1:00-2:30 p.m.
Exhibit Hall (CMCC lower level) |
Poster: 256
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| Lyczek, Sophie |
Morris, Caleb |
Navigating Washington D.C. Through the Demands of Polarizing Politics
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During the Spring of 2023, I participated in the Washington Semester Program (WSP) through the Honors College. The WSP allows students to work full-time at an internship of their choosing while taking two night classes in Washington D.C. I chose to apply for the program as I had no prior internship experience as a Junior in college and felt lost in my career path. During my semester, I worked for my own representative, Congressman Ralph Norman (SC-05). The internship provided me with my first hands-on application to politics and allowed me to see behind the scenes of legislation. More specifically, I was tasked with drafting constituent response letters, conducting tours of the Capitol, and researching different political issues to help staffers formulate bills. The most eye opening part of the semester was the reality of bipartisanship between members of Congress that is often not portrayed in the media. D.C. is the center of networking for politics and, thus, the capital for communication. I learned that to get legislation passed, compromise must occur. Participating in this program has reaffirmed my passion for pursuing a career in politics to help those at home. Because of this, I plan to move back to Washington D.C. and work on the hill come May.
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9:30-11:00 a.m.
Exhibit Hall (CMCC lower level) |
Poster: 283
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| Davis, Elizabeth |
Wirth, Michael
Dawson, Robin |
Crafting Resilience
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Background/Significance: Nursing is a physically and emotionally demanding profession. The varying challenges that come with the job, paired with the demands of the profession, lead to burnout among many nurses. This burnout has even been found to occur in nursing students. There is a lack of research about the role of resilience in navigating or avoiding burnout, what factors promote resilience, and how people develop resilience.
Purpose: The aim of this study was to explore personal factors and/or health behaviors (e.g., physical activity, sleep, and diet) associated with resilience in nursing students.
Methods: A cross sectional survey was used to collect resilience levels, demographics, health behaviors, and personal traits of nursing students. Correlations, ANOVA, and T-tests were used to examine proposed associations.
Results: Participants included ninety-one students enrolled at the College of Nursing, University of South Carolina. Factors such as good sleep, excellent self-perception of overall health quality, more physical activity, and strong social support were associated with higher resilience levels. No associations were observed between burnout and resilience.
Conclusion/Implications: These results may help guide students, nurses, and nursing programs with how to modify health habits to help this population increase their resilience levels. These results also suggest that resilience does not prevent burnout and further research is needed.
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1:00-2:30 p.m.
Exhibit Hall (CMCC lower level) |
Poster: 137
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| McClendon, Grayson |
Michalos, Alexis |
Reporting for the Carolina News and Reporter
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Abstract Text
Senior Semester is the capstone experience for Journalism and Broadcast Journalism majors at USC. The School of Journalism and Mass Communications became my home, where I met the 9am-5pm requirements Monday through Friday. Instead of taking Carolina Core classes, participating in an internship or having a job, the 13 other multimedia journalists and I fully embraced our Senior Semester experience. The purpose of Senior Semester is to give the students an opportunity to be in a newsroom-like setting. Our tasks were to report on local news, hold interviews, create video and capture images.
At the beginning of Senior Semester, we were told to pick a mini-beat, which is a journalist’s specific area of reporting. I chose to focus on local women entrepreneurs in Columbia, writing mostly about small businesses around the area. This started out with reporting on the opening of Farmers Market Xchange in the Vista and the rise in popularity of fitness studios in Columbia. These stories were both called dailies, which are stories that are on the shorter side and should be able to be completed in a day or so. We also wrote longform stories, which is a more in-depth story that takes three weeks to publish.
The most impactful longform story I wrote was titled The Beirut bombing 40 years later: Columbia’s Tony Rodriguez tells his survival story.
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1:00-2:30 p.m.
Exhibit Hall (CMCC lower level) |
Poster: 307
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| Izquierdo, Ciara |
Deweil, David |
Going Places
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Abstract Text
During my collegiate experience, I have studied abroad in San Jose, Costa Rica and Alicante, Spain. Broadening my global awareness, I have experienced differences in Spanish culture and their healthcare systems. I am an Exercise Science major with a double minor in Dance and Spanish, in hopes to matriculate in Emory’s DPT program June 2025. University of South Carolina’s Global classroom has offered a variety of countries and locations to visit while expanding the knowledge of cultures and first-hand experiences. The experiences I have undergone in Costa Rica and Spain were significant, which in turn led me to pursue physical therapy as preventative care. The time I spent abroad came with understanding the differences in healthcare systems and the health-disparities that affect everyone. My Spanish-speaking country experiences and travels, allowed me to recognize that taking preventative measures can lead to a decrease in illnesses and death. Through the experiences of serving the community of UofSC and Columbia, understanding cultural competency, and taking on preventative measures, I learned that it is important to take action and interact with a growing diverse population. Ultimately, these experiences led me to want to advocate to abolish health-disparities in the public healthcare system and create equitable opportunities for healthy living, specifically in the underserved population.
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1:00-2:30 p.m.
Exhibit Hall (CMCC lower level) |
Poster: 237
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| Guida, Jacob |
Morris, Caleb |
Situational Leadership
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Abstract Text
During the Summer of 2023, I attended a professional development training for the United States Air Force. This training took place in Montgomery, Alabama for three weeks. During this training I was placed into several different situations where I had to lead. I was in charge of 19 individuals and had to lead them through their Field Training, a requirement to commission into the Air Force as a Second Lieutenant. There were times that would come up that would require me to be more hands on and direct with the people I was in charge of. However, there were also times where I could sit back and let them lead and make the decisions for us. As time went on, I was able to adapt more to my role and figure out what each situation required from me as the leader. I believe that for someone to truly be a situational leader it takes them figuring out what it is they are tasked with first. Then figuring out how as a leader they can achieve the mission whether it is through themselves or through the people they lead.
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9:30-11:00 a.m.
Exhibit Hall (CMCC lower level) |
Poster: 340
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| Yergler, Patrick |
Wisinski, Jeffrey |
Shoulder work ahead: You have not seen this shoulder sign
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Abstract Text
History:
A 26-year-old right hand dominant male presented to an orthopedic office for evaluation of difficulty lifting overhead bilaterally. Patient states that he has always had difficulty with overhead activity, but that he recently started weight training and had significant weakness and balance issues with overhead activity compared to the rest of his workout routine. He decided to continue working out other muscle groups until he was able to be evaluated. He denied any issues participating in sports throughout his childhood but mentioned that he was always told that he had "interesting form" when it came to throwing and other overhead motion. The patient also described tenderness to deep palpation on his shoulders anteriorly and posteriorly as well as being bullied for the odd appearance of his shoulders
Physical Examination:
Bilateral bony prominences were appreciated 2 mm proximal to the glenohumeral joint, and superior to the distal clavicle. These bony prominences are 1 inch in height and are rounded at the end of the projection. Deep palpation of the prominences elicited pain and sensitivity unrelated to the pain causing presentation. Further physical exam revealed elicited pain with internal rotation of the shoulder and pronation of forearm on the left. He also had a positive O'brien's and a positive bicep load test. He was able to push superior against resistance with minimal weakness. Lastly, the boney structures of the scapular spine were not palpable
Differential Diagnosis:
1. Superior Labral Tear
2. Congenital Defect of the scapula
3. Supraspinatus Tendonitis
4. Supraspinatus tear
5. Bicep Tendonitis
Tests & Results:
Imaging of the shoulder started with an initial anteroposterior x-ray of bilateral shoulders. X-ray revealed bilateral absence of acromion processes/scapular spines with rotation and thickening of free-floating clavicular ends producing the bony prominences. The glenoid, coracoid, and humeral head remained in normal anatomical position. MRI confirmed anatomical malformation. Muscular attachments of the deltoid and trapezius were difficult to appreciate. No cuff tears noted. Superior labral tear.
Final/Working Diagnosis:
Bilateral agenesis of the scapular spine and acromion. Mild superior labral tear of left shoulder
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1:00-2:30 p.m.
Columbia Ballroom (CMCC upper level) |
Poster: 151
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| McCommon, Jackson |
Harik, Ramy |
Developing a Green-State Thickness Model of Thermoset Composites Manufactured with Automated Fiber Placement
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Abstract Text
The Automated Fiber Placement (AFP) process utilizes advanced composite materials to produce structures that are commonly used on aircraft and other aligning industries. The AFP process consists of laying strips of composite materials on a desired tool surface to construct a part. The strips are referred to as tows, and are placed onto the tool surface in groups, which are called courses. Courses are laid up until a desired surface area is covered, which constitutes a ply, and multiple plies are laid on top of each other to form a laminate. Tows can consist of materials like carbon, glass, and aramid fibers pre-impregnated with resin to construct a part. Once a full laminate has been laid up on the tool surface it is considered to be in a green state. The next phase is to cure the part which results in the final structure. The advantage the material used in AFP provides is the impressive mechanical strength that can be achieved while also maintaining lightweight properties. In the aerospace industry especially, AFP is becoming more prevalent every day, making every bit of optimization more valuable.
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1:00-2:30 p.m.
Exhibit Hall (CMCC lower level) |
Poster: 100
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| Buening, Kylie |
Spence, Gina |
Cultural Preservation and Impacts on Marine Science
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Abstract Text
My presentation will focus on the preservation of Maori culture in New Zealand and how culture and environmental/marine science go hand in hand. In order to make insights about these different topics, I have spent a Maymester in the Galapagos studying Biology and completed a two-month internship in New Zealand where I worked with a university research group studying different species of dolphins and toothed whales in the surrounding waters. My observations during these trips related back to multiple classes I took while at USC, including Oceans & Human Health, Linguistics, and Understanding Other Cultures. I will discuss the means in which Maori language usage has grown exponentially in recent years through governmental influence, and how indigenous and non-indigenous New Zealanders may feel differently about the everyday language implementations. I experienced this through everyday experiences such as reading emails, taking the bus back and forth to my internship, and conversing with my internship supervisor and family friends about the increased indigenous language use. I will also showcase the cyclical relationship between human and environmental health, especially through the usage of marine mammals as indicator species. This relates directly back to experiences I had in the Galapagos having to do with pollution and the public health issues in the area, as well as different observations I made about cetacean health in my New Zealand internship. Finally, I will detail how there are intricate relationships present between the public and environmental researchers, especially in New Zealand. This observation comes from my New Zealand internship, where research on stranded dolphins and whales was controlled by the decisions of Maori whose stretches of beach the animals landed on. My main takeaways from these beyond the classroom experiences were that the viewpoints of indigenous cultures by different groups in society are complicated, and that human health and environmental health go hand in hand.
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1:00-2:30 p.m.
Exhibit Hall (CMCC lower level) |
Poster: 246
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| Scott, LaPortia |
Hogan, Abigail |
Analysis of Expression of Social Fear in Children with Neurodevelopmental Disorders
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Abstract Text
Social anxiety is a socially debilitating form of anxiety that is characterized by extreme fear in social and unfamiliar environments due to the thought of negative evaluation from others. While social anxiety is often diagnosed and intervened on later in life, once the symptoms are fully expressed and debilitating, early intervention can help reduce the anxiety. Social fear, or fear of social situations and strangers, in early childhood is a strong indicator of later social anxiety. Among individuals with neurodevelopmental disorders, such as Fragile X Syndrome (FXS) and Autism Spectrum Disorders (ASD), social anxiety is one of most frequent co-occurring anxiety disorders and contributes to poorer outcomes and quality of life. Despite high rates of co-occurring social anxiety in these disorders, very little is known about early indicators of social anxiety (e.g., social fear). A better understanding of how social fear is expressed early in childhood in FXS and ASD can help improve early identification of children at elevated risk for social anxiety, which in turn facilitates early preventative intervention. The current study uses the Stranger Approach press of the Modified Anxiety Dimensional Observation Schedule (M-Anx-DOS) to investigate how children with FXS and ASD express social fear compared to typically developing (TD) children. Expressions of facial fear, verbal fear, and postural fear were coded from video and will be compared between groups to determine (a) if social fear is elevated in FXS and ASD; and (b) if the pattern of expression of social fear differs between children with FXS and children with ASD. The study includes 35 children with FXS, 48 children with ASD, and 24 TD controls, all between the ages of 2.83 and 6.56 years. Groups will be compared on the three fear variables (i.e., facial fear, verbal fear, postural fear) using analyses of variance (ANOVAs) to determine whether children with FXS and ASD exhibit elevated social fear and if they exhibit similar patterns of social fear expression.
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9:30-11:00 a.m.
Exhibit Hall (CMCC lower level) |
Poster: 131
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| Garrett, Morgan |
Hair, Nicole |
Marketing At Sea
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Abstract Text
Semester at Sea is a 4-month study abroad experience where you live on a ship and explore 11 different countries in 3 continents. On the boat, we took classes as a college would normally, and then every week we would stop in a new country to apply our classroom learning to. For each class, we would have one day in one country to go with our classmates to visit places of our professors choosing. For International Marketing, our field class was in Jordan. I have always been interested in International Marketing, so having the opportunity to take that class and apply the content to our field class in Jordan was such an eye-opening experience. As we learned about Hofstede’s Cultural Dimensions and how they apply to Asia and Europe along with what we know about the United States, I made connections that I would never see as clearly if I was only in the classroom. In Jordan, we visited two very different places and evaluated where the Cultural Dimensions compared and contrasted. Visually noticing different behaviors even within these two places in Jordan was very interesting. In my presentation, I will be talking about how I learned to tailor messages to different groups of people during my time abroad and how that changed my mind set for future marketing endeavors. I will be comparing both places marketing tactics and how Hofstede’s theory shifts the perspective to reach their target market best.
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9:30-11:00 a.m.
Exhibit Hall (CMCC lower level) |
Poster: 244
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| McLean, Madelin |
Keane-Dawes, Antony |
Finding Myself in Football
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Abstract Text
Last summer, I had the incredible opportunity of interning with the Los Angeles Rams within their football operations department. My internship lasted the entire duration of training camp where I had responsibilities that included overseeing the entire team’s day-to-day scheduling, the 45-person rookie class with their onboarding and engagement sessions as they transitioned into the world of professional football, coordinating team travel for over 100 individuals, and assisting all of the coaches and players when needed. Within team side operations, you often become a liaison for not only the team but for their 200+ family and friends to provide logistical information, in addition to all of the support staff working in various departments. This internship allowed me to be directly involved with our training camp practices, three preseason games, as well as joint practices with Las Vegas Raiders and Denver Broncos. I had the unique responsibility of being the team lead for our last preseason game versus the Broncos where I was a part of the 7-person advance team to Colorado. I was tasked with leading the preparation of the team’s arrival on top of overseeing the entire check in process for all of the players, coaches, and additional staff traveling from Los Angeles. This internship allowed me to gain proficiency in technological applications that included Teamworks, Figma, and flight manifests. As I pursue the professional and civic engagement pathway as a Sport and Entertainment Management major at the University of South Carolina (USC), this opportunity allowed me to gain firsthand experience in the football industry while being able to utilize what I have learned from within the classroom. Participating in this experience has reaffirmed my decision to continue pursuing football operations at the professional level upon graduating from USC. In regard to my final presentation, I will be discussing the pivotal moments that I experienced while working in various leadership roles throughout the Rams organization as well as how my responsibilities helped me to exponentially grow as an individual and better employee.
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1:00-2:30 p.m.
Exhibit Hall (CMCC lower level) |
Poster: 314
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| Samuel, Roshni |
Cranmer, Robyn |
Exploring the Healthcare Disparities and Culture of Panajachel
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Abstract Text
As the Capstone medical service-learning trip brought me to Panajachel, Guatemala, the breathtaking sight of Lake Atitlan and the majestic volcano that sat on its shores left me in awe. Amidst the enchanting beauty of this city and its surrounding landscape, it was impossible to overlook the reality that many of its residents faced: poverty, healthcare disparities, and the lack of other necessary resources. I was drawn to participating in this trip to gain clinical experience that would solidify my passion for medicine and to use my privilege of education to give back to a community in need. The very first day of clinic in the village included house visits, where we went from house to house with a local doctor to gather the medical histories of potential patients, to observe their living situations, and to invite them to the weeklong clinic that our Capstone cohort would be assisting. It was a truly eye-opening experience seeing how far apart the houses were, the lack of a proper toilet system, and the lack of water access. Being able to meet patients and gaining that understanding for how they live and seeing what they do for work was an experience I will never forget. The rest of the week consisted of our cohort being split into teams of three in which we worked alongside local doctors and translators to provide free medical care to the population of various Guatemalan villages. Our main tasks were to gather patients’ medical histories, obtain their vitals, and discuss possible diagnoses and treatment plans with the physicians. These interactions with patients not only provided valuable clinical exposure but also afforded me the opportunity to immerse myself in Guatemalan culture, observing customs, attire, and culinary practices. Beyond clinic hours, exploring Panajachel and engaging in cultural activities further enriched my understanding and appreciation of diverse perspectives. Participating in a medical mission trip abroad grew my passion for addressing healthcare disparities, embracing diversity, and the importance of health education.
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9:30-11:00 a.m.
Exhibit Hall (CMCC lower level) |
Poster: 251
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| Grogan, Marissa |
Morris, Caleb |
APPAS - Shaping Personal and Professional Development
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Abstract Text
Student organizations are a key part of getting acclimated, promoting personal growth, supporting academic success, meeting people with similar interests and goals, as well as pursuing to better yourself and those around you to foster long-lasting friendships and relationships. My most notable contribution to the University of South Carolina is my participation and commitment to guide others in their paths to graduate school, more specifically Physician Assistant school. As an active member of the Association of Pre-Physician Assistant Students, it became apparent how beneficial this organization was and how much the older students helped me in my beginning stages. I then decided to campaign for social director of the club where I was peer-elected for this position. Through this position, I have gained leadership skills as well as organizational and communication skills. I had to quickly learn and adjust my outlook to be fair and comparable to 150 other students. My presentation will discuss the insights I have gained on adjustments and leadership skills, as well as the crucial effects APPAS has had on molding me into the person I am today.
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1:00-2:30 p.m.
Exhibit Hall (CMCC lower level) |
Poster: 308
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| Reed, Bronwyn |
Tandon, Keah |
Cultural Immersion and Personal Growth: My Semester Abroad
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Abstract Text
In the Spring of 2023, I embarked on a transformative journey studying abroad in Madrid, Spain at IE University (Instituto de Empresa). This choice was driven by my enduring passion for the Spanish language and my dedication to cross-cultural communication. With a foundational understanding of Spanish from high school, and my Spanish minor at USC, I aimed to improve my language skills, traverse beyond my comfort zone, and broaden my worldview. Throughout my five-month semester abroad, I had the amazing opportunity to experience Madrid's rich cultural landscape. I participated in new academic environments and explored various European countries as well. I built on my classroom knowledge by making meaningful relationships with native Spanish speakers, and fostered enduring connections that transcended borders. Moreover, I experienced a diverse set of lifestyles, and learned a plethora of customs from other countries. Through these experiences, I not only strengthened my Spanish communication skills, but also cultivated resilience, adaptability, and perseverance. I navigated through the typical phases of study abroad: from the exhilarating highs of the "honeymoon phase" to the daunting challenges of culture shock, homesickness, and unfamiliarity. Gradually, I grew accustomed to my life in Europe and adapted to my surroundings. I developed a greater sense of independence, and maintained agility within difficult situations. My experience abroad has laid an incredibly solid foundation for my future endeavors. As I move forward, I am determined to approach my professional life with strength amidst uncertainty, and determination despite challenging circumstances. In an increasingly globalized world, I will strive to connect with individuals from diverse cultures and backgrounds to achieve common goals. In my personal life, I will cherish the relationships I forged abroad and remain confident in my ability to overcome any obstacle that arises.
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9:30-11:00 a.m.
Exhibit Hall (CMCC lower level) |
Poster: 252
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| Plakas, Christina |
Manick, Ashley |
Books Behind Bars: The Power of Book Clubs in Correctional Settings for Incarcerated Participants
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Abstract Text
The bulk of scholarly research on correctional programs is centered on evaluating formal long-term educational and vocational programs. These studies typically evaluate large-scale programs, such as GED classes, in order to determine if they decrease recidivism rates. These programs, however, often exclude large portions of the prison population, are susceptible to budget cuts & changing socio-political climates that affect the longevity and support for these programs, and do not focus on improving the mental well-being of incarcerated individuals. There is thus a lack of substantial research done to evaluate informal short-term programs that solely revolve around providing workshops and lessons that prioritize improving the mental health of detainees. I intend to address this gap in correctional literature by developing a conceptual framework as to why book clubs implemented in correctional settings have the potential to promote successful outcomes in the well-being of incarcerated individuals by promoting the following: education, community, and purpose. Book clubs are also a more inclusive and sustainable type of program as they welcome all detainees and they do not rely on taxpayer money, limiting the role politics has on the success of the program.
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1:00-2:30 p.m.
Columbia Ballroom (CMCC upper level) |
Poster: 26
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| Walker, Makayla |
Matthews, Sarah |
Being Comfortable with the Uncomfortable
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Abstract Text
I have spent every summer during college as a participant of the Medical Experience (MedEx) Academy with Prisma Health in Greenville, SC. The purpose of MedEx Academy is to expose students to various careers in healthcare to increase the number of healthcare providers in South Carolina. I was drawn to this program given the opportunity it provides to pursue my passion for medicine, be able to shadow physicians, and receive mentorship along my journey to applying for medical school. During the summer of 2023, I participated in Tier 4 of the program which consisted of shadowing experiences, medical school mock interviews, and application preparation. As a student intern in Tier 4, I had multiple shadowing experiences in specialties such as OB/GYN, pediatrics, and psychiatry. I also engaged in various workshops focused on different interview questions and formats for medical school such as group, multiple mini-interviews, and independent interviews. I also received guidance on my application, including curating my personal statement. Because my role consisted of a lot of independent work, I was tasked with setting goals and creating a timeline for myself to accomplish these goals. I was also responsible for reaching out to my lead interns, mentors, and peers for assistance with my application as needed. While rewarding, navigating this experience was unfamiliar and required vulnerability, especially while preparing applications, personal statements, and interview responses for medical school. The transferrable skills that I identified through UNIV101 as a first-year student, such as written and verbal communication, helped me navigate new situations and succeed in unfamiliar environments. Through my experience during MedEx, I have learned to be more comfortable with being uncomfortable. Vulnerability was the biggest takeaway from MedEx and I truly believe it is something that will allow me to be a better friend and an extraordinary physician in the future. I hope that others who find themselves in my position can learn to sit with their life experiences in hopes of being able to talk openly and freely about them.
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9:30-11:00 a.m.
Exhibit Hall (CMCC lower level) |
Poster: 320
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| Ngo, Nhi |
Roberts, Jane
Hunt, Erin |
Physiology, Anxiety, & Parenting Stress in Mothers of Children with Neurodevelopmental Disorders
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Abstract Text
Autism spectrum disorder (ASD) and Fragile X syndrome (FXS) are neurodevelopmental disorders (NDDs) marked by developmental delays and social-behavioral challenges. Mothers of children with FXS with the FMR1 premutation (FXp) are at increased risk for anxiety due to elevated genetic risk. Mothers of children with ASD and FXS also exhibit lower respiratory sinus arrhythmia (RSA), an index of physiological regulation shown to support emotional adaptation. Reduced capacity for physiological regulation, elevated anxiety, and child behavioral challenges may increase vulnerability for higher parenting stress. This study examines the associations between RSA, heart rate (HR), trait anxiety, and parenting stress in ASD and FXS mothers. We hypothesized that lower RSA and higher HR would be associated with greater anxiety symptoms and parenting stress across groups.
Participants included the FXp group (n=29; Mage =35.59, SD=6.39) and the ASD group (n=35, Mage =37.50, SD=4.79). Heart activity was recorded during a resting period and processed via CardioEdit/CardioBatch softwares (Porges, 2007). Trait anxiety (State-Trait Anxiety Inventory; Spielberger et al., 1983) and parenting stress (Parenting Stress Index-Fourth Edition, Short Form; Abidin, 2012) were measured via parent -rating scales. Pearson's correlations and multiple linear regressions were used to examine associations between variables and group differences. FXp and ASD groups did not differ on RSA, HR, trait anxiety, or parenting stress. Heart rate was significantly related to parenting stress for the ASD group only (r(34) = -.37, p<.02) and trait anxiety for the FXp group only (r(22) = .48, p <.02). RSA was not associated with trait anxiety or parenting stress for either group. Elevated trait anxiety (t = 2.10, p = .04), but not group or group*anxiety interaction, significantly predicted greater parenting stress (F(3,31) = 6.72, p < .01) across groups.
Findings suggest that parenting stress for the ASD group and trait anxiety for the FXp group are associated with physiological regulation likely driven by sympathetic input. Trait anxiety may predispose parents of children with NDDs for greater parenting stress. Similar results between groups suggest similar interventions and resources may benefit both FXp and ASD groups to help manage and support parenting stress and anxiety.
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1:00-2:30 p.m.
Exhibit Hall (CMCC lower level) |
Poster: 176
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| Hamilton, Bridget |
Dawson, Robin |
School Nurse Crisis in Georgia Impacting Student Outcomes: An Analysis of Staffing and Academic Outcomes
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Abstract Text
Background
School nurses have been identified as key personnel who foster connection, especially for the most marginalized of students by decreasing absenteeism and providing a “safe space” for students who are struggling in their relationships. It has been posited that school nurses affect academic outcomes due to these factors, but little research has explored this. This research project sought to understand if school nurses played a significant role in academic outcomes in schools across Georgia.
Methods
Secondary data was collected from GADOE College and Career Readiness Performance Index (CCRPI) and staffing headcounts by school district for the 2019 school year. Rural-Urban Continuum Codes (RUCC) from the USDA and Social Vulnerability Index (SVI) total scores from the CDC were also collected. Data was analyzed for relationships.
Results
Urban school districts had more school nurses as compared to rural districts. In addition, it was discovered that 7 school districts had no school nurses on staff. Districts located in counties that were the most urban had an average of 76.21 on the CCRPI, 20.3 school nurses, 5.76 nursing assistants, and 1.3 special education nurses. School districts located in the most rural counties had an average of 72.97 on the CCRPI, 1.88 school nurses, 0.13 nursing assistants, and 0 special education nurses. Urban counties with large populations of economically disparaged groups saw higher CCRPI scores and higher staffing levels of school nurses than their rural counterparts. Linear regression showed statistical significance between school nurse headcount numbers and CCRPI score.
Discussion
The analysis revealed school health staffing disparities across the state of Georgia with urban counties being better resourced in terms of school health personnel. The data indicates that rural schools with lower enrollment are often left without access to school health services. The analysis also revealed that school health resources may be impacting academic outcomes. It may be possible that the magnitude of this disparity is having an even greater effect, especially in the low resourced school districts post-COVID-19. Future work will focus on understanding the factors driving the disparity in school health personnel and further understanding how school nurses impact academic outcomes.
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1:00-2:30 p.m.
Columbia Ballroom (CMCC upper level) |
Poster: 30
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| Eubanks, Rachel |
Swain, Laura |
Theta Power and Emotion Regulation in Caregivers Before and After a Parenting-Focused Intervention
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Abstract Text
Emotion Regulation (ER) refers to mitigating emotions’ intensity (Ochsner and Gross, 2005), and is correlated with positive parenting behaviors and secure attachments with children. The Dialectical Skills Training for Parents (DBT4P) program was started in USCA this semester as an eight-session intervention aimed to improve behaviors known to increase parenting effectiveness, including ER. This is a novel intervention program that incorporates multiple therapeutic strategies, yet this intervention has not been experimentally tested to support whether ER skills do improve. Therefore, our study will utilize pre and post measurements to assess any improvements in targeted behaviors. My specific aspect of the study pertains to brain activity associated with these targeted behaviors, specifically ER.
Method: Electroencephalogram (EEG) sessions will occur pre- and post-DBT4P to help assess brain changes in the parent group between sessions and correlations in behavioral ER outcomes. More specifically, this is a within-subjects experimental design that will test the effect of DBT4P (independent variable) on ER and theta power (dependent variable). Participants (N = 20) will complete an EEG task that will involve a computer-based paradigm that randomly displays images of either neutral or negative visual stimuli paired with a command to regulate the induced emotion.
Analyses: Using a Fast Fourier transform, theta power will be examined from electrodes F3, Fz, and F4 after it is normalized using the ratio of theta during task (ER during the image) over baseline (pre-stimulus) theta power. Theta power as well as ER scores pre-and post-intervention will be analyzed using a repeated measures ANCOVA in SPSS, including age as a covariate. Additionally, theta power pre-intervention will be entered into a regression model to determine if this can predict the change in ER scores pre and post intervention (ERt2 - ERt1).
Conclusions: This research will help evaluate the effectiveness of the new DBT4P program as it pertains to changes in brain activity. Additionally, our results will determine if intervention success can be predicted by these neural changes. If treatment outcomes are successful, our research will help to identify predictors of this success for future implementation and guidance on parenting interventions.
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1:00-2:30 p.m.
Exhibit Hall (CMCC lower level) |
Poster: 197
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| Mason, Emily |
Cofsky, Caroline
Llorin, Hannah
Christensen, Kurt |
Perceptions of Alzheimer’s Actionability Among End Users of Direct-To-Consumer Genetic Tests
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Abstract Text
The APOE ε4 allele is the best-known genetic risk factor for developing late-onset Alzheimer’s disease. Although new evidence is emerging, the extent to which lifestyle improvements can reduce Alzheimer’s risk needs further investigation. Research suggests that individuals with a higher genetic risk may be more likely to engage in risk-reducing health behavior changes following results disclosure. This study aimed to better understand these findings by assessing the health behavior and perceptions of Alzheimer’s actionability among consumers of DTC genetic tests. Our study revealed that individuals with 2 copies of the APOE ε4 allele were less likely to make lifestyle modifications as compared to individuals with 1 copy of the allele (p=.015, Fisher's exact test). Furthermore, there was a nonsignificant trend towards lower perceived actionability among individuals with 2 copies of the APOE ε4 allele compared to those with 1 copy. Ultimately, our results appear to reflect a sense of genetic determinism among our highest-risk cohort, whereby a reduced sense of actionability or control regarding disease development translates into a reluctance to modify lifestyle factors. More research is needed to understand the different responses among our genotype groups, and how genetic deterministic mindset may serve as an adaptation to a high risk for late onset Alzheimer's disease. Our study did identify that the decision to make lifestyle changes is largely driven by family history (p=.027). This finding has been demonstrated broadly in the literature, suggesting that an individual’s personal health context is a more reliable predictor of post-test lifestyle modifications than genotype. The results of our study may have important implications for genetic counselors when discussing results interpretation and integration of genetic test results.
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1:00-2:30 p.m.
Columbia Ballroom (CMCC upper level) |
Poster: 80
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| Mazurkiewicz, Claudia |
Cranmer, Robyn |
Creating My Dream Job: Social Media Manager on a Movie Set
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Abstract Text
Being a marketing major, interning on a movie set is one of the last places I expected to find myself at the beginning of last summer, but by the end the experience had completely changed the trajectory of the career I want to pursue. Having an interest in social media, I decided to take the unique opportunity to work with Local Cinema Studios on-set of a feature film they shot capturing content for their social media platforms. Taking a less traditional internship allowed me to push me further creatively, grew my strategic thinking skills, allowed me to lead a team to execute my vision and gave me hands on skills and added to my portfolio. It gave me ownership over these accounts that I could make my own and allowed me to explore and grow a passion of mine which is to share the stories of others to bring people together. By the end of the summer, I decided that film marketing was something I wanted to pursue a career in, and it’s a direction that I want to take my business in. Without stepping out of my comfort zone, I would have never discovered a career option that makes me as excited as this one.
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9:30-11:00 a.m.
Exhibit Hall (CMCC lower level) |
Poster: 279
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| Jameson, Quentin |
Edwards, Kathryn |
Christian Kabbalah: Cornelius Agrippa’s Alternative to Early Modern Contemporary Christian Beliefs
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Abstract Text
With his De Occulta Philosophia, Agrippa aimed to deliver a way for early modern occultists to unify with God, in doing so he established theoretical and applied principles for Christian Kabbalah, through reinterpretation of both mystic and practical Jewish Kabbalah.
In his encyclopedia on occult science, De occulta philosophia, Heinrich Cornelius Agrippa gives detailed explanations and sources on natural, numerical, and ceremonial magic. Although Agrippa was influenced by Johann Reuchlin and Giovanni Pico della Mirandilo he delivered his own interpretations of Kabbalah in his De occulta philosophia, formally establishing theurgical and ecstatic principals for Christian Kabbalah.
To discuss Kabbalah, I define the word and explore how occultists during and before Agrippa’s time discussed its practical and mystical aspects using primary and secondary sources. In my research I point out kabbalistic influences in Agrippa’s magic, where he is influenced by Reuchlin and Pico, and where he separates from the two. I also discuss what sources Agrippa most likely read and where they originated from.
My poster board will visually show my abstract, who Agrippa was, and my primary source on the center part of the board. The left side will show Agrippa’s letterism and numeric talismans and compare it to Judaic practical kabbalah and use of numeric magic. The right side will show my evidence of intentionality with direct quotes, and photos comparing his 1530 De vanitate to the final draft of his 1533 De occulta philosophia.
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9:30-11:00 a.m.
Exhibit Hall (CMCC lower level) |
Poster: 9
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| Noland, Caroline |
Epps, Lauren
Adame, Dylan |
Merci Paris!
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Abstract Text
For all of 2023, I had the opportunity to study abroad through the Darla Moore School of Business. My study abroad experience was a part of my international business cohort called the RIL (Responsible International Leadership) cohort. From January to December 2023, I studied at ESSEC Business School right outside of Paris, France. My coursework focused on learning about sustainable marketing practices and strategies. Whilst being at the international university, I was able to expand my knowledge of different cultures and gain an increased cultural awareness. Through interaction with my classmates, I was able to gain valuable insight into working with people from backgrounds different from my own, which has prepared me for international work in the future.
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1:00-2:30 p.m.
Exhibit Hall (CMCC lower level) |
Poster: 247
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| Sanders, Ella |
Deckert, Jennifer
Megerdichian, André |
Motivation, Execution, and Effectiveness of a Pre-Semester Strength Training Intensive for Collegiate Dancers
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The objectives of this research were to examine the effectiveness of a pre-semester workshop in encouraging strength training behaviors and identify commonly experienced barriers to strength training for collegiate dancers. Dancers have reservations surrounding strength training due to unfounded fears of interference with artistic elements and aesthetic aspirations embedded in dance culture. As physical demands of new, innovative choreography continue to escalate, implementation of strength training in a dancer’s cross training regimen can significantly help reduce risk of injury, increase metrics of power and flexibility, and allow dancers to focus on artistry. Collegiate dance programs must equip their students with the knowledge of how to supplement their dance training with safe strength training form and principles.
This research was deemed exempt by the institution’s IRB review board. The workshop lasted two weeks; programming consisted of two upper body days, two lower body days, and one plyometric day. Four collegiate dancers who attended the pre-semester workshop consented to participate in surveys over the course of sixteen weeks. Data was exported and analyzed at the conclusion of the semester.
Results of the four case studies were analyzed independently, but several trends were observed including the inverse relationship between dance exposure hours and number of strength training sessions, desire for motivation through community, and intention to continue strength training. All four dancers described benefits of strength training in their responses to the open-ended questions. Time, fatigue/soreness, academic obligations, and social obligations were cited as the four most prevalent barriers to strength training.
An expansion of this pre-semester workshop into a semester-long, credit-bearing course may mitigate several of these barriers, especially time and academic obligations, as well as provide motivation of community. Further research with a larger and more gender diverse sample is needed to generalize findings to all collegiate dance programs. By seeking to understand dancers’ hesitations surrounding strength training, changes can be made at an institutional level to best prepare collegiate dancers for the professional realm.
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1:00-2:30 p.m.
Exhibit Hall (CMCC lower level) |
Poster: 15
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| Prillaman, Emily |
Wellman, Denise |
Campus Conversation: Connecting with Carolina Students
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Starting August 2023, I began working as a student editor of the university's undergraduate email. In this role, I keep people informed about campus events, write weekly feature articles, and conduct interviews with students. My goal is to provide students with quick and concise university-related information. I track click rates to provide students with the most relevant content, tailoring my writing each week to keep their attention. Developing website content has taught me valuable multitasking and analytical skills. This spring, I will train the next student editor on writing in AP style, website content creation, and interviewing to continue the tradition of sharing valuable information. My favorite part about my job is the Campus Conversation, an interview and photo of a student on a different topic of their choosing. The featured stories must remain neutral and applicable to all students, so this is an opportunity to spotlight unique voices. Each week, I pull a blurb from an interview with a student who discussed their passions, organizations, or leadership around campus. For instance, I interviewed the kicker of Gamecock football, a twirler in the band, students from the National Pan-Hellenic Council, and students who started their own clubs on campus. I find students through friends, clubs, or word-of-mouth, and I track potential stories on a running Excel document. Through my conversations, I discovered that USC students are extremely ambitious and talented. By highlighting the diversity of experiences and perspectives of students at USC, I represent the student body. The Campus Conversation has made USC feel smaller, and it has connected me to this campus.
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9:30-11:00 a.m.
Exhibit Hall (CMCC lower level) |
Poster: 353
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| Washington, Chiffon |
Morris, Caleb |
How Providing Social Support Improves Health Outcomes of NICU Babies
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I had the pleasure of volunteering in the NICU as a baby hugger for 9 months. Unfortunately, many babies did not have families to visit them. Those were the ones that I made sure to spend several weeks with, showering them with the love and comfort that they lacked. I also helped them reach developmental milestones such as the acquisition of hand-eye coordination. As a prospective pediatrician, acquiring an experience that involves interacting with babies in a clinical setting was like a dream. I searched for opportunities to become a baby hugger for months, as I faced many COVID-19-related barriers. Through this opportunity, I became adapted to nurturing infants who were addicted to drugs, those that recently underwent surgery, one baby with a bleeding stoma, and many other adverse circumstances. I learned how to read monitors, and the purpose of several pieces of equipment in the NICU. I also learned that babies without frequent visitors tend to be fussier, experience more medical complications, and reside in the NICU for longer. This experience sparked my desire to do similar work, so I recently became a volunteer for Make-A-Wish. During my gap year, I plan to continue volunteering and become a medical scribe in a children’s hospital. It has also impacted my career desires, as I now aspire to become a neonatologist, a pediatrician who specialize in neonatal care. I want others to know that devoting a few hours each week to holding sweet babies could significantly improve their health outcomes.
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1:00-2:30 p.m.
Exhibit Hall (CMCC lower level) |
Poster: 277
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| Bullard, Brooke` |
Murphy, Elizabeth |
Panaxynol improves crypt and mucosal architecture, suppresses colitis-enriched microbes, and alters the immune response to mitigate colitis.
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Ulcerative colitis (UC) is an idiopathic inflammatory disease of the large intestine, which impacts millions worldwide. Current interventions aimed at treating UC symptoms can have off-target effects, invoking the need for alternatives that may provide similar benefits with less unintended consequences. This study builds on our initial data, which showed that panaxynol can suppress disease severity in murine colitis. Here we explore the underlying mechanisms by which panaxynol improves both chronic and acute murine colitis. 14-week-old C57BL/6 female mice were either given 3 rounds of dextran sulfate sodium (DSS) in drinking water to induce chronic colitis or 1 round to induce acute colitis. Vehicle or panaxynol (2.5 mg/kg) was administered via oral gavage 3x/week for the study duration. Consistent with our previous findings, panaxynol significantly (p<0.05) improved the disease activity index and endoscopic scores in both models. Using the acute model to examine potential mechanisms, we show that panaxynol significantly (p<0.05) reduced DSS-induced crypt distortion, goblet cell loss, and mucus loss in the colon. 16s sequencing revealed panaxynol altered microbial composition to suppress colitis-enriched genera (i.e., Enterococcus, Eubacterium, and Ruminococcus). Additionally, panaxynol significantly (p<0.05) suppressed macrophage polarization and induced regulatory T-cells in the colonic lamina propria. The beneficial effects of panaxynol on mucosal and crypt architecture, combined with its microbial and immune-mediated effects, provide insight into mechanisms by which panaxynol suppresses murine colitis. Overall, this data is promising for the use of panaxynol to improve colitis in the clinic.
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1:00-2:30 p.m.
Columbia Ballroom (CMCC upper level) |
Poster: 55
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Pazienza, Grace
Lucas, Alexandria |
Battle, Sarah |
Diagnostic mystery: a case of extreme hyperferritinemia and persistent fever
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Case Summary: 63-year-old male with PMH of HTN and CAD presented with a 2-day history of left knee pain and a sore throat. He was found to have fever to 103+, leukocytosis of 18.5 with left shift, ESR >130, and CRP 205. Synovial fluid analysis showed only 12,198 white blood cells. Further infectious work up included negative blood cultures, negative gonorrhea/chlamydia PCR, and negative mononucleosis screen. His initial ferritin was surprisingly significantly elevated at 7,716 and trended upwards daily until it reached peak of >40,000 on hospital day 3. He also continued to have daily fevers to 103+ despite broad coverage antibiotics. Extreme hyperferritinemia (ferritin >25,000) has a small differential, including potentially fatal conditions like hemophagocytic lymphohistiocytosis (HLH)/macrophage activation syndrome (MAS), acute hepatitis, malignancy, and septic shock. HIV and acute Hepatitis A/B/C labs were negative. CT neck/chest/abdomen/pelvis with contrast revealed no malignancy. For concern for HLH/MAS, he had no splenomegaly, no cytopenias, had elevated fibrinogen (HLH would have hypofibrinogenemia), and triglycerides were not elevated. Hematology agreed that his clinical picture was not consistent with HLH/MAS. After all potentially fatal conditions were ruled out, he was evaluated for another cause of extreme hyperferritinemia, Adult Onset Still’s Disease (AOSD). He met four of the five major Yamaguchi criteria (fever >39°C lasting 1 week, arthralgia lasting 2 weeks, leukocytosis >10,000 with >80% polymorphonuclear cells, sore throat). He did not initially meet the final major criteria of typical rash, however wife later mentioned that she did remember him having a rash prior to admission. He also met several of the minor Yamaguchi criteria with abnormal liver function tests, negative ANA, and negative RF. Ultimately, he was diagnosed with AOSD and was started on prednisone and then transitioned to canakinumab infusions. At clinic follow up, his symptoms have completely resolved. In addition, his ferritin, CRP, and ESR have all normalized, further confirming rare diagnosis of AOSD.
Conclusion: Extreme hyperferritinemia is associated with a short list of rare and potentially fatal diseases. Thorough work-up must be done to exclude conditions such as HLH/MAS and lymphoma. Yamaguchi criteria can be used to support a diagnosis of AOSD.
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9:30-11:00 a.m.
Columbia Ballroom (CMCC upper level) |
Poster: 149
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| White, Sela |
Kubickova, Marketa |
Building Community Through Communities in Schools
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Communities in Schools of South Carolina is a nonprofit that works to build relationships with students K-12 who are facing challenges. I have been an intern with CIS at both Sandel Elementary School and Airport High School working with the site coordinator to support students who are facing attendance, academic, behavioral, or socioemotional challenges. I have had the opportunity to lead small groups and work one one-on-one with students who need extra support. I mentor around 8 students and check in with them weekly to look at grades and attendance, and just check in on how their lives have been going. It has been rewarding to see the trust grow with the students and see them meet their goals! Keeping children in school all the way to graduation is a part of Communities in Schools mission and I have been proud to work with students to let them know that there is someone who cares about them at school encouraging them to graduate! This opportunity has benefited my professional goals by allowing me to have my own clients as I gain more autonomy and be able to support the students. Having real-life experience to be able to apply to everything that has been learned in my Social Work courses has been extremely valuable in bringing meaning to everything that I have learned. I have learned how to connect with people who come from all different walks of life by hearing their stories and realizing the importance of having a listening ear and someone who is knowledgeable about local resources. I have worked with students who are food insecure, are in foster care, and students whose families are unsheltered. Getting to serve them and their families by connecting them with resources has allowed me to build my toolbox of resources in the community. Working with Communities in Schools of South Carolina has been a valuable experience to learn from the site coordinators and the students that I have worked with.
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9:30-11:00 a.m.
Exhibit Hall (CMCC lower level) |
Poster: 256
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| Renken, Kaili |
Hancock, C. Nathan |
Does the NHP6A Protein Affect mPing Transposition in Yeast?
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DNA transposable elements are found in virtually all eukaryotic organisms and can jump around the genome and insert/excise themselves from the DNA. mPing is a Tourist-like miniature inverted repeat transposable element derived from the autonomous element, Ping. Currently, mPing is being developed into a targeting insertion tool for genome editing in plants. It has been shown that mPing, mobilized by transposase proteins, can be inserted into Cas9-cleaved sites. Our goal is to identify proteins that promote transposition and thus, increase the efficiency of mPing-based gene discovery and genome editing. A study found that HMGB1 protein increased the mobility of a Mariner-type transposon, Sleeping Beauty, in mammalian cells by bending the transposase binding site to facilitate transposase binding. This project is testing if NHP6A, the yeast homolog of HMGB1, affects mPing transposition. An overexpression NHP6A construct was made amplifying NHP6A and Gateway cloning it into the pAG426 GPD plasmid. NHP6A null mutant yeast will also be transformed with a hp_mPing:URA3 construct, designed to integrate into the genomic copy of ADE2. Using an mPing transposition assay that measures excision from ADE2, we will be able to determine the hp_mPing transposition frequencies with various levels of NHP6A. We anticipate increased transposition when NHP6A is overexpressed and decreased transposition in the NHP6A knockout. Moving forward, our next steps would be to test if expression of a NHP6A homolog in Arabidopsis will also increase transposition in plants.
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1:00-2:30 p.m.
Exhibit Hall (CMCC lower level) |
Poster: 61
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| Reed, Gabi |
Polley, Jeremy |
Bringing The Classroom Out Into The SEC
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I attended a conference known as the SEC Career Tour. They invite a student-athlete through the Southeastern Conference to attend a weekend long conference in Atlanta, GA. They invite 27 other student-athletes from other SEC schools, and you can meet others in the same shoes as yours just at different campuses. I applied for this opportunity because it was with the Southeastern Conference and the career field, college sports, that I would like to work in. I also felt that as a senior this was a perfect way to get in front of people and start networking for jobs and meeting people that I can connect with when I graduate.
In the mornings we had leadership and professional building seminars and then went out into the city and toured different companies around the area. Touring these companies, we were able to hear from their former student-athletes on how to develop transferrable skills from athletics into the corporate world. This was also an opportunity we could use to network with these companies and connect with their employees. From my class HRSM 301: Professional Development Seminar I already had a background in how to start networking and “pitching” yourself to others. However, I have also struggled with the concept of networking because it seemed so impersonal and that I was using them, but after this class I learned that it was so much more than networking, but it was building a genuine relationship.
The biggest highlight for me was I found it very helpful when we had the seminars in the morning and then went out to the companies where we could put the material into practice. One of the mornings we had a lecture done by Randy Hain, an author on leadership and wisdom where he taught us the “Trust Formula”. This was (Authenticity + Vulnerability) x Credibility = Trust. Randy was teaching us that to build true relationships you must be authentic and vulnerable with yourself first, then mix in credibility where you get trust, and building relationships is all on the foundation of trust.
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9:30-11:00 a.m.
Exhibit Hall (CMCC lower level) |
Poster: 345
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| McGee, Chloe |
Reese, Mollie
Pancholi, Suchita |
Addressing Key Contributors to Uncontrolled Diabetes: A Clinic-based Intervention
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Diabetes mellitus (DM) affects one in seven adults in South Carolina (1). If left untreated, DM has significant consequences including high healthcare costs, blindness, chronic kidney disease, neuropathy, and infections. Ensuring both proper treatment and adequate glycemic control are important for prevention of these devastating complications. The goal of this project was to first determine the key contributors to uncontrolled DM and then implement meaningful change in a clinic to reduce the number of patients with uncontrolled DM. We performed a retrospective observational analysis utilizing data from January 2021-March 2023 from Prisma Health Internal Medicine Ambulatory Care Clinic in Columbia, South Carolina to identify patients with uncontrolled DM. We identified that 198 patients had uncontrolled DM as defined by a hemoglobin a1c value greater than 9%. Chart review of the 198 patients in the electronic medical record system revealed the top three key factors that contributed to uncontrolled DM were medication adherence, access to resources, and being lost to follow up. With these results, a multidisciplinary team meeting will be conducted to continue developing and ultimately, finalize several change ideas to target the identified key factors with the goal of improving the clinic’s overall DM control rate from 67.15% to 77% by December 2024. Plan-do-study-act cycles will take place during Spring of 2024 to implement process changes, determine the effect on DM control, and make additional improvements to best care for patients with DM in the clinic.
Citations:
1. Diabetes impact - SCDHEC. (2020, February). Retrieved February 25, 2023, from https://scdhec.gov/sites/default/files/media/document/DISC%20Diabetes%20Impact%202020.pdf.
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1:00-2:30 p.m.
Columbia Ballroom (CMCC upper level) |
Poster: 203
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| Trombley, Emma |
Boyken, Julie |
How Golf Tournaments Changed My Perspective on Leadership
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I worked three mega golf tournaments during my time at USC because I wanted something to add to my resume as industry-related experience. I came in with no expectations of my experience beyond earning some extra money, and I came away with a newfound love for the sport and invaluable life lessons regarding leadership and how to effectively build a team. Although not fully aware of the fact, I had only really experienced dysfunctional teams during my time in the workforce, and the management within these country clubs showed me that's not the way it always has to be. The Players Championship taught me the necessity of finding ways to motivate your team and keep them excited about their job despite long hours and mundane tasks. The Masters Tournament taught me the effectiveness of using mistakes as a learning opportunity rather than a reason for punishment. The Presidents Cup taught me the importance of establishing good and consistent communication amongst upper management so that it can filter down to the communication styles of even the lowest-level staff. As a student worker who was with each tournament for a week or two at most, I only got to see the surface level of each country club's unique operational style, and yet I was able to dissect that each club’s leadership style revolved around supporting and building up their team. I learned that you can not be an effective leader if you are only focusing on yourself and your own success, and I now bring that with me into every job and experience I have.
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9:30-11:00 a.m.
Exhibit Hall (CMCC lower level) |
Poster: 332
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| Nashbar, Isabella |
Matthews, Sarah |
Addressing Local Healthcare Needs in Alajuelita, Costa Rica with FIMRC
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During Spring Break of 2023, I went to Alajuelita, Costa Rica with the Foundation for International Medical Relief for Children (FIMRC). In Costa Rica, we helped run a volunteer-based clinic that served children and women without government medical coverage. I rotated through different jobs, working at the front desk, in the pharmacy, in the exam room, and in the office, filing patient records. In the afternoons, we did some form of community engagement activity.
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1:00-2:30 p.m.
Exhibit Hall (CMCC lower level) |
Poster: 278
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| Piihl, Ian |
Boyken, Julie |
Get Involved. Make an Impact
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Student organizations have such a big impact on a student’s life, big or small. Being a part of an organization there are different lessons and memories that come out of these experiences like communication skills, creating lifelong memories with a new friend, fostering growth through leadership or just being a part of a bigger community here at the University of South Carolina. Over my time at USC, one of my biggest accomplishments was being able to start from the bottom and be elected to Vice President of Events for Carolina Productions. Carolina Productions provides free and fun entertainment for the student body throughout the academic year. Starting as a general body member known as PIT (Programmers in Training) my freshman year, I was able to see growth in the organization by becoming an Event Coordinator during my second semester at USC and ended up serving two terms over two years in that position. Throughout my time with Carolina Productions, I wanted to see an improvement in the organization's overall reach to different demographics and also widen my event planning skills whether that was creative thinking, coming up with solutions to a problem, or working with vendors and artists. What I ended up learning was problem-solving skills and that I also saw myself grow as a leader which I never thought I would see myself doing when it came to planning events or overseeing four event coordinators. From start to finish, I saw the changes that not only came with the organization but also the changes in myself by seeing what the true leader in me has become over the past few years.
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9:30-11:00 a.m.
Exhibit Hall (CMCC lower level) |
Poster: 333
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| Vincent, Carly |
Jasnow, Aaron |
An amygdala-cortical circuit for encoding generalized fear
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A common symptom of anxiety disorders and trauma- and stress-related disorders is overgeneralizing fear. This is characterized by the expression of fear in new or ambiguous environments and can disrupt normative functioning. The anterior cingulate cortex (ACC) is a critical node in a larger circuit that regulates fear and adaptive generalization to contextual cues. Our work demonstrated that the ACC and its projections to the basolateral amygdala (BLA) control generalized fear when rodents experience new contexts in which threat is uncertain. However, the role of the ACC in context fear learning is not well understood. In this study, we used neuron activity analysis, pharmacological inactivation, NMDA receptor blockade, and circuit-specific manipulations of the ACC to determine its role in context fear learning. We found that pharmacological inactivation of the ACC and NMDA receptor blockade during context fear learning eliminates generalized fear when mice are tested in a novel context but do not alter specific fear to the training context. We then investigated the role of BLA inputs to the ACC during fear learning to determine circuit mechanisms involved in encoding generalized fear. We used a chemogenetic, intersectional approach to inactivate BLA-to-ACC projections during context fear learning. We used a similar chemogenetic approach to drive this circuit during weak fear training. Our data show that chemogenetic silencing of BLA-to-ACC projections during context fear learning eliminates fear in a novel context but leaves specific fear in the training context fully intact. Further, we found that driving the BLA-to-ACC inputs was sufficient to produce fear generalization under conditions that normally produce specific fear. These results suggest 1) a critical role for NMDAR-dependent plasticity in the ACC in encoding generalized memories and 2) that a BLA-ACC circuit is both necessary and sufficient for learning generalized fear. Thus, the role of the ACC may be to encode highly salient experiences that shape subsequent behavior in new similar environments or situations.
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1:00-2:30 p.m.
Columbia Ballroom (CMCC upper level) |
Poster: 56
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| Stalls, Kendall |
Fan, Daping
Velazquez, Kandy |
The Effects of Emodin on Cancer-related Pain – A Pilot Study
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Our research is focused on developing nutraceuticals that could potentially improve the quality of life of cancer patients by mitigating cancer and cancer treatment-associated cachexia, cardiovascular and gastrointestinal toxicity, chemobrain, and pain. Our previous studies have identified natural compound emodin as a versatile therapy for breast cancer in mouse models. Emodin could suppress breast tumor growth and lung metastasis, enhance the efficacy of doxorubicin, and ameliorate doxorubicin’s cardiotoxicity. A common mechanism underlying these effects is the ability of emodin in modulating macrophage activation in the tumor microenvironment. Since macrophage activation is also involved in cancer-associated pain, we aimed to performing a pilot study to examine if emodin can mitigate lung cancer associated pain in a mouse lung cancer model. Female C57BL/6 mice were injected Lewis Lung Carcinoma (LLC) cells intravenously to establish tumors in the lungs. Mice were thereafter treated with emodin or vehicle for two weeks. Mice without tumor cell injection were included as control. Three types of nociceptive assessments were performed before the cancer cell injection (baseline) and at various timepoints after cancer cell injection, including Von Frey Mechanical Sensitivity Test, Cold Plate Temperature Test, and Spatial Preference Test. The results showed a promise that emodin may be able to alleviate cancer-associated pain in the mice, but a larger study is needed to confirm the finding and draw a conclusion.
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9:30-11:00 a.m.
Columbia Ballroom (CMCC upper level) |
Poster: 126
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| Santibanez, Andrea |
Farrell, Carmen |
Ethnic Differences in Seeking Help After Exposure to Domestic Violence
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Domestic violence is highly prevalent worldwide and the United States is no exception. In 2020, the prevalence rate for victimization was 16.4 per 1,000 persons aged 12 or older (United States Bureau of Justice Statistics). As a member of the growing Latin community in the U.S., I want to learn more about its struggles. Domestic violence is something that can happen in these communities and people who need help may not seek it. Probably the biggest barrier in seeking help has been the language barrier, as it can be difficult to find resources for Spanish speakers here in the U.S. Citizenship status is another factor for many immigrants before they consider taking any action (Messing et al., 2022).
With these factors in mind, I wanted to find a dataset where I could understand differences across ethnicity and citizenship status. The national dataset I will use for this project is the National Crime Victimization Survey (United States Bureau of Justice Statistics) from 2021 with 8,982 participants. Through this dataset, this project will allow me to understand what communities need to be better served regarding this issue. I hypothesize that non-minority individuals will have higher rates of experiencing domestic violence in this dataset, but they will also have higher rates of seeking professional help after exposure. I also believe that citizenship status will impact how often people seek help. It is likely that people from minority backgrounds have issues seeking help that non-minorities in the U.S. do not have to even consider.
Based on the hypotheses, there are significant implications for the future and the local community. With national statistics confirming these discrepancies, the people in our local community may be at greater risk. With this project, I am taking the first important step in understanding what these statistics look like nationally, in hopes of bringing those numbers back to my local community and advocating for change.
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9:30-11:00 a.m.
Exhibit Hall (CMCC lower level) |
Poster: 16
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| Muraleedharan, Ahalya |
Nolan, Melissa
Dye-Braumuller, Kyndall
Zellars, Kia |
Advancing Tick Research: Establishing Sustainable Colonies and Upgrading Laboratory Capabilities for Future Experiments
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Tick-borne diseases constitute the majority of the reported vector-borne illnesses in the United States of America. Ticks serve as vectors for varying diseases, such as Rocky Mountain Spotted Fever, Ehrlichiosis, and Lyme disease. There are several unknowns about the transmission of disease from ticks, hence, the establishment of tick colones and upgrading laboratory facilities are imperative. The Institute for Infectious Disease Translational Research is establishing new colonies of lone star ticks (Amblyomma americanum), gulf coast ticks (Amblyomma maculatum), and the american dog tick (Dermacentor variabilis) to advance our understanding of how insect vectors become infected with novel pathogens and how disease transmission is propagated. As nationally only one tick colony existed previously, the establishment of this colony developed novel methodologies for innovative future research.This poster will present a ‘how-to’ guide to achieving biosafety protocols for a ACL-2 laboratory (arthropod containment biosafety level II), acquiring naive, non-infected ticks, and sustaining ticks through multiple life cycles. Further, this study will describe the hypotheses and brief approaches for future studies to be executed in summer 2024: Rickettsia parkeri and Rickettsia amblyommatis interference studies, and tick chemotaxis attractant behavior studies.
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9:30-11:00 a.m.
Exhibit Hall (CMCC lower level) |
Poster: 132
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| Mason, Emma |
Twiss, Jeff
Smith, Terika |
Role of Axonal g3bp1 Granules in Regeneration-Challenging Situations
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Axonal mRNAs are translated into new proteins after neurotrauma and these new proteins are needed for regeneration. We previously showed that the stress granule protein G3BP1 serves as a mRNA storage depot in axons and slows axon growth after injury. Exogenously expressing the acidic domain of G3BP1 disassembles axonal G3BP1 granules and accelerates PNS axon growth. A cell-permeable peptide (CPP) consisting of G3BP1 amino acids 190-208 triggers rapid disassembly of axonal G3BP1 granules and promotes axon growth in culture. Here, we show that the 190-208 CPP increases axon regeneration and acutely improves NMJ reinnervation when applied 2 d after nerve crush. G3BP1 granules are also seen in CNS axons, including in the spinal cord. Following spinal cord transection, injured reticulospinal axons will grow into the permissive environment of a peripheral nerve graft (PNG) but halt growth upon reaching the distal cord. AAV transduction of reticulospinal neurons with the G3BP1 acidic domain accelerates growth within the PNG. Similarly, AAV transduction of retinal ganglion cells with G3BP1 acidic domain increased axon regeneration following optic nerve crush, indicating thatG3BP1 granules attenuate CNS axon regeneration. Surprisingly, injecting the 190-208 CPP into the proximal transected spinal cord triggered sprouting-type growth within a PNG. In contrast, injecting 190-208 CPP directly into the graft promoted axon growth across the distal interface back into the spinal cord. Finally, returning to the PNS, treatment with the 190-208 CPP did not increase regeneration in chronically injured sciatic nerve axons. Together with the sprouting response in reticulospinal neurons, this raises the interesting possibility that response to the 190-208 CPP, which triggers G3BP1 granule disassembly in acutely injured axons, is context-dependent and possibly influenced by the environment of the injured axon.
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9:30-11:00 a.m.
Exhibit Hall (CMCC lower level) |
Poster: 215
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| Rogers, Caroline |
Cranmer, Robyn |
Helping Others the Best We Can
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Over the past two years, I have worked as an intern at the South Carolina Attorney General’s Office in the Constituent Services division. As a criminal justice major who will begin attending law school next fall, I applied for this job because I wanted to learn more about how the legal field works, especially in my state. My ultimate career goal is to become a prosecutor, so I thought that working for the chief prosecutor of South Carolina would give me some good insight and networking opportunities. Although this experience was not what I originally thought it would be, I have learned so much about how to work with the public, what legal resources are available to residents of South Carolina, and how to help vulnerable individuals evaluate their legal options. Many residents who wrote to my supervisor and I suffered from mental illness or were going through a traumatic situation, so it was imperative that we handled the situation with care and did our best to provide support. Throughout my time working at the Attorney General’s Office, I have gained an enhanced sense of compassion and understanding that I will carry with me as I enter into the legal field, never forgetting to take the time to help those who need it the most.
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9:30-11:00 a.m.
Exhibit Hall (CMCC lower level) |
Poster: 359
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Petee, Hayden
Lovejoy, Madison |
Dawson, Robert |
Utilizing Virtual Reality to Teach Empathy in Young Healthcare Professionals
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Abstract Text
In every healthcare profession it is necessary to maintain and build an empathetic approach when engaging with clientele. According to Derksen et al. (2013) there is a positive correlation between physician empathy and patient satisfaction. Understanding the feelings and perspectives of everyone will result in better clinical outcomes and improved patient-physician relationships. However, for budding healthcare professionals, this concept can be difficult to grasp and apply in everyday interactions. For example, the development of empathy can be stunted by high volumes of patients, lack of adequate time, and the absence of education on empathy (Moudatsou et al., 2020). To address these shortcomings researchers applied a virtual reality intervention focused on the teaching of empathy and the enhancement of skills necessary to maintain it. Virtual reality has been identified as one of the most promising resources in the development of empathy. Especially in empathetic interactions towards stigmatized groups and individuals (Marques et al., 2022). Thus, making it an excellent choice in the improvement of empathy education.
To measure the impact of this intervention a sample size of around 40 University of South Carolina physician’s assistant students between the ages of 22-28 was recruited. These students were then enrolled in a two hour long “empathy” class that utilized three different virtual reality apps. All three apps highlighted the sensitivities and perspectives of different patient populations. After the completion of the class a 10-question survey was sent to measure their newfound attitudes and empathetic understanding.
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9:30-11:00 a.m.
Columbia Ballroom (CMCC upper level) |
Poster: 6
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| Smith, Jonathan |
Duncan, Alexander |
Symmetries of del Pezzo surfaces
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Abstract Text
The classification of automorphism groups of del Pezzo surfaces over any algebraically closed field was recently completed in a sequence of papers by I. Dolgachev, A. Duncan, and G. Martin. We will discuss results toward the classification of automorphism groups of del Pezzo surfaces over any field of characteristic zero. These groups are instrumental in the classification of finite subgroups of the plane Cremona group, the group of birational automorphisms of the projective plane, up to conjugacy. Namely, any subgroup up to conjugacy in the plane Cremona group is realized as a group of regular automorphisms of a rational del Pezzo surface or a conic bundle. For this reason, we also examine the rationality of the del Pezzo surfaces that exhibit various automorphism groups.
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9:30-11:00 a.m.
Columbia Ballroom (CMCC upper level) |
Poster: 29
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| Urban, Robin |
Hill-Chapman, Crystal |
The Autistic Adult's Perspective on Genetic Testing in the Prenatal and Cancer Settings
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Prenatal and cancer genetic tests are recommended by many professional medical organizations. Previous studies have shown that autistic adults have a negative opinion towards genetic testing for autism but have not explored if this sentiment is shared for other types of genetic testing. We used a descriptive, web-based survey of autistic adults to assess their attitudes towards prenatal and cancer genetic testing (n=36). Our data showed that overall attitudes towards prenatal and cancer genetic testing are positive. Notably, participants had slightly more positive attitudes towards prenatal genetic testing related to neurodevelopmental disorders when compared to testing for disorders primarily affecting physical health. Free response answers suggested concern for a eugenics movement related to neurodevelopmental disabilities. Overall, autistic adults have a more positive attitude towards prenatal and cancer genetic testing compared to genetic testing specifically for autism. Future research should continue to explore the autistic adult perspective on genetic testing, as this research suggests a nuanced view.
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1:00-2:30 p.m.
Columbia Ballroom (CMCC upper level) |
Poster: 75
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| Alluri, Sri Chaitanya Varma |
Cai, Chao |
Medication Adherence Impact on Cost and Outcomes of Schizophrenia Patients
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Abstract Text
This research project was dedicated to a thorough examination of how the complex effect of medication adherence impacts healthcare outcomes, such as hospitalization rates, and the associated costs for schizophrenia patients, with a particular emphasis on the comparative analysis of oral and injectable medication forms. Medication adherence emerges as a pivotal element in the management of schizophrenia, where poor adherence is often correlated with increased healthcare utilization and escalated medical expenses. Medication adherence, particularly, is a critical factor that can significantly alter the disease's progression, affecting both clinical outcomes and healthcare expenditures. The primary objective was to uncover how adherence to prescribed medication regimens influences overall healthcare utilization and associated economic burdens in this vulnerable population. The investigation is structured around a multifaceted analysis, aiming to dissect the multifarious roles of medication adherence as an interactive (interaction term), mediating (mediator), and confounding factor (confounder). This approach is intended to shed light on its influence over treatment effectiveness, the frequency of healthcare service engagement, and the consequent financial ramifications for both individuals living with schizophrenia and the broader healthcare infrastructure. Utilizing a comprehensive third-variable analysis framework, this study aimed to assess the relationship between medication adherence, healthcare utilization, and cost implications. By categorizing medications based on their route of administration—oral versus injectable—this research seeks to understand how these different administration routes influence adherence patterns and, subsequently, patient outcomes and costs. Through this exploration, the research anticipates offering evidence-based recommendations that can guide clinicians, policy-makers, and healthcare stakeholders toward informed decisions aimed at enhancing care quality for schizophrenia patients while also addressing the economic considerations of treatment sustainability.
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1:00-2:30 p.m.
Columbia Ballroom (CMCC upper level) |
Poster: 116
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| Mattison, Kamryn |
Childs, Matthew |
Learning Social Work Through Community Service
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In an effort to improve the lives of individuals and families by giving back to the community, I pursued community service and internship opportunities that helped me to better understand and apply concepts I have learned in my Social Work courses. I have a passion for advocacy and activism, so I began volunteering in various places to help others take steps to achieve their goals and succeed. Eventually, I realized that my calling included children, adolescents, and the homeless population with an emphasis on mental health and education. I volunteered and interned at places to help further the education of children and adolescents as well as to enhance the mental health of minors, the homeless population, or minors who have or were experiencing homelessness. Initially, my service was for myself because I just wanted to help others; however, when I switched my major to Social Work, I began to see correlations between what I was learning in classes and the work I was doing. Through being a counselor at multiple summer camps for kids and an intern at Wil Lou Gray Opportunity School, I have gotten to work closely with the stated populations. In particular, I have been able to see firsthand how theories, concepts, and frameworks such as ACEs, human behavioral theories, and environmental effect frameworks have played a role in the lives of different populations. With the knowledge I have gained, I will be able to better assist and advocate for my clients and their needs in my professional career.
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9:30-11:00 a.m.
Exhibit Hall (CMCC lower level) |
Poster: 263
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| Shafer, Julia |
Reinhardt, Sara |
Growing From Student to Registered Nurse
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Abstract Text
This past summer, I had the opportunity to work as a Student Nurse Extern at Jersey Shore University Medical Center, back home in New Jersey. In this role, I worked alongside a registered nurse full-time for 10 weeks and gained insight into what a career in nursing is like. As a BSN student at USC, I have participated in 8 clinical rotations on different hospital units. Taking part in this externship complemented my clinical experiences with USC because I had a more individualized learning environment. I was placed on the Cardiovascular Step-down unit where I took care of post-operative heart patients in addition to medical and surgical patients. For the duration of the summer, my preceptor worked with me on skills related to assessment, documentation, education and nursing interventions. I experienced firsthand how valuable providing compassionate care is and how a supportive environment impacts patient outcomes. Additionally, I rotated through several units including the Pediatric ICU and ER, CVICU, Labor and Delivery and the Operating Room. With this externship under my belt, I felt more confident to take on my capstone in the Surgical and Cardiovascular Intensive Care Unit. On my capstone unit, the patient population has similar health conditions as those from my externship, but these patients need a higher level of care. Throughout my experiences as a nursing student, I have developed a passion for providing care to patients in a vulnerable state, opening my eye to the world of critical care nursing. The skillset I have cultivated up to this point serves as a strong foundation for the knowledge and expertise I intend to develop throughout my career.
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9:30-11:00 a.m.
Exhibit Hall (CMCC lower level) |
Poster: 307
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| Egan, Caroline |
Kubickova, Marketa |
Connecting Leadership and the Campus Community
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Abstract Text
Changing Carolina Peer Leaders (CCPL) is a club at the University of South Carolina that has taught me how to advocate for my peers while practicing my leadership and professional skills. Changing Carolina Peer Leaders strive to educate students about free resources on and off campus for mental, physical, and sexual health, as well as information about keeping a healthy lifestyle to improve students' health and well-being. As a CCPL, I made social media content for mental health practices. One example is the “Is My Friend Having Mental Health Issues” Instagram post to help our students recognize signs of mental health issues in their friends and how they can safely and respectfully help. My second responsibility is to attend University 101 classes and hold events on Greene Street to connect with students and have conversations to discuss healthy lifestyle skills. I gained my skills for these responsibilities in Practicum in Health Promotion, HPEB 301, as it taught me the Social-Ecological Theory. This theory discusses how the environment shapes who we are and how we shape the environment around us. By understanding the Social-Ecological Theory, I understood the importance of being a Changing Carolina Peer Leader and how we can improve the campus community around us. As a nursing major, I have always been interested in health and finding reasonable resources our community has to offer; by joining CCPL my freshman year I was able to dive into becoming a well-rounded nurse who understands how to find free community services for my patients. Through these experiences, I learned many students do not know about the free resources our university offers and I made an effort to resolve this issue while improving my professional skills by presenting and reaching out to students to connect them with the resources suited for their personal needs. Through this, I learned many students on campus have similar experiences and needs. By increasing my awareness of campus resources and gaining leadership skills to communicate this to other students, I can improve the environment around me and grow into the leader I am today.
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9:30-11:00 a.m.
Exhibit Hall (CMCC lower level) |
Poster: 299
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Fox Tran, Greyson
Sadik Gendi, Rafik |
DiPette, Donald
Magee, Matthew
McCall, Buckley
Pettis, Jaron |
Advancement of a Vertically Integrated Training Program: Introspective Assessment and Expansion
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Abstract Text
Mentorship led by medical students is essential to develop compassionate physician leaders of the future. The Vertically Integrated Training Program is an organization led by medical students at the University of South Carolina School of Medicine, Columbia that mentors pre-medical undergraduates at the University of South Carolina. As an established pre-medical mentorship organization, VITP has refined its strategies over the past seven years. Frequent self-evaluation and passionate leaders have led to innovative events and insightful guidance. The program has attained a level of maturity where it can be replicated across South Carolina and beyond. This poster offers an analysis of the current program, recent successes, effects of the COVID-19 pandemic, initial plans for expansion, and potential challenges.
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9:30-11:00 a.m.
Columbia Ballroom (CMCC upper level) |
Poster: 133
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| Karabas, Chloe |
REinhardt, Sara |
Serving the Community as a Future Registered Nurse
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Abstract Text
Since the beginning of my freshman year, I have been involved with USC’s Relay for Life. Originally it was just a way to get involved on campus, but after I lost a close friend of mine to cancer, it quickly became an organization that I was passionate about and proud to be a part of. Losing a friend to cancer was an experience I never knew I would have to navigate but being involved in Relay for Life gave me a purpose and a community that inspired me to make a change. I knew I wanted a bigger role in the organization, so I joined the executive board my junior year as Cancer Advocacy Chair and have been in the position ever since. In this position, I worked with local cancer survivors and caregivers, educated the community on cancer awareness and prevention, and raised money for the American Cancer Society. Throughout the year, our organization worked towards our Main Event. Relay for Life’s Main Event is a twelve-hour event to celebrate survivors, remember those we’ve lost to cancer, and fight back by raising money for the American Cancer Society. As Cancer Advocacy Chair, in addition to fundraising, my responsibilities included leading various ceremonies. I planned the Luminaria ceremony, where Blatt field was covered in illuminated paper bags, with each bag telling a story to remember those touched by cancer. Additionally, I lead ceremonies to celebrate cancer survivors in attendance and was responsible for promoting our mission of working towards a world without cancer. This experience opened my eyes to the number of people that have been touched by cancer. Together as an organization, we raised $206,494 for the American Cancer Society during our Main Event last year. Overall, being involved in Relay for Life has surrounded me with a community of like-minded people that worked towards the same goal of fighting against cancer. As I graduate and begin my career as a nurse, I will continue to be passionate about cancer advocacy, and I feel driven to provide the best care possible for my future patients.
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9:30-11:00 a.m.
Exhibit Hall (CMCC lower level) |
Poster: 289
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| Bennett, Amanda |
McDonnell, Karen
Davis, Jean
Wirth, Michael
Fouladbakhsh, Judith |
Sleep Quality and Quantity Assessment Among African American Survivors of Lung Cancer With and Without Chronic Obstructive Pulmonary Disease (COPD)
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Abstract Text
Background: Improving the quality of life of survivors of early-stage lung cancer (NSCLC, Stages I - IIIa) requires attention to persistent, burdensome symptoms, including sleep disturbances. While research exists regarding sleep quality in cancer survivors, minimal research targets this minority survivor population.
Purpose: To measure and assess sleep quality and quantity among African American survivors of lung cancer. Based on the Symptom Management Theory, our comprehensive assessment focuses on a racial minority group and multiple diagnostic groups (COPD vs. No COPD).
Methods: This two-group, cross-sectional, descriptive study utilized cancer registry data to recruit survivors. Measurement tools included sleep and symptom-focused questionnaires, accelerometry, sleep diary and interviews. After consent was obtained, participants answered study specific questionnaires, wore a waist accelerometer for 7 days, kept a 7-day sleep diary, and completed an interview.
Results: Most participants were female (68.8%, n = 11), with a mean age of 68.9 years, average time since diagnosis of 6.5 years, 56.3% had Stage I lung cancer (n = 9), and 50% (n = 8) had COPD with a mean of 4.3 comorbidities. Preliminary results reveal the mean global PSQI score was 11.4 (range 8 - 16) for participants with COPD and was 8.1 (range 1 – 12) for participants without COPD; mean reported hours asleep per night was 5.5 (range 3.5 - 8) and 93.8% (n = 15) scored 5 or higher, indicating poor sleep quality.
Implications: This study provides insight into a historically understudied minority group. Survivors of early-stage lung cancer experience poor sleep. Our study provides new evidence that sleep is an important clinical problem among this population, providing support for effective assessment strategies to understand and improve sleep. Elucidating a thorough understanding of sleep will help vulnerable survivors recover from their cancer treatments, lower risk of cancer recurrence, and manage the burden of co-morbidities.
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9:30-11:00 a.m.
Columbia Ballroom (CMCC upper level) |
Poster: 2
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| Simpson, Savannah |
McQuillin, Samuel
Goodrum, Nada |
Building Bridges: A Behavior-Based Measure for Culturally Responsive Mentoring
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Abstract Text
Youth mentoring programs have the potential to promote positive youth development. However, disparities in mentor demographics, with a prevalence of White mentors, raise concerns about potential harm to BIPOC (Black, Indigenous, and people of color) youth. The current project aims to address this gap by developing and testing a behavior-based measure assessing mentors’ cultural responsiveness within mentoring relationships. This presentation will delve into the measurement development process following Bandalos’ (2018) test development guidelines. Future directions for this project include conducting a large-scale field test to assess the measure’s effectiveness across diverse mentoring programs. This critical step aims to evaluate the measure’s performance, reliability, and potential contributions to assessing and enhancing mentors’ cultural responsiveness in mentoring relationships.
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9:30-11:00 a.m.
Columbia Ballroom (CMCC upper level) |
Poster: 50
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| Lyu, Tianchu |
Liang, Chen
Vignato, Julie |
Assess the racial disparities and predict the occurrence of preeclampsia using machine learning and integrated electronic health records data from All of Us
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Abstract Text
A model of preeclampsia prediction was created using the All of Us database V7. From the 16,1663 pregnancies, those with preeclampsia were from areas with a higher deprivation index (112.3 vs. 44.7). The risk of PE was highest in Asian patients (1.99-fold), followed by Black patients (1.37-fold) and Hispanic/Latino patients (1.23-fold). In addition, expected risk factors such as obesity (p<0.001), hypertension (p<0.001), proteinuria (p<0.001), CKD (p=0.008), and shorter gestation lengths (p<0.001) were significantly associated with preeclampsia. This study is among the first using a national EHR and service database that emphasizes the critical need for tailored preeclampsia prediction approaches for diverse, underserved populations.
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9:30-11:00 a.m.
Columbia Ballroom (CMCC upper level) |
Poster: 98
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| Pignatelli, Anthony |
Dallas, Tad |
The relationship between environmental variability and community synchrony in freshwater macroinvertebrates
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Aquatic macroinvertebrates are key components in headwater streams (1st-3rd order). Macroinvertebrates process organic matter and energy through the food web, but are highly sensitive to environmental fluctuations in stream temperature and discharge. As temperature and discharge become more variable, macroinvertebrates are expected to be negatively affected. We can examine this effect by calculating community synchrony, a measure of species abundance correlations in a community over time. Communities that are more synchronous are at higher risk for extinction. Additionally, species turnover, the rate at which species composition changes over time, is expected to lead to more asynchronous communities with some streams seeing higher turnover than others. We expected that higher temperature and discharge variability will lead to lower community synchrony because of macroinvertebrates' high sensitivity to changes in abiotic drivers and their relatively narrow tolerance range. Additionally, community synchrony is expected to decrease with increasing species turnover due to higher changes in community composition. We examined the relationship between environmental variability (temperature and discharge) and species turnover with community synchrony across a time-series (2014-2022) in 18 streams in the United States using macroinvertebrate data from the National Ecological Observatory Network. Environmental variability was calculated as the standard deviation across the time-series for temperature and discharge. We found that temperature variability was significantly negatively associated with community synchrony across all sites (r = -0.53, p = 0.02, Pearson's Correlation Coefficient) while discharge variability was found to have no significant relationship with community synchrony(r = -0.12, p = 0.63, Pearson's Correlation Coefficient). Species turnover also had no significant relationship with community synchrony (r = 0.005, p = 0.99, Pearson's Correlation). Overall, temperature variability was a driving factor of community synchrony unlike discharge variability and species turnover, highlighting the important role of temperature in shaping community structure.
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9:30-11:00 a.m.
Columbia Ballroom (CMCC upper level) |
Poster: 41
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| Ou, Junlin |
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GPU-enabled Path Planning based on Global Evolutionary Dynamic Programming and Local Genetic Algorithm Optimization
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Abstract Text
This paper presents a novel path planning method for real-time robotic path planning in a dynamic environment involving moving obstacles. It combines on a holistic platform a global approach to rapidly generate initial paths of prominent diversity and a heuristic approach to enable local path refinement for enhanced computational efficiency, exploration, and robustness. The global approach innovates a formulation that treats a path planning problem with a visibility graph as a Markov decision process and decomposes the process into many subproblems. A new evolutionary dynamic programming approach (EDP) is proposed to solve these subproblems in an iterative manner using GPU computing to allow backpropagation of state values from goal to start points. The EDP generates multiple feasible initial paths with salient state values, each initializing an independent GA optimization on waypoints only near the mobile robot, and all GAs are run in parallel on GPU, further improving exploration and convergence speed. The strategy to fully utilize CPU/GPU resources for various components in the pipeline is also established. The proposed algorithms are then implemented on an edge computing device (Jetson AGX Xavier) onboard a mobile robot (TurtleBot 3 Waffle Pi). Optimal paths can be continuously generated at the rate of 0.1 seconds/path, enabling successful obstacle avoidance and robot navigation through dynamic environments and, hence, verifying the real-time capabilities and accuracy of the present method.
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1:00-2:30 p.m.
Columbia Ballroom (CMCC upper level) |
Poster: 229
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| Sanders, Ja'Moni |
West, Delia |
Alleviating Stress through an Innovative Mental Health App for Young Adults; Prototype
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Abstract Text
The project proposal aims to address the critical need for creative mental health interventions that are especially designed to reduce stress in American young adults. Based on the growing occurrences of stress-related issues in this population, the project focuses on outlining a novel mental health phone-based application to reduce stress. The project aspires to enhance the well-being of young adults by advocating for the adoption of effective and evidence-based stress reduction strategies. Through a comprehensive approach, the project incorporates insights from diverse disciplines, including psychological, technological, and user-centric perspectives. This integration is facilitated by synthesizing valuable insights derived from extensive literature reviews in psychology, technology and user experience. By amalgamating these perspectives, the projects aims to create a holistic and informed framework for developing a robust stress reduction intervention that is tailored to meet the unique needs of young adults.
The project will offer a theory-based conceptualization with research to support it. The prototype mHealth app's screenshots will be essential for graphically communicating the intended features and functionalities in line with the theory-based conceptualization. The conceptual framework will take into account the transactional nature of stress and the significance of individual differences in stress appraisal and coping strategies, drawing on theories of stress and coping. Additionally, the project will use components of positive and behavioral psychology to design features that support young adults aging 18-25 in psychological wellbeing and positive behavior change. In conclusion, this prototype app presents a personalized mobile solution designed to actively involve young adults in effectively mitigating stress within the context of their daily lives. It lays the foundation for comprehensive research aimed at assessing the intervention's efficacy within this high-risk population, marking a significant step toward understanding the enhancing stress reduction strategies tailored to the unique challenges faced by young adults.
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9:30-11:00 a.m.
Columbia Ballroom (CMCC upper level) |
Poster: 74
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| Farrell, Emma |
Reed, Rico |
The Importance of Networking
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Abstract Text
I developed an interest in politics in high school, during the 2016 Presidential Election. Ever since then, I’ve been heavily involved within the political sphere. Since the beginning of my undergrad, I’ve been involved in the Turning Point USA chapter at the University of South Carolina – a student, non-partisan political organization that values small government, free markets, the Constitution, and low taxes. I became the President of this organization my senior year, organizing and leading a group of 160+ students. Out of the numerous events our organization hosted, one of my standout initiatives was Range Day— a hands-on learning opportunity for students to properly learn how to safely operate firearms from professionals within our community, aiming to promote individual learning and reduce stigma around the use of firearms. In the process of planning and executing Range Day, I realized the immense potential that networking holds. Little did I know that a connection made with Jay Harris, a retired US Army Ranger and instructor at Panteo Sportsman Club, during a firearms class in my sophomore year would unfold into a remarkable opportunity. Jay Harris, now the CEO of Champion Defense, became a valuable connection. Through this established relationship, I was able to secure a generous discount for the Range Day event. This experience prompted me to reflect on the art of persuasion, a skill extensively studied in my courses SPCH260: Argumentation and Debate, ENGL102: Rhetoric and Composition, and PHIL213: Communicating Moral Issues. These courses delved into the pillars of ethos, logos, and pathos but omitted the explicit link between persuasion and networking. Exploring this connection revealed a shared goal—achieving objectives through collaboration and influence. As I navigate my legal career, I now recognize the enduring impact of networking. Connections I make in law school could potentially open doors to legal opportunities beyond what formal education might provide. Networking with fellow law students, professors, and legal professionals may unveil avenues that align with my aspirations. This realization underscores the indispensable role of networking in shaping not only specific events but also the trajectory of my professional and personal future.
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9:30-11:00 a.m.
Exhibit Hall (CMCC lower level) |
Poster: 324
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| Norris, Ashton |
Conner, James |
Papillary Renal Cell Carcinoma in an Ectopic Intrathoracic Kidney within Bochdalek Hernia: A Case Report
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Abstract Text
Introduction:
Intrathoracic kidneys, a rare form of ectopic kidneys often associated with congenital diaphragmatic hernias, present unique challenges in diagnosis and management. This case highlights the complexity of managing renal tumors in ectopic locations, particularly in the context of an intrathoracic kidney. We discuss the clinical presentation, diagnostic challenges, treatment modalities, and postoperative outcomes in a patient with papillary renal cell carcinoma (pRCC) arising in an intrathoracic kidney within a Bochdalek hernia.
Case:
A 72-year-old male with hypertension, CAD, COPD, renal cysts, urolithiasis, and known intrathoracic left kidney within a chronic Bochdalek hernia presented with upper abdominal pain and shortness of breath. Imaging revealed a stable hernia and an intermediate-density renal lesion, concerning for malignancy. Preoperative diagnosis was T1a pRCC, and the patient underwent robotic-assisted partial nephrectomy and hernia repair. Pathology confirmed grade 1 pRCC with 1-2mm margins. Postoperative course was uneventful, and at 6-month follow-up, imaging showed no recurrence or metastasis.
Discussion:
The presentation of pRCC in an intrathoracic kidney associated with Bochdalek hernia is exceedingly rare, often posing diagnostic challenges due to atypical symptoms. While the patient lacked classical symptoms of pRCC, including hematuria and flank pain, the incidental finding of the renal mass warranted further investigation. Treatment guidelines for RCC in intrathoracic kidneys are undefined due to its rarity. Options include partial nephrectomy, ablation, or active surveillance, each carrying risks. Radical nephrectomy is standard, though its applicability varies. Regular surveillance is crucial to monitor for malignancy development. While the link between ectopic kidneys and malignancy is unclear, monitoring is essential to mitigate potential complications. This case underscores the importance of tailored management and vigilant follow-up in patients with intrathoracic ectopic kidneys.
Conclusion:
This case highlights the importance of regular surveillance in patients with intrathoracic kidneys to monitor for potential complications, including malignancy. The rarity of pRCC in intrathoracic kidneys highlights the challenges in diagnosis and management, necessitating further research to establish optimal treatment approaches. Despite the challenges, timely diagnosis and appropriate management can lead to favorable outcomes in these rare clinical scenarios.
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1:00-2:30 p.m.
Columbia Ballroom (CMCC upper level) |
Poster: 158
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| Williams, Jordan |
Wilson, Kiesha |
Epigenetic regulation of macrophages in SEB induced ARDS treated with CBD
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Abstract Text
Acute Respiratory Distress Syndrome (ARDS) is a life-threatening condition characterized by severe lung inflammation, resulting in rapid respiratory deterioration. Its global prevalence ranges from 10 to 86 cases per 100,000 individuals. Despite its severity, there is currently no definitive cure, and palliative care is the mainstay of treatment. This investigation delves into the potential therapeutic efficacy of cannabidiol (CBD), a phytocannabinoid from the cannabis sativa plant, in alleviating ARDS induced by Staphylococcal Enterotoxin B (SEB), which is produced by the bacterium Staphylococcus aureus. Utilizing 8-week-old mice exposed to SEB, followed by CBD treatment at 5mg/kg, the study examines CBD's impact on pro-inflammatory and anti-inflammatory markers, revealing a reduction in lung inflammation. Results from enzyme-linked immunosorbent assay (ELISA) revealed that CBD caused an increase in the anti-inflammatory cytokine IL-10 and a decrease in the pro-inflammatory cytokine TNF-α. Additionally, DNA sequencing of lung cells explains the molecular mechanisms underlying CBD's modulation of ARDS. This research contributes to our understanding of novel therapeutic approaches for managing ARDS and related inflammatory lung conditions. (Supported by NIH R00GM147910).
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9:30-11:00 a.m.
Columbia Ballroom (CMCC upper level) |
Poster: 84
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| Chupak, Anna |
Kaczynski, Andrew |
Identifying Disparities in the Relationship Between Neighborhood Walkability and Active Transportation Safety Within South Carolina
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Abstract Text
Background: Pedestrian and bicyclist crashes are of great concern in the Southeast U.S., especially within disadvantaged neighborhoods with poor infrastructure. Little research has evaluated how characteristics of the built environment are associated with active transportation safety, or how this association may differ by neighborhood disadvantage. This study examined the relationship between neighborhood walkability and pedestrian and bicyclist crashes, including variations by social vulnerability across census tracts in South Carolina (SC).
Methods: Four key variables were collected for each census tract in SC (N=1,103): walkability, pedestrian crashes, bicyclist crashes, and social vulnerability (SV). Walkability was measured by the EPA’s National Walkability Index (NWI), which scores block groups from 1-20 (low to high) and includes key indicators for intersection density, proximity to transit, and land-use diversity; scores were averaged across block groups to determine walkability per tract. Pedestrian (N=10,689) and bicyclist (N=4,802) crash count and severity were obtained from SCDOT [2011-2021], aggregated per tract and adjusted for average trips per day. SV, the degree of susceptibility of a community to hazards, was measured via the CDC SV Index (SVI); a higher percentile rank indicates greater SV. Stepwise linear regressions were conducted to determine the relationship between neighborhood walkability and pedestrian and bicyclist crash count and severity, including interactions between NWI and SVI.
Results: Across all SC census tracts, there was a significant and negative relationship between neighborhood walkability and pedestrian crash count (B=-0.005, SE=0.001) and severity (B=-1.073, SE=0.193) per trip, and for bicyclist crash count (B=-0.020, SE=0.003) and severity per trip (B=-2.831, SE=0.492). This relationship significantly varied by SVI; as walkability increased, crash count and severity declined, especially within tracts at mean and high SV compared to low SV values.
Conclusion: As neighborhood walkability worsened, pedestrian and bicyclist crash count and severity increased, especially within tracts at high levels compared to low levels of SV. These findings help identify neighborhoods in SC in need of infrastructure improvements to address active transportation safety, thereby facilitating greater physical activity, reducing chronic disease, and creating equitable environments for all.
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9:30-11:00 a.m.
Columbia Ballroom (CMCC upper level) |
Poster: 65
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| Steele, Morgan Grace |
Derrick, Maureen |
The Importance of Community Through the Lens of U101
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Abstract Text
The University 101 program is one of the key factors in USC continually having a top-ranked overall freshman experience – 5 years in a row, to be exact. Freshman seminar courses are designed to aid in the transition from high school to college – holistic student success is the key driver of U101 at USC. Serving as a U101 peer leader for two years allowed me to have a first-hand look at all of the good things that come from U101 – my favorite being the emphasis on community. Community is something that humans inherently crave – it is in our DNA to have relationships with each other. A huge part of U101 is forming relationships and creating a lasting community. One goal of mine through both of my semesters as a peer leader has been that each of my students leaves the course with one person they would consider to be a friend – someone they could sit down in the Gamecock Park dining hall with and have a meal. It all comes back to community and feeling like USC is somewhere you truly belong. As a U101 student, then peer leader, and now pursuing a career in higher education, there is nothing that has impacted my college years more than U101. In guiding students through this transition, I learned about the role that community plays and how it is a determiner of success.
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9:30-11:00 a.m.
Exhibit Hall (CMCC lower level) |
Poster: 264
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| Hamlin, Madison |
Hancock, Nathan |
Developing Hyperactive Cargos for Targeted mPing Insertion
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Abstract Text
DNA transposons are sequences that can jump in and out of the genome using the enzyme transposase. These elements naturally produce genetic variation along with changes to gene function and expression. A method to direct the mPing transposon from rice into specific locations in plant genomes using Cas9 targeting was recently developed. This provides a mechanism to place specific genetic cargos that modify the expression and function of plant genes. The Hancock lab previously discovered a hyperactive (hp) version of mPing with twenty-one bases altered near the three-prime end. We made the same alterations to an mPing carrying a BAR herbicide-resistance cargo and mPing carrying six heat shock elements (HSE) cargos to see if transposition frequency would be increased. These elements were tested in an established yeast transposition assay where element excision results in colonies on Gal-CSM-Ade-His-Leu-Ura plates. We observed that hp-mPing BAR and hp-mPing HSE had significantly increased transposition compared to the control elements. These hyperactive elements will be tested in Arabidopsis to determine if they improve Cas9 targeted insertion efficiency in plants.
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1:00-2:30 p.m.
Exhibit Hall (CMCC lower level) |
Poster: 67
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| de Arellano, Andrew |
Flory, Kate
Rother, Yvette |
Rejection Sensitivity as a Potential Influence in ADHD-Related Alcohol and Cannabis Use Among College Students
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Abstract Text
College students with ADHD are more likely to use alcohol and cannabis regularly than their non-ADHD peers. Additionally, peer group behavior has been found to influence substance use in college students with ADHD. Thus, social challenges linked with ADHD may also affect substance use. One such social challenge is rejection sensitivity, or a skewed perception and heightened fear of rejection by others. The current literature regarding the association between ADHD and rejection sensitivity shows mixed findings. Further, no previous studies have investigated the potential associations among rejection sensitivity, ADHD, and substance use. The current study examines the relation between ADHD symptoms and alcohol/cannabis use (as well as problems associated with use) in college students with rejection sensitivity as a potential moderator. Participants (n= 4,748; mean age=19.7) in the multisite Undergraduate Learning, Emotion, and Attention Research Network (U-LEARN) study across 7 U.S. universities were administered an online survey during the Fall 2021 and Spring 2022 semesters that included measures of rejection sensitivity, cannabis use/consequences related to use, alcohol use/consequences related to use, and ADHD symptom severity. Bivariate correlations showed associations between ADHD symptom severity and rejection sensitivity, ADHD symptom severity and alcohol/cannabis use associated problems, and rejection sensitivity and alcohol/cannabis use associated problems. Rejection sensitivity predicted problems associated with alcohol use and cannabis use as outcomes and moderated the relation between ADHD symptom severity and problems associated with cannabis use, such that at high levels of ADHD symptom severity, rejection sensitivity is protective against problems associated with cannabis use. No other moderation effects were detected. Our findings indicate that rejection sensitivity and ADHD symptoms are related, and that rejection sensitivity plays a moderating role in problematic cannabis use for college students with ADHD. Mixed findings regarding rejection sensitivity and ADHD necessitate further research; however, ADHD-related interventions for college students should begin to consider the implications of rejection sensitivity in minimizing adverse substance use outcomes.
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1:00-2:30 p.m.
Exhibit Hall (CMCC lower level) |
Poster: 169
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Zito, Jerzy
Michaels, Lauren |
Dawson, Robert |
Esports and Biofeedback
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Abstract Text
At present, there is limited literature on e-sports as it relates to rehabilitation and recovery. There is even less research available on e-sports as a measure of biofeedback. We are exploring the role e-sports can play in the mental and physical rehabilitation of female collegiate athletes with sports injuries. For Discovery USC, we will not yet have gathered data, and thus will present our study in the form of a dissertation proposal. We will be performing a minimal risk study utilizing mixed methods explanatory sequential design. We plan to examine the efficacy of heart rate beats per minute (BPM) as a biofeedback measure of emotion regulation. We will be determining whether virtual reality and e-sports is an effective recovery technique for female athletes. We have finished our literature review and are working on finalizing our methods. We will be collecting quantitative data and analyzing it with a linear regression. We also plan to collect qualitative data through interviews and utilize In Vivo coding (thematic analysis). By the day of the presentation at Discover USC, we plan to have a proposal submitted to the Institutional Review Board and potentially begin sampling for participants. Our study aims to bridge the gap between physical and mental rehabilitation with focuses on holistic treatment, translational treatment, and rehabilitation and recovery.
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9:30-11:00 a.m.
Columbia Ballroom (CMCC upper level) |
Poster: 7
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| Valakos, Matthew |
Sarzynski, Mark |
Attenuated Cardiometabolic Benefits From Exercise Training in Individuals With Genetically Predicted High Lp(a) Levels
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Abstract Text
Background: High levels of lipoprotein(a) [Lp(a)] are a causal risk factor for cardiovascular disease. Lp(a) levels are primarily determined genetically, around 90%. Although Lp(a) remains a risk factor for cardiovascular disease, little is known about how individuals with genetically elevated levels of Lp(a) respond to exercise training.
Purpose: This research investigates whether the cardiometabolic responses to exercise differs based on LPA genotype.
Methods: We measured LPA genotype (SNP rs3798220) and phenotypes in 666 Black and White participants of the HERITAGE Family Study who completed 20 weeks of exercise training. Phenotypes were measured before and after training, including body composition, cardiopulmonary exercise tests, lipid panels, inflammatory markers, and measures of glucose homeostasis. Student’s t-tests and general linear models were used to determine whether mean training-induced changes in phenotypes differed between LPA genotypes. P<0.05 was used to determine significance.
Results: At baseline, individuals with genetically predicted high levels of Lp(a) (rs3798220 CT genotype, n=22) had a generally worse cardiometabolic profile (e.g., higher concentration of triglycerides, apoB, and small LDL) compared to the TT genotype (n=644). For several phenotypes both LPA genotypes experienced similar improvements in response to training, including increases in VO2max and HDL-C and decreases in submaximal exercise blood pressure (all p<0.05 for within group changes). However, the rs3798220 CT genotype group experienced some training responses in an unexpected direction, including significant increases in resting blood pressure (+3.0 (6.6) mmHg SBP; +3.0 (6.1) mmHg DBP) and LDL-C (+7.7 (15.5) mg/dL) that were not observed in the TT genotype.
Conclusions: LPA genotype reflects a subset of the population with higher lifetime CVD risk that may experience unfavorable cardiometabolic responses to exercise training for select phenotypes. These findings may have important clinical implications, as individuals with genetically predicted high Lp(a) levels should still exercise for its many other beneficial effects. However, these individuals may need to focus on dietary and pharmacological interventions to maximally reduce CVD risk. Larger studies with measured Lp(a) levels are needed to validate these genetic findings.
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9:30-11:00 a.m.
Exhibit Hall (CMCC lower level) |
Poster: 152
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| DuBois, Isabella |
Montie, Eric
Marian, Alyssa
Jones, Patrick
Doyle, Katherine |
Bottlenose Dolphin Surveys in the Port Royal Sound Area (PRSA), South Carolina Indicate the Existence of Resident and Migratory Populations
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Abstract Text
Atlantic common bottlenose dolphins, Tursiops erebennus, serve as sentinel species for the health of estuaries in the Southeast USA. Considering the massive population growth of Beaufort County, South Carolina (263% from 1969 – 2021) and associated risk of human-based stressors, we initiated a population monitoring program in 2016 for the Port Royal Sound Area (PRSA). In this study, our overall goal was to investigate the population patterns of bottlenose dolphins in the PRSA. Do abundance patterns change seasonally? Is there evidence for resident and migrant dolphins? To answer these questions, we conducted monthly, boat-based visual surveys in two areas: (i) the May River (2016 - 2023) and (ii) Chechessee Creek, Chechessee, Colleton, and Okatie Rivers (2019 - 2023). For each sighting, our team recorded the abundance of neonates, calves, and sub-adults/adults as well as their GPS locations. Over the last eight years, we acquired high resolution photographs of dorsal fins to create a photo-ID catalog and to assist in tracking individual dolphins. After each survey, we used the photo identification program Darwin to accurately identify individuals from our catalog. Next, we determined site fidelity for each unique individual using the following equation: total number of sightings/the number of surveys X 100%. This percentage helped determine whether the dolphin was a resident (i.e., sighted in all seasons in multiple years), seasonal resident (i.e., sighted during the same seasons in multiple years), or non-resident (i.e., sighted only in 1 or 2 seasons). In both survey areas, abundance followed similar patterns and increased in the spring and summer to 30 – 50 dolphins at each site, then decreased in the fall and winter to 10 – 15 animals. These data provide ample evidence that non-resident dolphins migrate into the PRSA in the spring/summer and contribute to the overall abundance (i.e., residents plus migrants). The PRSA has a very small resident population (i.e., low winter abundance) and a larger non-resident, migrant population (i.e., high summer abundance). Moving forward, our Team will continue to monitor resident and migrant populations in the PRSA to determine if human population growth negatively impacts local abundance.
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1:00-2:30 p.m.
Exhibit Hall (CMCC lower level) |
Poster: 62
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| Walther, Sam |
Reynolds, Alexandria |
Associations Between Depression, Anxiety, Stress, Sleep Quality, and Perceived Academic Performance in College Students
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Abstract Text
Introduction: There is a significant amount of research which suggests that college students who exhibit poor sleep quality tend to have worse academic performance. Additionally, studies have shown correlations between stress levels and academic performance. In the current study, it was expected that college students with higher stress levels and lower sleep quality would report worse perceived academic performance.
Methods: Participants included 130 (male=21) full-time undergraduate students (mean age=19.65, SD=1.54 years). Participants completed an online survey that consisted of a series of questionnaires that examined demographics, perceived levels of academic performance, depression, anxiety, stress (Depression Anxiety Stress Scale; DASS-21), and sleep quality and duration (Pittsburgh Sleep Quality Index, PSQI).
Results: Preliminary data analyses were conducted. Average sleep duration (PSQI) was 7.00 hours per night (SD=1.36) and sleep quality (PSQI) was poor (M=6.86, SD=3.33). Mean depression (M=21.66) and stress (M=28.46) scores fell into severe categories, whereas anxiety scores (M=23.06) were extremely severe. Pearson correlations revealed that depression (r=.472, p<.001), anxiety (r=.419, p<.001), and stress (r=.527, p<.001) were related to sleep quality.
A One-Way ANOVA (F(4, 124)=2.507, p=.045) revealed that students who perceived making all A’s had the best sleep quality (M=5.22) compared to those who perceived making mostly A’s (7.00) or A’s/B’s (7.57). Depression, anxiety, and stress were not significantly related to perceived academic performance.
Conclusion: Higher rates of depression, anxiety, and stress were associated with poorer sleep quality. Students with better sleep quality perceived better academic performance compared to those with poorer sleep quality. A ceiling effect may have occurred with stress, potentially explaining the lack of relationship with perceived academic performance.
Limitations include preliminary data analyses and the surveys were completed by participants within the last three weeks of the semester. The end of the semester likely contributed to high levels of stress and anxiety.
Support: None.
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9:30-11:00 a.m.
Exhibit Hall (CMCC lower level) |
Poster: 180
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| Reed, Aishah |
Harrison, Theresa |
Connecting Through Care: A Journey of Self-Exploration
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Abstract Text
As a senior nursing student, I have come to understand the inherent responsibility within our profession to understand our community and make a difference in it. It is essential for us to know their pain, suffering, and limitations that then lead to them being in our care. The way I saw it, the only way to understand the community of patients I would be caring for, is by meeting and getting to know them. Giving back to my community, and putting myself in uncomfortable situations was my ultimate goal as a freshman. I started by being an active member of the Capstone Scholar’s Service team because the mission and community that they built on campus was something that drew me in, and ultimately was the foundation that had me yearning for new experiences. I gave back to my very own community, by becoming a Teaching Aide at the Islamic School that I attended. This allowed me to be transferred into the mind of a child which proved to be very helpful during my clinical orientations, and learn about the importance of communication. For my final adventure, I went on a service trip to going to Honduras during Spring Break and worked with a team of professionals to provide free healthcare to the areas that have limited resources and aid. This allowed my passion to cross oceans, and see a whole new variety of people, cultures, and practices that I was not have been familiar with until then. Whilst on this trip, I had the role of the Communications Director where I conversed with the locals and gathered their stories to share with the HQ in Charleston. This allowed us to spread awareness about the health disparities and situations of people living in that area. I will have now by the end of my four years have accumulated more than 500+ hours of community service, and through this, I have formed my own reasoning, communication techniques, and leadership abilities that I will forever carry with me as I progress in my career.
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9:30-11:00 a.m.
Exhibit Hall (CMCC lower level) |
Poster: 265
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| Steichmann, Nicholas |
Speiser, Daniel |
Four Eyes, One Vision: Shedding Light on the Function of Decapod Accessory Eyes
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Abstract Text
Eyes are physiologically costly organs to produce and maintain, making the development of secondary eyes intriguing. Caridean Shrimp possess reflecting superposition primary eyes, but some species across fourteen families possess an additional pair of eyes called accessory eyes along the dorso-posterior margin of the primary eyes. Some shrimp may optimize their visual system’s efficiency by using accessory eyes to communicate directly with endocrine organs in their eyestalks. The X-organ sinus gland complex in the shrimp eyestalk releases hormones which serve a variety of functions, including regulating pigment dispersal within chromatophores, which is a light influenced behavior. The function of accessory eyes is not known, however we have shown using electroretinography (ERG) that they are responsive to light between 380-700 nm in Saron marmoratus. We are using histology and optic nerve tracing to ask how the accessory and primary eyes of caridean shrimp connect to the X-organ sinus gland complex and the optic neuropils of the brain in S. marmoratus. We predict that the nerve tracts carrying information from the accessory eyes lead directly to the sinus gland and from there to a direct hormonal response, whereas information proceeding from the primary eye is integrated separately in the brain. We propose that this is used by the shrimp to quickly adapt their chromatophores to their environment without affecting with the tasks of the primary eyes.
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1:00-2:30 p.m.
Columbia Ballroom (CMCC upper level) |
Poster: 89
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Wohlfeld, Christian
Orth, Alexis |
Fadel, Jim |
Peripherally-Administered Semaglutide Modulates the Activity of Distinct Neuronal Populations in Healthy Adult Rats
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Abstract Text
GLP-1 agonists have seen a recent expansion in clinical use and have provoked considerable research interest. Beyond glycemic control and weight loss, the recent results of the SELECT trial indicate cardiovascular benefit in non-diabetic, obese patients. Preclinical evidence suggests multiple neuroprotective and anti-inflammatory effects facilitated by GLP-1 agonists. Concomitantly, dozens of clinical trials have emerged to assess GLP-1 agonist effectiveness in various neurodegenerative diseases. However, the fundamental mechanisms by which GLP-1 agonists function in the central nervous system are inadequately characterized. Some basic research is confounded because peripherally administered GLP-1 agonists exhibit regional specificity in their distribution throughout the mammalian brain. The effects of GLP-1 agonists on feeding and other integrative physiological functions suggest the involvement of hypothalamic regulatory centers such as the lateral hypothalamus. A prime candidate for mediating GLP-1 responses in this area is the orexin/hypocretin system, which projects to many areas of the brain including the basal forebrain cholinergic system (BFCS), habenula, and locus coeruleus.
Here, our goal was to begin to elucidate the potential mediators of GLP-1 agonist effects on neural functions. Adult male rats received an acute intraperitoneal administration of the GLP-1 agonist, semaglutide (0.12 mg/kg) or vehicle (1:8 DMSO: NS). Two hours later, the animals were euthanized, and their brain processed for immunohistochemical detection of c-Fos, a marker of neuronal activation. Dual labeling was performed to further examine the phenotype of semaglutide-activated neurons. Semaglutide treatment elicited significantly increased activity in hypothalamic orexin neurons and cocaine and amphetamine-related transcript (CART) neurons in the habenula (Hb). In the brainstem, there was a trend towards decreased activity in noradrenergic neurons in the locus coeruleus, and no effect in dopaminergic neurons in the substantia nigra or ventral tegmental area. These anatomical regions and cell populations are components of neural circuits that regulate feeding, metabolism, sleep, cognition and behavior, and immune function. Accordingly, pharmacologic modulation of these specific neuronal populations may underscore observed clinical adverse effects and/or unrealized therapeutic potential with the GLP-1 agonists. Further inquiry into the neural mechanisms of GLP-1 agonist neuroprotective effects is needed as these drugs become more prescribed in clinical populations.
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9:30-11:00 a.m.
Columbia Ballroom (CMCC upper level) |
Poster: 85
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| Ho-Olinger, Angelica |
Dawes, Molly
Lohrbach, Emily |
Why Students Do Not Tell Teachers About Bullying
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Abstract Text
Bullying is harmful. For victimized youth, it can have significant consequences on their development including low self-esteem, depressive symptoms, anxiety, social rejection or isolation, and difficulties in the completion of schoolwork (Juvonen & Schacter, 2017; Menesini & Salmivalli, 2017; Cantone et al., 2015). Teachers play a crucial role in anti-bullying efforts (Yoon & Bauman, 2014). As the adult figures in the classroom, they are most likely to witness bullying and are responsible for addressing these issues (Troop-Gordon, 2015; Veenstra et al., 2014). However, sometimes teachers do not get involved. This could be because they do not see it or because victims do not disclose their experience to them (Frisén et al., 2012). To better understand why students may not tell their teacher about bullying, this study asked emerging adults to share their reasons for not disclosing their experience with their teacher. Participants were undergraduate students enrolled in a course from a large southeastern university in the United States. Students were asked whether they were bullied during K-12 and if yes, whether they spoke with the teacher about the bullying. For those that responded “never,” they were asked to write out their response to the question: “Why didn’t you tell the teacher about the bullying?” Responses were coded according to content (i.e., open coding). Similar codes were then connected via axial coding into thematic categories. Results suggest that students do not tell their teacher for a variety of reasons which include: (1) fear of getting in trouble, (2) wanting to handle the situation independently, (3) doubting the teacher’s willingness or capacity to help, and (4) fear of escalating the situation among others. Implications for antibullying efforts in schools are discussed.
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1:00-2:30 p.m.
Exhibit Hall (CMCC lower level) |
Poster: 24
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| Cardaci, Thomas |
Murphy, Angela |
Cancer cachexia increases skeletal muscle lipid deposition and decreases lipid droplet-mitochondrial contact
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Abstract Text
Cancer cachexia is the unintentional loss of lean mass and directly contributes to functional dependency, poor treatment outcomes, and decreased survival in cancer patients. While the pathogenicity of cachexia is multifactorial, metabolic dysfunction remains a key contributor to its progression. Despite this, there is a lack of evidence investigating the role of altered muscle lipid homeostasis, lipid droplet dynamics, and lipid droplet-mitochondrial interactions in contributing to this wasting syndrome. Therefore, the purpose of this study was to investigate the impact of cancer cachexia on skeletal muscle dysfunction and mass loss, intramyocellular lipid droplet content and morphology, and lipid droplet-mitochondrial contact using the Lewis Lung Carcinoma (LLC) murine model. C57/BL6 male mice (n=20) were implanted with LLC cells [106] in the right flank or underwent sham surgery. Skeletal muscle was excised for transmission electron microscopy (TEM; soleus), oil red o/lipid staining (tibialis anterior), and protein (gastrocnemius) 25 days following implantation. One-way ANOVAs were used to assess statistical differences (p<.05). TEM analysis unveiled LLC mice had greater number (232%; p=0.0055) and size (130%; p=0.0226) of intramyocellular lipid droplets further supported by increased oil-red o positive fibers (87%; p=0.0109) compared to controls. Additionally, morphological analyses of lipid droplets show altered morphometrics (i.e. roundness, circularity, aspect ratio, etc.) as well as decreased lipid droplet-mitochondria contact (86%; p=0.0042) and dysregulation in lipid droplet regulatory proteins in cachectic muscle (p<0.05). Collectively, these data demonstrate that cancer cachexia induces myosteatosis, alters lipid droplet morphology, and decreases mitochondrial interactions likely contributing to the decrements in skeletal muscle mass and function experienced by cancer patients.
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1:00-2:30 p.m.
Columbia Ballroom (CMCC upper level) |
Poster: 57
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| Wilson, Hanne |
Matthews, Sarah |
Stereotypes About Poverty in Brazil
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Abstract Text
As a part of the International Business Education Alliance (IBEA) Cohort, I studied abroad three times across three continents throughout my time in college, with destinations including Germany, Singapore, and Brazil. I decided to join this cohort in order to learn more about other cultures and become a more well-rounded citizen of the world. In the fall of 2023, I spent six months in Brazil and fell in love with the country. During my time there, I wanted to give back to the community that I loved so much, which is how I came across the non-profit Edumais. While working there, I was able to draw connections between the class I took at the University of South Carolina on Brazilian film (PORT 309) and my real-world experience. In the class, we discussed the ways that favelas are portrayed in Brazilian media, specifically focusing on stereotypes and how they can be harmful. We discussed how Brazilian media portrays everyone living in favelas as extremely poor and violent. During my semester abroad in Rio de Janeiro, a city comprised of many favelas, I was able to teach within a favela and learn a considerable amount from the experience. I found that poverty looks different for everybody and within underprivileged communities, there are different social classes. I also learned how stereotypes can be harmful to communities who are trying the cycle of poverty. Through this experience, I gained a new perspective on favelas in Brazil while building meaningful connections with students at the same time.
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1:00-2:30 p.m.
Exhibit Hall (CMCC lower level) |
Poster: 238
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| Hammock, Julia |
Spence, Gina |
HR Intern at the South Carolina Attorney General's Office
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Abstract Text
My internship in the Human Resources Division at the South Carolina Attorney General’s Office has been an eye-opening experience, revealing the paramount importance of adaptability in both individual roles and overall organizational dynamics. Throughout my role as an intern, adaptability emerged as a central skill, requiring me to seamlessly transition between diverse tasks and respond to the ever-changing demands of HR. Whether immersed in meaningful assignments or navigating through routine tasks, the need for adaptability became evident, especially as I observed my supervisor and colleagues addressing the complexities of HR with grace and flexibility.
The dynamic nature of HR, centered around dealing with people and their various needs, underscored the indispensable nature of adaptability. From handling challenging hiring processes to managing resistance to organizational changes, such as telecommuting initiatives, adaptability became a critical aspect of successful HR practices. Additionally, witnessing representatives from other agencies react to our organizational practices, like our recent adoption of a business casual dress code and the absence of casual Fridays, highlighted the potential hindrance posed by a lack of adaptability to modern practices within the public sector. Reflecting on these experiences, my internship has reshaped my perspective on the role of adaptability in state agencies. The challenges faced by the Attorney General’s Office, including high turnover rates and resistance to modern HR practices, point to the necessity of fostering a culture of adaptability. I firmly believe that embracing adaptability as a core value is not just beneficial but imperative for the growth and effectiveness of state organizations. Personally, I have incorporated these insights into my work style, taking more initiative, offering assistance beyond my usual tasks, and seeking substantial projects. As I move forward, I am committed to advocating for and embodying a culture of adaptability, recognizing its transformative potential in the ever-evolving landscape of HR and state governance.
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1:00-2:30 p.m.
Exhibit Hall (CMCC lower level) |
Poster: 361
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| Knudsen, Sophia |
Cai, Chao |
Naloxone Prescribing Trends Among Regions and Providers of the United States: Analysis of Medicare Part D Prescriber Data 2013–2020
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Abstract Text
This study analyzes the naloxone prescribing trends among regions and providers in the United States (US) to Medicare Part D beneficiaries. The opioid overdose epidemic continues to take tens of thousands of lives each year in the US, and there is a gap in knowledge about how Medicare Part D beneficiaries are being impacted. Naloxone hydrochloride, commonly referred to as naloxone or Narcan, is an opioid overdose antidote that reverses opioid-induced respiratory depression and/or central nervous system depression. This project serves to fill gaps in the current literature around the opioid epidemic and the understanding of how providers, such as physicians, nurse practitioners, and physician assistants have been prescribing naloxone to Medicare Part D beneficiaries over the 2013-2020 time period. This project is a cross-sectional, descriptive study. The study data was obtained from US Centers for Medicare & Medicaid Services (CMS) website’s most recent Medicare Part D Prescriber Public Use Files (PUF). SAS statistical software and R are used to analyze data that will later be descriptively discussed in the context of the current literature surrounding state differences in naloxone prescribing laws and recommendations, the opioid epidemic statistics, and factors impacting naloxone prescribing among different provider specialties. The data analysis is focused on descriptive statistics to detail how prescribers across the US and across different disciplines have changed prescribing habits. This will show the trajectory of future naloxone prescribing trends and highlight what geographic regions and specialties could benefit from interventions, including education, state laws, changes in recommendations, or targeted programs. The variables describing the cohort of prescribers and the prescription claims will be compared across years, regions, and provider types. Preliminary results indicate a vast increase in opioid prescriptions from all prescriber types and in all US states from 2013 to 2020. The providers prescribing the highest volume of naloxone are nurse practitioners, family practice physicians, physician assistants, internal medicine physicians, and pain management physicians. Naloxone prescriptions to Medicare Part D patients h expanded from 4 states in 2013 to all 50 states and the District of Columbia in 2020. Data analysis is still being conducted.
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1:00-2:30 p.m.
Columbia Ballroom (CMCC upper level) |
Poster: 209
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| Mohammadi, Tannaz |
Ely, Bert |
Characterization of newly discovered broad host range ssDNA and dsDNA bacteriophages that infect Caulobacter and non-Caulobacter strains
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Abstract Text
Bacteriophages are viruses that infect bacteria, and most phages have double-stranded DNA genomes, although some have RNA or single-stranded DNA genomes. To better understand the diversity and biology of bacteriophages and their hosts in natural environments, I have conducted extensive sampling of plant roots and soil sampling sites along Rocky Branch Creek on the University of South Carolina campus. I have isolated 56 phages from a soil and plant roots sampling site next to Rocky Branch Creek, and a high percentage of the soil bacteriophages sampled are phages that appear to have ssDNA genomes. A total of 41 phages are ssDNA phages with turbid plaques, and 15 phages are dsDNA phages with clear plaques. This is the first time anyone has isolated a single-stranded DNA phage that infects Caulobacter. The morphology of these bacteriophages was observed through transmission electron microscopy, and their genome sizes were determined using pulsed-field gel electrophoresis. Additionally, the characteristic plaque size and appearance of the plaques generated by each bacteriophage were documented. A high percentage of bacteriophages have a broad host range, as they infect not only a wide variety of our laboratory Caulobacter and soil Caulobacter strains but also different bacterial genera. The morphology and genome size of dsDNA phages are similar to that of CbK phages, ranging from approximately 190 to 240 kbps. The genome size of ssDNA phages is 8 kbps, and they form turbid plaques with a broad range of larger plaque sizes. Interestingly, the ssDNA phages usually have titers of 1010-1011. My preliminary results suggest that a high percentage of soil bacteriophages sampled are not lytic phages. Since these phages were isolated from soil and plant roots, we anticipate that they represent new species, new genera, or even new families of viruses.
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1:00-2:30 p.m.
Columbia Ballroom (CMCC upper level) |
Poster: 83
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| Boateng, Nana Ama |
Banerjee, Meeta |
Exploring the Impact of Vicarious Discrimination Among BIPOC Population with Regards to Policing and Neighborhood Problems
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Abstract Text
Researchers have pointed to perceived racism and racial discrimination as contributors to health inequities and a wide range of negative health outcomes for both adults and children (Williams & Mohammed, 2009). Police interactions with Black, Indigenous, and people of color (BIPOC) continue to make news waves due to discriminatory actions by officers (Kahn et al., 2017). The current study aims to understand how BIPOC beliefs about discrimination impact their interactions with interpersonal domains. The first research question examines whether there are racial and ethnic differences in the perception of differential treatment by race in police interaction. The second research question expands the first question to precisely identify the racial and ethnic groups who perceive unequal treatment with police interaction concerning discrimination. Lastly, is there a significant relationship between the perception of discrimination by police interaction and physical and mental health outcomes?
The current study is based on National Public Radio, the Robert Wood Johnson Foundation, and Harvard T.H. Chan School of Public Health data. For this study, we primarily utilized the sample of 802 African Americans, 803 Latino individuals, 500 Asian Americans, 342 Native Americans, and 902 white Americans.
A crosstabs analysis indicated that Black non-Hispanic individuals reported that they believe they experienced personal discrimination when interacting with police officers due to their race compared to ethnic minority counterparts. To address the second question, ANOVAs were conducted to explore racial/ethnic differences in relation to discrimination by police. Findings suggest that there were significant group differences in experiencing discrimination when interacting with police by race [F (5, 950) = 23.71, p <.001]. Lastly, hierarchical regressions were conducted, focusing primarily on the Black sample and controlling for gender. We found that there was a significant association between perceptions of Black individuals experiencing discrimination when interacting with police and physical health outcomes (B=0.08; SE=0.04, p<.05), suggesting that discrimination experiences are deleterious to physical health.
These findings indicate that physical health is negatively impacted by perceptions of discrimination due to police interactions. Implications of these findings will be discussed in how community-wide interventions are needed with regard to police and community interactions.
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9:30-11:00 a.m.
Columbia Ballroom (CMCC upper level) |
Poster: 47
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| Thurlow, James |
Childs, Matt |
Indigenous Resistance to Spanish Colonialism
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Abstract Text
My research examines the extent and success of Indigenous resistance to Spanish Colonialism after Spain firmly established settlements in the closing years of the fifteenth century. To examine this issue in detail, I am particularly focused on the islands of Puerto Rico, Cuba, and Haiti. Because of the eventual dominance of colonial powers and near extinction of local populations to disease, the timeline for my research is Columbus’s landing in 1492 to approximately 1580. I seek to answer the question of where and how did natives most successfully resist the Spanish colonization after colonies were reliably established? My research is based on primary sources that include Spanish Government records, correspondence between Spanish Colonial Governors and the Spanish Crown, and surviving first-hand accounts. This research shows the strong desire to not submit to Spanish rule by indigenous tribes and highlights ways in which local cultures survived Spanish contact intact.
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1:00-2:30 p.m.
Exhibit Hall (CMCC lower level) |
Poster: 16
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| Smith, Julia |
Harrison, Theresa |
There Is a Need for Mental Health Advocacy and Teacher Education on Mental Health Within Elementary Schools
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Abstract Text
My name is Julia Smith, and I am a senior Elementary Education major pursuing graduation with leadership distinction in professional and civic engagement. I am part of a program at the University called Teaching Fellows, a professional organization and fellowship geared towards building professional relationships and growing as an educator. Teaching Fellows as a program has been influential in my college career as it has provided me with numerous professional development sessions that have impacted my view on education. These professional development sessions have led me to inquire about mental health within education, both for teachers and students, as well further shaping the belief that I hold that relationships are an integral part of a successful classroom.
In this program I am head of the mentor-mentee committee which has shaped me into a leader with a focus on relationships. Throughout my team as the head of this committee I have grown in my belief in the importance of relationships, especially when in leadership. By maintaining a strong professional relationship with those in my committee I have become more flexible when dealing with personal issues and have been able to relate to those I am leading.. In my internship, which is a third grade public school classroom setting, relationships are an important part of how the classroom is run and is included in the 4.0 rubric under classroom community, which is the rubric that all teachers in South Carolina are graded upon. I have built a relationship with my students and from this relationship have learned where my students are in content areas. Through trust that has been built through relationships, my students will listen to me and know that I care about them and will therefore be more engaged and listen to what I have to say and demonstrate learning. This is the goal of relationships in a classroom, that these relationships will lead to student growth and learning and by forming these relationships students are able to learn.
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9:30-11:00 a.m.
Exhibit Hall (CMCC lower level) |
Poster: 257
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| Chambers, Kareem |
Welshhans, Kristy |
Dysregulated Adhesions and Local Translation in Down Syndrome Fibroblasts
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Abstract Text
Down Syndrome (DS) results from the triplication of human chromosome 21. Due to the high number of genes located on chromosome 21, people with DS exhibit varied phenotypes, including congenital heart defects, intellectual disability, and slow wound healing. Fibroblasts are cells critical for appropriate wound healing. The motility of fibroblasts depends strongly on focal adhesions, which are connections between the cell’s actin cytoskeleton and the extracellular matrix. Previous work from our lab has shown that the morphology and motility of fibroblasts are altered in DS. These findings suggest that focal adhesions are also altered in DS through dysregulation of protein expression, but due to the high number of proteins involved in focal adhesion formation, it is unknown which proteins are affected. Here, we use fibroblasts from 1- and 2-year-old individuals with DS and matched apparently healthy individuals. We examined multiple proteins involved in focal adhesion formation, including talin, receptor for activated C kinase 1 (RACK1), and paxillin. Additionally, we examined translation at the leading edge of fibroblasts using a puromycin assay. In fibroblasts from a 1-year-old with DS, we find increases in cell area and perimeter and increases in protein expression of RACK1, talin, and paxillin. In fibroblasts from a 2-year-old with DS, we find decreases in area and perimeter, an increase in the expression of talin, decreases in the expression of RACK1 and paxillin, and a decrease in translation at the leading edge. Results gained from this study will be used in the future to normalize protein expression in DS fibroblasts and determine if that can rescue the altered motility phenotypes; this information is important for individuals with DS who exhibit the slow wound healing phenotype and could help restore the fibroblasts’ ability to mediate the inflammatory response. Furthermore, when neurons innervate their synaptic targets during development, they utilize similar mechanisms to control their movement. Thus, these results will also inform experiments in human induced pluripotent stem cell-derived neurons. Taken together, this research is highly relevant to improving our understanding of both the slow wound healing and intellectual disability phenotypes of DS.
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1:00-2:30 p.m.
Columbia Ballroom (CMCC upper level) |
Poster: 90
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| Kucinski, Aaron |
Dallas, Tad
Holian, Lauren |
The Transgenerational Effects of Habitat Composition on Tribolium Castaneum Population Growth Rate
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Abstract Text
A maternal stressor can negatively influence the survival and reproduction of offspring raised in ideal conditions. The degree to which offspring generations are negatively impacted and their ability to recover is directly related to the magnitude of maternal stress. If a maternal generation of red flour beetles (Tribolium castaneum) is reared in a habitat containing corn flour (a substandard resource), offspring generations exhibit transgenerational effects of decreased population growth rate, and increased extinction probability despite being raised in an ideal environment. The intensity of these transgenerational effects is expected to be proportional to the percentage of corn flour in the maternal habitat. To assess our expectations, we examined populations of T. castaneum along a gradient of maternal (treatment) habitats with varying ratios of wheat (good resource) to corn (bad resource) flour. Across each treatment (0, 20, 40, 60, 80, and 100% corn flour), maternal populations (n=10) were reared in their respective habitats, while their offspring were placed into ideal (100% wheat flour) habitats and were allowed to reproduce for several generations. Across all treatments, we observed a significant decline in population growth rate as a result of maternal habitat treatment. Further, we saw increased extinction risk in more corn-dominated treatments. The treatments that fell between these two extremes, i.e. a combination of wheat and corn flour, experienced a decrease in population growth rate proportional to their percentage of corn media. In later generations, the population growth rates of all treatments increased and eventually stabilized to a baseline. Together, these results suggest that if a maternal generation of T. castaneum is subjected to an environmental stressor such as corn flour, their offspring will exhibit transgenerational effects of decreased population growth rate, and increased extinction probability despite being raised in an ideal environment and that the magnitude of these effects is directly proportional to the severity of the corn flour stressor.
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1:00-2:30 p.m.
Exhibit Hall (CMCC lower level) |
Poster: 82
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| Becker, Jacob |
Arent, Shawn |
HEART RATE MEASURE VALIDITY ON APPLE WATCH AND POLAR GRIT X COMPARED TO POLAR H10 SENSOR
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Abstract Text
Heart rate (HR) measure agreement between wrist-worn devices and standard chest straps during non-steady-state exercise is unclear. PURPOSE: To assess agreement between wrist-based photoplethysmography (PPG) devices (Apple Watch Series 8 [AW], Polar Grit X [PX] compared to Polar H10 chest electrocardiographic device (H10) estimated HR.
METHODS: After determining velocity at VO2max (vVO2max), participants (50% male; age 18-35) completed two testing days wearing the PX, AW, and H10. Day 2 consisted of two, 4-minute bouts on the treadmill at 50% and 75% of vVO2max followed by an 8-min interval effort (30:30) at 100-120% of vVO2max. Day 3 consisted of a high intensity functional training (HIFT) protocol comprised of 3 rounds of 5 exercises with a 40:20 work:rest ratio. Agreement between HR from wrist-based PPG and H10 devices were analyzed via inter-class correlation coefficient (ICC) with 95% confidence intervals. An alpha level of 0.05 was used to determine statistical significance.
RESULTS: There were strong significant correlations between H10 and AW all interval intensities for average and max HR (Average50%: ICC=0.99, CI=0.98-1.00; Average75%: ICC=0.84, CI=0.62-0.94; Average100%: ICC=0.95, CI=0.84-0.98; P<0.0001; Max50%: ICC= 0.97, CI=0.91-0.99; Max75%: ICC=0.97, CI= 0.91-0.99; Max100%: ICC=0.97, CI=0.91-0.99; P<0.0001). In contrast, average HR between PX and H10 were significantly moderately correlated at 50% and 75%, but not 100% ( Average50%: ICC=0.70, CI=0.18-0.89; Average75%: ICC=0.50, CI= 0.01,-0.80; P<0.01), and max HR between PX and H10 was only significantly correlated at 50% (Max50%: ICC=0.79, CI=0.50-0.92; P<0.001). There was strong agreement between AW and H10 (ICC=0.92, CI =0.59-0.98; P<0.0001) but not PX (ICC=0.19, CI =-0.11-0.55; P=0.05), during HIFT.
CONCLUSION: While AW shows strong agreement across multiple exercise intensities and modalities, the PX does not demonstrate as strong of agreement. The PX showed decreased agreement as running interval intensity increased and poor agreement during HIFT. While the non-invasive nature, affordability, and convenience of PPG shows promise, consumers and researchers should take this information into account when selecting a PPG device. The novel inclusion of HIFT sets this study apart and indicates the need for agreement testing across multiple exercise modalities in the field.
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9:30-11:00 a.m.
Columbia Ballroom (CMCC upper level) |
Poster: 75
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| Steger, Neve |
Berge, Nicole |
Creating Value-Added Products from the Hydrothermal Carbonization of Food Waste: Hydrochar Post Processing Needs
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Abstract Text
The hydrothermal carbonization (HTC) treatment of food wastes and other wet wastes has shown the ability to recover and convert resources into environmentally beneficial value-added carbonized products (hydrochar). Hydrochar is considered a promising, possibly advantageous soil amendment. For the HTC process to be adopted in the food waste management area, a more thorough understanding of the post-treatment processes required to make food waste-derived hydrochar a viable soil additive is important. Post treatment processes—water-washing and solvent-washing—are being conducted on hydrochar generated from the HTC of five representative food waste feedstocks at different temperature conditions—200 °C and 250 °C. Germination index and testing of soil fertility related chemical compounds including Nitrogen, Phosphorous, and volatile acids, were performed on the varying hydrochars. Analysis of the resulting phytotoxicity and chemical concentrations is currently being performed to: (a) understand how food waste properties and HTC reaction conditions affect chemical properties of carbonization products and their potential use as a soil amendment; (b) determine the post treatment needs for using hydrochar as a soil amendment; and (c) generate life cycle inventory (LCI) data to perform a life cycle assessment (LCA) of the HTC process. Results from this work will be used to identify the factors that influence the environmental impact of carbonization product use so that environmentally beneficial and economically attractive operational strategies of the HTC of food waste can be developed.
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9:30-11:00 a.m.
Columbia Ballroom (CMCC upper level) |
Poster: 25
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| Arnold, Meaghan |
Matesic, Lydia
Pittman, Douglas
Wright, Ymani |
Exploring the Interaction Between WWP1 and WBP2 in the Human Heart
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Abstract Text
WW domain-containing protein 1 (WWP1) is a member of the C2-WW-HECT family of E3 ubiquitin ligases and has been shown to mediate the post-translational modification (ubiquitination) of a multitude of substrates, particularly those containing proline-rich regions known as PY motifs. WWP1-mediated ubiquitination can influence target protein subcellular localization, stability, and/or function, thus serving an important regulatory role in homeostasis. While dysregulation of WWP1, specifically through its overexpression, is associated with a number of prevalent pathologies like human cancers or heart failure, the molecular mechanisms by which WWP1 promotes these phenotypes remain underexplored. Therefore, to identify proteins that interact with WWP1 in the human heart, a yeast two hybrid (Y2H) screen of a human heart library was performed using WWP1 as the “bait”. From this screen, 22 putative interactors of WWP1 were identified. Chief among these was the oncoprotein WW-domain binding protein 2 (WBP2) whose function in the heart is completely unknown, but, because of the parallels between WBP2 and WWP1 in oncogenesis, this interaction was further scrutinized. The specificity of this WWP1-WBP2 interaction was verified by switching the open reading frames of these proteins within the “bait” and “prey” constructs of the GAL4 Y2H system and noting activation of reporter genes only when both WWP1 and WBP2 were present in the same cell. In order to elucidate which domains of WBP2 mediate this interaction, site-directed mutagenesis was used to create WBP2 mutants with one or more nonfunctional PY motifs. The relative effects of these sequence-confirmed mutants on WBP2’s interaction with WWP1 were subsequently evaluated through serial dilution assays and β-galactosidase activity assays, revealing that the second and third PY motifs of WBP2 were essential for its interaction with WWP1. Co-immunofluorescence studies are currently underway to determine whether these proteins co-localize endogenously in the human heart. This study represents a critical step in understanding the regulation of key signaling pathways involved in human disease phenotypes in order to identify novel therapeutic interventions targeting one or both of these proteins.
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9:30-11:00 a.m.
Exhibit Hall (CMCC lower level) |
Poster: 35
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| Pia, Jessica |
Sides, Andrew |
Persistent Altered Mental Status Secondary to SGLT2 Inhibitor-Induced Euglycemic Diabetic Ketoacidosis: A Case Report
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Abstract Text
Euglycemic diabetic ketoacidosis (EuDKA) represents only 2.6-3.2% of all DKA cases and is characterized by blood glucose less than 250 mg/dL with metabolic acidosis and ketonemia. Sodium-glucose cotransporter 2 inhibitors (SGLT2i) are a new, popular class of oral diabetes medications. However, recent studies suggest that there is a sevenfold increased risk of EuDKA in type 2 diabetic patients taking an SGLT2i with an overall incidence of approximately 0.1%. DKA is a medical emergency and euglycemia often hinders making this diagnosis. When left untreated, DKA can have catastrophic consequences such as severe dehydration, cerebral edema, and coma. This is a case of a 50-year-old female with type 2 diabetes mellitus who had been taking insulin Detemir 28 units daily and Canagliflozin 300 mg daily. Upon admission for encephalopathy, she was found to have severe metabolic acidosis, elevated anion gap, blood glucose of 270 mg/dL, ketonemia, and marked glucosuria and ketonuria. The diagnosis of DKA was made and intravenous insulin and fluids were started. After 3 days of treatment blood glucose remained under 200 mg/dL, bicarbonate improved to 21, and anion gap was consistently closed. Thus, DKA was presumably resolved and transition to subcutaneous insulin was made. However, she unexplainedly remained without improvement in mental status. This prompted more extensive work-up including lumbar puncture, autoimmune encephalitis panel, EEG, head imaging, urinalysis, and repeat blood cultures. All findings were unremarkable, except urine was found to still have high levels of glucose and ketones. Repeat blood testing showed persistent ketonemia. With these new findings, the diagnosis of EuDKA was made and insulin drip was restarted. After 2 more days of aggressive hydration and intravenous insulin the patient’s mental status began improving with concomitant decrease of ketones in the blood. The patient’s Canagliflozin was held during the admission and later presumed to be the culprit of her unusual EuDKA presentation. Currently, resolution of DKA is defined by normalization of blood glucose, serum bicarbonate, pH, and anion gap. There are no guidelines describing the need to trend urine or blood ketone levels in DKA patients, but this case may suggest otherwise.
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1:00-2:30 p.m.
Columbia Ballroom (CMCC upper level) |
Poster: 134
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| Thomson, Elizabeth |
Goldberg, Kelly |
Breaking Academic Stereotypes: A Peer Leader's Journey
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Abstract Text
Students often feel a negative stigma and embarrassment when it comes to seeking academic help, especially in the collegiate level. Through working with the Student Success Center and Leadership and Service Center, I have worked to destigmatize requesting resources through proactive outreach to students. However, I have also seen a misunderstanding with some students equating using academic resources to admitting failure when in reality, these services are meant to support students at all levels. As a peer leader, I have learned the importance of effective communication with students while maintaining a peer relationship. Most students that attend places like the Student Success Center see positive changes in their academics. In my experience, I have discovered how fulfilling it is to create a positive impact. I hope to continue to work with others and provide support to make a positive impact on my peers and beyond.
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9:30-11:00 a.m.
Exhibit Hall (CMCC lower level) |
Poster: 258
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| Aloi, Sarah |
Schumpert, Charles |
The Identification and Analysis of the Gene TBK1 in the Daphnia Pulex Genome
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Abstract Text
Our study examined the relative levels of mRNA expression of the gene TBK1 in Daphnia pulex exposed to various hypoxic environments. Daphnia pulex, a common planktonic crustacean model organism, were chosen as the model organism because they have a homologous gene to the human TBK1 gene, they are quick and easy to rear, and they can respond rapidly to their environment (Ebert, 2022). The loss of function of TBK1 in humans can cause neurodegenerative diseases (Xu, 2018). Another risk factor for neurodegenerative diseases in humans is exposure to neurotoxins such as heavy metals (Reuben, 2019). Daphnia have been used for decades in the study of heavy metal exposures (and are commonly used by water treatment facilities to analyze treated water). We hypothesized that Daphnia reared in an environment that had toxic heavy metals present would stop expressing TBK1. In the tests completed using two of our three designed primers, TBK1 was expressed in both the control and experimental groups, which did not support our hypothesis that the expression of TBK1 would be silenced in Daphnia reared in an environment with heavy metals. However, we were successful in finding two primers that effectively isolate the TBK1 gene in the Daphnia genome. Our future directions include changing the concentration of heavy metals, analyzing protein expression of TBK1, and determining the impacts of knocking down the expression of TBK1 in Daphnia pulex exposed to heavy metals. With neurodegenerative diseases on the rise, studies such as ours are crucial steps in finding potential therapies and hope for a truly debilitating set of diseases.
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9:30-11:00 a.m.
Exhibit Hall (CMCC lower level) |
Poster: 63
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| Bates, Logan |
Morris, Caleb |
Navigating the Supply Chain: A Journey Through Internship and Classroom Leadership
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Abstract Text
During the Summer I worked with DHL at their Mann Hummel site in Cowpens, South Carolina. DHL is a world leader in third-party logistics (3PL), hired to control warehouse operations and other logistic roles within companies. My position during the summer was as an Operations Intern, meaning I helped the operations team with day-to-day tasks and sometimes week-long projects. As a Operations and Supply chain major here at the University of South Carolina, my internship provided me with a summer full of professional experience and knowledge. I had the opportunity to aid in the completion of warehouse projects, and other challenges thrown our way. The Mann Hummel site was 1.6 million sq feet (about half the area of The Vatican) and was packed full of various air and oil filters waiting to be distributed to customers. Our Primary customers were big companies such as Ford, Tesla, Walmart, and AutoZone. Specifically, I managed Excel spreadsheets and helped solve cases in the warehouse where something along the distribution process may have gone wrong, resulting in an unhappy customer. Near the end of the Summer, I had the pleasure of being able to attend DHL’s Capstone event in Ohio. This is a major networking event for interns across the company over the summer. My time with DHL has allowed me to fall in love with the world of supply chain, and fully know what I want my career path to look like going forward.
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9:30-11:00 a.m.
Exhibit Hall (CMCC lower level) |
Poster: 346
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| Calvery, Jack |
Epps, Lauren |
GLD in Global Learning
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Abstract Text
This is my GLD presentation through the Globalization pathway. My name is Jack Calvery. I am a current senior, majoring in Marine Science with a concentration in biology, and minoring in Anthropology. While at the University of South Carolina I have learned multiple lessons through classwork, which were then reinforced in extracurricular activities, and seen implemented while traveling abroad. My first lesson includes the importance of movement, primarily in the marine field through migration, but more importantly in my life while pursuing goals. My second lesson was on the value of cooperation, especially in conducting research but also in becoming the fullest version of myself. Finally, I focused solely on the act of service, and how important it is to be of service to others. While abroad I spent four months in Ecuador and another four in Ireland. My time in Ecuador was spent living with two host families, one for seven weeks in Quito, and another for ten weeks on San Cristobal Island, in the Galapagos. My second semester was spent living in an apartment style in Dublin, Ireland. Here I travelled across Europe visiting Switzerland, Slovakia, Northern Ireland, Austria and Portugal.
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1:00-2:30 p.m.
Exhibit Hall (CMCC lower level) |
Poster: 332
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| Schwertfeger, Julia |
Colascione, Megan |
Finding Myself by Helping Others
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Abstract Text
For the past three years, I have worked as a Resident Assistant (RA) in Patterson Hall, helping incoming freshmen adapt to life in college. I applied for this position in my freshman year of college when I realized I wanted to build more connections on campus and ensure students had an enjoyable experience in their first year. During my time in this position, I have been responsible for various tasks including responding to high-stress situations, managing floor events, building connections with over sixty residents, and enforcing housing policies. My main goal in this position was to provide students with a role model they felt comfortable bringing problems to and whom they could trust. I did this by fostering personal relationships with every resident on my floor and being a constant figure in the building that they could count on. I discovered that the best way to foster these relationships was to have an open and clear line of communication. Treating residents with care and compassion when they have problems, using an understanding tone, and being open about my own struggles made students feel understood and seen. Communication is the best way to build connections across different backgrounds. This presentation will show the insights I have gained about my leadership abilities and how this experience has not only shaped my college experience, but also me as a person.
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1:00-2:30 p.m.
Exhibit Hall (CMCC lower level) |
Poster: 318
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| Rabon, Sydney |
Keane-Dawes, Antony |
Professional and Civic Engagement Within Civil Engineering
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Abstract Text
I have been working as an intern at Rummel, Klepper & Kahl (RK&K). RK&K is a multi-discipline civil engineering firm, and I work at their downtown Columbia location in their roadway department. As a civil engineering major at the University of South Carolina, my internship allowed me to experience the design of projects first-hand. I was given the opportunity to research design criteria for roadways and apply the information I’d learn to designing a project. I was also able to assist in other disciplines of civil engineering when needed. I’ve worked on numerous projects, such as intersection improvements, bridge replacements, scour reports, design-builds, and many more. I also had the opportunity to attend my first Public Interest meeting (PIM) on an intersection improvement, when I had designed the PIM poster. I was able to experience the social aspect of civil engineering since community impacts are an important concern. I got to speak with many community members and explain the design and its improvement, as well as how it would affect them as a community during and post construction. During my first two internships I started to doubt my decision to pursue engineering. However, during this internship I found a passion for road design and for this career, and I will be working full time at RK&K post-graduation.
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9:30-11:00 a.m.
Exhibit Hall (CMCC lower level) |
Poster: 311
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Tembo, Penias
Price, Sherry |
Hebert, James
Murphy, Angela
Hofseth, Lorne |
A Transdisciplinary Approach to Reducing Metabolic Dysregulation in Obese Dyads and Risk of Colorectal Cancer (REMEDY)
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Abstract Text
Introduction
In recent decades the incidence of early-onset colorectal cancer (EOCRC) in individuals <50 years old has increased at an alarming rate (Hofseth et al., 2020). Adiposity and diet drive metabolic dysregulation (Kabat et al., 2018; Reilly et al., 2020) and thus understanding their interaction is key to understanding the genesis of EOCRC. However, there is an absence of critical clinical trials and mechanistic studies involving lifestyle interventions to address this problem. This NCI Funded U01 study aims to address this gap. We focus on dietary modulation of gut microbes to reduce metaflammation and subsequent metabolic dysfunction in obesity with a goal of preventing EOCRC. This study aims to (1) establish the metabolic protective effects of an anti-inflammatory diet in obese, high-risk African-American and European-American adults and children (2) establish gut microbes as mediators between anti-inflammatory dietary input and reversal of metabolic dysfunction and associated CRC risk.
Methods
We are conducting an anti-inflammatory dietary intervention trial in dyads of adults and children at elevated risk for CRC. We are also conducting a complementary mechanistic animal study. This work is supported by infrastructure built over the past decades in two key centers at the University of South Carolina (1) Center for Colon Cancer Research (2002 - present – which specializes in mouse models of CRC); and (2) the Cancer Prevention and Control Program (CPCP, 2000 - present –which specializes in the epidemiology of cancer and lifestyle intervention trials for cancer, with a focus on cancer disparities).
Hypothesis
We hypothesize that an anti-inflammatory dietary intervention will reverse metabolic dysfunction, and this will be associated with reduced inflammation as indicated by Homeostatic Model Assessment for Insulin Resistance (HOMA-IR), IGF-1, Tumor Necrosis Factor alpha, Interleukin 6, and C-Reactive Protein, and a more favorable microbiome signature.
Conclusion
Results from this work will address the role of metabolic dysregulation in relation to factors that are known to be important in carcinogenesis, that therefore could have profound effects on EOCRC, have implications for other obesity-related cancers, and have great promise for moving the field forward by addressing mechanisms that drive large health-related disparities that consistently disfavor African Americans.
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9:30-11:00 a.m.
Columbia Ballroom (CMCC upper level) |
Poster: 91
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| Steiniger, Jacob |
Tribble, Reid |
Short Interval Recurrence of Pneumothoraxes in Birt-Hogg-Dube Syndrome
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Abstract Text
Birt-Hogg-Dubé syndrome (BHDS) is a rare disorder that includes a variety of symptoms primarily affecting the skin, lung, and kidneys. Specific manifestations include fibrofolliculomas, lungs cysts, and variants of renal cell carcinoma. This case describes a 49-year-old male with Birt-Hogg-Dubé presenting with bilateral lung cysts resulting in two spontaneous pneumothoraxes in the span of six months. Surgical intervention and future goals of care are discussed given the patient’s high risk of recurrence.
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9:30-11:00 a.m.
Columbia Ballroom (CMCC upper level) |
Poster: 160
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| Schroeder, Amelia |
Stubblefield, Brittany |
Empowering Futures: My Journey as a Peer Leader at the University of South Carolina
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Abstract Text
The University of South Carolina U101 Program continues to be ranked the number one first-year experience in the nation and much of that achievement can be attributed to the peer leadership program. The program plays a large part in promoting academic success, aiding in transition, and giving students an immediate community to feel recognized within. In my college career, I was able to devote my time to being a peer leader for 56 first-year students as well as work as a Senior Peer Leader in the Teacher as Manager course, EDLP 520. Working with these students proved to be greatly beneficial for me. In these roles, I became more familiar with various learning styles, honed my skills in effective communication, and adapted to the dynamic needs of the classroom environment. It was in this context that I experienced significant growth as a leader. During my presentation, I will delve into the insights I’ve gained about my personal capabilities both inside and outside the classroom, reflecting on how the University 101 program has influenced my college journey and equipped me for navigating life beyond academia.
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9:30-11:00 a.m.
Exhibit Hall (CMCC lower level) |
Poster: 271
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| Stofik, Sarah |
Lauterbach, Jochen
Naglic, Jennifer |
Decomposition of Tritiated Ammonia from Nuclear Fusion Through Ru-Based Catalysts
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Abstract Text
Nuclear fusion reactions power the sun and are currently being researched as a viable alternative energy source on earth. Fusion operates by joining together two hydrogen-isotope nuclei to form a helium atom and a high energy neutron. However, there are many challenges that are posed in this process. Aside from the large energy requirements to make this a reality on earth, there are also concerns related to the treatment of the radioactive materials that result as byproducts, such as tritiated ammonia. In the reaction, tritium is used as a starting material but will react with nitrogen to form tritiated ammonia. Due to the limited quantities of tritium, there is a goal to recycle the tritium back to the reactor to fuel the fusion process. Therefore, it is advantageous to catalytically decompose the tritiated ammonia that is produced and recycle the tritium back to the reactor.
This study determined an optimal trimetallic ruthenium-based catalyst for the decomposition of tritiated ammonia. To determine the weight loadings of ruthenium, yttrium, and potassium for the catalyst, a statistical design of experiments was conducted, and the catalyst’s activity was tested with 5% ammonia balanced in both argon and hydrogen over a temperature range of 250°C-450°C. The catalytic activity decreased when tested in a hydrogen balance due to hydrogen poisoning. To reduce the effects of hydrogen poisoning, a palladium membrane was utilized, and it was found that when the inlet ammonia concentration was 4 vol%, only 2 ppm of ammonia was detected in the outlet, which demonstrates the high activity of the catalyst. The reaction conditions were also changed to mimic the conditions of the fusion reactor to determine the thermal and chemical stability of the catalyst. While imposing a thermal cycle between 25°C-450°C, the catalyst was found to be stable when placed in a reducing environment. To test the chemical stability of the catalyst, it was exposed to oxygen, carbon dioxide, and water vapor. The impurities had an initial negative effect on the catalytic activity; however, the catalyst reached stability and full conversion over time.
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9:30-11:00 a.m.
Exhibit Hall (CMCC lower level) |
Poster: 110
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| Francis, Matthew |
Epps, Lauren |
Peer Leading and Learning
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Abstract Text
Peer leading plays a crucial role in many challenging courses and aspects of life, benefiting not only the teachers and students but also peer leaders. Over the past five semesters, I've been a part of the Student Success Center, initially as a Peer Financial Consultant (PFC) and later transitioning into a Supplemental Instructor (SI) during my junior year.
My motivation for joining the SSC came from many places. I sought to share the knowledge and skills I had acquired, contribute to my personal development, and participate in fostering a collaborative culture of learning within our USC community. From assisting students with financial matters to leading supplemental instruction sessions, I've directly interacted with hundreds of students, supporting them in achieving their academic and financial goals.
Through this enriching experience, I've not only positively impacted my peers, but also greatly enhanced my own educational and personal growth. I've cultivated essential qualities such as empathy, patience, and effective communication, while also supporting the creation of a supportive and inclusive learning environment. This journey was very significant to me, echoing my dedication to academic excellence and professional and civic engagement.
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9:30-11:00 a.m.
Exhibit Hall (CMCC lower level) |
Poster: 259
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| Krstanovic, Katerina |
Jabbari, Esmaiel |
Plant Protein-Based Scaffolds for Cell-Based Meat
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Abstract Text
Most people are familiar with the biomedical applications of tissue scaffolds. However, tissue scaffolds can also be utilized as an animal-friendly way to engineer cell-based meat that produces lower carbon dioxide emissions than the current meat industry. Various types of scaffolds exist, as well as different modes of scaffold and tissue preparation. This research highlights methods that have been documented in recent decades to support the growth of in-vitro skeletal muscle tissue for the purpose of cell-based meat production. The research that was carried out was literature-based, and this presentation is entirely focused on methods that have been utilized by past research teams to produce cell-based meat scaffolds and areas of improvement.
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9:30-11:00 a.m.
Exhibit Hall (CMCC lower level) |
Poster: 111
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| Eta, David |
Reinhardt, Sara |
Integrating Computer Science Across Disciplines: A Multifaceted Approach to Problem Solving
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Abstract Text
In the summer of 2023, I had the opportunity to get experience with an internship at the AI Institute. Here, I worked with a multidisciplinary team to analyze medical data on preterm infants. The aim was to apply data science to predict sepsis in pre-terms, a critical challenge in neonatal care. This work showed the importance of integrating computer science with healthcare. Demonstrating a practical application of Uncle Iroh's wisdom: drawing insights from various fields to avoid rigidity in problem-solving.
The internship involved a detailed analysis of data collected from nurses across five universities and hospitals. The approach combined data cleaning, exploratory data analysis, and the application of predictive modelling techniques to identify patterns indicative of sepsis in preterm babies. Collaboration was key. As I held discussions with doctors and medical interns to ensure the accuracy and relevance of the findings. This interdisciplinary method emphasized the importance of leveraging expertise from various domains.
While specific outcomes of the research are confidential, the process led to a deeper understanding of the factors contributing to sepsis in preterm infants and improved predictive models. The internship experience underscored the potential of data science in transforming healthcare by providing actionable insights that can lead to better patient outcomes.
The findings from this internship reinforced the initial belief in the value of interdisciplinary collaboration. Applying computer science techniques in the medical field not only broadened my skill set but also provided a unique perspective on solving healthcare challenges. This experience has implications for future research, particularly in exploring other areas where data science can be applied to improve healthcare outcomes.
The internship was a profound learning experience, emphasizing the significance of drawing wisdom from different disciplines. It has solidified my interest in applying computer science to healthcare and underscored the impact of technology in advancing medical care. Through this experience, I have gained valuable insights into the complexities of neonatal care and the potential for data science to make a meaningful difference.
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9:30-11:00 a.m.
Exhibit Hall (CMCC lower level) |
Poster: 308
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| Brabham, Truman |
Paul, Titan |
Comparative Study of Pressure Drop of Nanoparticle Enhanced Ionic Liquids (NEILs) with Traditional Heat Transfer Fluids (HTFs)
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Abstract Text
The conventional methods of energy generation have been found to have a detrimental impact on the environment. As a result, researchers are actively investigating alternative, clean, and renewable sources of energy. Among these options, solar power has emerged as a highly efficient and sustainable means of generating electricity. One of the methods for employing solar power Is the utilization of concentrated solar power systems (CSPs) systems where heat energy is stored in heat transfer fluids (HTFs) from mirrors or lenses that are positioned to concentrate sunlight to a small area. Traditional HTFs that have been used in the past to produce steam for energy production include Therminol VP-1 (eutectic mixture of biphenyl and diphenyl oxide), thermal oil, and molten salt. The problems associated with traditional HTFs are high melting points and low decomposition temperatures which increase operation costs, reduce system efficiency, and diminish energy storage potential. Ionic liquids are a class of organic salts that have low melting points, low volatility, low flammability, and high thermal conductivity which make them ideal candidates for HTFs. Additionally, ionic liquids have been found to possess negligible vapor pressure and high thermal stability that simplify the heat transfer process. Nanoparticle-enhanced ionic liquids (NEILs) are a new class of HTFs created by dispersing metal/metal oxide nanoparticles into ionic fluid. Subsequently, metallic nanoparticles have high thermal conductivities and thereby increase the thermal properties of NEILs. Although the thermophysical properties of NEILs have escalated, little research has been conducted to demonstrate their feasibility in existing CSPs. In order for NEILs to be utilized on a commercial scale, it is imperative that they can be employed without incurring expensive modifications to CSPs. A crucial aspect that necessitates investigation is the efficiency of pumping NEILs within the confines of pre-existing CSPs. Here it is proposed to show a comprehensive study of the pressure drop of nanoparticle-enhanced ionic liquids (NEILs) compared to other currently used heat transfer fluids in concentrated solar power plants.
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9:30-11:00 a.m.
Exhibit Hall (CMCC lower level) |
Poster: 117
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| Berber, Bsmla |
Goldberg, Kelly |
Nurturing Successful College Transitions Through Meaningful Connections as a Resident Assistant
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Abstract Text
The key to successfully transitioning to college has always been developing meaningful connections within the new college environment. In my three years as a Resident Assistant at Preston Residential College, I have had the privilege of cultivating meaningful connections with my residents, playing an essential and positive role in their transition to college. Prioritizing empathy in all my interactions, I dedicated myself to fostering an environment of support and inclusion. My desire to serve as a Resident Assistant stemmed from my deep-rooted passion to support others in their times of greatest need. In this role, I saw the impact of seemingly small gestures, like remembering names and offering a listening ear, on my residents. These simple acts opened doors to meaningful connections and taught me the fundamentals of building trust. Alongside strengthening my administrative, crisis, and risk management skills, this role expanded my social network by 90 peers. I take pride in having built and maintained the majority of these connections today. The same passion that guided me in this role has also fueled my ambition to pursue a career as a physician. As I apply to medical school after graduation, I am confident that the skills I have gained, particularly in relationship building and fostering success, will be extremely valuable in the next chapter of my life.
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9:30-11:00 a.m.
Exhibit Hall (CMCC lower level) |
Poster: 312
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| Checa Torres, Nicolas |
Floyd, Alex |
English as a Global Tennis Player
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Abstract Text
file:///C:/Users/Admin/Downloads/Nicolas-Checa-Abstract-Text.html
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9:30-11:00 a.m.
Exhibit Hall (CMCC lower level) |
Poster: 360
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| Johnson, Margaret |
Hudac, Caitlin
Wingard, Ezra
Uvalle, Mariana
Nelson, Cailee |
Do I Know You? Brain Responses to Familiar and AI-Generated Faces
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Abstract Text
As artificial intelligence (AI) is becoming more advanced and readily available, so is its impact on people. AI is rapidly progressing in its ability to generate realistic faces and videos, which has significant social implications when considering the advancements of deepfakes—which are realistically generated videos of real people who can be made to say/do anything— and virtual friends/influencers. Prior research suggests that the brain is typically able to distinguish between photo-realistic, artificially generated images and authentic images, even if the individual does not know they perceive the difference (Moshel et al., 2022; Tarchi et al., 2023). It is unknown how this processing intertwines with processing at different levels of facial familiarity. This study aims to identify how the brain differentiates between (1) AI generated faces and real faces and (2) familiar intimate (friend), familiar non-intimate (celebrity), and unfamiliar (stranger) faces using electroencephalograph (EEG) recording. We expect that there will be a difference in amplitude between the familiar and unfamiliar faces (Collins et al., 2018) and between AI generated faces and real faces. There may be less of a difference in response to AI-generated faces and real ones for white faces, as AI tends to be trained with majority white facial data, so those faces appear more realistic (Miller et al., 2023). To do this, we will use AI programs on photos of the participants’ friends to generate the AI-generated stranger photos and match known celebrities to friends based on similar facial features, which allows for the generated images and matched celebrities to share facial commonalities to the friends while still being unfamiliar and/or non-intimate. To better establish differences in responses to AI generated photos and real photos, we will also include real photos of strangers that are matched to the friend photo based on age, gender, and race. We will examine adolescent and adult brain responses to faces based upon type (photograph versus AI) and context (familiar friend, familiar celebrity, stranger). Amplitude and latency will be extracted for the three primary EEG outcomes, post-face onset: P1 component (80-150ms), N170 (180-300ms), and P2 component (180-300ms).
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1:00-2:30 p.m.
Exhibit Hall (CMCC lower level) |
Poster: 198
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| Rajbanshi, Abhinna |
Jin, Rongying |
Evidence for nontrivial topological properties of GeSb2Te4 single crystals
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Abstract Text
GeSb2Te4 has widespread applications in thermoelectricity, memory devices, and quantum information process. We have successfully synthesized GeSb2Te4 single crystals by the modified Bridgeman method. Its electrical resistivity exhibits metallic behavior in temperatures between 2 K and 400 K. Positive Hall coefficient (R_{H}) suggests dominant holelike carriers with carrier concentration to be 7.2 x 1020 cm^-3 at the room temperature. While it is both temperature and magnetic field dependent, the magnetoresistance (MR) falls into a single curve when plotted as a function of H/\rho_{0}, where H is the magnetic field and \rho_{0} is the resistivity at 0 T. This indicates that the system follows Kohler’s rule, reflecting the semimetallic electronic structure of GeSb2Te4. Moreover, MR shows linear field dependence above ~ 6 T at all measured temperatures, which can be attributed to its nontrivial topology of the electronic structure.
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9:30-11:00 a.m.
Columbia Ballroom (CMCC upper level) |
Poster: 30
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| Henry, Sophia |
Krizek, Beth |
Investigating the Expression of Growth-Regulating Factor2 (GRF2) in Arabidopsis Thaliana
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Abstract Text
Flowering plants are incredibly important organisms in Earth’s ecosystems and the study of molecular processes within plants has exploded in recent years. Arabidopsis thaliana is a model organism that is used in laboratories across the world for the study of cellular and molecular processes in plants. GROWTH-REGULATING FACTOR 2 (GRF2) is a transcription factor that promotes leaf growth in Arabidopsis. It is a member of a family of transcription factors that is conserved across all land plants. Previous studies have characterized GRF2 expression in leaves, but GRF2 expression in floral organs has not been studied as extensively. GRF2 acts redundantly with other members of the GRF transcription factor family during floral development. grf1/2/3/5 quadruple mutants show malformed gynoecia, severe fusions between floral organs, and a reduction in the number of stamens and/or petals. These defects are much more severe than in grf1/3/5 triple mutants. Here, we created a pGRF2:GUS transcriptional reporter to visualize the transcriptional activity of the GRF2 gene in Arabidopsis flowers. Inflorescences from transformed plants were embedded in wax and sectioned via microtome. Tissues that express the GUS enzyme under the transcriptional control of the GRF2 promoter are stained blue, allowing us to visualize the transcriptional activity of GRF2. We found that GRF2 is expressed in the inflorescence meristem and broadly in young flowers. The staining is somewhat variable with dark spots of GUS staining visible in some tissue sections. Further work is needed to elucidate the regulatory networks responsible for controlling GRF2 expression. In particular, additional translational reporters are being made to investigate whether GRF2 expression is regulated by MIR396a in flowers, as it is in leaves. This study provides valuable insights into the expression of GRF2 in Arabidopsis.
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1:00-2:30 p.m.
Exhibit Hall (CMCC lower level) |
Poster: 74
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| Al Mansi, Sarah |
Hayes, Edwin
Battle, Sarah |
Beyond the Biomarkers: The Importance of the Clinical Constellation in Diagnosing Listeria monocytogenes Rhombencephalitis
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Abstract Text
Introduction:
Listeria monocytogenes, a gram-positive intracellular bacterium, can cause invasive disease, often dismissed initially as viral gastroenteritis before progressing to neurolisteriosis in immunocompromised individuals. We present a case of an elderly patient with listeria bacteremia and signs of rhombencephalitis.
Aim:
In the era of nucleic acid amplification tests such as PCR, there may be a tendency to rely unilaterally on these tests for diagnostic decision-making. The common meningoencephalitis panel may miss Listeria monocytogenes below 1000 CFU/mL due to its reliance on a single undisclosed gene target. This case underlines neurolisteriosis, identified through positive blood cultures and clinical signs, despite negative cerebrospinal fluid studies.
Case presentation:
An 86-year-old woman, receiving prednisone and biweekly tocilizumab for giant-cell arteritis and polymyalgia rheumatica, presented with a 3-day decline in function. She had an ataxic gait but was afebrile on initial emergency room evaluation. Laboratory data is included in Table 1. CT scans of the head, abdomen, and pelvis were unremarkable. Twenty-seven hours later, two sets of blood cultures collected on admission, revealed aerobic and anaerobic growth of gram-positive rods. Later, identified as Listeria monocytogenes. This triggered an infectious disease consultation with further workup including transthoracic and then transesophageal echocardiograms with no valvular vegetations. MRI brain with and without contrast revealed new infiltrative signal abnormalities affecting the cerebellum and pons. A lumbar puncture with 17 cm H2O opening pressure and 12 mL of blood-tinged spinal fluid was obtained. An analysis of this is outlined in Table 2. Intravenous Ampicillin 2 g every 4 hours was planned for six weeks along with Gentamicin 3 mg/kg/day of which she tolerated for one week. Post-treatment, she followed in the infectious disease clinic where she showed improvement with no residual neurological sequelae. A Follow-up MRI brain proved the resolution of the earlier abnormalities.
Conclusion:
Listeria monocyogenes rhomboencephalitis is a rare entity of the neurolisteriosis spectrum with high mortality and morbidity associated with significant neurological sequelae. Advanced diagnostics, while helpful, need to be interpreted in the context of their limitations and the larger clinical picture. Incorporating history and physical exams remains the cornerstone of diagnosis.
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1:00-2:30 p.m.
Columbia Ballroom (CMCC upper level) |
Poster: 170
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| Karns, Hailey |
Hirsch, Katie
Persaud, Katelynn
Comegys, Katie
Mota, Jacob
Blue, Malia |
Representation of Race and Ethnicity in Nitric Oxide Promoting Nutritional Supplement Research
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Abstract Text
Nitric oxide is a vasodilator that can cause favorable blood circulation, muscle growth, and recovery outcomes. Due to its significant impact on vasodilation, studies related to nutritional support of nitric oxide production may provide insight on racial and ethnic differences in cardiovascular related outcomes. Because of this, racial and ethnic representation in nitric oxide production research is important.
Purpose:
To evaluate current reporting of race and ethnicity of participants in sports science research regarding nitric oxide promoting nutritional supplementation.
Methods:
Five thousand sixteen academic papers published in top sport science journals between 2018 and 2023 were initially identified. An initial screening of the abstracts revealed that of these papers, thirty-seven included either nitric oxide, nitrate, citrulline- malate, L-citrulline, beetroot, or pomegranate as the supplement being studied. Full-text screening was used to extract information on reported race and ethnicity, study country, participant demographics, sport, and competition level. Prevalence of reporting race/ethnicity was evaluated using frequencies and percentages; all other study characteristics were evaluated using descriptive statistics.
Results:
Of the thirty-seven identified studies on nitric oxide promoting supplementation, no studies (0%) reported race as participant demographics. Only one study (3%) reported ethnicity (non-Hispanic). Thirteen studies were conducted in the United States, seven in the UK, and the rest (n=17) were conducted in other countries. Recreational athletes were studied in twenty-nine of the thirty-seven studies. The remaining studies (n=8) had participants that were either college, professional, or master athletes.
Conclusion:
Results demonstrate that there is low prevalence of reporting race and ethnicity in nitric oxide supplement research and there were no studies that examined the differences between racial and ethnic participants in relation to the effect of nitric oxide supplementation. Reporting of racial and ethnic profile has important performance, recovery, and health implications for nitric oxide supplementation. Future studies should evaluate this supplement to determine if it plays a role in the different cardiovascular outcomes between races.
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1:00-2:30 p.m.
Exhibit Hall (CMCC lower level) |
Poster: 138
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| Persaud, Katelynn |
Hirsch, Katie
Comegys, Katherine
Karns, Hailey
Mota, Jacob
Blue, Malia |
Prevalence of Reporting Racial/Ethnic Profiles in Athlete-Based Body Composition Research
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Abstract Text
Background:
Race and ethnicity are major determinants of body composition, including fat and fat-free mass and distribution. In turn, body composition is a significant factor affecting sport performance, injury risk/prevention, training, and nutritional interventions. Due to high racial and ethnic representation within sport, it is important to account for race and ethnicity in studies characterizing body composition to ensure valid representation of athletic populations and accurately apply the findings.
Purpose:
To determine the prevalence of reporting the racial and ethnic profile of athletes in body composition research.
Methods:
Fifty-two studies pertaining to body composition with an athletic population were identified from an initial pool of 5,016 sports science studies. Studies were deemed eligible for inclusion if they included a healthy collegiate or professional athletic population with a mean age ≥ 18 years and assessed body composition components such as fat mass, fat-free mass/lean mass, body mass, or body fat percentage. From the included studies, prevalence of reporting race/ethnicity was evaluated using frequencies and percentages. Other participant characteristics, including country, mean age, sport, and competition level were also extracted.
Results:
Approximately 13% (n=7) of studies reported race/ethnicity in their participant data. The most reported race/ethnicity was Caucasian/white (n=5 studies), followed by Native Hawaiian/Pacific Islander (n=2), other (non-specified; n=2), Asian (n=1), African American/Black (n=1), and Hispanic (n=1). An additional 10% (n=5) of studies reported entering race/ethnicity into body composition software but did not report race/ethnicity in participant data.
Conclusion:
There is a low prevalence of reporting race/ethnicity among athletes in body composition research. The majority of those studies reported Caucasian/white participant populations suggesting an uneven and insufficient representation of race and ethnicity in research investigating body composition. Future studies should aim to report race/ethnicity in participant demographics as it would allow for more accurate applications of the findings.
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9:30-11:00 a.m.
Exhibit Hall (CMCC lower level) |
Poster: 153
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| Unger, Christian |
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Estrogen and its Receptor in Male Liver Glucose Metabolism: A Balancing Act in Diet-Induced Obesity
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Abstract Text
BACKGROUND: Obesity is associated with impaired glucose metabolism which is thought to play a role in a variety of obesity-linked comorbidities. These metabolic impairments are evident in the liver as it plays a pivotal role in glucose metabolism. Thus, developing liver-centric therapies is a viable option to remedy the metabolic perturbations seen in obesity. Administration of systemic exogenous sex steroids has previously been shown to beneficially impact metabolic processes, however, the off-target effects and potential negative health risks associated with global steroid therapies hinder their use clinically. Therefore, there is a critical need to understand the tissue-specific effects of steroid action to develop targeted therapeutics which bypass any potential unwanted side effects. PURPOSE: The purpose of these experiments was to interrogate the role of liver estrogen receptor alpha (ERα ) as well as aromatase expression in regulating metabolic outcomes as well as the potential therapeutic applications. METHODS: We developed three novel mouse models that allow for inducible deletion of liver estrogen receptor alpha (Liver- ERα ID), inducible overexpression of liver ERα (Liver-ERα↑), as well as inducible aromatase overexpression in the liver (Liver-Arom↑). Male mice were fed either a purified LFD or HFD for 13 weeks Liver-Arom↑ and Liver-ERα↑ study, and only HFD was given to the Liver- ERα ID study for 13 weeks. Body weight was assessed throughout the course of the experiment, while body composition (DEXA), glucose tolerance tests, and insulin tolerance tests were performed near the termination of dietary treatment. RESULTS: Each genetic manipulation had little to no effect on bodyweight, however, glucose tolerance and insulin tolerance test results were impaired with aromatase overexpression and estrogen receptor alpha deletion in the liver, however, estrogen receptor alpha overexpression lead to an improved glucose tolerance test with significantly lowered insulin levels independent of changes to liver weight or adiposity metrics. CONCLUSION: There appears to be a Goldilocks principle in estrogen receptor signaling within the liver, where an excess of ligand-receptor interaction is undesirable, complete deletion is harmful, and elevated expression of estrogen receptor alpha could achieve the optimal level.
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9:30-11:00 a.m.
Columbia Ballroom (CMCC upper level) |
Poster: 227
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| Srivastava, Vandana |
O'Reilly, Christian |
Using ECG to Measure Autonomic Activity
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Abstract Text
The autonomic nervous system (ANS) regulates involuntary physiological processes such as heart rate and blood pressure. The two branches of the ANS, the sympathetic (SNS) and parasympathetic (PNS) systems, are activated in stressful and restful conditions, respectively. Their combined complementary action is referred to as autonomic activity. In this project, we implemented two measures, the sympathetic activity index (SAI) and the parasympathetic activity index (PAI), as defined by Valenza et al. [1], to characterize ANS activation in clinical populations.
To evaluate these indices, we used an ECG dataset from PhysioNet comprising ten subjects recorded during postural changes (slow tilt, fast tilt, stand up, rest) [2]. From the literature, we expected the SAI to dominate in slow tilt, fast tilt, and stand up, and PAI during rest. We used this expectation to validate the behavior of the indices. This method models heartbeat dynamics as a function of a weighted sum of past inter-beat intervals and Laguerre functions. We used the recursive least square method to estimate model parameters. The indices were calculated at each time t as a combination of parameters and clinically derived sympathetic and parasympathetic coefficients. Our preliminary results show the average correlation between SAI and postural angle as -0.1528, PAI and postural angle as 0.1370, and SAI and PAI as .1319. Although sharp changes in SAI and PAI values at the transition between postures support their sensitivity to ANS modulations, the directionality of these correlations is opposite to expectations and needs further investigation.
SAI and PAI have great potential to assess the dynamics of the ANS. Monitoring this system is essential for conditions characterized by a dysregulation of the ANS like Autism Spectrum Disorder (ASD). Pathological mechanisms in such conditions may affect SNS and PNS differently, highlighting the importance of reliably assessing their separate influences. In future work, we plan to apply these indices to ECG recordings in ASD to better understand and monitor this condition.
[1] Valenza G, et al. (2018) J Appl Physiol. 125(1):19-39.
[2] Heldt T, Oefinger MB, Hoshiyama M, Mark RG. (2003) Comput Cardiol, 30:263–266.
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1:00-2:30 p.m.
Columbia Ballroom (CMCC upper level) |
Poster: 10
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| Hiner, Kaitlyn |
Derrick, Maureen |
“I Don’t Need Easy, I Just Need Possible” - Being an Advocate for All
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Abstract Text
Greek life at the University of South Carolina has played a pivotal role in my college experience. Joining Alpha Gamma Delta has allowed me to connect with like-minded individuals who have helped me grow socially, personally, and mentally. In the spring of 2022, I learned that my sorority would no longer have a house on campus due to our lease ending with the fraternity we were leasing from. With the importance that a house holds in Greek Life, I had to decide if I was up for the challenge of running as Chapter President, and ready to navigate the issues that come with such drastic housing changes. As it turns out, I was more ready than I thought. Through my time serving as Chapter President, I was able to be an advocate for my chapter while we determined the best course of action for this unchartered territory. Although this new, unexpected chapter of life was thrown upon the sorority, we were greatly supported by our international headquarters to solve the issue at hand. I worked closely with my sorority’s international headquarters to address this issue with the help from Chapter members who served on the housing committee previously and currently. From the time that I served as Chapter President, I learned to become confident in my decision-making skills, how to communicate effectively, and be the voice for many. My presentation will discuss the knowledge I gained from being my sorority’s advocate and the impact it had on my leadership development.
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9:30-11:00 a.m.
Exhibit Hall (CMCC lower level) |
Poster: 321
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| Swager, Emily |
Patel, Rekha |
Mechanism of PKR activation in response to endoplasmic reticulum (ER) stress
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Abstract Text
PERK, an ER resident protein kinase senses ER stress to activate signaling pathways for restoring cellular homeostasis. PERK phosphorylates the α subunit of the eukaryotic translation initiation factor 2 (eIF2α), which prevents translation initiation, leading to a decrease in general protein synthesis while allowing induction of selected genes (e. g. ATF4) that promote cellular recovery. PKR is another protein kinase that phosphorylates eIF2α, however, it is normally activated by double-stranded RNA present during viral infections. Previous research from our lab has shown that PKR is activated in response to ER stress by its protein activator PACT. Although it was established previously that PACT phosphorylation in response to ER stress is essential for PKR interaction and activation, the identity of the kinase that phosphorylates PACT has remained unknown. I hypothesized that PERK phosphorylates PACT directly, which in turn binds to and activates PKR. To test this, I compared the activation of PERK and PKR in PERK, PKR, and PACT knockout mouse embryonic fibroblasts (MEFs) to that of wild type MEFs after inducing ER stress with tunicamycin. PERK and PACT deficient cells failed to activate PKR under ER stress indicating that PERK and PACT are essential for PKR activation. PACT and PKR deficient cells also showed delayed ATF4 induction indicating that PKR activation is essential for timely eIF2 phosphorylation leading to ATF4 induction. This suggests that PKR is activated by PACT after ER stress in a PERK dependent manner and that PACT may be a direct substrate of PERK. Further research to demonstrate a direct interaction of PACT with PERK using coimmunoprecipitation analysis, and PERK kinase assays to test direct phosphorylation of PACT by PERK will conclusively prove PERK’s essential role in activating PKR via PACT after ER stress.
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9:30-11:00 a.m.
Columbia Ballroom (CMCC upper level) |
Poster: 42
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| Tatchell, Julia |
Dunn, Robert
Clyburn, Rebecca
Batchelder, Liam
Kimball, Matthew |
Gut Content Analysis of Blue Catfish in Winyah Bay, South Carolina
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Abstract Text
Invasive species pose a severe threat to ecosystems by preying on native species, outcompeting native species for resources, and lowering biodiversity. Blue catfish, Ictalurus furcatus, are a predatory fish native to freshwater river basins in North America. Through stocking, blue catfish were introduced to the southeastern United States, and they are now considered an invasive species. The impacts of invasive blue catfish have been extensively studied in the Chesapeake Bay region but are understudied in the southeast, including South Carolina. This research aims to quantify the diet of juvenile blue catfish in Winyah Bay, an open-water estuarine ecosystem that drains a large, impacted watershed in South Carolina. Findings from this research will provide insight into the ecology of blue catfish in estuaries, predator-prey dynamics within Winyah Bay, and the impact of blue catfish on native prey populations. With this information, we can develop constructive management strategies to reduce their negative impacts on critical coastal ecosystems.
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1:00-2:30 p.m.
Exhibit Hall (CMCC lower level) |
Poster: 68
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| Belcher, Erin |
Broude, Eugenia
Roninson, Igor
Mack, Zachary
Chen, Mengqian |
The Discovery and Classification of a Spontaneous Murine Tumor Arising from a Patient-Derived Xenograft of Estrogen Receptor-Positive Breast Cancer
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Abstract Text
The estrogen receptor-positive subtype of breast cancer (ER+BC) represents the majority of breast cancer diagnoses in clinical practice, highlighting the urgent need to research effective therapeutic strategies targeting this subtype. While several cell lines derived from human ER+BC tumors are widely used in cancer research, the use of such cell lines for in vivo studies is challenging, since their growth as xenografts in immunodeficient mice requires frequently toxic estrogen supplementation, and estrogen-supplemented xenograft tumors still grow slowly. Patient-derived xenograft (PDX) models have emerged as indispensable models for cancer research, largely maintaining heterogeneity of the patient’s tumor, in contrast to immortalized cell lines. In our in vivo efficacy studies of drug combinations, we turned to PEN027, a PDX model derived from the ER+ aggressive human tumor. We found that PEN027 PDX was growing very rapidly and did not require estrogen supplementation. We used this PDX model to investigate the interaction of palbociclib (IBRANCE®), an inhibitor of the cell cycle-promoting cyclin-dependent kinases 4 and 6 (CDK4/6), approved by the FDA for the treatment of ER+BC, with SNX631, an inhibitor of transcription-regulating Mediator kinases CDK8/19. Combining these two drugs extended the survival PEN027-bearing mice relative to mice receiving vehicle control or individua drugs. However, despite its initial classification as ER+ BC, PEN027 was found to lack estrogen receptor expression at both protein and RNA levels, presenting a puzzling deviation from expected characteristics. Furthermore, RNAseq data revealed a staggering 99.83% alignment to mouse-specific genes, corroborated by qPCR findings. Analysis of the expression of 119 lineage markers from RNAseq suggests that PEN027 are likely to be of murine hematological origin. These findings indicate that PEN027 represents an aggressive mouse tumor that spontaneously arose during the initial propagation of the human PDX in mice, underscoring the necessity for comprehensive characterization of PDX models.
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9:30-11:00 a.m.
Exhibit Hall (CMCC lower level) |
Poster: 36
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| Simon, Tricia |
Patel, Rekha |
Characterizing the pathobiology of Drug-Induced Dystonia
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Abstract Text
Dystonia is the third most common movement disorder in USA, the first two being essential tremor and Parkinson’s disease and gaining mechanistic knowledge about its pathobiology is essential for effective therapies. Therapies currently available are invasive procedures such as deep brain stimulation or frequent botulinum toxin injections, it is critical to understand the underlying mechanisms leading to dystonia. A maladaptive integrated stress response (ISR) involving dysregulation of the eukaryotic translation initiation factor (eIF2) mediated signaling is observed in DYT-PRKRA patient cells. Recent research has indicated that dysregulated eIF2 signaling is a convergent mechanism in etiologically diverse, genetically inherited primary dystonias. Secondary dystonia is triggered by antipsychotic therapy, and in this study, we investigated if ISR is induced in response to antipsychotic drugs possibly leading to drug-induced dystonia (DID). This was done by using western blot analysis to study induction of the transcription factor ATF4 after endoplasmic reticulum (ER) stress with or without prior treatment with the antipsychotic drugs. Our results indicate that the antipsychotic drugs alter the ISR by either changing the intensity or the duration of the response. Precise regulation of eIF2 signaling in neurons is critical and both up- or down-regulation of ISR pathway can have significant negative consequences. To investigate the effects of antipsychotics on neuronal function, a mouse neural crest-derived cell line was used, the induction of ATF4 and its target gene CHOP were investigated in response to treatment with antipsychotics. Results showed that all 7 antipsychotics induced ATF4 and CHOP expression, demonstrating that antipsychotics activate ISR in neuronal cells. To characterize any involvement the known ISR kinases, we tested the effect of C16, GCN2iB, GSK2656157 inhibitors on ATF4 induction by Aripiprazole. Results indicate that C-16 and GSK2656157 attenuate ATF4/CHOP expression, thereby indicating that Aripiprazole activates PERK as well as PKR. Some studies have indicated that modulation of ISR may contribute to neuroprotection and/or neuronal development as measured by neurite outgrowth in N2A cells. Thus, future studies will include investigating effects of antipsychotics on neurite outgrowth using High-Content Imaging/Analysis. The results will offer important mechanistic knowledge about the pathobiology of DID.
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9:30-11:00 a.m.
Columbia Ballroom (CMCC upper level) |
Poster: 43
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| Davolio, Alyssa |
Gibson, Stephanie |
Increasing the Use of Transcutaneous Bilirubin Measurement in Infants Born Greater Than 34w6d in the Special Care Nursery and NICU
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Abstract Text
Hyperbilirubinemia is a common condition affecting over half of term and preterm infants in the first week of life. The American Academy of Pediatrics recommends screening all neonates for elevated bilirubin levels within the first 72 hours of life via either a total serum bilirubin measurement (TsB) or via transcutaneous bilirubinometry (TcB). Although TsB measurements are considered the gold standard for hyperbilirubinemia screening, TcB measurements offer the benefits of being a non-invasive, pain-free tool that can be repeated easily and provides instantaneous results. Implementing a protocol for the use of TcB measurements for term and late preterm infants can help reduce patient discomfort and complications in addition to reducing overall health costs.
Chart review was conducted using the slicer dicer feature on epic. Patient lists were sorted by pulling patient charts who met the following parameters: Gestational age at delivery of greater than 246 days, patient's born at Prisma Health Richland, and admission to the neonatal intensive care unit or special care nursery. The pre-intervention group included infants that met the previously listed parameters who were born from January 1, 2022 through January 30, 2022. The post-intervention group included infants that met the previously listed parameters who were born from July 1, 2022 through December 31, 2022.
A total of 133 infants qualified for the pre-intervention group. 63 of the 133 infants were screened with transcutaneous bilirubin measurement as their initial hyperbilirubinemia screening with 70 of the 133 screened with serum total bilirubin measurements. The rate of transcutaneous bilirubin measurements as the initial screening for hyperbilirubinemia in the pre-intervention group was 47%. A total of 172 infants qualified for the post-intervention group. 114 of the 172 infants were screened with transcutaneous bilirubin measurement as their initial hyperbilirubinemia screening with 58 of the 172 screened with serum total bilirubin measurements. The rate of transcutaneous bilirubin measurements as the initial screening for hyperbilirubinemia in the post-intervention group was 66%.
Our results showed an improvement of 19% for the use of transcutaneous bilirubin measurement for the initial screening for hyperbilirubinemia.
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1:00-2:30 p.m.
Columbia Ballroom (CMCC upper level) |
Poster: 191
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| Cox, Hunter |
Frizzell, Norma |
Detection of Immunometabolite Derived Cysteine Modifications
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Abstract Text
The immunometabolite itaconate accumulates during lipopolysaccharide (LPS) stimulation of macrophages and microglia. Itaconate non-enzymatically reacts with cysteine residues to generate 2,3-dicarboxypropylcysteine (2,3-DCP), referred to as protein dicarboxypropylation. The tricarboxylic acid (TCA) cycle metabolite fumarate non-enzymatically reacts with the amino acid cysteine to form S-(2-succino)-cysteine (2SC), resulting in irreversible protein succination. Since fumarate and itaconate levels dynamically change in activated immune cells, the levels of both 2SC and 2,3-DCP reflect the abundance of these metabolites and their capacity to modify protein structure and function. We generated esters of 2SC and 2,3-DCP from protein hydrolysates and used stable isotope dilution liquid chromatography-tandem mass spectrometry (LC-MS/MS) to determine the abundance of these in LPS-stimulated Highly Aggressively Proliferating Immortalized (HAPI) microglia. Itaconate derived 2,3-DCP, but not fumarate derived 2SC, increased in LPS-treated HAPI microglia. Stoichiometric measurements demonstrated that 2,3-DCP increased from 1.57 to 9.07% of total cysteines upon LPS stimulation. This methodology was extended to the quantification of 2SC in serum from experimental autoimmune encephalitis (EAE) mice treated with the fumarate ester, dimethyl fumarate (DMF), an immunosuppressive compound. As expected, DMF resulted in pronounced succination resulting in elevated 2SC levels. The quantification of 2SC in serum samples may have utility for monitoring DMF exposure in patients treated with DMF for multiple sclerosis (marketed as Tecfidera®). Lymphocyte counts are routinely measured in patients treated with DMF to prevent severe lymphopenia, while also suppressing disease relapses. Monitoring 2SC levels may provide a direct measurement of the effect of fumarate esters on irreversible cysteine modification in at-risk patients.
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1:00-2:30 p.m.
Columbia Ballroom (CMCC upper level) |
Poster: 58
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| Wicker, MacKenzie |
Childs, Matt |
How Did the Desire for Sugar Transform Labor and Create New Industries in Caribbean Colonies?
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Abstract Text
The need for sugar within the European countries was high and strong causing the farming industries to become much more commercialized. Sugar as a delicacy, drove much of the slave trade within the Caribbean and created the need for an inexpensive labor resource. Using slavery to lower the expenses for harvesting and growing the high amount of sugar, colonizer countries were able to create more money than lose it. One of the most important things in agriculture is ensuring that you can make a profit off of the product that you are growing and selling. This also includes knowing if you can make money based off of how much work and money you are putting into the product. By not paying for labor with slavery, you are able to cut down the cost of production and create larger industries off of less money. Also, the slave trade itself, helped to make sugar a worldwide commodity. By creating such cheap labor, European countries were able to make sugar a needed product all throughout the world and made it much more mainstream than it usually was. This led to the creation of Colonization causing large scale sale in products that were not usually a mainstream product. This became a trend in colonization countries but was popularized by the need for sugar and the use of slaves to make such a cheap labor source.
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9:30-11:00 a.m.
Exhibit Hall (CMCC lower level) |
Poster: 29
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| Vrh, Sophia |
Mousseau, Timothy
Dallas, Tad |
The Effects of Ionizing Radiation and Environmental Covariates on the Distribution and Abundance of Wild Boar (Sus scrofa) Surrounding the Fukushima-Daiichi and Chernobyl Nuclear Power Plants
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Abstract Text
In 1986 and 2011, the infamous Chernobyl and Fukushima-Daiichi Nuclear Power Plant disasters occurred, respectively. Following the release of large amounts of radioactive contamination, exclusion zones were created to surround each site and minimize citizen exposure. In the absence of anthropogenic disturbances, native animal populations remain and freely roam each zone. We examined how the interaction of chronic radiation exposure, a lack of human disturbance, and environmental variables influence the distribution and abundance of Sus scrofa (wild boar) in Fukushima and Chernobyl. A camera trap network was established in each zone to capture images of medium- to large-sized mammals and it was hypothesized that cameras in areas of high ambient radiation would record fewer sightings of wild boar than those in areas of low ambient radiation. Additionally, because the Fukushima accident is more recent, it was hypothesized that the relative abundance of wild boar would increase each year during the study period whereas Chernobyl’s would remain relatively constant because its population has had more time to rebuild and stabilize. Based on the camera trap data, ecological models were developed to discern which factors most strongly influence wild boar distribution. Moreover, a relative abundance index (RAI) was calculated at each camera per year to quantify changes in population size. In Fukushima, wild boar abundance exhibited an increasing trend each year but Chernobyl’s numbers were variable, not exhibiting a clear pattern. Across both sites, however, radiation levels did not prove to be the most important variable driving boar distribution, falling behind some environmental factors. Ultimately, this work is important for differentiating the acute and chronic effects of ionizing radiation exposure on wild boar populations and adding to the limited body of knowledge on the ecological effects of nuclear disasters.
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9:30-11:00 a.m.
Exhibit Hall (CMCC lower level) |
Poster: 64
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| Taylor, Katie |
Ricker, Erin |
Order Up: Implementing a Designated Order Set to Decrease Ventilator Associated Pneumonia in Intubated Patients Requiring Pentobarbital
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Abstract Text
Pentobarbital is an important medication used in the pediatric intensive care unit (PICU) setting for multiple diagnoses including status epilepticus, traumatic brain injury (TBI) and sedation. However, the use of pentobarbital in intubated patients increases their risk of developing a ventilator associated pneumonia (VAP) due to the immunosuppressive qualities of this drug. The use of famotidine (Pepcid), MetaNebs and Pulmozyme has been shown to reduce incidences of VAP in intubated patients individually, but there have been few studies analyzing their cumulative effect on the incidence of VAP. The goal of this quality improvement project is to create a Pentobarbital order set, including the order for the pentobarbital, along with preventative famotidine, MetaNebs and Pulmozyme, with the aim of decreasing the incidence of ventilator associated pneumonia (VAP) in intubated patients in the Prisma Health Midlands PICU requiring pentobarbital by 10% within a year of this order set going live. This QI study then utilized retrospective chart review for data collection. The charts of patients who were given the diagnosis of VAP prior to the release of this Pentobarbital order panel were isolated using the Slicer Dicer feature of Epic and their charts were then thoroughly reviewed for gastrointestinal (GI) prophylaxis, use of MetaNebs and the use of Pulmozyme. Then, the charts of patients who developed VAPs and requiring pentobarbital after the release of the Pentobarbital order panel were also reviewed. These pre- and post-intervention patients and their orders were then compared in a systematic fashion. In the Prisma Health Midlands PICU from 2018-2022, prior to the release of the Pentobarbital order panel, 50% of the VAPs were associated with pentobarbital usage. After the release of the Pentobarbital order set, in all patients receiving pentobarbital, there were no cases of VAPs. The Pentobarbital order set created from this QI project is successful at decreasing the incidence of VAP in ventilated patients in the Prisma Health Midlands PICU who require pentobarbital.
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1:00-2:30 p.m.
Columbia Ballroom (CMCC upper level) |
Poster: 192
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| Bollmeyer, Jada |
Frost, Dan |
The Light Element in the Inner Core Constrained with Seismic Anisotropy
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Abstract Text
Recent seismic studies have proven that the inner core is seismically anisotropic with the western hemisphere recording stronger anisotropy than the eastern hemisphere. This anisotropy, measured with PKIKP waves that traverse the inner core, increases with depth in the inner core along a temperature and pressure gradient. The anisotropy is thought to result from preferred alignment of iron crystals caused by deformation as the inner core grows. Using previous ab initio calculations that determine properties of iron at varying temperatures and pressures, we are seeking to determine through visco-plastic self-consistent (VPSC) modelling which light element (C, O, S, or Si) mostly likely comprises the inner core. First, we use pre-calculated isothermal and isobaric elastic constants (Cij) of eight different hexagonally close packed Fe-X alloy single crystals (Zhang et al., 2022) and interpolate across the pressure and temperature range of the inner core. For each Fe-X alloy, we then use VPSC to calculate the effect of the growing inner core on the alignment of these single crystals at all pressures and temperatures within the inner core. Lastly, we compare each light element’s simulated inner core anisotropy with seismically observed PKIKP travel time anomalies to determine which best matches, thus mostly likely comprises the inner core. The current best fit is Fe60O4 at 2000K and 340 GPa; however, this is highly subject to change as there are further Fe-X alloys to test. Given that any of the eight Fe-light element alloys tested here closely fit the observed anisotropy models, it can be determined that the crystals comprising the inner core are hexagonally close packed as opposed to perfectly aligned [1 1 1] body centered cubic iron as argued in the past. Additionally, this work will provide more insight regarding Earth’s formation, age, and thermal geodynamic elastic properties.
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9:30-11:00 a.m.
Exhibit Hall (CMCC lower level) |
Poster: 84
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| Christian, Noah |
Norton, Duncan |
Bettering Resident Physical Exam Skills During COVID-19 Pandemic Challenges
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Abstract Text
Medical education was replaced with necessary medical interventions during the COVID-19 pandemic¹. As such, there is a generation of young doctors who did not have the same pre-clinical experience or clinical rotations as in years past. To better assess intern comfort level and ability at performing a physical exam, and then describing those findings, the intern class of Prisma Health-Midlands in 2022 were asked a series of questions pertaining to their comfort level of performing physical exam maneuvers. Interactive, in-person lectures on organ based systems were created and taught to interns after the completion of the survey. Afterwards, interns were again asked on their comfort level and perceived ability to perform a competent physical exam. Interns was also surveyed for recommendations on improving the lectures. Overall, interns felt more comfortable with performing, explaining, and describing the exams and exam findings after the lectures.
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9:30-11:00 a.m.
Columbia Ballroom (CMCC upper level) |
Poster: 134
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| Andrews, Jacob |
Blackburn, MElanie |
Its Beginning to look a lot like sepsis
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1:00-2:30 p.m.
Columbia Ballroom (CMCC upper level) |
Poster: 193
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| Contreras, Rogelio |
Lownes, Steven |
Mexican Family: Spanish in the Home and Spanish Abroad
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Abstract Text
During my time in Mexico, I spent most of my time with my grandparents. Even though I did not officially attend school over there, I still learned many valuable things. This was my first time outside the country and being away from my immediate family. When I first went at fifteen, I was not the greatest Spanish speaker and had to learn from my grandparents and cousin. The way that they spoke and the differences in cultures are something that I learned that I will never forget. I also learned about the Mayan language “Cho’l” and where it came from, by my cousins. This indigenous language was surprisingly everywhere in this region of Mexico and it was fascinating the way that it was blended in with their everyday Spanish. I wanted to keep learning as much as possible, but I only had a small amount of time there; therefore, when I returned, I decided to keep learning more about Mexico and the Spanish language so I took Spanish 109 and 110 in order to improve my Spanish and learn more about the culture.
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9:30-11:00 a.m.
Exhibit Hall (CMCC lower level) |
Poster: 238
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| Carrigan, Ellie |
Derrick, Maureen |
Education is Invaluable: My Time at the SC House of Representatives
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Abstract Text
This year I have had the opportunity to serve as an intern for the South Carolina House of Representatives Education and Public Works. The committee has six subcommittees, including K-12, Higher Education, Early Childhood, Public Safety, Transportation and Motor Vehicles. Throughout my time, I have worked closely with the representatives and staff of the committee. My primary roles included researching education policies and preparing for and attending meetings. I applied for my internship to learn more about the pivotal role education plays in shaping individuals and societies. I was eager to contribute to the development of policies that would enhance educational opportunities for all students. I saw my internship as an invaluable opportunity to gain a deeper understanding of state government and expand my network in the field. I have gained insight into the legislative process and the development and implementation of policies. Over the last seven months, I have been able to enhance my research, analytical, and communication skills while also learning about educational challenges and opportunities. My internship has been a compelling factor in shaping my future career goals. Through my experiences with the committee, I have solidified my passion for advocating for children’s rights, which has motivated me to continue working towards creating a more inclusive educational system.
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9:30-11:00 a.m.
Exhibit Hall (CMCC lower level) |
Poster: 284
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| Heidelbach, Ian |
Armstrong, Alissa |
Examining the Effects of Diet on the Immune Response in Drosophila Melanogaster
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Abstract Text
Obesity remains a pressing public health concern in America, with rates continuing to rise over recent decades. This complex condition stems from a number of factors, including genetic predispositions, environmental influences, and dietary habits. Studies have suggested a link between obesity and alterations in the innate immune response, particularly in the context of chronic low-grade inflammation.
Drosophila melanogaster, commonly known as fruit flies, serve as a valuable model organism for understanding various biological processes in humans, including immunity and metabolism. Recent research has focused on exploring the innate humoral immune system of fruit flies and its potential implications for human health, including obesity. The humoral immune response in flies involves the production of antimicrobial peptides (AMPs), which play a crucial role in defending against microbial pathogens.
For this study, our goal is to better understand the link between obesogenic diets and chronic inflammation. Specifically, we investigate how high-sugar and high-fat diets impact the expression of AMPs in Drosophila melanogaster by utilizing quantitative real-time polymerase chain reaction (qRT-PCR) as a molecular tool. In fruit flies, there are 20 AMPs across seven different classes that mediate immune defense against gram-negative and gram-positive bacteria, fungi, and viruses. We have designed qRT-PCR primers to measure transcript expression for 17 AMPs and are currently testing their efficiency. Following primer validation, we will measure AMP expression from the fat body, which is the primary organ that mediates the immune response in fruit flies. We will test high-sugar and high-fat diets that vary in sugar and fat concentration across different time points. Ultimately, this research holds promise for informing strategies to combat diet-induced obesity-associated chronic inflammation and related metabolic disorders through targeted dietary interventions.
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1:00-2:30 p.m.
Exhibit Hall (CMCC lower level) |
Poster: 42
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| Cain, Sarah |
Chamberlain, Kimberly |
Transitioning New Students to College Life Using Effective Communication
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Abstract Text
I have always enjoyed being a leader. From student counsel to varsity sports, I feel so rewarded when I help others progress forward. The summer after my freshman year of college I served as an Orientation Leader for the University of South Carolina. I was part of a team of fifty-four other Orientation Leaders, and we worked together to lead new students around campus and introduce them to university culture. As an Orientation Leader, I had the opportunity to shape new student’s perspectives from the very beginning. I would take them to their academic colleges, facilitate important discussions, and help them register for classes. My role as an Orientation leader taught me the importance of communication and listening. I learned how to deliver information to a large audience and an intimate group. My connection to the university also grew as I learned about the history and traditions of USC. I gained an abundance of skills and knowledge from my time as an Orientation Leader.
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1:00-2:30 p.m.
Exhibit Hall (CMCC lower level) |
Poster: 326
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| Smith, Brandon |
Dodson, Cortney
Cox, Jenna |
Optimizing Pharmacist Team-Integration for ICU Patient Management (OPTIM): Patient Outcomes with Single – Versus Multiple-Unit Pharmacist Coverage
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Abstract Text
Background: There is currently no standardization related to optimal intensive care unit (ICU) pharmacist coverage models related to patient outcomes. As a result, there may be wide variability in the number of patients and units that ICU pharmacists are responsible for. Pharmacists have become a regular part of the interdisciplinary team, with objective data demonstrating increased healthcare cost avoidance. As an ICU census or number of units covered increases, it is relatively unknown if this would hinder the pharmacist’s ability to provide the same level of care. Currently, there are several studies examining patient outcomes regarding intensivist or physician to patient ratio. Up to this point, however, there has not been any objective data examining patient outcomes related to ICU pharmacist-to-patient or pharmacist-to-unit ratio. This study aims to assess if increased ICU pharmacist unit coverage results in worse patient outcomes.
Methods: This is a single part of a larger multi-center, observational cohort study. Patients admitted to an ICU at Prisma Health Richland between August 7th, 2023 and November 15th, 2023, for which the pharmacist covering the medical or cardiopulmonary ICU during first day of admission, were included. Data collection occurred in two phases: a prospective phase, where pharmacist-to-patient and pharmacist-to-unit ratios were collected, and a retrospective phase examining patient outcomes. Data collected consisted of hospital/ICU length of stay, mortality, duration of mechanical ventilation, SOFA score at 24 hours from ICU admission, and MRC-ICU score. The primary outcome is ICU length of stay for patients seen by an ICU pharmacist covering one unit versus more than one unit during the first day of admission. Secondary outcomes include days of mechanical ventilation, and duration of hospital and ICU length of stay.
Results: In progress
Conclusions: In progress
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9:30-11:00 a.m.
Columbia Ballroom (CMCC upper level) |
Poster: 195
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| Wheeler, Alexandra |
Pierce, Charles |
Navigating the Consulting World: How the Intern Challenge Prepared Me for Success
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Abstract Text
During the summer, I worked as a technology consultant intern at Protiviti, a global consulting firm. My Protiviti internship experience consisted of hands-on client projects in SAP, many networking opportunities, and most notably, The Intern Challenge. The Intern Challenge was a four-day event that signaled the start of the internship, where all Protiviti interns from around the country were taught how to be a consultant and engaged in Protiviti’s culture. As a technology intern, I learned how to be an effective team member on a new team with diverse strengths and skillsets. We were challenged to approach a client’s business problem from a consultant perspective, collaborating to make decisions and find effective solutions, ask critical questions, and communicate important information to our managers and the client. One specific challenge we had to solve was within the client’s enterprise financial system, since they had user permissions incorrectly configured. This experience taught me how to translate the technical information I know regarding cybersecurity to my team members who were not as knowledgeable about technology. From there, our team could effectively brainstorm solutions, make a final decision about possible next steps, and relay our strategy to our manager and the client. Participating in The Intern Challenge reshaped how I can be an effective team member on a consulting team where members come from different backgrounds and was great preparation for my internship and my future career as a consultant.
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9:30-11:00 a.m.
Exhibit Hall (CMCC lower level) |
Poster: 325
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| Hoops, Hayden |
Cranmer, Robyn |
Pursuing the Development of Emotional Awareness When Taking on a Leadership Role
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Abstract Text
Since I was a little girl, I found myself yearning to fulfill the need of being a part of something bigger than myself. I would find myself later in life at a large SEC school hoping to find my worth amongst a sea of students looking for the same thing. I joined Greek life my freshman year and was immediately enriched with the tools to pursue countless leadership roles. The summer going into senior year I would join the Panhellenic Recruitment Staff where I would take on the role of Potential New Member (PNM) Relations. On paper, I was advocating and enriching the experience of all girls going through the recruitment process. But the role was far beyond this. It is here that I learned just how important it is to have emotional awareness in a role where people are looking to you to be their voice. Continuously educating myself on the proper ways to address situations, becoming a strategical thinker, and knowing the impact you have on others are all tactics I learned to enhance my success in this role. Many times, it is not about how much you think you are ready for something, but how you will handle the pressure once a situation has arisen. To become a pivotal role in the lives of others while maintaining a voice of authority creates a balance that is often overshadowed by analytical aspects of a position. To dive into a position that makes everybody feel like somebody is a powerful tool that I learned that I will carry with me to every leadership position I take on.
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9:30-11:00 a.m.
Exhibit Hall (CMCC lower level) |
Poster: 341
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| Carter, Piper |
Epps, Lauren |
Turning Golf That Matters Into Collaboration That Matters
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Abstract Text
At Discover USC I will be presenting a summary of my experience working with Pro Links Sports and the 3M Open. I worked with 9 other interns representing different majors, home states, levels of experience in the sports industry, etc. which was a great experience, but brought about many challenges. Throughout the summer we worked on many projects together that culminated in 4 Pro-Ams and a tournament hosting 100,000 people. I worked as the Corporate Partnerships and Pro-Am intern meaning I worked with our Pro-Am Director on the organization of 4 different Pro-Ams including a sponsors Pro-Am, a tournament suppliers Pro-Am, a celebrity Pro-Am, and a 3M Leadership Pro-Am, as well as worked on contract fulfillment for some of our tournament sponsors and suppliers. Through my presentation I hope to convey the information I learned that is applicable to the sports industry as a whole such as working in partnership fulfillment, sponsorship activation, general sales, and working as a team. I will discuss the general everyday topics that I worked on in my internship as it relates to working with people with different communication styles outlined through the framework of True Colors. I will discuss what is necessary to create a Pro-Am, as well as working with partners, sponsors, and all those that make sporting events possible.
I will also outline some of the difficulties and frustrations I encountered over the course of my internship, and how my second key insight developed through those experiences, as well as how I have applied the key insight to projects, collaborative efforts, etc.. I will connect my experience working at the 3M Open with a group project I recently completed, and how that showed the growth I have seen in myself since my internship. I feel confident now in my skills, and I believe that, professionally, I will have greater success working with others because I now feel more comfortable with open communication, and I realize that this open communication is the very thing needed to establish understanding with other team members, co-workers, colleagues, etc. in order to effectively collaborate.
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1:00-2:30 p.m.
Exhibit Hall (CMCC lower level) |
Poster: 339
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| Ranaldi, Nicole |
Stubblefield, Brittany |
Experience as a Research Assistant
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Abstract Text
Starting in the Fall of my senior year I began working as a research assistant in the Exercise Oncology Lab at the University of South Carolina. The Exercise Oncology Lab is a research team dedicated to studying the effects of exercise, nutrition, and psychology in combating the side effects of cancer before, during, and after treatment. As an exercise science major at the University of South Carolina, this research position has provided me with firsthand experience in creating and executing exercise protocols. I had the opportunity to familiarize myself with the scientific process by collecting and analyzing data. I also was able to participate in a meta- analysis.
Specifically I worked closely with three participants and created personalized exercise programs for each of them. I then worked with them individually for 8-10 weeks until the completion of the exercise program. I led each participant through baseline testing and was able to compare their fitness levels at the beginning of the study and the end of the study. I also had the opportunity to assist in a muscle biopsy procedure. Participating in this research project reaffirmed my decision to pursue a career in healthcare and grew my research skills greatly.
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1:00-2:30 p.m.
Exhibit Hall (CMCC lower level) |
Poster: 257
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| Zhang, Yichi |
Moskowitz, Marc |
Play Softcore in a Hard Way: The Softcore Sexual Transaction Behind Virtual Lover Service on Chinese Social Media
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Abstract Text
During the COVID-19 pandemic, young people in China faced prolonged isolation, which prompted many to turn to the Internet to establish intimate relationships and social connections. Against this backdrop, some online shops began offering "virtual lover" role-playing services to meet the needs and desires for interpersonal interaction during times of societal upheaval. However, in the transaction process, such services not only fulfill emotional needs but also involve erotic performances.
This article, framed within the theories of erotic capital and softcore pornography, delves into the emerging trends of the pornographic industry within contemporary Chinese Internet culture, focusing on in-depth interviews with digital laborers represented by virtual lovers. The study explores how virtual lovers eliminate potentially censored elements in traditional hardcore sexual transactions, dedicate themselves to nurturing sexual fantasies and mobilizing their agency through subtle self-branding. This approach involves negotiation and interaction with the national censorship system. The research also examines how, in contrast to the regulatory system, the affordances of communication software and the actions of their managers inadvertently facilitate or even tacitly endorse the proliferation of erotic transactions despite of the explicit prohibitions. Additionally, the study reveals how, within the seemingly safer and more liberated online sex industry, female performers are lured into the field with the illusion of controlling their bodies but end up being alienated and ruthlessly stripped of the surplus value of their work. By addressing these issues, this article, based on the consumption of sexual services by contemporary young people on the Chinese Internet landscape, aims to present a distinct sexual landscape with Chinese characteristics.
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1:00-2:30 p.m.
Columbia Ballroom (CMCC upper level) |
Poster: 25
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| Desai, Ashna |
Nathaniel, Thomas |
Pharmacological and Demographic Factors Among Male and Female Alzheimer’s Disease Patients Diagnosed with Attention Concentration Disorder and Cognitive Communication Disorder
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Abstract Text
Abstract: Objective: The current study investigates differences in male and female Alzheimer’s Disease (AD) patients with Attention Concentration Disorder (ACD) and Cognitive Communicative Disorder (CCD) using pharmacological and demographic factors.
Method: Data for this study was collected from the Prisma Health Upstate Alzheimer’s patient registry between 2016-2021. Multivariate analysis was used to predict pharmacological and demographic factors associated with males and females with ACD and CCD.
Results: A total of 64.24% ACD and 35.76% CCD patients were identified. In the adjusted analysis, male AD patients that were administered Memantine [OR=0.189, 95% CI, 0.091-0.393, p<0.001], and Aripiprazole [OR = 0.065, 95% CI, 0.015-0.278, p<0.001] were more likely to be associated with ACD, increasing age [OR = 1.023, 95% CI, 1.017-1.028, p<0.001] was associated more with CCD. In women with AD, ETOH use [OR =0.807, 95% CI, 0.643 – 1.011, p=0.062] and Escitalopram use [OR = 0.782, 95% CI, 0.588 – 1.039, p=0.090] was more likely to be associated with ACD. Increasing age [OR =1.034, 95% CI, 1.029-1.039, p<0.001], Citalopram use [OR = 2.470, 95% CI, 1.751-3.484, p<0.001], African Americans [OR = 1.643, 95% CI, 1.229 – 2.196, p<0.001] were associated with CCD.
Conclusion: Our findings identified specific demographic and pharmacological factors that were associated with males and females with ACD and CCD. These findings suggest the need to develop strategies to eliminate disparity in the care of AD patients with ACD or CCD patients.
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9:30-11:00 a.m.
Exhibit Hall (CMCC lower level) |
Poster: 181
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| Curry, Gianna |
Derrick, Maureen |
Implementing Care Back Into Healthcare
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Abstract Text
Throughout my academic journey, I have had the wonderful opportunities to discover various fields of healthcare. My experiences range from shadowing physician assistants, physical therapists, and nutritionists to working as patient transport at CentraState Medical Center and finally to being an accredited Personal Care Aid with Caring Inc. in Columbia, South Carolina. As a Public Health major pursuing a Bachelor of Science degree, these experiences brought insight into what a career in healthcare really looks like. Countless encounters with frustrated patients afflicted curiosity within me to bring change to the current system. While taking Introduction to Public Health, PUBH 302, with Professor Galloway, we dove into the reality of the flaws that lie within the United States Healthcare system. Learning about various factors such as physicians being paid per patient, the trajectory of chronic diseases and the over-prescription of pharmaceuticals, it was clear to me that changes are needed immediately. I correlated my out of classroom experiences as a bikini body builder, working with a nutritionist, and being a personal care aid to reflect the importance of physical activity, proper nutrition, and a fixed healthcare system. Through my experiences, I have shifted my focus towards ensuring I will not be a healthcare worker who prioritizes a quota over the well being of my patients.
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1:00-2:30 p.m.
Exhibit Hall (CMCC lower level) |
Poster: 279
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| Wood, Gabrielle |
Hollis, Fiona
Gorman-Sandler, Erin |
Determining the Early Molecular Effects of Nicotinamide on a Rodent Model of Postpartum Depression
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Abstract Text
Up to 20% of women following childbirth are impacted by postpartum depression (PPD)-- a challenging mood disorder. Women with PPD report difficulty bonding with offspring, a reduction in energy levels, and feelings of hopelessness. Furthermore, PPD’s impact extends beyond the mother, as the offspring of afflicted women have a greater risk of developing psychiatric conditions both during childhood and later on in life. Despite the detrimental effects of PPD on both maternal and offspring health, the underlying pathology of the condition is largely understudied.
Mitochondria are dynamic organelles involved in numerous crucial cellular processes and potential mediating targets due to their pivotal role in the physiological changes occurring during pregnancy and the postpartum period. We previously established that gestational stress decreased postpartum mitochondrial complex I protein expression and function in the prefrontal cortex (PFC) in association with PPD-relevant behaviors. Here we hypothesized that enhancing mitochondrial complex I respiration during gestational stress would prevent the effects of gestational stress on mitochondrial and metabolic protein expression in the PFC.
To test our hypothesis, we subjected primiparous (pregnant) and nulliparous (virgin) rats to chronic, mild, unpredictable stress with a co-treatment of Nicotinamide (NAM) or Vehicle (VEH, water) in the drinking water during gestation. NAM is a vitamin B3 derivative known to enhance mitochondrial respiration. We then measured postpartum behavior. In the mid postpartum, dams were euthanized and the PFC was dissected out and prepared for respirometry and protein analysis via western blot.
Preliminary data suggest that NAM treatment during gestational stress altered both the expression levels of proteins associated with mitochondrial complex-I coupled respiration and PPD-related behaviors in the mid-postpartum. Future studies will further explore the effect of NAM on the physiological changes transpiring in the late postpartum.
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1:00-2:30 p.m.
Exhibit Hall (CMCC lower level) |
Poster: 199
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| Clinton, Gabriel |
Blackburn, Melanie |
Sepsis QI
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Abstract Text
Sepsis QI project
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1:00-2:30 p.m.
Columbia Ballroom (CMCC upper level) |
Poster: 194
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Jones, Virginia
Zamorano, Pilar |
zur Loye, Hans-Conrad
Morrison, Gregory |
Crystal Growth of Alkaline Rare Earth Borates Using Molten Salt Flux Synthesis
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Abstract Text
The rise in use of nuclear power has proposed a need for safe storage of nuclear waste. A higher level of safety can be ensured through the creation of nuclear waste forms. Such waste forms are created through reactions that sequester elements of the nuclear waste into a crystalline lattice. The purpose of my research is to synthesize alkali metal lanthanide borates and evaluate their ability to act as a nuclear waste form for Am3+ and Cm3+ (common nuclear wastes). To accomplish such a synthesis, a method known as molten salt flux growth is utilized. Salt flux growth refers to the use of salt materials that upon heating to above their melting point act as a solvent to facilitate the formation and control of crystalline products. A molten salt flux helps to control the kinetics of a desired reaction, allowing them to form at lower temperatures and to a desired lattice structure. Using this method, alkali metal lanthanide borates of new structures will be synthesized and evaluated for their ability to react with Am3+ and Cm3+. We report on the use of salt fluxes for the growth of alkaline earth lanthanide borates. Their synthesis, structures, and optical properties are presented.
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9:30-11:00 a.m.
Exhibit Hall (CMCC lower level) |
Poster: 99
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| Nanda, Chitra |
Newman-Norlund, Roger |
Oral Health and Recovery in Chronic LH Stroke with Aphasia
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Abstract Text
Significant research supports the idea that oral health is a powerful predictor of cognitive function in both healthy older adults as well as various clinical populations (ie.. Alzheimer’s and related dementias). While oral health typically declines as individuals get older, a recent study in which total tooth count was manually extracted from magnetic resonance images (MRIs) of healthy older adults suggests that the number of teeth a person retains can provide important prognostic information regarding cognition, above and beyond chronological age alone. The current study attempts to extend these findings by examining the relationship between oral health and aphasia severity and treatment response in an open-access retrospective longitudinal convenience sample (N ≈ 150) of individuals with left hemisphere stroke and chronic aphasia that were scanned at the MCBI over the last two decades. Based on data from healthy older adults suggesting a significant relationship between oral health and cognition, we hypothesized that oral health would also be an important factor in aphasia recovery. Accordingly, we predicted that individuals with poorer oral health (MRI-derived total tooth count) would 1) have more severe aphasia and 2) show smaller treatment responses than individuals with better oral health. As predicted, total teeth went down with age, rho(84) = -0.207, p < 0.05. A series of planned Pearson’s correlations revealed that there was neither a significant correlation between total teeth and aphasia severity (as measured by the Western Aphasia Battery [WAB]), rho(94)=0.009, p = 0.533, nor was there a relationship between total teeth and treatment response, rho(29)=0.019, p = 0.460. The relationship between oral health and recovery in chronic stroke is complicated, and likely complex and bidirectional. Current null findings could be due to limited sample size, interactions between stroke severity and oral care as well as other factors. Future studies could address some of these issues by examining the relationship between oral health and cognition in larger, acute stroke samples.
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9:30-11:00 a.m.
Exhibit Hall (CMCC lower level) |
Poster: 154
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| Nanda, Chitra |
Newman-Norlund, Roger |
Relationship Between Oral Health, Brain Health and Severity in Acute Stroke
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Abstract Text
Significant research supports the idea that oral health is a powerful predictor of cognitive function in both healthy older adults as well as various clinical populations (i.e. Alzheimer’s and related dementias). While oral health typically declines as individuals get older, a recent study in which total tooth count was manually extracted from magnetic resonance images (MRIs) of healthy older adults suggests that the number of teeth a person retains can provide important prognostic information regarding cognition, above and beyond chronological age alone. The current study attempts to extend these findings by examining the relationship between oral health, brain health and stroke severity in an open-access retrospective convenience sample (N ≈ 200) of individuals with acute stroke in the state of SC. We predicted that individuals with poorer oral health (MRI-derived total tooth count) would 1) have more severe impact of stroke (NIHSS scores), 2) have larger lesions and 3) have worse brain health (i.e. brain age gap [BAG] and white matter hyperintensities [WMH load]). We conducted a series of planned Pearson’s correlations controlling for age, sex, race and BMI. NIHSS scores were significantly worse in individuals with fewer teeth, r(165) = -0.130, p = 0.049. Individuals with more teeth also had significantly larger lesion sizes, r(164) = -0.213, p = 0.003. Finally, individuals with fewer teeth had significantly greater WMH load, r(162)=-0.186, p = 0.009, and had larger BAG values indicating a larger discrepancy between chronological age and brain age calculated based on tissue integrity. Contrary to our findings in individuals with chronic stroke, our data show that oral health is strongly related to critical acute stroke metrics including lesion size, brain health and stroke severity. Future studies could address the impact of oral health in other chronic or neurodegenerative diseases.
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9:30-11:00 a.m.
Exhibit Hall (CMCC lower level) |
Poster: 155
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Borglum, Kristina
Benedict, Chelsea |
Witherspoon, Patricia |
Implementation of Social Determinants of Health Screening Tool to Improve Health Disparities at a Local Free Medical Clinic
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Abstract Text
Background/Aim
Med Students Making Change (MSMC) is a student-led organization that works with The Free Clinic in Columbia, SC to help improve diabetic control in uninsured patients. Nationally, 10% of adults do not have health insurance. However, this number in Richland county is a staggering 24.5% (1). The lack of health insurance is associated with a variety of additional social determinants of health (SDOH), making it the strongest predictor of health outcomes in diabetic patients (2). One of the goals of MSMC is to ensure that the barriers to care and treatment compliance that patients face are able to be addressed. It’s necessary to address these obstacles from multiple directions – on one end as volunteers by providing them with knowledge of community resources they can utilize, and secondly by relaying that information to The Free Clinic physicians in notes on the EMR. The first step in addressing these barriers was figuring out what specific SDOH are most affecting this patient population.
Methods
Working with the USC School of Public Health, MSMC created a SDOH screening tool that volunteers can use on phone calls with the patients. This partnership resulted in a 5 question screening tool that addresses food insecurity, barriers to exercise, transportation, and housing insecurity. Additionally, a second form that goes more in depth was designed for patients who have additional SDOH barriers covering mental health, substance use, disability, and public safety.
Results
Using this screening tool so far, MSMC has identified that 30% of patients have housing insecurity, 23% of patients have transportation barriers, and 23% of patients do not have sufficient money for food and/or medications.
Discussion
A better understanding of how phrasing questions elicits improved responses from patients has greatly improved volunteers' understanding of what SDOH are most prevalent in South Carolina’s uninsured diabetic population. The ability to quickly and effectively identify these barriers allows MSMC volunteers more time addressing potential solutions to help improve their patient’s access to care.
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9:30-11:00 a.m.
Columbia Ballroom (CMCC upper level) |
Poster: 135
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| Smith, Meghan |
Moore, Teresa |
Nutrition for Whitewater Kayakers
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Abstract Text
Whitewater kayaking is an extreme outdoor sport that is growing in popularity. Difficulty can range from easier, Class I and II rivers with low risk to extreme, high-risk Class IV and V rivers. The nature of whitewater kayaking requires above-average physical fitness and adequate nutrition to fuel the activity, especially for paddlers who are on the water for extended periods of time. Kayakers need to react quickly to avoid obstacles while maintaining enough stored energy to paddle for several hours or on multi-day trips. This becomes more important as the difficulty level rises. While some research has been conducted on the nutrition of endurance athletes and the energy requirements of adventure sports, there is a lack of specific research into the nutritional habits of whitewater kayakers. The purpose of this study is to identify the current nutritional habits of whitewater kayakers and evaluate the efficacy of these diets. Through an online survey, we have compiled data regarding the current nutritional habits of 19 whitewater kayakers: 12 male and 7 female. With this information, we have developed basic nutrition recommendations for both male and female whitewater kayakers as well as specific suggestions for meals and snacks before, during, and after paddles. These findings will give whitewater kayakers a basic understanding of adequate and effective intake that will support performance on the water.
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9:30-11:00 a.m.
Exhibit Hall (CMCC lower level) |
Poster: 159
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| Adams, Ethan |
zur Loye, Hans-Conrad
Morrison, Gregory |
Conversion of Chloride Salts to Oxychlorides for Use in CERMET Wasteforms
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Abstract Text
The next generation of advanced nuclear reactors are expected to produce high-level wastes including metals, oxides, and halide salts. A ceramic-metallic composite waste, CERMET, is one possible waste form for this waste. In order to form a suitable CERMET for the immobilization of the waste, the water-soluble halide salts need to first be converted into durable oxyhalide ceramics. Herein, reaction pathways to convert the expected chloride salts into oxychlorides are presented.
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9:30-11:00 a.m.
Exhibit Hall (CMCC lower level) |
Poster: 93
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| Conrad, Sophie |
Spence, Gina |
The Media as Both Enemy and Ally of the Iran Women’s Movement
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Abstract Text
Since 1979, Iranian women have been fighting against the Islamic Republic of Iran for gender equality. However, in September 2022, this fight gained renewed momentum among Iranian women and, subsequently, renewed urgency in the public eye following the suspicious death of a young Iranian woman that can reportedly be traced back to the Islamic Republic of Iran’s police forces (Nahvi). Despite the Islamic Republic of Iran’s strict censorship in regard to news outlets and media platforms, Iranian women utilized social media and online forums to raise awareness of their dire situation and to organize protests and support groups amongst themselves. In addition to Iranian women utilizing media resources, external news platforms have reported on the Iran Women’s Movement through a myriad of lenses highlighting varying aspects of the issue. In the current digital age, it is clear that the media plays a central role in the development of social movements such as the Iran Women’s Movement. However, whether that role is beneficial or detrimental to the social movement at hand is not always clear. It is essential to the vitality of a social movement such as the Iran Women’s Movement—which, as a result of strict governmental censorship, relies on citizen journalism and external media coverage—that the role of the media is ultimately beneficial. Given these stakes, this research and analysis aims to uncover both the negative and positive effects of the media on the women’s movement in Iran and to identify areas in which improvements can be made.
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9:30-11:00 a.m.
Exhibit Hall (CMCC lower level) |
Poster: 245
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| Heslin, Sun (Lindsay) |
Sikirzhytskaya, Sasha
Shtutman, Michael |
Modifying EcoHIV to track HIV/HAND in Primary Neuronal Cultures
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Abstract Text
HIV-associated neurocognitive disorder (HAND) are complex neurocognitive diseases related to HIV and remain difficult to model. EcoHIV, also known as chimeric HIV, has been developed to model HIV in rodents and does not infect humans. This was achieved by putting the gp120 envelope protein from HIV-1 into the envelope protein of the rodent retrovirus, Moloney Leukemia Virus. As a result of this modification, the chimeric virus gains the ability to infect rodent cells but cannot infect humans. However, tracking infected cells using this model within a cell culture or in animals is challenging. We modified the virus to express mScarlet, a bright red fluorescent protein, along with the HIV genes. When we infected primary rat neuronal cell cultures with the virus, we determined the red fluorescents of microglial cells and were able to capture the motility of microglia cells. In the future, we will test the virus in animal brains to determine HIV-infected microglia's in vivo distribution and movement.
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1:00-2:30 p.m.
Exhibit Hall (CMCC lower level) |
Poster: 204
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Maccou, Elana
Lamm, Jacqueline |
Hessey, Jacob |
Surgical stabilization of rib fractures (SSRF): Can we improve outcomes for our most frail trauma patients with rib fractures?
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Abstract Text
Background: Compared to younger patients with similar injuries, patients > 55 years old with chest wall injuries have a higher risk of adverse outcomes, such as respiratory complications, ventilator use, and increased hospital length of stay (LOS), 1,2 Current data indicates that among elderly patients (>80 years old) with rib fracture, SSRF is associated with improved mortality compared to their counterparts who undergo non operative management. There is no published literature, however, which evaluates the effect of patient frailty on SSRF outcomes compared to non-operative management in patients of similar frailty in elderly age groups. Using the modified frailty score, we hypothesize that at similar times to operative intervention (early vs late), surgical stabilization of rib fractures (SSRF) improves mortality at all frailty levels versus nonoperative treatment.
Methods: We are in the process of reviewing the Prisma Richland Trauma Registry and conducting a retrospective chart review of 2,072 trauma patients with rib fractures age 55 and older. 132 were treated with SSRF between January 1, 2014, to February 12, 2024. This study seeks to prove that operative management of rib fractures via surgical stabilization of rib fractures (SSRF) improves mortality at all frailty levels when compared to nonoperative management (NOM) in patients of similar frailty and at similar time to operative intervention. Primary outcome measures include 30-day mortality, length of stay (LOS), number of ventilator days, tracheostomy, ICU LOS, incidence of pneumonia and discharge disposition.
Results and Conclusions: Ongoing
References:
1. Shi HH, Esquivel M, Staudenmayer KL, Spain DA. Effects of mechanism of injury and patient age on outcomes in geriatric rib fracture patients. Trauma Surg Acute Care Open 2017; 2: e000074.
2. Bulger EM, Arneson MA, Mock CN, Jurkovich GJ. Rib fractures in the elderly J Trauma. 2000;48:1040–6.
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1:00-2:30 p.m.
Columbia Ballroom (CMCC upper level) |
Poster: 175
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| Regmi, Paras |
Jin, Rongying |
Extremely Large Unconventional Hall Effect Observed in EuZn2As2
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Abstract Text
The search for topologically non-trivial magnetic materials with unique electronic properties has become the focal point in condensed matter physics. One effective way to study the unusual electronic properties is via Hall effect measurements, which stand as a pivotal experimental avenue for probing novel transport phenomena. We report the experimental investigation of the Hall effect in EuZn2As2, which is within the realm of emergent magnetic materials. Careful analysis of the Hall resistivity reveals the presence of ordinary Hall resistivity (\rho_{xy}^0), anomalous Hall resistivity (¬\rho_{xy}^{AHE}) and the residual Hall resistivity (\Delta\rho_{xy})\ above and below the antiferromagnetic transition temperature TN = 19 K. The magnitudes of ¬\rho_{xy}^{AHE} and \Delta\rho_{xy}\ are extremely large and spread in a wide temperature and magnetic field range. Our results indicate unusually strong field and topological effects in EuZn2As2 despite its simple crystal and magnetic structure at zero field.
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1:00-2:30 p.m.
Columbia Ballroom (CMCC upper level) |
Poster: 91
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| France, Elliott |
Tandon, Keah |
Ground 0 of South Carolina State Politics: The Page Office
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Abstract Text
Since Highschool I have had an interest in politics. I became a political science major at the University of South Carolina to further my interest and because of the unique opportunity of going to school in a Capital City. My project will be about my time at the South Carolina House of Representatives where I have worked since sophomore year as a page. I was assigned to the Labor, Commerce, and Industry Committee Chaired by Representative Sandifer III who I worked directly under. During the Spring semester, the state house is in session and legislators are present on the State House grounds debating legislation on the floor Tuesday through Thursday. While they are debating my duty is to run correspondence and legislation through the state house grounds and help the lawyers and law clerks with research on legislation. It is a lot of behind-the-scenes work, but when legislation that I have worked on is presented on the floor it is very fulfilling. I was motivated to take this position because I knew it would help me with connections in future jobs and better understand the South Carolina State Legislature. I was able to learn much about the state legislature as I had hoped along with the processes and type of legislation that is passed in South Carolina. I was also able to create connections and this being my first in-person internship, I learned how to be a professional in a very conservative setting. I will be able to use this information to apply for jobs with lobbyists and congressional figures that I have already forged connections with. I want to continue working around Columbia in a government relations job or at a lobbying firm after college. Having the knowledge and connections that I do now about how the South Carolina Government works I will be able to transition into one of these roles easier than if I had not had this experience.
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1:00-2:30 p.m.
Exhibit Hall (CMCC lower level) |
Poster: 265
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| Gardner, Chloe |
Chhetri, Sher
Lastimoso, Denzyl
Ngoam, Ngaru |
Multiple Linear Regression for Modeling Rainfall Data
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Abstract Text
It is useful to be able to predict rainfall for a variety of reasons. The practice of rainfall agriculture relies on predicting rainfall. In preparation for the rainy season, farmers prepare their fields for planting crops. Floods can also occur if we don't know how much rain is expected. Rainfall can be predicted based on a variety of climate factors. Five predictors were collected based on data sets available from 1995 to 2021 from NOAA and Weather Underground. In this work, a variety of statistics, such as r-squared, adjusted r-squared, and multiple regression lines, will be presented, followed by a discussion of their usefulness based on real data.
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1:00-2:30 p.m.
Exhibit Hall (CMCC lower level) |
Poster: 88
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| Taylor, Jacqueline |
Tandon, Keah |
Motivated by Service: Leadership Rooted in Sustainability
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Abstract Text
As a Biology major with plans to become further educated on sustainability practices, I applied for a peer leadership position with Sustainable Carolina. Sustainable Carolina is the student branch of The Office of Sustainability at the University of South Carolina. I served as a peer leader on three different teams: K-12, Environmental Justice, and the garden team. Through various methods of outreach (team meetings, youth lesson plans, garden maintenance, professional development workshops, coaching meetings, and group volunteer work) I was able to work in partnership with other students to promote sustainability practices within the campus and community. Through my peer leadership experience, I learned how to build a community, challenge ideas and perspectives, and efficiently work together to serve one another. This peer leadership experience had significant impact on not only the type of student I am, but also the person I am. My experience as a peer leader has fine-tuned my communication and leadership skills through one-on-one career planning and professional developmental workshops. This experience will allow me to achieve my future goals which are centered around growth and community partnership. The impact this leadership experience had on me is unparalleled. It gave me the why behind my actions, built up my key life values, and has shaped me into an individual motivated by service.
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1:00-2:30 p.m.
Exhibit Hall (CMCC lower level) |
Poster: 333
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| Folz, Andrew |
Tandon, Keah |
Hydrogeology Internship
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Abstract Text
During the summer of 2022, I was fortunate enough to secure an internship with Terry Environmental Services. Terry Environmental is an environmental consulting company based in Summerville, South Carolina that focuses on groundwater testing and remediation. While I worked here, I obtained valuable, hands-on experience as an Environmental Technician. I participated in activities such as conducting groundwater sampling and constructing monitoring wells. As a student studying Geological Sciences here at the University of South Carolina, I have been able to connect my knowledge from the classroom with what I saw in the field. Classes such as ‘Environmental Hydrogeology’ and ‘Structural Geology and Tectonics’ have been vital to my understanding of how water moves through aquifers, and how contaminants can potentially seep into them. Pairing the internship opportunity at Terry Environmental Services with what I have learned in the classroom has helped me gain a solid understanding of the mechanics and importance of the world of environmental consulting, and has inspired me to pursue a career in this field of work.
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9:30-11:00 a.m.
Exhibit Hall (CMCC lower level) |
Poster: 354
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| Park, Jooyeon |
Tandon, Keah |
To Another 5,187 Miles Away – What “Home” Means to Me
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Abstract Text
During Spring semester of 2023, I studied abroad at the WU (Wirtschaftsuniversität Wien) in Vienna, Austria. Studying abroad in Austria has a personal significance because it was my first-time visiting Europe. Vienna has a significant global presence, especially as a world capital of art and culture, which resonated with me as a violinist.
My time in Vienna also provided me an opportunity to start learning a new language, German, as my fourth language. I took the CEFR A1 level pre-semester German course, which happened for 2 weeks. Joining the language class was a chance to expand my global network further; I met people from all around the world, such as Australia, Taiwan, Japan, Luxembourg, and Greece. I also believed traveling around the different countries in Europe while studying abroad will steer me to step outside of the comfort zone and to immerse myself in different cultures. I traveled to 17 cities in 10 countries, most of the time as a solo traveler.
This experience of being alone in a country where I was visiting for the first time, trying to adjust in a new environment, helped me to rediscover myself: what I like to do, what makes me happy, what my strengths are. Meeting people with different identities and diverse ideas taught me how to stay culturally sensitive. As an international student from South Korea, studying in the U.S. and Austria, my experience of living in 3 different continents helped me to envision and expand the meaning of “home.” I learned that home can be where we are heading to – new or visited does not matter, but where our heart lies in. As a person who will work in multinational company post-graduation, all this learning will help me to communicate with and to understand better my colleagues. Also, one of my life goals is to live in different countries, while working as a professional. Perceiving a new place as my home will assist me to cope actively with the changing environments and enjoy life, aligning with my future endeavors.
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1:00-2:30 p.m.
Exhibit Hall (CMCC lower level) |
Poster: 239
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| Tremolada, Marta |
Tandon, Keah |
Pouring the Foundation for a Career in Training and Development
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Abstract Text
During the summer of 2023, I worked for The SEFA Group, now acquired by the German multinational building materials company, Heidelberg Materials. The core of SEFA Group's business is to process and market fly ash for use in concrete. In addition to fly ask marketing and sales, SEFA is home to 3 other business units: CCP services, Transportation, and Industrial construction services, all of which provide for a large and diverse employee base. Because of my Psychology Minor and Business major, the company offered me an internship in which I was both able to work in the Human Resources and Marketing department simultaneously. For the greater half of my typical week, I worked alongside the Corporate HR Team to help facilitate new hire employee orientations, file important employee documentation, and assist with the transition their new HR and Payroll software, Kronos. I was also able to work with the Training and Development department branch of HR, helping create training lessons and follow-up knowledge tests for employees. In the marketing department, I designed several social media posts, researched current competitor press releases, and assembled new hire employee welcome boxes with company merchandise. Through this internship, I was able to discover which area of business administration I loved most and find my true passion in the Training and Development department, which combined my love for teaching with the business world. Because of this experience, I will be looking to continue my education in this field by completing a Masters in HR and pursuing a career in the Training and Development department after graduation.
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9:30-11:00 a.m.
Exhibit Hall (CMCC lower level) |
Poster: 355
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| Mast, Laura |
Spence, Gina |
Barcelona: A Journey Through Design, Culture, and Community Engagement
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Abstract Text
This submission and experience - all wrapped into one - explores life in Barcelona while experimenting in the arts, specifically in digital design. For a total of 15 weeks in Barcelona, I attended a historically known design university while exploring Catalan culture, the diversity of Spain, and a constant collaboration with other artists/designers from around the world. The scope of this experience going abroad was to accomplish two things. Primarily to be exposed to new processes of design and learn how to create realistic solutions to help very existent and common problems our communities face. Secondly, to leave Barcelona bi-linguial in Spanish, even though Spanish is not the first language spoken in that region.
The courses I completed while abroad were a mix of unfamiliar design tracks and fine art mediums I have never tapped into before. I was able to indulge in Food Design, Film and Videography, Visual Merchandising & Retail Design, and Documenting Historical Contexts of Barcelona. I learned so much living in Barcelona whether it be professionally, socially, creatively, and I encountered so many new experiences. The biggest impact for me was meeting so many unique people, collaborating with different designers, and having the opportunity to help teach English in a local elementary school. I also was able to participate in traditional Catalan holidays, festivals, and public city events that let me understand the history of this community and what they are working towards for the future of Catalonia. My professors and classes opened my mind in so many ways with how I can communicate important messages or feelings while selling concepts, research, and more. Most of my case studies and projects at Elisava were collaborative, which often meant working with different work-styles, language barriers, and culturally different backgrounds. This allowed and encouraged a great amount of experimentation using unfamiliar methods/materials: food, video, motion graphics, 3D modeling, public installations, and walking tours. I discuss the profound shifts in my academic and personal life both inside and outside the classroom, following my return from a transformative global learning journey!
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1:00-2:30 p.m.
Exhibit Hall (CMCC lower level) |
Poster: 240
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Greenwalt, Hayden
Tindall, Mary |
Montie, Eric
Marian, Alyssa
Blake, Lily
Willford, Garrett
Miller, Jessica
McClellan, Warren |
The Estuarine Soundscape Observatory Network in the Southeast (ESONS) – Ten Years of Listening to Estuaries in South Carolina!
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Abstract Text
Understanding the temporal rhythms and spatial patterns of underwater soundscapes is an emerging field in marine ecology. Soundscapes are composed of acoustic signals of biological origin, naturally occurring geophysical sounds, and human-made noise. Soundscape data can be used to monitor animal behavior at multiple levels of biological complexity (e.g., from snapping shrimp to fish to marine mammals), and current technology allows one to remotely detect these sounds at time scales ranging from minutes to years. A key advantage of this technology for marine ecology is that acoustic recorders allow for high temporal sampling (e.g., 24 samples per day), which is not possible through traditional abundance or biodiversity surveys. In the present study, our goal was to illustrate data from the Estuarine Soundscape Observatory Network in the Southeast (ESONS), which listens to underwater sounds in four estuaries of South Carolina (SC) – the May River (2013-present), Chechessee Creek/Colleton River (2019-present), Charleston Harbor (2017-present), and North Inlet-Winyah Bay National Estuarine Research Reserve (2020-2023). From our longest listening stations in the May River estuary (i.e., a ten-year dataset), we provide a heat map time series of high frequency sound pressure levels (SPLs), which illustrates how sound levels change seasonally following the acoustic behavior of snapping shrimp. In addition, we present a heat map, time series of low frequency SPLs, which illustrates how sound levels change daily and seasonally following the collective courtship sounds of fish. The soundscape approach provides the ability to ‘eavesdrop’ on key behaviors of marine animals, which can change rapidly or gradually in response to environmental changes and human impacts. This approach can provide a measure of resilience or shifting baselines in a globally changing environment.
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1:00-2:30 p.m.
Exhibit Hall (CMCC lower level) |
Poster: 83
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| Colon-LaBorde, Victoria |
Jalilvand, Golareh |
Investigating the Effect of Carbon Material on Mechanical Stability of Sulfur Cathodes in Lithium Sulfur Batteries
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Abstract Text
Flexible batteries are the key enabler of a broad range of applications from wearable biomedical sensors to foldable electronics for the Internet of Things (IoT). There has been a considerable enhancement in flexible battery research owing to the progress in lithium-ion battery (LIB) technology. This progress has been primarily in the electrochemical performance of LIBs. Yet, modern LIBs, with graphite-based anodes and transition metal oxide-based cathodes, lack structural stability when exposed to mechanical fatigue, which is inevitable in flexible gadgets. Therefore, alternative material chemistries and electrode designs for flexible batteries are imperative.
In the search for alternative cathode material, Sulfur has become a promising candidate. Because of its high theoretical capacity, low price, and non-toxicity, sulfur cathode is the optimal choice to create high-energy-dense batteries, known as lithium-sulfur batteries (LSBs). Sulfur intrinsically does not offer significant mechanical stability, however its processing methods during electrode preparation addresses this issue. Sulfur is an insulating material, which inhibits electron transfer through the electrode. Therefore, it is normally mixed with a combination of conductive carbon materials. This results in a mechanically robust sulfur/carbon composite that can stand the repeated stresses under curvature, while providing sufficient electrical conductivity.
In this project, the impact of carbon materials and ratios on sulfur cathode performance were studied in lithium-sulfur batteries. Two types of carbon materials were selected including Ketjen Black and Graphene. The Ketjen Black:Graphene ratios of 100:0, 50:50 to 25:75, 15:85, 5:95, and 0:100 were investigated. The sulfur and carbon mix were combined with a binder solution to create an ink, which was coated onto an aluminum foil current collector using doctor blade technique. The cohesion and integrity of coated electrodes were studied as a function of carbon chemistry and content. The study reveals that a 5:95 ratio of Ketjen Black to Graphene yields the most significant capacity improvement and crack reduction, making it promising for flexible batteries. Future research will focus on transitioning to mechanically stable substrates like bucky paper to mitigate battery degradation under mechanical stress.
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1:00-2:30 p.m.
Exhibit Hall (CMCC lower level) |
Poster: 101
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| Frick, Marla |
Fadel, Jim
Reagan, Lawrence |
Orexin/hypocretin modulation of neuroinflammation in a rodent model: implications for age-related cognitive decline
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Abstract Text
The orexin/hypocretin neuropeptide system, primarily found in the lateral hypothalamus and perifornical region, modulates sleep, wakefulness, appetite, and cognitive function. One region with dense orexinergic projections is the basal forebrain (BF), which is the major source of acetylcholine in the neocortex and limbic structures such as the hippocampus. The basal forebrain cholinergic system mediates cognition and dysfunction is one of the key hallmarks of Alzheimer’s disease. We have previously shown significant reductions in orexin signaling and orexinergic innervation of cholinergic cells within the BF of aged rodents. Loss of orexin impairs cholinergic neurotransmission and cognition, but the mechanisms responsible remain poorly understood. Recent evidence suggests neuroinflammation as a contributing factor to the pathogenesis of Alzheimer’s disease. It has been suggested that orexin may be neuroprotective, and we hypothesize that the age-related loss of orexin neurons diminishes the brain’s anti-inflammatory response, leading to basal forebrain cholinergic dysfunction.
Here, we administered lentivirus mediated expression of Preproorexin antisense or sense into the lateral hypothalamus of young adult (3 months; antisense) and aged (22-26 months; sense), male and female Fisher 344/Brown Norway F1 hybrid rats. Three weeks later, a neuroinflammatory response was induced with an acute lipopolysaccharide (1 mg/kg, intraperitoneal) challenge. 6 hours later, brains were removed and bilaterally dissected with one hemisphere post-fixed for immunohistochemical analysis and one hemisphere frozen for cytokine analysis.
Lentivirus efficacy was verified using immunohistochemistry for green fluorescent protein expression and changes in orexin expression within the lateral hypothalamus and terminal regions. There was no significant difference in total Iba-1 (a marker of microglia—the brain’s resident immune cells) in the basal forebrain, but there was a shift in activation state towards a pro- inflammatory, “M1” phenotype in the orexin antisense-treated rats. In addition, there was an increase in the inflammatory cytokines, IL-6 and TNF-alpha in the prefrontal cortex of orexin antisense treated male rats.
Loss of orexin expression in aging may facilitate neuroinflammatory processes in key regions, such as the BF and prefrontal cortex, and thereby contribute to neurodegeneration and cognitive decline.
Supported by NIH R01 AG050518 and 2RF1 AG050518.
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9:30-11:00 a.m.
Columbia Ballroom (CMCC upper level) |
Poster: 86
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| Howard, Sydney |
Tandon, Keah |
Finding My Niche Through Legislative Tracking at the SC State House
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Abstract Text
During the Spring of 2023, I worked as a Legislative Tracking Intern at Hannah News Service in Columbia, SC. Hannah News Service is a legislative news provider that tracks the status of current and past legislation, sends out updates on statehouse news, and researches trends. Located just a few blocks from the South Carolina State House, Hannah News Service is a useful tool for lobbyists, lawyers, legislators, and anyone with interest in state policies. As a pre-law student at the University of South Carolina, and aspiring environmental law student, my internship at Hannah News Service served as an opportunity to learn the ins and outs of the state legislature, different types of legal careers, and commonly used data tracking systems. In my role, I was responsible for taking detailed notes on committee meetings, compiling data in the tracking system, and updating clients through the portal. Because of my experience as well as my class in environmental advocacy, I am better able to inform my future career decisions and in what sector I want to practice environmental law. Instead of finding a career in government, like I originally thought I would want, I now know that public interest environmental law is where I should focus my career goals. I think that other students considering legal or government careers would benefit from a legislative tracking internship, and that it would help them narrow their career interests – just like it helped me do.
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1:00-2:30 p.m.
Exhibit Hall (CMCC lower level) |
Poster: 266
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| Brockhard, Anabel |
Metcalfe, Christi
Suiter, Emily |
Unpacking the Purpose and Goals of Adult Mental Health Court Across the U.S.: A Qualitative Analysis of the Mission Statements
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Abstract Text
An estimated 43% of people in state prisons have been diagnosed with a mental disorder. The effects of a mental disorder can include impaired decision-making, reasoning, and cognitive understanding capabilities, which often co-occurs with substance abuse disorders and other challenges, such as unemployment, homelessness, and poverty. Each of these factors can increase the likelihood of committing a criminal offense, make it infinitely more difficult for a person to understand and successfully complete their sentence, and significantly increase their risk of reoffending. Mental Health Courts have been established throughout America to address concerns regarding the incarceration, rehabilitation, and recidivism of mentally ill criminal offenders. Unfortunately, there remains a considerable void in the general understanding of MHCs, which are left to largely operate upon their own discretion. Investigation into the specific practices and missions of these MHCs can provide a strong basis to influence policy regarding the treatment of mentally ill criminal offenders. As such, the purpose of this research project is to narrow the gap in knowledge surrounding the missions and practices of these Mental Health (MHCs). First, using information provided online and by contacting individual MHCs, the research term created a cumulative database of adult MHCs around the country. Then, the research team qualitatively coded and analyzed mission statements found on the respective websites of each of these courts, identifying key themes in the missions of these courts.
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9:30-11:00 a.m.
Exhibit Hall (CMCC lower level) |
Poster: 17
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| Khabibullina, Polina |
Chamberlain, Kimberly |
Navigating Real-World Challenges at The Carolina Agency
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Abstract Text
In the Fall 2023 semester, I had the chance to intern at The Carolina Agency (TCA) as the Co-Director of Accounts. The Carolina Agency is a full-service strategic communication agency in the School of Journalism and Mass Communications at the University of South Carolina. It is a student-run agency that produces a variety of deliverables to real clients.
In The Carolina Agency, we had three different departments: Accounts, Creative, and Research. I had the chance to contribute to the agency’s development by leading the Accounts team of 15 students alongside my coworker Lindsey. We collectively managed nine clients, such as Game Changers, CreateAthon, and others. I was responsible for advising our team’s students on effective communication with clients and providing guidance on managing workload and client expectations. I also practiced my writing skills by being responsible for proofreading and editing all of the media pitches and other writing materials that needed to be received by clients.
Interning at TCA gave me an opportunity to get a hands-on experience and improve my previously gained skills. I wanted to see what it was really like to work in the public relations field, and I couldn’t have found a better way for that. Collaborating with such a diverse group of individuals and witnessing their success was definitely inspiring. Facing challenges of working with real clients has made a great impact on my professional approach. With TCA, I learned how to manage my time better and deal with unexpected changes and potential crises. I got a clearer understanding of the concepts that I had previously learned in my Principles of Management and Principles of Public Relations classes. For instance, Lindsey and I had to deal with our students not reaching all the goals in their work and us making last minute changes to prevent the clients being affected. My experience at The Carolina Agency has not only allowed me to apply knowledge and leadership skills but has also deepened my comprehension of the public relations field and conflict management.
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1:00-2:30 p.m.
Exhibit Hall (CMCC lower level) |
Poster: 327
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| Gettleman, Brandon |
Christ, Alexander |
Surgical Intervention of Chondroblastoma in Pediatric Patients May Lead to Future Angular Deformity
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Abstract Text
Background:
Chondroblastoma is a rare, benign bone tumor that comprises approximately 5% of all benign bone tumors and 1% to 2% of all primary bone tumors. These tumors are known to have a propensity for the epiphyses of long bones in skeletally immature patients, with surgical management being the preferred treatment modality. Thus, this study aims to investigate the clinical outcomes and recurrence rate of surgically managed chondroblastoma of the extremities.
Methods:
A retrospective review was performed at a tertiary pediatric hospital between 2004 and 2019. Inclusion criteria consisted of patients treated surgically for pathologically confirmed chondroblastoma with a minimum of 6 months of follow-up. Patients with initial treatment at the institution for a recurrent tumor or incomplete records were excluded. Electronic medical records were used to collect patient demographics, lesion location, treatment technique, incidence of recurrence, and presence of deformity. Statistical analyses were performed through STATA and Microsoft Excel.
Results:
Thirty-three patients met inclusion criteria with a mean age of 13.82 ± 2.08 years (range 9-18) and a mean follow-up of 2.15 ± 1.13 years. The cohort consisted of 25 males and 8 females. The tumors were most commonly located in the femur (15, 45.5%). Recurrence was found in 3 (9.1%) individuals, and angular deformity developed in 5 (15.2%). The mean tumor size was 2.8 ± 1.4 cm. There was no significant correlation between age and recurrence (p = 0.616) and tumor size and recurrence (p = 0.247).
Conclusion:
With a recurrence rate of 9% and a deformity rate of 9.1%, our results are consistent with previous literature. All studied adjuvants appear equally effective although potentially underpowered to detect a difference. Importantly, this study identified the development of angular deformities in 15% of patients, with each patient requiring subsequent treatment. Thus, it may be important for physicians to consider these findings when determining patient follow-up and counseling families on long-term outcomes during the treatment of chondroblastomas.
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1:00-2:30 p.m.
Columbia Ballroom (CMCC upper level) |
Poster: 222
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| Headen, Jordan |
Welshhans, Kristy |
BDNF increases the adhesion protein paxillin in growth cones of the developing mammalian nervous system
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Abstract Text
The health of the nervous system is dependent upon axons successfully traveling to their synaptic targets during neural development. The accuracy of this process relies on axonal structures and their ability to respond appropriately to extracellular cues. Growth cones, transient structures enriched in microtubules and actin and present on the ends of axons during neural development, are the main drivers behind axon guidance. Dynamic adhesion sites within growth cones, termed point contacts, link the extracellular matrix (ECM) to the intracellular actin cytoskeleton and generate force to direct growth cone motility. When a chemoattractant is encountered, point contacts increase on the side of the growth cone closest to the cue. When a chemorepellent is encountered, point contacts disassemble on the side of the growth cone closest to the cue. This dynamism of point contacts is vital for the precise navigation of growth cones through the developing nervous system. Paxillin, talin, and vinculin are adhesion proteins that localize to and collectively can adjust the amount of force within the adhesion sites. Brain-derived neurotrophic factor (BDNF) is an attractive guidance cue that has been shown to affect point contact dynamics in Xenopus neurons. However, much remains unknown about adhesions and the role BDNF plays in forming adhesion sites within the developing mammalian nervous system. Here, we show that BDNF increases the overall fluorescent intensity of paxillin, but not talin or vinculin, in embryonic murine cortical neuron growth cones. BDNF also does not increase the colocalization between the proteins paxillin, talin, and vinculin. Lastly, we show that BDNF does not alter the average fluorescent intensity of colocalized puncta of the three proteins. These results suggest that BDNF signaling increases the localization of paxillin within growth cones during neural development, indicating that BDNF may regulate adhesion formation to mediate axon growth and guidance. Together, these analyses allow us to understand better the dynamics of adhesion sites that are critical to the formation of the mammalian nervous system.
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9:30-11:00 a.m.
Columbia Ballroom (CMCC upper level) |
Poster: 44
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Hoyer, Erica
Okoro, Chiesoiro |
Dawson, Robert |
The Effects of Online Video Games on Prosocial Behavior
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Abstract Text
Prosocial behavior, behaviors that are beneficial to an individual’s needs, has been a subject of interest in research as it relates to video games. Research has shown that exposure to prosocial video games can lead to an increase in prosocial thoughts and behaviors (Li & Zhang, 2022). This association is mediated by the impact of prosocial video games on individuals’ affect and thoughts, indicating a potential mechanism through which these games influence behavior (Greitemeyer & Osswald, 2010). Furthermore, cooperative gameplay has been found to increase cooperation, emphasizing the positive effects of playing video games cooperatively (Greitemeyer & Cox, 2013). Results have indicated that playing collaborative games increases cooperation in prosocial individuals by facilitating trust within their gaming partners (Zheng, et al., 2020). However, it is important to note that the relationship between video games and prosocial behavior is complex. While cooperative gameplay has been associated with positive outcomes, there is also evidence suggesting that engagement with violent video games may not necessarily lead to increases in aggression or reductions in prosocial behavior (Hollingdale & Greitemeyer, 2014). Furthermore, multiplayer video games may also pose challenges that promote competitiveness and cooperation among players. Li and Zhang (2023) discovered that utilizing prosocial video games, games where players must cooperate in order to succeed (Harrison & O’Connell, 2016), helps encourage prosocial thoughts, thus promoting prosocial behavior. This highlights the need for further research to comprehensively understand the impact of different types of video games on cooperation and prosocial behavior (Ruiz-Fernandez, et al., 2021). In conclusion, the literature suggests that cooperative gameplay in video games has the potential to enhance cooperation, teamwork, and prosocial attitudes; however, the relationship between video
games and prosocial behavior is multifaceted, and further research is needed to fully understand the mechanisms through which video games influence cooperation and prosocial behavior.
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9:30-11:00 a.m.
Columbia Ballroom (CMCC upper level) |
Poster: 8
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| Reagan, Judi |
Cranmer, Robyn |
Studying in Morocco and Examining Diverse Perspectives
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Abstract Text
I will be presenting on my experience studying abroad in Morocco for two weeks with the Preston and Maxcy Living and Learning Communities in the spring of 2022. I chose to go on this trip because I wanted to push myself to experience the world outside of the United States in order to gain a fuller understanding of the diversity of culture and language and develop a better understanding of the experiences of Moroccan people. A small group of about twenty UofSC Students travelled to Morocco with the organization CIEE, which allowed us to experience the country with native guides. While in Morocco, I discovered a beautiful nation that operates very differently from the United States in both governmental organization and daily life. The experience allowed me to truly understand the variety of perspectives that exist in the world and helped me examine my own views, beliefs, and biases. This experience will help me to better communicate and work with people of varying opinions and beliefs in my future internationally focused career.
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1:00-2:30 p.m.
Exhibit Hall (CMCC lower level) |
Poster: 248
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| Hildreth, Ally |
Childs, Matt |
Justifications for Caribbean Colonization From the 15th to 19th Century
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